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The map label for this gene is atpB

Identifier: 83594576

GI number: 83594576

Start: 3740381

End: 3741106

Strand: Reverse

Name: atpB

Synonym: Rru_A3246

Alternate gene names: 83594576

Gene position: 3741106-3740381 (Counterclockwise)

Preceding gene: 83594577

Following gene: 83594575

Centisome position: 85.95

GC content: 57.99

Gene sequence:

>726_bases
GTGCATAGTCCGGTTGAACAGTTCGCGATCAAACCACTCGTCAGCATCCAGGTCGCGGGTGTCGACGTGTCCTTCACCAA
CTCTTCGCTGCTCATGCTCCTGACCGTTGGTCTGGCGGCCGCGTTCTTCTGGAACGCGACGGCGCGGCGCACCCTGATTC
CGGGGCGCCTGCAGAGCGCGGCCGAGATGCTGTACGAATTCGTCGCCAATATGATCCGCGACAACGTGGGCAAGGAAGGG
ATGAAGTACTTTCCCTATATCCTGACCCTGTTCGTTTTCGTGTTTCTTGGCAATATGCTGGGCATGCTGCCTTATTCCTT
CACGTTCACCAGCCATATCGCGGTTACCGCGGCGCTGGCCGTGGGAATCTTCATCGCCGTCACCATCATTGGTTTCGCCC
GACACGGATTTCATTACTTTCGGATGTTCTTCCCGCATGGCGCCCCGCTGTTGACGGCGCCGCTGCTGATCCCGATCGAA
CTGATCTCCTATCTGTCGCGGCCCTTCAGCCTGTCGGTCCGACTGTTCGCCAACATGACCGTCGGCCACATCATGCTGAA
GGTTCTGGCCGGTTTCGTGATAATGCTGGGTGTCGTCGGCGGTGTCGTGCCGTTCGCCGTCGTCCTTGGCGTGACCGTGC
TCGAGTTCTTCATTGCCGCCTTGCAGGCCTATGTCTTCACCATCTTGACCTGCATCTATCTCAACGACGCCATCAACATG
CACTAA

Upstream 100 bases:

>100_bases
GGGGTGATGAATGCCTATCGCGTGGTCAAGGGCCTGGATGATTCCGTGGGCCTGGGCCGGGCGATCGAGCGCAAAGAGAA
AGCGGAAGGGAACAAAGACC

Downstream 100 bases:

>100_bases
AGGCCGATAGCGCCCCCGGCGCTGTCTTCCGAAATGCTGTCGGTGGCTGAGGCGAGCCCCTCACCCCTGTCCAACTTGGT
TCTTTTGAAAGGGTAAACTC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MHSPVEQFAIKPLVSIQVAGVDVSFTNSSLLMLLTVGLAAAFFWNATARRTLIPGRLQSAAEMLYEFVANMIRDNVGKEG
MKYFPYILTLFVFVFLGNMLGMLPYSFTFTSHIAVTAALAVGIFIAVTIIGFARHGFHYFRMFFPHGAPLLTAPLLIPIE
LISYLSRPFSLSVRLFANMTVGHIMLKVLAGFVIMLGVVGGVVPFAVVLGVTVLEFFIAALQAYVFTILTCIYLNDAINM
H

Sequences:

>Translated_241_residues
MHSPVEQFAIKPLVSIQVAGVDVSFTNSSLLMLLTVGLAAAFFWNATARRTLIPGRLQSAAEMLYEFVANMIRDNVGKEG
MKYFPYILTLFVFVFLGNMLGMLPYSFTFTSHIAVTAALAVGIFIAVTIIGFARHGFHYFRMFFPHGAPLLTAPLLIPIE
LISYLSRPFSLSVRLFANMTVGHIMLKVLAGFVIMLGVVGGVVPFAVVLGVTVLEFFIAALQAYVFTILTCIYLNDAINM
H
>Mature_241_residues
MHSPVEQFAIKPLVSIQVAGVDVSFTNSSLLMLLTVGLAAAFFWNATARRTLIPGRLQSAAEMLYEFVANMIRDNVGKEG
MKYFPYILTLFVFVFLGNMLGMLPYSFTFTSHIAVTAALAVGIFIAVTIIGFARHGFHYFRMFFPHGAPLLTAPLLIPIE
LISYLSRPFSLSVRLFANMTVGHIMLKVLAGFVIMLGVVGGVVPFAVVLGVTVLEFFIAALQAYVFTILTCIYLNDAINM
H

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=190, Percent_Identity=30.5263157894737, Blast_Score=98, Evalue=7e-21,
Organism=Escherichia coli, GI1790176, Length=217, Percent_Identity=28.110599078341, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6226527, Length=249, Percent_Identity=35.3413654618474, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_RHORT (Q2RPA4)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428328.1
- ProteinModelPortal:   Q2RPA4
- SMR:   Q2RPA4
- STRING:   Q2RPA4
- GeneID:   3836693
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3246
- NMPDR:   fig|1085.1.peg.888
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   NISPNAR
- PhylomeDB:   Q2RPA4
- ProtClustDB:   PRK05815
- BioCyc:   RRUB269796:RRU_A3246-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26498; Mature: 26498

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1254a66c)-; HASH(0x11f02524)-; HASH(0x40729660)-; HASH(0x11a245c0)-; HASH(0x11f59140)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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H
>Mature Secondary Structure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H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA