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The map label for this gene is livH [H]

Identifier: 83594858

GI number: 83594858

Start: 4060257

End: 4061621

Strand: Reverse

Name: livH [H]

Synonym: Rru_A3529

Alternate gene names: 83594858

Gene position: 4061621-4060257 (Counterclockwise)

Preceding gene: 83594860

Following gene: 83594857

Centisome position: 93.31

GC content: 69.52

Gene sequence:

>1365_bases
ATGGCCTGGATGCGGGCTTTGGCGGTTTTGGTGTCGTGGCTGGTCGTGTCTCTGGTCGGCGCCTGCGCCCCCATCGACAG
CTTTCAGGCCGGTTTATGCGAGCGCGCCCTGCTCGCCCTGGTGCCGGCCGAGGCGCCGGTGGCGATCCTCGACCGCGCCA
GCTTTTCCACCGCCGATGGCGGAGCCGGTTTGCGCCTGACCTATCAACTGGGATCGGGGGAATCCACGGGGGCGCTGACC
TGCCTGTTCGCCGGCCAAGGCCTTGATGCCAACCGCCTGGAGCTGCGTGCCGTGGTCGACGAGGGGCGTGGGCCCTTATC
GGCGGCCCGGCTGCATATGCTCAAACGCTTCTGGCTTGATCGGCCCGAGGCCGGGGCCGAGCGCACGGCGCGGCTGGCCG
ACGGCGCCCTGGCGGTGGTGGCCGAGATCCCGATCGATCTCGCCTATTTCCTCCAGCAAACCCTTAACGCCCTGCCGGTG
ATCGCGCTTTATGGCCTGCTGGCCGCCAGTTACACCCTGATCTATGCCCTGGGCCGGACGATCCTGCTGGTGTTTGGTGA
ACTGGCGATGATCGGCGCCATGGCCTGTTTCGCCGGGGTGGCGCTTTTCTCGGGGCTGGGCGGGCTGGGGACCGCCGGGG
TGGTGGGCGGCGCTGTGGTCTTCGCCCTGCTCGCCAGCGCCGTTCACGGCGACGCCCTGCGCCGTCTGGTGCTTCAGCCC
GCCGCCGGGCGCACGCCGCTTGCCCTTCTCGTCGCCTCCTTCGCCCTGGCCATCGTTGTTCAGGACTATGTCCGCTTGTC
GCAAGACGCCGGCGACCGGCTGTTGCCCACCCTTCCCGGGCGGACCCATGTGCTGGCCCGCGCCGGCGAGTTTGTCGTCG
CCGTTACCGATTTCCAACTTGTTCTGGTTGGCGGCGCCGGCATTGTGCTTGGCGCCCTGGTTTGGGGGATGGGGCGCGGG
CGCTTTGGCCGATGCTGGCGGGCGATGGCCGAGGATCCGCAGATGGCAACCCTGTGCGGGGTGTCGAAAACCCGGCTGTG
GGCGATCTGCTTCGCCCTGGCGGCTACCCTCGCCGGGCTGGCCGGCGTGGTGGTGCTGCTGCGCTTTGGTTTGGCCAATG
CCTTCATGGGCGCCATGCTCGGCTTCAAGGCGCTGACGGCCGCCGTGGTCGGCGGGATCGGCCGCATCCAGGGCGCCATC
CTGGGAGCGGTGGTGATCGGCGGCCTGGAGACCTATTGGGCCGCCTATTTCGACATGGCCTGGCGCGATGTCGCCGTTTT
CGCCCTGCTCGCCGCCGCCCTGGTGCTGCGTCCCCAGGGGCTGGTCGGACTTGCCGAGCGGCCCGACCGGGTGCTCCGGC
CCTGA

Upstream 100 bases:

>100_bases
TAAATGTTCTTATGGCGGAAGAGCGGGCCGCCCGGCGATGATTCCGTGACCCGCCCGGGCGGGGCGAAGGGCCCGGAGAG
GGGAGACAGAGGGGGAAGCA

Downstream 100 bases:

>100_bases
TGTTGCGGCAAACGCACTTCATGTTCTGTCAATGAAAAAATAAAATTTAGGATCTTTTTCCTCGGGGGGGCGTTAAAATA
GCAACAGACGGTCCCACATC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MAWMRALAVLVSWLVVSLVGACAPIDSFQAGLCERALLALVPAEAPVAILDRASFSTADGGAGLRLTYQLGSGESTGALT
CLFAGQGLDANRLELRAVVDEGRGPLSAARLHMLKRFWLDRPEAGAERTARLADGALAVVAEIPIDLAYFLQQTLNALPV
IALYGLLAASYTLIYALGRTILLVFGELAMIGAMACFAGVALFSGLGGLGTAGVVGGAVVFALLASAVHGDALRRLVLQP
AAGRTPLALLVASFALAIVVQDYVRLSQDAGDRLLPTLPGRTHVLARAGEFVVAVTDFQLVLVGGAGIVLGALVWGMGRG
RFGRCWRAMAEDPQMATLCGVSKTRLWAICFALAATLAGLAGVVVLLRFGLANAFMGAMLGFKALTAAVVGGIGRIQGAI
LGAVVIGGLETYWAAYFDMAWRDVAVFALLAAALVLRPQGLVGLAERPDRVLRP

Sequences:

>Translated_454_residues
MAWMRALAVLVSWLVVSLVGACAPIDSFQAGLCERALLALVPAEAPVAILDRASFSTADGGAGLRLTYQLGSGESTGALT
CLFAGQGLDANRLELRAVVDEGRGPLSAARLHMLKRFWLDRPEAGAERTARLADGALAVVAEIPIDLAYFLQQTLNALPV
IALYGLLAASYTLIYALGRTILLVFGELAMIGAMACFAGVALFSGLGGLGTAGVVGGAVVFALLASAVHGDALRRLVLQP
AAGRTPLALLVASFALAIVVQDYVRLSQDAGDRLLPTLPGRTHVLARAGEFVVAVTDFQLVLVGGAGIVLGALVWGMGRG
RFGRCWRAMAEDPQMATLCGVSKTRLWAICFALAATLAGLAGVVVLLRFGLANAFMGAMLGFKALTAAVVGGIGRIQGAI
LGAVVIGGLETYWAAYFDMAWRDVAVFALLAAALVLRPQGLVGLAERPDRVLRP
>Mature_453_residues
AWMRALAVLVSWLVVSLVGACAPIDSFQAGLCERALLALVPAEAPVAILDRASFSTADGGAGLRLTYQLGSGESTGALTC
LFAGQGLDANRLELRAVVDEGRGPLSAARLHMLKRFWLDRPEAGAERTARLADGALAVVAEIPIDLAYFLQQTLNALPVI
ALYGLLAASYTLIYALGRTILLVFGELAMIGAMACFAGVALFSGLGGLGTAGVVGGAVVFALLASAVHGDALRRLVLQPA
AGRTPLALLVASFALAIVVQDYVRLSQDAGDRLLPTLPGRTHVLARAGEFVVAVTDFQLVLVGGAGIVLGALVWGMGRGR
FGRCWRAMAEDPQMATLCGVSKTRLWAICFALAATLAGLAGVVVLLRFGLANAFMGAMLGFKALTAAVVGGIGRIQGAIL
GAVVIGGLETYWAAYFDMAWRDVAVFALLAAALVLRPQGLVGLAERPDRVLRP

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=306, Percent_Identity=34.640522875817, Blast_Score=145, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 47134; Mature: 47003

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWMRALAVLVSWLVVSLVGACAPIDSFQAGLCERALLALVPAEAPVAILDRASFSTADG
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCC
GAGLRLTYQLGSGESTGALTCLFAGQGLDANRLELRAVVDEGRGPLSAARLHMLKRFWLD
CCCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
RPEAGAERTARLADGALAVVAEIPIDLAYFLQQTLNALPVIALYGLLAASYTLIYALGRT
CCCCCHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLVFGELAMIGAMACFAGVALFSGLGGLGTAGVVGGAVVFALLASAVHGDALRRLVLQP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AAGRTPLALLVASFALAIVVQDYVRLSQDAGDRLLPTLPGRTHVLARAGEFVVAVTDFQL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEECCCEEEEEECEEE
VLVGGAGIVLGALVWGMGRGRFGRCWRAMAEDPQMATLCGVSKTRLWAICFALAATLAGL
EEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
AGVVVLLRFGLANAFMGAMLGFKALTAAVVGGIGRIQGAILGAVVIGGLETYWAAYFDMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRDVAVFALLAAALVLRPQGLVGLAERPDRVLRP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWMRALAVLVSWLVVSLVGACAPIDSFQAGLCERALLALVPAEAPVAILDRASFSTADG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCC
GAGLRLTYQLGSGESTGALTCLFAGQGLDANRLELRAVVDEGRGPLSAARLHMLKRFWLD
CCCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
RPEAGAERTARLADGALAVVAEIPIDLAYFLQQTLNALPVIALYGLLAASYTLIYALGRT
CCCCCHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLVFGELAMIGAMACFAGVALFSGLGGLGTAGVVGGAVVFALLASAVHGDALRRLVLQP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AAGRTPLALLVASFALAIVVQDYVRLSQDAGDRLLPTLPGRTHVLARAGEFVVAVTDFQL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEECCCEEEEEECEEE
VLVGGAGIVLGALVWGMGRGRFGRCWRAMAEDPQMATLCGVSKTRLWAICFALAATLAGL
EEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
AGVVVLLRFGLANAFMGAMLGFKALTAAVVGGIGRIQGAILGAVVIGGLETYWAAYFDMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRDVAVFALLAAALVLRPQGLVGLAERPDRVLRP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]