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The map label for this gene is cobA [H]

Identifier: 83594691

GI number: 83594691

Start: 3874488

End: 3875363

Strand: Reverse

Name: cobA [H]

Synonym: Rru_A3362

Alternate gene names: 83594691

Gene position: 3875363-3874488 (Counterclockwise)

Preceding gene: 83594692

Following gene: 83594690

Centisome position: 89.03

GC content: 70.09

Gene sequence:

>876_bases
ATGAAACAGTCTTTCGCCTTTTCCCGACTCGGGTTGGCCCTTCCTCCCGTCGAACCCGGCTGGGTGTGGCTGGTTGGCGC
CGGTCCGGGCGATCCCGGCCTGCTGACCGTGCTGGCCGCCCATGCCCTGGCCGAGGCCGATGTGGTGGTCCACGACGCCC
TGATCGACGGCCGGGTCCTTGGCTTGGCGCGCGAGGAGGCCGTGTTGATCCCGGCGGGCAAACGCGGCGGCCGCCCCTCG
CATAGCCAGCCCGATATTTCGGCCCGGCTGGTCGATCTGGCACGGGCCGGCAAGCGGGTCGTCCGTCTCAAGGGCGGAGA
TCCCTTTGTCTTCGGGCGCGGCGCCGAGGAGGCGCGGACCCTGGTCGCCGCCGGCGTGCCCTTTCGCATCGTCCCCGGGG
TGACGGCCGGGGTGGGCGGGCTGGCCTATGCCGGCATTCCCGCCACCACCCGCGACACCAATGCCACCGTGACCTTCGTC
ACCGGCCATGCGGCGACCGGCGAGGTTCCCGATACCTTCGATTGGGAAGCCCTGGCCCGCTTGCCGGTGCTGGTTTTCTA
CATGGCGCTCAAAACCCTTGATGTGATCGCCGCCCGGCTGATGGAGCATGGCCGGTCGGGCGAAACGCCGGTCGCCTTCG
TCTCCGACGCCACCACCGCCGCCCAAAGGGTCCATATCACCACCCTGGCCCAGGCGGTGACGGAGCGCGATCGCCTGGGC
ATCGCGCCGCCGGCCCTGGTGGTTCTGGGCGATGTGGTGCCGCTGGCCCGCGATCTGGCCTGGTGGAGCCCGCCCAAGCA
GGGGTGCGGTGGCGAGGTCTGGCCCGATCCCATGCAATCGATTCCCGGATCGGCGACCCCGCTGATTGGCGATTAG

Upstream 100 bases:

>100_bases
GGAACCCGCTCCGCGCCCCGACCTGTTATCGACGGGGGCGGGTGAAAAAGCCGTCACCCGCCACTGGAAATTCACCATCG
CGTCGGTGTAGCGTGCCGCC

Downstream 100 bases:

>100_bases
AGCGAAAAGGCGCGCCCCATGGACCAGCAGGCCGTTCTTCTGGCCATCCTCGAGTCCGGGATCGCCCATTGTCAGGCCGT
CGTCGTCTCCGAGGGCGGGA

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKQSFAFSRLGLALPPVEPGWVWLVGAGPGDPGLLTVLAAHALAEADVVVHDALIDGRVLGLAREEAVLIPAGKRGGRPS
HSQPDISARLVDLARAGKRVVRLKGGDPFVFGRGAEEARTLVAAGVPFRIVPGVTAGVGGLAYAGIPATTRDTNATVTFV
TGHAATGEVPDTFDWEALARLPVLVFYMALKTLDVIAARLMEHGRSGETPVAFVSDATTAAQRVHITTLAQAVTERDRLG
IAPPALVVLGDVVPLARDLAWWSPPKQGCGGEVWPDPMQSIPGSATPLIGD

Sequences:

>Translated_291_residues
MKQSFAFSRLGLALPPVEPGWVWLVGAGPGDPGLLTVLAAHALAEADVVVHDALIDGRVLGLAREEAVLIPAGKRGGRPS
HSQPDISARLVDLARAGKRVVRLKGGDPFVFGRGAEEARTLVAAGVPFRIVPGVTAGVGGLAYAGIPATTRDTNATVTFV
TGHAATGEVPDTFDWEALARLPVLVFYMALKTLDVIAARLMEHGRSGETPVAFVSDATTAAQRVHITTLAQAVTERDRLG
IAPPALVVLGDVVPLARDLAWWSPPKQGCGGEVWPDPMQSIPGSATPLIGD
>Mature_291_residues
MKQSFAFSRLGLALPPVEPGWVWLVGAGPGDPGLLTVLAAHALAEADVVVHDALIDGRVLGLAREEAVLIPAGKRGGRPS
HSQPDISARLVDLARAGKRVVRLKGGDPFVFGRGAEEARTLVAAGVPFRIVPGVTAGVGGLAYAGIPATTRDTNATVTFV
TGHAATGEVPDTFDWEALARLPVLVFYMALKTLDVIAARLMEHGRSGETPVAFVSDATTAAQRVHITTLAQAVTERDRLG
IAPPALVVLGDVVPLARDLAWWSPPKQGCGGEVWPDPMQSIPGSATPLIGD

Specific function: Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=245, Percent_Identity=46.9387755102041, Blast_Score=203, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6322922, Length=254, Percent_Identity=30.7086614173228, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 30307; Mature: 30307

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSFAFSRLGLALPPVEPGWVWLVGAGPGDPGLLTVLAAHALAEADVVVHDALIDGRVL
CCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEHHHHCCEEE
GLAREEAVLIPAGKRGGRPSHSQPDISARLVDLARAGKRVVRLKGGDPFVFGRGAEEART
EEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHH
LVAAGVPFRIVPGVTAGVGGLAYAGIPATTRDTNATVTFVTGHAATGEVPDTFDWEALAR
HHCCCCCEEECCCCCCCCCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHH
LPVLVFYMALKTLDVIAARLMEHGRSGETPVAFVSDATTAAQRVHITTLAQAVTERDRLG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
IAPPALVVLGDVVPLARDLAWWSPPKQGCGGEVWPDPMQSIPGSATPLIGD
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKQSFAFSRLGLALPPVEPGWVWLVGAGPGDPGLLTVLAAHALAEADVVVHDALIDGRVL
CCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEHHHHCCEEE
GLAREEAVLIPAGKRGGRPSHSQPDISARLVDLARAGKRVVRLKGGDPFVFGRGAEEART
EEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHH
LVAAGVPFRIVPGVTAGVGGLAYAGIPATTRDTNATVTFVTGHAATGEVPDTFDWEALAR
HHCCCCCEEECCCCCCCCCCCEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHH
LPVLVFYMALKTLDVIAARLMEHGRSGETPVAFVSDATTAAQRVHITTLAQAVTERDRLG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
IAPPALVVLGDVVPLARDLAWWSPPKQGCGGEVWPDPMQSIPGSATPLIGD
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520; 2546914 [H]