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The map label for this gene is hisB

Identifier: 83594926

GI number: 83594926

Start: 4138932

End: 4139531

Strand: Reverse

Name: hisB

Synonym: Rru_A3597

Alternate gene names: 83594926

Gene position: 4139531-4138932 (Counterclockwise)

Preceding gene: 83594930

Following gene: 83594925

Centisome position: 95.1

GC content: 55.83

Gene sequence:

>600_bases
ATGCGACAGGCCACCGTCACGCGCGCAACCAAGGAAACAGAGATAACCGTCTGGCTCGACCTGGATGGAACCGGGCAATA
CGAGGTTTCAACGGGCATCGGCTTCCTTGACCACATGCTGGAGCAAGTATCGCGCCATAGTTTGATGGATCTGCGGGTAC
ATGCCAAAGGTGATACTCACATCGATTTCCACCACACGACCGAGGACACTGGACTGGCGATCGGTCAGGCGGTGACCCAA
GCGTTAGGAGATCGCAAGGGAATTCAACGGTATGGCTCGGCTCTCATCCCTATGGACGAGGCGCTGACCCAGGTTGCGGT
GGATCTGTCCAATCGGCCCTACCTCATCTGGAAGGTCGATTTTTCCCGGGACAAGCTAGGCGATATGGATACCGAACTCT
TCAAGGAATGGTTCCAGGCATTCTCTCAAACAGCCGGCGTAACGTTGCACGTTGCAAATCACTATGGGGAAAACAACCAC
CACATCGTTGAATCCTGCTACAAAGCCTTGGCACGCGCGCTCCGCCAAGCTTGGGAAATAGATCCCAGGAAAGCGGATGC
GGTCCCCTCCACCAAAGGGGTGCTTGGTGGCACCCTCTAG

Upstream 100 bases:

>100_bases
AGTTCTTTCAAAGGCTGGGCGGCGATGATGGCTTTTTTTATCCTTGCATTCCGCCCATTTACCGCATCCTGACTAGGATG
CTTTTGGAGAAATACTCGGC

Downstream 100 bases:

>100_bases
AACACGTTGAGACCGTTTTCCTCATCCTTTGGTCGGATGTTTCGGAAACGGCCGGCGGTAACTGACCATGGAATAATTCA
ACTCGCAAGTAGATTGAGCA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MRQATVTRATKETEITVWLDLDGTGQYEVSTGIGFLDHMLEQVSRHSLMDLRVHAKGDTHIDFHHTTEDTGLAIGQAVTQ
ALGDRKGIQRYGSALIPMDEALTQVAVDLSNRPYLIWKVDFSRDKLGDMDTELFKEWFQAFSQTAGVTLHVANHYGENNH
HIVESCYKALARALRQAWEIDPRKADAVPSTKGVLGGTL

Sequences:

>Translated_199_residues
MRQATVTRATKETEITVWLDLDGTGQYEVSTGIGFLDHMLEQVSRHSLMDLRVHAKGDTHIDFHHTTEDTGLAIGQAVTQ
ALGDRKGIQRYGSALIPMDEALTQVAVDLSNRPYLIWKVDFSRDKLGDMDTELFKEWFQAFSQTAGVTLHVANHYGENNH
HIVESCYKALARALRQAWEIDPRKADAVPSTKGVLGGTL
>Mature_199_residues
MRQATVTRATKETEITVWLDLDGTGQYEVSTGIGFLDHMLEQVSRHSLMDLRVHAKGDTHIDFHHTTEDTGLAIGQAVTQ
ALGDRKGIQRYGSALIPMDEALTQVAVDLSNRPYLIWKVDFSRDKLGDMDTELFKEWFQAFSQTAGVTLHVANHYGENNH
HIVESCYKALARALRQAWEIDPRKADAVPSTKGVLGGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=48.4536082474227, Blast_Score=189, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=41.743119266055, Blast_Score=176, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_RHORT (Q2RNA4)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428678.1
- HSSP:   P34047
- ProteinModelPortal:   Q2RNA4
- SMR:   Q2RNA4
- STRING:   Q2RNA4
- GeneID:   3837053
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3597
- NMPDR:   fig|1085.1.peg.1900
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q2RNA4
- ProtClustDB:   PRK00951
- BioCyc:   RRUB269796:RRU_A3597-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22204; Mature: 22204

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQATVTRATKETEITVWLDLDGTGQYEVSTGIGFLDHMLEQVSRHSLMDLRVHAKGDTH
CCCCHHCCCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCHHEEEEEECCCCE
IDFHHTTEDTGLAIGQAVTQALGDRKGIQRYGSALIPMDEALTQVAVDLSNRPYLIWKVD
EEEECCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEE
FSRDKLGDMDTELFKEWFQAFSQTAGVTLHVANHYGENNHHIVESCYKALARALRQAWEI
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
DPRKADAVPSTKGVLGGTL
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRQATVTRATKETEITVWLDLDGTGQYEVSTGIGFLDHMLEQVSRHSLMDLRVHAKGDTH
CCCCHHCCCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCHHEEEEEECCCCE
IDFHHTTEDTGLAIGQAVTQALGDRKGIQRYGSALIPMDEALTQVAVDLSNRPYLIWKVD
EEEECCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEE
FSRDKLGDMDTELFKEWFQAFSQTAGVTLHVANHYGENNHHIVESCYKALARALRQAWEI
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
DPRKADAVPSTKGVLGGTL
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA