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The map label for this gene is pqqL [C]

Identifier: 83594564

GI number: 83594564

Start: 3729364

End: 3730629

Strand: Direct

Name: pqqL [C]

Synonym: Rru_A3234

Alternate gene names: 83594564

Gene position: 3729364-3730629 (Clockwise)

Preceding gene: 83594563

Following gene: 83594565

Centisome position: 85.68

GC content: 65.88

Gene sequence:

>1266_bases
ATGAGCCAGTCCGTCCGTGTCACCCGCCTGCCCGGCGGGTTGACCGTCGCCACCGATTTCGTACCCTCGGTGGAAAGCCT
AACCCTTGGTGCCTGGGTCGCCACCGGCACCCGCCACGAGGCCCCCGCCGTCAACGGCGTGTCCCATCTGCTCGAACACA
TGGCCTTCAAGGGCACGCGCAAGCGCAGCGCCCGCCAGATCGCCGAAGAGATCGAAGCGGTCGGCGGCCATCTCAACGCC
TATACCAGCCGCGAGAACACCGCCTATTACGCCCGCGTGCTGCGCGAGGACGAAGACGTGGCGCTCGATATCCTGGGCGA
CATCCTTCAACATTCGACCTTCGATCCGACCGAGCTGGGCCGCGAGCGCGAGGTGGTGGTTCAGGAGATCTATCAGGCGA
TCGATACGCCCGATGACATCATCTTCGATCATTTCCAGGAAACCGCCTTCCCCGATCAGGCACTGGGCCGGCCGGTGCTG
GGCACCGAAAAGGTGGTGCGCGGCCTGACCCGCGAGATCGTCGACGGCTATATGCGCGCCCATTACGCGCCCGAGCGCAC
GGTGGTCGCCGCCGCTGGCCGCATCGATCACGACGCCTTCGTCGCCAAGGTCACCGAGCACTTCTCGGCCCTGCCCGGCC
GGGGGATTCCCGCCGAGGAACCCGGTCGCTATGCCGGTGGCGTTTTCCGCGAGGAACGCGACCTTGAACAGGTCCACATC
GTTCTGGGATTCGAGGGCATCTGCCACGGCGATGACGATTATTACGCCGCCAGCGTGCTCTCCACCCTGCACGGCGGCGG
CATGTCGTCGCGGCTGTTCCAGGAAATCCGCGAGAACCGGGGGCTGGCCTATTCGATCTACAGCTTCTCGTCGAGCTATC
AGGATACCGGGCTTTACGCCATCTACGCCGGAACCAGCGAGAAGGAAGCCGCCGAGCTGATCCCGGTGTTGTGCGACGAG
ACCGCCCGGCTGGCCGATAGCCTGACCGAGGTCGAGGTGGCCCGCGCCCGCGCCCAGCTCAAGGCCAGCATCCTGATGGC
CCTGGAAAGCACCTCGTCGCGCTGCGAGCAGATGGCCCGCCAGATCCAGGTCTATGGCCGGCCGATCGGCATCGACGAGG
TGGTGGCCAAGCTTGATGGCGTCACCATCGATCAAGTCGCCGCCTGCGCCCGACGGATCTTTACCCGCCCCCCCACCCTG
GCGGCGATCGGACCTTTGGCCGGGGTCGAGGACTACGATAAGATCGTCGCCCGCCTGAAGCCGTGA

Upstream 100 bases:

>100_bases
ACCTTTTGACCCGACCCGAACGCCGGGCCGAGGTCGCCAACGACCCCGAGGCGGTGAAAGCGCTGGTGCGCAGCCTCTCG
CGGGTCCCTGGAGCATCCGC

Downstream 100 bases:

>100_bases
CAAGATCGTCGCCCGCCTGAAGCCGTGATGGAAAGGCGGGGAGGAAATGGCCCGAGCGCCGTTTCCTCCCCGCTTACCGA
TTTGTAATTCCCCGCCCATG

Product: processing peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSQSVRVTRLPGGLTVATDFVPSVESLTLGAWVATGTRHEAPAVNGVSHLLEHMAFKGTRKRSARQIAEEIEAVGGHLNA
YTSRENTAYYARVLREDEDVALDILGDILQHSTFDPTELGREREVVVQEIYQAIDTPDDIIFDHFQETAFPDQALGRPVL
GTEKVVRGLTREIVDGYMRAHYAPERTVVAAAGRIDHDAFVAKVTEHFSALPGRGIPAEEPGRYAGGVFREERDLEQVHI
VLGFEGICHGDDDYYAASVLSTLHGGGMSSRLFQEIRENRGLAYSIYSFSSSYQDTGLYAIYAGTSEKEAAELIPVLCDE
TARLADSLTEVEVARARAQLKASILMALESTSSRCEQMARQIQVYGRPIGIDEVVAKLDGVTIDQVAACARRIFTRPPTL
AAIGPLAGVEDYDKIVARLKP

Sequences:

>Translated_421_residues
MSQSVRVTRLPGGLTVATDFVPSVESLTLGAWVATGTRHEAPAVNGVSHLLEHMAFKGTRKRSARQIAEEIEAVGGHLNA
YTSRENTAYYARVLREDEDVALDILGDILQHSTFDPTELGREREVVVQEIYQAIDTPDDIIFDHFQETAFPDQALGRPVL
GTEKVVRGLTREIVDGYMRAHYAPERTVVAAAGRIDHDAFVAKVTEHFSALPGRGIPAEEPGRYAGGVFREERDLEQVHI
VLGFEGICHGDDDYYAASVLSTLHGGGMSSRLFQEIRENRGLAYSIYSFSSSYQDTGLYAIYAGTSEKEAAELIPVLCDE
TARLADSLTEVEVARARAQLKASILMALESTSSRCEQMARQIQVYGRPIGIDEVVAKLDGVTIDQVAACARRIFTRPPTL
AAIGPLAGVEDYDKIVARLKP
>Mature_420_residues
SQSVRVTRLPGGLTVATDFVPSVESLTLGAWVATGTRHEAPAVNGVSHLLEHMAFKGTRKRSARQIAEEIEAVGGHLNAY
TSRENTAYYARVLREDEDVALDILGDILQHSTFDPTELGREREVVVQEIYQAIDTPDDIIFDHFQETAFPDQALGRPVLG
TEKVVRGLTREIVDGYMRAHYAPERTVVAAAGRIDHDAFVAKVTEHFSALPGRGIPAEEPGRYAGGVFREERDLEQVHIV
LGFEGICHGDDDYYAASVLSTLHGGGMSSRLFQEIRENRGLAYSIYSFSSSYQDTGLYAIYAGTSEKEAAELIPVLCDET
ARLADSLTEVEVARARAQLKASILMALESTSSRCEQMARQIQVYGRPIGIDEVVAKLDGVTIDQVAACARRIFTRPPTLA
AIGPLAGVEDYDKIVARLKP

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=428, Percent_Identity=37.1495327102804, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI46593007, Length=427, Percent_Identity=31.615925058548, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI24308013, Length=441, Percent_Identity=25.8503401360544, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI50592988, Length=413, Percent_Identity=25.181598062954, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71999683, Length=409, Percent_Identity=31.7848410757946, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17510601, Length=464, Percent_Identity=26.2931034482759, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17553678, Length=419, Percent_Identity=27.2076372315036, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17569737, Length=420, Percent_Identity=21.6666666666667, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17555260, Length=304, Percent_Identity=23.0263157894737, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=435, Percent_Identity=35.1724137931034, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321813, Length=418, Percent_Identity=27.9904306220096, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319426, Length=434, Percent_Identity=25.1152073732719, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21357875, Length=424, Percent_Identity=36.0849056603774, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24646943, Length=424, Percent_Identity=36.0849056603774, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI19921772, Length=450, Percent_Identity=27.5555555555556, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24665395, Length=417, Percent_Identity=26.8585131894484, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24641429, Length=192, Percent_Identity=27.6041666666667, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46094; Mature: 45963

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSVRVTRLPGGLTVATDFVPSVESLTLGAWVATGTRHEAPAVNGVSHLLEHMAFKGTR
CCCCCEEEECCCCCEEHHHCCCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCHH
KRSARQIAEEIEAVGGHLNAYTSRENTAYYARVLREDEDVALDILGDILQHSTFDPTELG
HHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHC
REREVVVQEIYQAIDTPDDIIFDHFQETAFPDQALGRPVLGTEKVVRGLTREIVDGYMRA
CHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
HYAPERTVVAAAGRIDHDAFVAKVTEHFSALPGRGIPAEEPGRYAGGVFREERDLEQVHI
HCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCHHHEEE
VLGFEGICHGDDDYYAASVLSTLHGGGMSSRLFQEIRENRGLAYSIYSFSSSYQDTGLYA
EEECCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEE
IYAGTSEKEAAELIPVLCDETARLADSLTEVEVARARAQLKASILMALESTSSRCEQMAR
EEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIQVYGRPIGIDEVVAKLDGVTIDQVAACARRIFTRPPTLAAIGPLAGVEDYDKIVARLK
HHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCC
P
C
>Mature Secondary Structure 
SQSVRVTRLPGGLTVATDFVPSVESLTLGAWVATGTRHEAPAVNGVSHLLEHMAFKGTR
CCCCEEEECCCCCEEHHHCCCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCHH
KRSARQIAEEIEAVGGHLNAYTSRENTAYYARVLREDEDVALDILGDILQHSTFDPTELG
HHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHC
REREVVVQEIYQAIDTPDDIIFDHFQETAFPDQALGRPVLGTEKVVRGLTREIVDGYMRA
CHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
HYAPERTVVAAAGRIDHDAFVAKVTEHFSALPGRGIPAEEPGRYAGGVFREERDLEQVHI
HCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCHHHEEE
VLGFEGICHGDDDYYAASVLSTLHGGGMSSRLFQEIRENRGLAYSIYSFSSSYQDTGLYA
EEECCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEE
IYAGTSEKEAAELIPVLCDETARLADSLTEVEVARARAQLKASILMALESTSSRCEQMAR
EEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIQVYGRPIGIDEVVAKLDGVTIDQVAACARRIFTRPPTLAAIGPLAGVEDYDKIVARLK
HHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]