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The map label for this gene is mutY [H]

Identifier: 83594581

GI number: 83594581

Start: 3746569

End: 3747648

Strand: Direct

Name: mutY [H]

Synonym: Rru_A3251

Alternate gene names: 83594581

Gene position: 3746569-3747648 (Clockwise)

Preceding gene: 83594571

Following gene: 83594584

Centisome position: 86.07

GC content: 69.91

Gene sequence:

>1080_bases
ATGACCGCCCCAACCCCCGATTCGCTGCCCCCCGCCAGCGTGCTTGGCGAGCGCCTGCTTGACTGGTACCGGCGCAACGC
CCGGACCCTGCCCTGGCGCGCGCCCTTTGGCGAGCGCACCGACCCCTATCGGGTCTGGCTATCCGAGGTCATGCTCCAGC
AAACGACGGTGCCGGCCGTCATCCCCTATTTCCAGGCCTTCCTCGCCCGCTGGCCCACCGTCACCGATCTTGCCGCCGCC
CCCCTGGACGAGGTGCTGACCGCCTGGGCCGGCCTTGGCTATTACGCCCGGGCCCGCAATCTGCACAAATGCGCCCAGAC
CATCGCCACTTGGCGCGACGGAACCTTCCCGGCGACCGAGGACGAGTTGCACACCCTGCCCGGCATCGGCACCTATACCG
CCGCCGCCATCGCCGCCATCGCCTTCGGCCAGCCCGCCGTGGTCATGGATGGCAATATCGAACGGGTAATGGCCCGACTG
TTCGCCGAGACCGAGCCTTTGCCCCAGGGCAAAAAGGCGCTCTACGCCCGCGCCGCCCAATTGACGCCGACCGCCCATCC
CGGCGAGCACGCCCAGGCGCTGATGGATCTGGGGGCGACGTTGTGCACCCCGCGCAAGCCGGCCTGCGGCCTGTGTCCCT
GGCGCGATCCCTGCCTGGGCCGCCGGCTGGGTCTGGCCGAGACCCTGCCGGCCAAGGCGCCGAAAAAACTGAAGCCGACG
CGCTGTGGCATCGCCTTTTGGGTCACCCGACCCGATGGCACCGTGCTGTTGCGCCGCCGCCCGGAAAGCGGCCTGCTGGG
CGGCATGATCGAAGTGCCCTCGACCCCTTGGCGGGAAGACCCCTGGACCCTGGCCGAGGCGCGGGCCGAAGCGCCGCTGC
CCGCCGAGTGGGTGCCGCTGGCCGGACGCGTTCGCCATACCTTCACCCATTTCCACCTCGACCTCGATGTCGTCGCCGGC
CGGGTCGGCGCCAGGGCCAATGCCCGGGGGCTGTGGGTGCCCTTTGACCAGTTCGATCGCCATGCCTTGCCCGCCGTGAT
GCTCAAAGTCGTGCGACTGGCTTTGGCGCGCACCCATTGA

Upstream 100 bases:

>100_bases
CCGTGGGTCCTTTCGTGATGAAGGGCGGCCTTGACCCGGCCGCCCGCCCCGATGATAGGGTATGGTCCCCCCGTAAGGGA
ACCGATGAAGCGCCCCGGAC

Downstream 100 bases:

>100_bases
CTGGCTTTTCAGGCGTTTTTTTTAAAGGCTGTAACCGTTGGTATCTTTTAGAAAAATTTTACTTAAGCGGCTTTGACACA
GAACTTATGCCGATCGTTCT

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTAPTPDSLPPASVLGERLLDWYRRNARTLPWRAPFGERTDPYRVWLSEVMLQQTTVPAVIPYFQAFLARWPTVTDLAAA
PLDEVLTAWAGLGYYARARNLHKCAQTIATWRDGTFPATEDELHTLPGIGTYTAAAIAAIAFGQPAVVMDGNIERVMARL
FAETEPLPQGKKALYARAAQLTPTAHPGEHAQALMDLGATLCTPRKPACGLCPWRDPCLGRRLGLAETLPAKAPKKLKPT
RCGIAFWVTRPDGTVLLRRRPESGLLGGMIEVPSTPWREDPWTLAEARAEAPLPAEWVPLAGRVRHTFTHFHLDLDVVAG
RVGARANARGLWVPFDQFDRHALPAVMLKVVRLALARTH

