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The map label for this gene is proC [H]

Identifier: 83594611

GI number: 83594611

Start: 3778417

End: 3779241

Strand: Direct

Name: proC [H]

Synonym: Rru_A3281

Alternate gene names: 83594611

Gene position: 3778417-3779241 (Clockwise)

Preceding gene: 83594610

Following gene: 83594612

Centisome position: 86.8

GC content: 72.61

Gene sequence:

>825_bases
ATGGGTTGCCTGACCACCGATACCCCGCTTGCGGGGGTTTCGTTGTTGCTGCTGGGCTGCGGGAAGATGGGCGGCGCCCT
GCTGAACGGCTGGCTGGGCCGTGGCCTTGAGCCGAGCGCGGTCCATGTCGTCGATCCCCTGGCCGATCTGCCCGCCGGCG
TCACCCGGCTGACCGCCGAGCAGGCCGTGGCCCTGCCGCCGCCCGACGTCTGTCTGGTGGCGATCAAGCCCCAGGTCGTC
CCCGAGGTTCTGCCGGCCTATGCCCCGCTGGCCCAGGCCGGAACGGTGTTCTTGTCGGTGGCGGCGGGCAAGACGATCGA
TGGCCTGTCGGGCCTGCTGGGCGGCGATGCCGCCGTGGTCCGAGCGATGCCCAACACCCCGGCCGCCGTCGGCCGGGGCG
CCAGCGTGCTCTGCGCCAACGCCCGGGTGCCGGCGCCGACGCGCGCCCTGTGCGAAACCCTGATGGCCGCCGTCGGCACC
GTCGAATGGGTCGATGACGAATCGCTGATCGACGCGGTGACGGCCCTGTCGGGCGGCGGCCCGGCCTATGTGTTCTTGCT
GGTCGAATGCCTGGCCGAAGCCGGGCGGGCCAACGGCCTGCCGGCCGATCTGGCGATGCGGCTGGCGCGCAGCACGGTCG
CCGGCTCGGGCGCCCTGCTTGACGGCAGCGCCGAAGACGCCGCCACCTTGCGCAAGAACGTCACCAGCCACAAGGGCACG
ACCGCCGCCGCCCTGGCGGTGCTGATGGCCGAAGACGCCCTTCAGCCCATGGTCACCCGCGCCATCGCCGCCGCCGCCGA
ACGCTCGCGCGAACTGGCTTCCTAA

Upstream 100 bases:

>100_bases
GAGCGCTTCTATCCCGCCTTCCAGTTCGCCATCTGGGGCGGCAAAAGCGCGCGGGAGGCCGTGGAGGCCGCCCTTTTGGA
AACCGCTGGAGAAGCTTGAG

Downstream 100 bases:

>100_bases
CGCCCCGTCGCCCGCGCCTCTTTTGCAAAAGGCTTTCACCGCCCATATCCAAGGGAGAAAGACGTCACAAGGAGCGGGGC
TATTTCATGGTCAATGCCAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MGCLTTDTPLAGVSLLLLGCGKMGGALLNGWLGRGLEPSAVHVVDPLADLPAGVTRLTAEQAVALPPPDVCLVAIKPQVV
PEVLPAYAPLAQAGTVFLSVAAGKTIDGLSGLLGGDAAVVRAMPNTPAAVGRGASVLCANARVPAPTRALCETLMAAVGT
VEWVDDESLIDAVTALSGGGPAYVFLLVECLAEAGRANGLPADLAMRLARSTVAGSGALLDGSAEDAATLRKNVTSHKGT
TAAALAVLMAEDALQPMVTRAIAAAAERSRELAS

Sequences:

>Translated_274_residues
MGCLTTDTPLAGVSLLLLGCGKMGGALLNGWLGRGLEPSAVHVVDPLADLPAGVTRLTAEQAVALPPPDVCLVAIKPQVV
PEVLPAYAPLAQAGTVFLSVAAGKTIDGLSGLLGGDAAVVRAMPNTPAAVGRGASVLCANARVPAPTRALCETLMAAVGT
VEWVDDESLIDAVTALSGGGPAYVFLLVECLAEAGRANGLPADLAMRLARSTVAGSGALLDGSAEDAATLRKNVTSHKGT
TAAALAVLMAEDALQPMVTRAIAAAAERSRELAS
>Mature_273_residues
GCLTTDTPLAGVSLLLLGCGKMGGALLNGWLGRGLEPSAVHVVDPLADLPAGVTRLTAEQAVALPPPDVCLVAIKPQVVP
EVLPAYAPLAQAGTVFLSVAAGKTIDGLSGLLGGDAAVVRAMPNTPAAVGRGASVLCANARVPAPTRALCETLMAAVGTV
EWVDDESLIDAVTALSGGGPAYVFLLVECLAEAGRANGLPADLAMRLARSTVAGSGALLDGSAEDAATLRKNVTSHKGTT
AAALAVLMAEDALQPMVTRAIAAAAERSRELAS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=32.967032967033, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=32.967032967033, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=32.319391634981, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=32.8301886792453, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17569021, Length=261, Percent_Identity=32.5670498084291, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540664, Length=298, Percent_Identity=25.8389261744966, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=30.8771929824561, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=39.3939393939394, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=40.3508771929825, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648116, Length=222, Percent_Identity=29.7297297297297, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27329; Mature: 27198

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCLTTDTPLAGVSLLLLGCGKMGGALLNGWLGRGLEPSAVHVVDPLADLPAGVTRLTAE
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHCCHHHCCCHHHHHHHH
QAVALPPPDVCLVAIKPQVVPEVLPAYAPLAQAGTVFLSVAAGKTIDGLSGLLGGDAAVV
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCHHEE
RAMPNTPAAVGRGASVLCANARVPAPTRALCETLMAAVGTVEWVDDESLIDAVTALSGGG
EECCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCC
PAYVFLLVECLAEAGRANGLPADLAMRLARSTVAGSGALLDGSAEDAATLRKNVTSHKGT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCH
TAAALAVLMAEDALQPMVTRAIAAAAERSRELAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GCLTTDTPLAGVSLLLLGCGKMGGALLNGWLGRGLEPSAVHVVDPLADLPAGVTRLTAE
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHCCHHHCCCHHHHHHHH
QAVALPPPDVCLVAIKPQVVPEVLPAYAPLAQAGTVFLSVAAGKTIDGLSGLLGGDAAVV
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCHHEE
RAMPNTPAAVGRGASVLCANARVPAPTRALCETLMAAVGTVEWVDDESLIDAVTALSGGG
EECCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCC
PAYVFLLVECLAEAGRANGLPADLAMRLARSTVAGSGALLDGSAEDAATLRKNVTSHKGT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCH
TAAALAVLMAEDALQPMVTRAIAAAAERSRELAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]