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The map label for this gene is htpX

Identifier: 83594908

GI number: 83594908

Start: 4122796

End: 4123677

Strand: Direct

Name: htpX

Synonym: Rru_A3579

Alternate gene names: 83594908

Gene position: 4122796-4123677 (Clockwise)

Preceding gene: 83594905

Following gene: 83594911

Centisome position: 94.72

GC content: 65.53

Gene sequence:

>882_bases
ATGAGCTTCTTCCGCGTCGCCGTGATGTTGGCCGCCATGACCGGCCTGTTCCTTGCCGTCGGCTATCTGATCGGCGGCCA
GAGCGGCATGGTCATCGCCTTTCTGGTCGCCGGCGGCATGAACCTGTTCGCCTATTGGAATTCCGACAAGATGGTGCTGC
GCATGCACAATGCGCGCGAGGTCGACGAACGCAGCGCGCCCGACCTGTATGGCATCGTCCGCCAGTTGACCCAGCGCGGC
GGCCTGCCGATGCCCAAGGTCTATGTGATCGACACCCCCCAGCCCAATGCCTTCGCCACCGGCCGCAATCCGCAAAACGC
CGCCGTGGCGGCGACGACCGGGCTGATGCGGGCGCTCACCCCCCAGGAACTGGCCGGAGTGATGGCCCATGAACTGGCCC
ATGTCCGCCATCATGACACCCTGACCATGACCCTGACCGCCACCCTGGCCGGCGCCATCTCGATGCTGGCGAATTTCGCC
TTCTTCTTTGGCGGCAACCGCGACAACAACAATCCGCTGGGCGCCGTCGGCATGATCGTGATGATGATCCTGGCGCCTTT
GGCGGCGATGATGGTGCAGATGGCGATTTCACGCACCGCTGAATACCGCGCCGATCGCGGCGGCGCCGAGATCTGCGGTC
AGCCGCTGTGGCTGGCCAGCGCCCTTGAAAAGATCGAACGCGCCGCGCGCGGCATCGAAAACCCCTCGGCCGAACAGAAT
CCGGCCACCGCCCATCTGTTCATCATCAATCCCTTGAACGGCCATCGGATGGACAATCTGTTCACCACCCATCCCAGCAC
CGCCAACCGCGTGGCCAAGCTGCGCGCCCTGGCCAGTGGCGACCTCGCTCAGCCCCGGCCCCAGCGCGGCCCCTGGGGCT
GA

Upstream 100 bases:

>100_bases
GGCCCCATGCGCAGGGCCGCCACCCGTCATCGGTGACTTGACGGGGCTTTCCCTTGCCTTATCTCAGGATCGCCGCCCCG
TCCATCCTGGAGAACCCGCG

Downstream 100 bases:

>100_bases
GCGGCGGGCGGGCTCAGCCCCCGCGCTTTGATCTGGCGAGCATCGACTTGCCCGCCAGCAGGGCGCCGCCAACGATCAAC
AGGCAGGCGGCGCCGACCAG

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSFFRVAVMLAAMTGLFLAVGYLIGGQSGMVIAFLVAGGMNLFAYWNSDKMVLRMHNAREVDERSAPDLYGIVRQLTQRG
GLPMPKVYVIDTPQPNAFATGRNPQNAAVAATTGLMRALTPQELAGVMAHELAHVRHHDTLTMTLTATLAGAISMLANFA
FFFGGNRDNNNPLGAVGMIVMMILAPLAAMMVQMAISRTAEYRADRGGAEICGQPLWLASALEKIERAARGIENPSAEQN
PATAHLFIINPLNGHRMDNLFTTHPSTANRVAKLRALASGDLAQPRPQRGPWG

Sequences:

>Translated_293_residues
MSFFRVAVMLAAMTGLFLAVGYLIGGQSGMVIAFLVAGGMNLFAYWNSDKMVLRMHNAREVDERSAPDLYGIVRQLTQRG
GLPMPKVYVIDTPQPNAFATGRNPQNAAVAATTGLMRALTPQELAGVMAHELAHVRHHDTLTMTLTATLAGAISMLANFA
FFFGGNRDNNNPLGAVGMIVMMILAPLAAMMVQMAISRTAEYRADRGGAEICGQPLWLASALEKIERAARGIENPSAEQN
PATAHLFIINPLNGHRMDNLFTTHPSTANRVAKLRALASGDLAQPRPQRGPWG
>Mature_292_residues
SFFRVAVMLAAMTGLFLAVGYLIGGQSGMVIAFLVAGGMNLFAYWNSDKMVLRMHNAREVDERSAPDLYGIVRQLTQRGG
LPMPKVYVIDTPQPNAFATGRNPQNAAVAATTGLMRALTPQELAGVMAHELAHVRHHDTLTMTLTATLAGAISMLANFAF
FFGGNRDNNNPLGAVGMIVMMILAPLAAMMVQMAISRTAEYRADRGGAEICGQPLWLASALEKIERAARGIENPSAEQNP
ATAHLFIINPLNGHRMDNLFTTHPSTANRVAKLRALASGDLAQPRPQRGPWG

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=268, Percent_Identity=30.2238805970149, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_RHORT (Q2RNC2)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428660.1
- ProteinModelPortal:   Q2RNC2
- SMR:   Q2RNC2
- STRING:   Q2RNC2
- MEROPS:   M48.004
- GeneID:   3837035
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3579
- NMPDR:   fig|1085.1.peg.1917
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- PhylomeDB:   Q2RNC2
- ProtClustDB:   PRK01345
- BioCyc:   RRUB269796:RRU_A3579-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31567; Mature: 31436

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

HASH(0x1249e838)-; HASH(0x128ced00)-; HASH(0x13405fc4)-; HASH(0x1321da84)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFRVAVMLAAMTGLFLAVGYLIGGQSGMVIAFLVAGGMNLFAYWNSDKMVLRMHNARE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCEEEEEECCCHH
VDERSAPDLYGIVRQLTQRGGLPMPKVYVIDTPQPNAFATGRNPQNAAVAATTGLMRALT
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHCC
PQELAGVMAHELAHVRHHDTLTMTLTATLAGAISMLANFAFFFGGNRDNNNPLGAVGMIV
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MMILAPLAAMMVQMAISRTAEYRADRGGAEICGQPLWLASALEKIERAARGIENPSAEQN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
PATAHLFIINPLNGHRMDNLFTTHPSTANRVAKLRALASGDLAQPRPQRGPWG
CCEEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH
>Mature Secondary Structure 
SFFRVAVMLAAMTGLFLAVGYLIGGQSGMVIAFLVAGGMNLFAYWNSDKMVLRMHNARE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCEEEEEECCCHH
VDERSAPDLYGIVRQLTQRGGLPMPKVYVIDTPQPNAFATGRNPQNAAVAATTGLMRALT
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHCC
PQELAGVMAHELAHVRHHDTLTMTLTATLAGAISMLANFAFFFGGNRDNNNPLGAVGMIV
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MMILAPLAAMMVQMAISRTAEYRADRGGAEICGQPLWLASALEKIERAARGIENPSAEQN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
PATAHLFIINPLNGHRMDNLFTTHPSTANRVAKLRALASGDLAQPRPQRGPWG
CCEEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA