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The map label for this gene is cysK [H]

Identifier: 83595123

GI number: 83595123

Start: 4344000

End: 4345019

Strand: Reverse

Name: cysK [H]

Synonym: Rru_A3794

Alternate gene names: 83595123

Gene position: 4345019-4344000 (Counterclockwise)

Preceding gene: 83595124

Following gene: 83595122

Centisome position: 99.82

GC content: 66.47

Gene sequence:

>1020_bases
ATGGAACTGGAAAAAGCCATGACCGTGATCGCTCCGTCCGCCGCCTCCGAGTCCGTCGGCACCAGCGCGACCGACATCGA
GTTCCGCGGCAAGGTCTATGACTCGATCGTCGACACCATCGGCGCCACGCCGCTGGTCCGGCTGGCGCGCTTTTCCAAGG
CCCATGGCGTGGTCGCCGACCTGCTTGGCAAATGCGAATTCTTCAATCCGCTGGCCAGCGTCAAGGACCGCATCGGCTTC
GCCATGATCGATGCCGCCGAACGCGACGGCCGCATCAAGCCCGGCGCCACCCTGGTCGAACCGACCTCGGGCAATACGGG
CATCGCCCTGGCCTTCGTTTGCGCCGCGCGCGGCTACCGGCTGATCTTAACCATGCCCGAAAGCATGTCGATCGAGCGCC
GCAAGATGCTGACCCACCTCGGCGCCGAAATCGACCTGACCCCGGCGGCCAAGGGCATGAAGGGCGCCGTCGCCCGCGCC
CAGGAACTGGTCGAGAGCATTCCCGGCGCCGTGCTGCTTCAGCAGTTCGACAATCCGGCCAACCCCGAGATCCATCGCCA
GACCACCGCCCAGGAAATCTGGAACGATACCAACGGCGCCGTTGATATCGTGGTGTCGGGCGTGGGCACCGGCGGCACGG
CGACCGGCATCGCCAGCGTCCTCAAAAAGCTCAAGCCCAGCGTCAAGCTGGTGGTCGTCGAGCCCGAGGACAGCCCGGTG
ATCAGCGGTGGCGCCCCGGGGCCCCACAAGATCCAGGGCATCGGCGCCGGCTTCATTCCGGGCAATCTCGATGTCAGCCT
GATCGATGAAGTGGTCAAGGTCGCCAACGAAACCGCCTTCGCCACCGCCCGCGCCGTCGCCCGTCAGGAAGGCGTGCCGG
TGGGGATTTCCTCGGGCGCGGCCCTGGCCGCCGCCGTCGAGGTCGGCCAGCGCCCGGAAAACAAGGATAAAACCCTGGTG
GTCATCCTGCCCAGCTTCGCCGAGCGCTATCTGTCGACGCCGCTGTTCGAGCAGCCCTGA

Upstream 100 bases:

>100_bases
GCGGGTGGCCAAGCCCGGGAAAACGCCGGGAATCATTTGACATCGGCCGATGCCGGTGTAAATACAGATCAATAGGTGTT
TATGCCTTTCTAATTACACA

Downstream 100 bases:

>100_bases
GCGGCCGATCGCCCCGGGCGGGGTGGTGGCTCTCGCCCCGGGCGGGGCGGTGGCTCTCGCCCCAGGCGGGGCGGTGGCTG
TTGAACTCGGCGCGGATTCC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MELEKAMTVIAPSAASESVGTSATDIEFRGKVYDSIVDTIGATPLVRLARFSKAHGVVADLLGKCEFFNPLASVKDRIGF
AMIDAAERDGRIKPGATLVEPTSGNTGIALAFVCAARGYRLILTMPESMSIERRKMLTHLGAEIDLTPAAKGMKGAVARA
QELVESIPGAVLLQQFDNPANPEIHRQTTAQEIWNDTNGAVDIVVSGVGTGGTATGIASVLKKLKPSVKLVVVEPEDSPV
ISGGAPGPHKIQGIGAGFIPGNLDVSLIDEVVKVANETAFATARAVARQEGVPVGISSGAALAAAVEVGQRPENKDKTLV
VILPSFAERYLSTPLFEQP

Sequences:

>Translated_339_residues
MELEKAMTVIAPSAASESVGTSATDIEFRGKVYDSIVDTIGATPLVRLARFSKAHGVVADLLGKCEFFNPLASVKDRIGF
AMIDAAERDGRIKPGATLVEPTSGNTGIALAFVCAARGYRLILTMPESMSIERRKMLTHLGAEIDLTPAAKGMKGAVARA
QELVESIPGAVLLQQFDNPANPEIHRQTTAQEIWNDTNGAVDIVVSGVGTGGTATGIASVLKKLKPSVKLVVVEPEDSPV
ISGGAPGPHKIQGIGAGFIPGNLDVSLIDEVVKVANETAFATARAVARQEGVPVGISSGAALAAAVEVGQRPENKDKTLV
VILPSFAERYLSTPLFEQP
>Mature_339_residues
MELEKAMTVIAPSAASESVGTSATDIEFRGKVYDSIVDTIGATPLVRLARFSKAHGVVADLLGKCEFFNPLASVKDRIGF
AMIDAAERDGRIKPGATLVEPTSGNTGIALAFVCAARGYRLILTMPESMSIERRKMLTHLGAEIDLTPAAKGMKGAVARA
QELVESIPGAVLLQQFDNPANPEIHRQTTAQEIWNDTNGAVDIVVSGVGTGGTATGIASVLKKLKPSVKLVVVEPEDSPV
ISGGAPGPHKIQGIGAGFIPGNLDVSLIDEVVKVANETAFATARAVARQEGVPVGISSGAALAAAVEVGQRPENKDKTLV
VILPSFAERYLSTPLFEQP

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=343, Percent_Identity=40.5247813411079, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI295821200, Length=343, Percent_Identity=40.5247813411079, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4557415, Length=343, Percent_Identity=40.5247813411079, Blast_Score=238, Evalue=7e-63,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=56.8253968253968, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=41.3907284768212, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=53.3112582781457, Blast_Score=307, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=51, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=51.4563106796116, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=51.5254237288136, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=51.3071895424837, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=49.0566037735849, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17534315, Length=334, Percent_Identity=41.9161676646707, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI25147552, Length=336, Percent_Identity=38.9880952380952, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=50.8620689655172, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71996324, Length=302, Percent_Identity=24.5033112582781, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=40.1273885350318, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=33.2326283987915, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24643623, Length=335, Percent_Identity=37.3134328358209, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI20129101, Length=335, Percent_Identity=37.3134328358209, Blast_Score=204, Evalue=9e-53,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35400; Mature: 35400

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEKAMTVIAPSAASESVGTSATDIEFRGKVYDSIVDTIGATPLVRLARFSKAHGVVAD
CCHHHHHHEECCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHH
LLGKCEFFNPLASVKDRIGFAMIDAAERDGRIKPGATLVEPTSGNTGIALAFVCAARGYR
HHHHHHHCCHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCE
LILTMPESMSIERRKMLTHLGAEIDLTPAAKGMKGAVARAQELVESIPGAVLLQQFDNPA
EEEECCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NPEIHRQTTAQEIWNDTNGAVDIVVSGVGTGGTATGIASVLKKLKPSVKLVVVEPEDSPV
CCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCE
ISGGAPGPHKIQGIGAGFIPGNLDVSLIDEVVKVANETAFATARAVARQEGVPVGISSGA
ECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEECCCCC
ALAAAVEVGQRPENKDKTLVVILPSFAERYLSTPLFEQP
HHHHHHHHCCCCCCCCCEEEEECCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MELEKAMTVIAPSAASESVGTSATDIEFRGKVYDSIVDTIGATPLVRLARFSKAHGVVAD
CCHHHHHHEECCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHH
LLGKCEFFNPLASVKDRIGFAMIDAAERDGRIKPGATLVEPTSGNTGIALAFVCAARGYR
HHHHHHHCCHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCE
LILTMPESMSIERRKMLTHLGAEIDLTPAAKGMKGAVARAQELVESIPGAVLLQQFDNPA
EEEECCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NPEIHRQTTAQEIWNDTNGAVDIVVSGVGTGGTATGIASVLKKLKPSVKLVVVEPEDSPV
CCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCE
ISGGAPGPHKIQGIGAGFIPGNLDVSLIDEVVKVANETAFATARAVARQEGVPVGISSGA
ECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEECCCCC
ALAAAVEVGQRPENKDKTLVVILPSFAERYLSTPLFEQP
HHHHHHHHCCCCCCCCCEEEEECCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]