Sequences:

>Translated_359_residues
MTAPTPDSLPPASVLGERLLDWYRRNARTLPWRAPFGERTDPYRVWLSEVMLQQTTVPAVIPYFQAFLARWPTVTDLAAA
PLDEVLTAWAGLGYYARARNLHKCAQTIATWRDGTFPATEDELHTLPGIGTYTAAAIAAIAFGQPAVVMDGNIERVMARL
FAETEPLPQGKKALYARAAQLTPTAHPGEHAQALMDLGATLCTPRKPACGLCPWRDPCLGRRLGLAETLPAKAPKKLKPT
RCGIAFWVTRPDGTVLLRRRPESGLLGGMIEVPSTPWREDPWTLAEARAEAPLPAEWVPLAGRVRHTFTHFHLDLDVVAG
RVGARANARGLWVPFDQFDRHALPAVMLKVVRLALARTH
>Mature_358_residues
TAPTPDSLPPASVLGERLLDWYRRNARTLPWRAPFGERTDPYRVWLSEVMLQQTTVPAVIPYFQAFLARWPTVTDLAAAP
LDEVLTAWAGLGYYARARNLHKCAQTIATWRDGTFPATEDELHTLPGIGTYTAAAIAAIAFGQPAVVMDGNIERVMARLF
AETEPLPQGKKALYARAAQLTPTAHPGEHAQALMDLGATLCTPRKPACGLCPWRDPCLGRRLGLAETLPAKAPKKLKPTR
CGIAFWVTRPDGTVLLRRRPESGLLGGMIEVPSTPWREDPWTLAEARAEAPLPAEWVPLAGRVRHTFTHFHLDLDVVAGR
VGARANARGLWVPFDQFDRHALPAVMLKVVRLALARTH

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=403, Percent_Identity=35.2357320099256, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI115298654, Length=403, Percent_Identity=35.2357320099256, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI115298652, Length=403, Percent_Identity=35.2357320099256, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI115298650, Length=403, Percent_Identity=35.2357320099256, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI6912520, Length=403, Percent_Identity=35.2357320099256, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI190358497, Length=403, Percent_Identity=35.2357320099256, Blast_Score=198, Evalue=8e-51,
Organism=Escherichia coli, GI1789331, Length=333, Percent_Identity=43.5435435435435, Blast_Score=251, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39582; Mature: 39451

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTPDSLPPASVLGERLLDWYRRNARTLPWRAPFGERTDPYRVWLSEVMLQQTTVPAV
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHH
IPYFQAFLARWPTVTDLAAAPLDEVLTAWAGLGYYARARNLHKCAQTIATWRDGTFPATE
HHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
DELHTLPGIGTYTAAAIAAIAFGQPAVVMDGNIERVMARLFAETEPLPQGKKALYARAAQ
HHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LTPTAHPGEHAQALMDLGATLCTPRKPACGLCPWRDPCLGRRLGLAETLPAKAPKKLKPT
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCC
RCGIAFWVTRPDGTVLLRRRPESGLLGGMIEVPSTPWREDPWTLAEARAEAPLPAEWVPL
CCCEEEEEECCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCC
AGRVRHTFTHFHLDLDVVAGRVGARANARGLWVPFDQFDRHALPAVMLKVVRLALARTH
CCHHHHHHHHHEEEHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAPTPDSLPPASVLGERLLDWYRRNARTLPWRAPFGERTDPYRVWLSEVMLQQTTVPAV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHH
IPYFQAFLARWPTVTDLAAAPLDEVLTAWAGLGYYARARNLHKCAQTIATWRDGTFPATE
HHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
DELHTLPGIGTYTAAAIAAIAFGQPAVVMDGNIERVMARLFAETEPLPQGKKALYARAAQ
HHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LTPTAHPGEHAQALMDLGATLCTPRKPACGLCPWRDPCLGRRLGLAETLPAKAPKKLKPT
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCC
RCGIAFWVTRPDGTVLLRRRPESGLLGGMIEVPSTPWREDPWTLAEARAEAPLPAEWVPL
CCCEEEEEECCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCC
AGRVRHTFTHFHLDLDVVAGRVGARANARGLWVPFDQFDRHALPAVMLKVVRLALARTH
CCHHHHHHHHHEEEHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]