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The map label for this gene is thrC [H]

Identifier: 83594563

GI number: 83594563

Start: 3727955

End: 3729367

Strand: Direct

Name: thrC [H]

Synonym: Rru_A3233

Alternate gene names: 83594563

Gene position: 3727955-3729367 (Clockwise)

Preceding gene: 83594562

Following gene: 83594564

Centisome position: 85.64

GC content: 65.89

Gene sequence:

>1413_bases
GTGAGATATGTAAGCACACGGGGTCAGGCCCCGGTCCTGTCCTTTGATGATGTCCTGCTGGCCGGGCTGGCCAGTGACGG
GGGGCTTTATGTCCCGCAGACCTGGCCCAGTTTCTCCGAAGACGATATCCGGGACATGCGCGCGCTGACCTATCAGGAGT
TGGCGGTGCGGGTGATGGGCCCCTTCATGGGCGCCGCCGTCACCGATGACGAATTGACCGAGGTGGTCGAACAGGCCTAT
GCCGGCTTTTCCCATCCCGCCGTCGCCCCGCTGGTGCAGATCGGCGCCCACGACTGGGTGATGGAGCTGTTCCACGGTCC
GACCCTGGCCTTCAAGGATTACGCCCTGCAGGTCGTCGGCGGCCTGTTCGACCTGATCCTCACCCGGCGCGGCAGCCGCA
TCACCGTTGTCGGCGCGACCAGTGGCGATACGGGCAGCGCCGCCATCGAGGCCTGCCGCGACCGCGAGGCGGTCGATGTC
ATCATCTTGCTGCCCAAGGGCCGGGTCTCGGAGGTCCAGCGCCGCCAGATGACGACGGTGACCAGCTCCAACGTCCATGC
CATCGAGGTCGAAGGCACCTTCGATGATTGTCAGGCCCTGGTGAAGGCGCTGTTCAACGACCCCGCCTTCCGCTCCGAGG
TCAATCTGGCGGCGGTCAATTCCATCAACTGGGCGCGGATCATGGCCCAGACGGTTTATTACTTCTGGGCCGCCCTGCAG
CTTGGCGCGCCCGACCGCTCGCTTGGCTTCAGCGTGCCCACCGGCAATTTCGGCAATGTGCTGGCGGGCTATTGCGCCAA
GCGCATGGGCCTGCCGATCGACCGTCTGGTGGTCGGCTCCAACAGCAACGACATCCTGACCCGCTTCCTGGAAACCGGCA
CCATGCAGTCGCGCGGCGTGGTTCAGACCCACAGCCCGTCGATGGACATCCAGGTGTCGAGCAACTTTGAGCGCCTGCTG
TTCGAGGTGGTCGACCGCGACAGCGCCGAGGTCGAGCGGCTGATGGCCCAATTCGCCCTGACCGGCGGCTATACCCTTGA
TAGCGCCCTTCATCAGGAGCTTCTTGGGCTGTTCCGCGGCTTCCGGGTTGATAACGACGCCACCTTGCGCGCCATCGCCG
AACTTTACGCCGCCACCGGCATGATCCTTGATCCCCATAGCGTCATCGGCGTCATCGCCGGGCGCGAAGCCGGCCACCGC
GACACCGGCACTCCGATGGTCGCCCTGGCCACCGCCCATCCGGCCAAATTCGCCGATGTGGTTGAACAAGCCACCGGCCA
GCGCCCGGCCCTGCCCGGCGCGCTTTCCGACCTTTTGACCCGACCCGAACGCCGGGCCGAGGTCGCCAACGACCCCGAGG
CGGTGAAAGCGCTGGTGCGCAGCCTCTCGCGGGTCCCTGGAGCATCCGCATGA

Upstream 100 bases:

>100_bases
CGTTATCTGGAAGACCGCTAAGCTTGCCCGCCGGGGAACGGGGCATTACTGTCCCGCCGGCGAGCGCGCTTTCCCGCCAC
CCGTGCTGGAGTCCGAACAG

Downstream 100 bases:

>100_bases
GCCAGTCCGTCCGTGTCACCCGCCTGCCCGGCGGGTTGACCGTCGCCACCGATTTCGTACCCTCGGTGGAAAGCCTAACC
CTTGGTGCCTGGGTCGCCAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MRYVSTRGQAPVLSFDDVLLAGLASDGGLYVPQTWPSFSEDDIRDMRALTYQELAVRVMGPFMGAAVTDDELTEVVEQAY
AGFSHPAVAPLVQIGAHDWVMELFHGPTLAFKDYALQVVGGLFDLILTRRGSRITVVGATSGDTGSAAIEACRDREAVDV
IILLPKGRVSEVQRRQMTTVTSSNVHAIEVEGTFDDCQALVKALFNDPAFRSEVNLAAVNSINWARIMAQTVYYFWAALQ
LGAPDRSLGFSVPTGNFGNVLAGYCAKRMGLPIDRLVVGSNSNDILTRFLETGTMQSRGVVQTHSPSMDIQVSSNFERLL
FEVVDRDSAEVERLMAQFALTGGYTLDSALHQELLGLFRGFRVDNDATLRAIAELYAATGMILDPHSVIGVIAGREAGHR
DTGTPMVALATAHPAKFADVVEQATGQRPALPGALSDLLTRPERRAEVANDPEAVKALVRSLSRVPGASA

Sequences:

>Translated_470_residues
MRYVSTRGQAPVLSFDDVLLAGLASDGGLYVPQTWPSFSEDDIRDMRALTYQELAVRVMGPFMGAAVTDDELTEVVEQAY
AGFSHPAVAPLVQIGAHDWVMELFHGPTLAFKDYALQVVGGLFDLILTRRGSRITVVGATSGDTGSAAIEACRDREAVDV
IILLPKGRVSEVQRRQMTTVTSSNVHAIEVEGTFDDCQALVKALFNDPAFRSEVNLAAVNSINWARIMAQTVYYFWAALQ
LGAPDRSLGFSVPTGNFGNVLAGYCAKRMGLPIDRLVVGSNSNDILTRFLETGTMQSRGVVQTHSPSMDIQVSSNFERLL
FEVVDRDSAEVERLMAQFALTGGYTLDSALHQELLGLFRGFRVDNDATLRAIAELYAATGMILDPHSVIGVIAGREAGHR
DTGTPMVALATAHPAKFADVVEQATGQRPALPGALSDLLTRPERRAEVANDPEAVKALVRSLSRVPGASA
>Mature_470_residues
MRYVSTRGQAPVLSFDDVLLAGLASDGGLYVPQTWPSFSEDDIRDMRALTYQELAVRVMGPFMGAAVTDDELTEVVEQAY
AGFSHPAVAPLVQIGAHDWVMELFHGPTLAFKDYALQVVGGLFDLILTRRGSRITVVGATSGDTGSAAIEACRDREAVDV
IILLPKGRVSEVQRRQMTTVTSSNVHAIEVEGTFDDCQALVKALFNDPAFRSEVNLAAVNSINWARIMAQTVYYFWAALQ
LGAPDRSLGFSVPTGNFGNVLAGYCAKRMGLPIDRLVVGSNSNDILTRFLETGTMQSRGVVQTHSPSMDIQVSSNFERLL
FEVVDRDSAEVERLMAQFALTGGYTLDSALHQELLGLFRGFRVDNDATLRAIAELYAATGMILDPHSVIGVIAGREAGHR
DTGTPMVALATAHPAKFADVVEQATGQRPALPGALSDLLTRPERRAEVANDPEAVKALVRSLSRVPGASA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=452, Percent_Identity=36.5044247787611, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI153792148, Length=497, Percent_Identity=32.9979879275654, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI1786185, Length=460, Percent_Identity=31.5217391304348, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319901, Length=455, Percent_Identity=43.0769230769231, Blast_Score=355, Evalue=1e-98,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50714; Mature: 50714

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVSTRGQAPVLSFDDVLLAGLASDGGLYVPQTWPSFSEDDIRDMRALTYQELAVRVMG
CCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
PFMGAAVTDDELTEVVEQAYAGFSHPAVAPLVQIGAHDWVMELFHGPTLAFKDYALQVVG
HHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHH
GLFDLILTRRGSRITVVGATSGDTGSAAIEACRDREAVDVIILLPKGRVSEVQRRQMTTV
HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHEE
TSSNVHAIEVEGTFDDCQALVKALFNDPAFRSEVNLAAVNSINWARIMAQTVYYFWAALQ
ECCCEEEEEECCCHHHHHHHHHHHHCCCCHHCCCCEEEECCCHHHHHHHHHHHHHHHHHH
LGAPDRSLGFSVPTGNFGNVLAGYCAKRMGLPIDRLVVGSNSNDILTRFLETGTMQSRGV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHCCCCCCCE
VQTHSPSMDIQVSSNFERLLFEVVDRDSAEVERLMAQFALTGGYTLDSALHQELLGLFRG
EEECCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
FRVDNDATLRAIAELYAATGMILDPHSVIGVIAGREAGHRDTGTPMVALATAHPAKFADV
CCCCCHHHHHHHHHHHHHCCCEECCHHHHEEEECCCCCCCCCCCCEEEEECCCCHHHHHH
VEQATGQRPALPGALSDLLTRPERRAEVANDPEAVKALVRSLSRVPGASA
HHHHCCCCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRYVSTRGQAPVLSFDDVLLAGLASDGGLYVPQTWPSFSEDDIRDMRALTYQELAVRVMG
CCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
PFMGAAVTDDELTEVVEQAYAGFSHPAVAPLVQIGAHDWVMELFHGPTLAFKDYALQVVG
HHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHH
GLFDLILTRRGSRITVVGATSGDTGSAAIEACRDREAVDVIILLPKGRVSEVQRRQMTTV
HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHEE
TSSNVHAIEVEGTFDDCQALVKALFNDPAFRSEVNLAAVNSINWARIMAQTVYYFWAALQ
ECCCEEEEEECCCHHHHHHHHHHHHCCCCHHCCCCEEEECCCHHHHHHHHHHHHHHHHHH
LGAPDRSLGFSVPTGNFGNVLAGYCAKRMGLPIDRLVVGSNSNDILTRFLETGTMQSRGV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHCCCCCCCE
VQTHSPSMDIQVSSNFERLLFEVVDRDSAEVERLMAQFALTGGYTLDSALHQELLGLFRG
EEECCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
FRVDNDATLRAIAELYAATGMILDPHSVIGVIAGREAGHRDTGTPMVALATAHPAKFADV
CCCCCHHHHHHHHHHHHHCCCEECCHHHHEEEECCCCCCCCCCCCEEEEECCCCHHHHHH
VEQATGQRPALPGALSDLLTRPERRAEVANDPEAVKALVRSLSRVPGASA
HHHHCCCCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]