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The map label for this gene is hisC

Identifier: 83594594

GI number: 83594594

Start: 3762915

End: 3764021

Strand: Reverse

Name: hisC

Synonym: Rru_A3264

Alternate gene names: 83594594

Gene position: 3764021-3762915 (Counterclockwise)

Preceding gene: 83594595

Following gene: 83594593

Centisome position: 86.47

GC content: 67.03

Gene sequence:

>1107_bases
ATGACCAAAGCGATTATTCCTCAGCCCCGTCCCGGCATCATGGAGATCAGCCCCTATGTCGGGGGCGAGTCCAAGCTGGC
CGGTGTCGATCGGATCATCAAGCTGTCGTCCAACGAGGGCGCCCTGGGGGCGAGCCCGCGGGTGCGCGACGCGCTGATCG
CTTCGGCCGGCGAGGCCCATCGCTATCCCGACGGCAACGCCACCGCCCTGCGCGAGGCCCTGGGGCGCACCCATGGCCTT
GATCCGGCGCGCATCGTCTGCGGCGCCGGGTCCGATGAACTGATCGGTCTTTTGTGCCGCGCCTATGCCGGCCCGGGCGA
TAGCATCGTGCAAAGCGCCTATGGCTTCCTGATGTATGGCATCTATGCGCGCGGCGTCGGGGCCGAGCCGATTCTCGCCC
CGGAAAGCGATCTGACGGCCGATATCGACGCCATGCTGGCCGCCGTGCGCGACACCACCAAGCTGGTGTTCCTGGCCAAT
CCCAATAATCCGACCGGCACCTGCCTGCCGACCTCGGAAGTCGTGCGCCTGCGCGAGGGCCTGCGCGACGACATCATCCT
GGTCGTCGACGCCGCCTATGCGGAATATGTCGAGCGCAACGATTACGACGCGGGCGCCCGGCTGGTCGACAGCCACCCCA
ATACGGTGATGCTGCGCACTTTCTCGAAGATCGGCTTGGGCGGTCTGCGGCTGGGCTGGAGCTATGGCCCGGCCCATATC
ATCGACGTTCTCAACCGCGTGCGCGGGCCGTTCAATATTTGCGGTCAGGCGCTGGTGGCCGGCGAAGCGGCGCTGGCGGA
CCCGGCCTTTACCGATCTGTCGCGGGCCCATAATTCCCTGTGGCGGGAGTGGACGCGCGCAAAACTGCAGGCGATGGGCA
TCCGGGTTGGCGAGTCCTCGGGCAATTTCGTTCTTGCCACCTTCGATGCCGAAGGCCCCTTCACCGCCCTGGCCGCCGAC
GCCGCCTTGCGCCAGCAGGGCATCATCTGCCGCCGGGTGGCGGGCTATGGCCTGCCCAACTGCCTGCGCATCACCATCGG
CCGCGATGACGAGATGCAGGCGGTGGTCGAAGCCCTTGGCGCCTTCATGGCTGGCGAGGGGCGGTGA

Upstream 100 bases:

>100_bases
GAGATCAAAGTTTCCGCGTTAAAGGGGTAGCATTTAACGCGGTTTGATCGAGGCGCGCCCACGATCCTTGTCGTTTTCCG
TCCAGCGAAGGCATCGGACC

Downstream 100 bases:

>100_bases
CGACGGCGCCGTCCTCTGCGCTGTTTGACCGCGTCGCCCTGATCGGCGTTGGGCTGATCGGGTCGTCGCTGGCCCGCGCC
ATCAGGCGCCATGGGCTGGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTKAIIPQPRPGIMEISPYVGGESKLAGVDRIIKLSSNEGALGASPRVRDALIASAGEAHRYPDGNATALREALGRTHGL
DPARIVCGAGSDELIGLLCRAYAGPGDSIVQSAYGFLMYGIYARGVGAEPILAPESDLTADIDAMLAAVRDTTKLVFLAN
PNNPTGTCLPTSEVVRLREGLRDDIILVVDAAYAEYVERNDYDAGARLVDSHPNTVMLRTFSKIGLGGLRLGWSYGPAHI
IDVLNRVRGPFNICGQALVAGEAALADPAFTDLSRAHNSLWREWTRAKLQAMGIRVGESSGNFVLATFDAEGPFTALAAD
AALRQQGIICRRVAGYGLPNCLRITIGRDDEMQAVVEALGAFMAGEGR

Sequences:

>Translated_368_residues
MTKAIIPQPRPGIMEISPYVGGESKLAGVDRIIKLSSNEGALGASPRVRDALIASAGEAHRYPDGNATALREALGRTHGL
DPARIVCGAGSDELIGLLCRAYAGPGDSIVQSAYGFLMYGIYARGVGAEPILAPESDLTADIDAMLAAVRDTTKLVFLAN
PNNPTGTCLPTSEVVRLREGLRDDIILVVDAAYAEYVERNDYDAGARLVDSHPNTVMLRTFSKIGLGGLRLGWSYGPAHI
IDVLNRVRGPFNICGQALVAGEAALADPAFTDLSRAHNSLWREWTRAKLQAMGIRVGESSGNFVLATFDAEGPFTALAAD
AALRQQGIICRRVAGYGLPNCLRITIGRDDEMQAVVEALGAFMAGEGR
>Mature_367_residues
TKAIIPQPRPGIMEISPYVGGESKLAGVDRIIKLSSNEGALGASPRVRDALIASAGEAHRYPDGNATALREALGRTHGLD
PARIVCGAGSDELIGLLCRAYAGPGDSIVQSAYGFLMYGIYARGVGAEPILAPESDLTADIDAMLAAVRDTTKLVFLANP
NNPTGTCLPTSEVVRLREGLRDDIILVVDAAYAEYVERNDYDAGARLVDSHPNTVMLRTFSKIGLGGLRLGWSYGPAHII
DVLNRVRGPFNICGQALVAGEAALADPAFTDLSRAHNSLWREWTRAKLQAMGIRVGESSGNFVLATFDAEGPFTALAADA
ALRQQGIICRRVAGYGLPNCLRITIGRDDEMQAVVEALGAFMAGEGR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=310, Percent_Identity=30.6451612903226, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322075, Length=382, Percent_Identity=27.7486910994764, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_RHORT (Q2RP86)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428346.1
- ProteinModelPortal:   Q2RP86
- SMR:   Q2RP86
- STRING:   Q2RP86
- GeneID:   3836711
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3264
- NMPDR:   fig|1085.1.peg.905
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   HNIREAN
- PhylomeDB:   Q2RP86
- ProtClustDB:   PRK02731
- BioCyc:   RRUB269796:RRU_A3264-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39049; Mature: 38918

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAIIPQPRPGIMEISPYVGGESKLAGVDRIIKLSSNEGALGASPRVRDALIASAGEAH
CCCCCCCCCCCCCEEECCCCCCCHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHCCCCCC
RYPDGNATALREALGRTHGLDPARIVCGAGSDELIGLLCRAYAGPGDSIVQSAYGFLMYG
CCCCCCHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IYARGVGAEPILAPESDLTADIDAMLAAVRDTTKLVFLANPNNPTGTCLPTSEVVRLREG
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHC
LRDDIILVVDAAYAEYVERNDYDAGARLVDSHPNTVMLRTFSKIGLGGLRLGWSYGPAHI
CCCCEEEEEEHHHHHHHHHCCCCCCCEEECCCCCEEEEEEHHHHCCCCEEECCCCCHHHH
IDVLNRVRGPFNICGQALVAGEAALADPAFTDLSRAHNSLWREWTRAKLQAMGIRVGESS
HHHHHHCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC
GNFVLATFDAEGPFTALAADAALRQQGIICRRVAGYGLPNCLRITIGRDDEMQAVVEALG
CCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
AFMAGEGR
HHHCCCCC
>Mature Secondary Structure 
TKAIIPQPRPGIMEISPYVGGESKLAGVDRIIKLSSNEGALGASPRVRDALIASAGEAH
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHCCCCCC
RYPDGNATALREALGRTHGLDPARIVCGAGSDELIGLLCRAYAGPGDSIVQSAYGFLMYG
CCCCCCHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IYARGVGAEPILAPESDLTADIDAMLAAVRDTTKLVFLANPNNPTGTCLPTSEVVRLREG
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHC
LRDDIILVVDAAYAEYVERNDYDAGARLVDSHPNTVMLRTFSKIGLGGLRLGWSYGPAHI
CCCCEEEEEEHHHHHHHHHCCCCCCCEEECCCCCEEEEEEHHHHCCCCEEECCCCCHHHH
IDVLNRVRGPFNICGQALVAGEAALADPAFTDLSRAHNSLWREWTRAKLQAMGIRVGESS
HHHHHHCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC
GNFVLATFDAEGPFTALAADAALRQQGIICRRVAGYGLPNCLRITIGRDDEMQAVVEALG
CCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
AFMAGEGR
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA