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The map label for this gene is gcvPB [H]

Identifier: 83594378

GI number: 83594378

Start: 3510730

End: 3512244

Strand: Reverse

Name: gcvPB [H]

Synonym: Rru_A3048

Alternate gene names: 83594378

Gene position: 3512244-3510730 (Counterclockwise)

Preceding gene: 83594379

Following gene: 83594376

Centisome position: 80.69

GC content: 66.93

Gene sequence:

>1515_bases
ATGACCGCGACCTTCACCGGCAACCGCGGGCTTCAGCTTGAAGAGCCCCTGATTTTCGAACTCGACACCCCCGGCTCGAC
GGCGGTCGATCTGACGCCGCCCGCCCCCTTCACCGACCGCCTGGGCGGTTTGACGCGCCAGGGGCCGATCGGCCTGCCCG
GACTGTCCGAGCCCCAGGTGGTGCGCCACTACACCCGCCTGTCGCAAAAGAACTACAGCATCGATGCCGGCTTCTATCCG
CTGGGCTCGTGCACCATGAAGTATAACCCGCGGCTGAACGAGCGCATGGCCCGGCTGCCCGGCTTCGCCGATATCCACCC
CTTCCAGCCGGTCTCCACCGTTCAGGGCGCCCTGGCCTTGATGGACCATTTGGCGCGCTGGTTGAAGGAATTGACTGGCA
TGCCCGCCGTCGCCCTGTCGCCGGCGGCCGGGGCGCATGGCGAGTTGTGCGGGATGATGGCGATCCGCGCCGCCCTGCAG
GCGCGCGGCGATGAGCGCAAGGTGGTGCTGGTTCCCGAAAGCGCCCATGGCACCAATCCGGCGACGGCGGCGGCCTGCGG
CTTCAAGGTCGAGACCATCCCCGCCGACGCCCGGGGCCGGGTCGACAGCGCCGTGCTGACCGCCCGCCTGGGGCCCGATG
TGGCGGCGGTGATGCTGACCAACCCCAATACCTGCGGCCTGTTCGAAGGCGACATCATCACCCTGTCCAAGGCCGTTCAC
GCGGCGGGTGCCTTTTTCTATATGGATGGCGCCAATTTCAATGCCATCGTCGGCCGGGTGCGGGTTGGCGATCTGGGCGC
CGACGCCATGCATATCAATCTGCACAAGACCTTCTCGACGCCGCACGGCGGCGGCGGCCCCGGCGCCGGCCCCACGGTGC
TGTCAGAAGCCCTCGCTCCCTTCGCGCCGCTGCCCTATGTGGTTCATGACACGGAGGGCTTCCGCCTGATCGAGACCGAT
CTTGACGCCCAGGCCGACGGCACCGCGCCCTTTGGCCGGCTCAAGGGCTTCCATGGCCAGTTCGGCGTGTTCGTGCGCGC
GCTCTGCTACATGATGAGCATGGGCAAGGACGGCTTGCGTCAGGCCAGCGGCGATGCGGTGCTCAATGCCAATTACCTGC
TAGCCAGCCTCAAGGACACACTGTCGGCGTCGTTCGAGGGGCCCTGCATGCACGAGGCGCTGTTTGACGATCGCTTCCTC
AAGGATACCGGGGTCAGCACCCTTGATTTCGCCAAGGCGCTGATCGACGAGGGCTATCACCCGATGACCATGTATTTCCC
GCTGGTCGTCCATGGGGCGCTGTTGATCGAGCCGACGGAAACCGAAAGCCGCCAGACCCTTGATCTGTTCATCGCGACGC
TGAAGGATCTGGCCCGGCGCGCCCGCGAAAACGGCGCCGAAGCCTTCAAGGCGGCGCCGCAGCTGACGCCGCGCCGTCGC
CTTGATGAAACCCTGGCCGCCCGCAAGCCGGTGCTGCGCTGGACGCCGCCGGCCCTCAAGGACGCCGCCGAATAA

Upstream 100 bases:

>100_bases
CTATCCCGAGCTGGCCAATCTGCTGCTGGTCAACGCCACGGAATTGACCACGCCCGAGGATGCCGACGCCCTGGTGGCCG
CCCTGAAAGAGGTGCTTTAA

Downstream 100 bases:

>100_bases
GAGCGCCGATCCCCCCGACCGCGCGCGTTGTGCGGCCGGGGGGCGTTTTAGCCGGGCGGCAGCACGGGCACCGGTTCGGC
CGCGGCCAGTTTGGCCGCCG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTATFTGNRGLQLEEPLIFELDTPGSTAVDLTPPAPFTDRLGGLTRQGPIGLPGLSEPQVVRHYTRLSQKNYSIDAGFYP
LGSCTMKYNPRLNERMARLPGFADIHPFQPVSTVQGALALMDHLARWLKELTGMPAVALSPAAGAHGELCGMMAIRAALQ
ARGDERKVVLVPESAHGTNPATAAACGFKVETIPADARGRVDSAVLTARLGPDVAAVMLTNPNTCGLFEGDIITLSKAVH
AAGAFFYMDGANFNAIVGRVRVGDLGADAMHINLHKTFSTPHGGGGPGAGPTVLSEALAPFAPLPYVVHDTEGFRLIETD
LDAQADGTAPFGRLKGFHGQFGVFVRALCYMMSMGKDGLRQASGDAVLNANYLLASLKDTLSASFEGPCMHEALFDDRFL
KDTGVSTLDFAKALIDEGYHPMTMYFPLVVHGALLIEPTETESRQTLDLFIATLKDLARRARENGAEAFKAAPQLTPRRR
LDETLAARKPVLRWTPPALKDAAE

Sequences:

>Translated_504_residues
MTATFTGNRGLQLEEPLIFELDTPGSTAVDLTPPAPFTDRLGGLTRQGPIGLPGLSEPQVVRHYTRLSQKNYSIDAGFYP
LGSCTMKYNPRLNERMARLPGFADIHPFQPVSTVQGALALMDHLARWLKELTGMPAVALSPAAGAHGELCGMMAIRAALQ
ARGDERKVVLVPESAHGTNPATAAACGFKVETIPADARGRVDSAVLTARLGPDVAAVMLTNPNTCGLFEGDIITLSKAVH
AAGAFFYMDGANFNAIVGRVRVGDLGADAMHINLHKTFSTPHGGGGPGAGPTVLSEALAPFAPLPYVVHDTEGFRLIETD
LDAQADGTAPFGRLKGFHGQFGVFVRALCYMMSMGKDGLRQASGDAVLNANYLLASLKDTLSASFEGPCMHEALFDDRFL
KDTGVSTLDFAKALIDEGYHPMTMYFPLVVHGALLIEPTETESRQTLDLFIATLKDLARRARENGAEAFKAAPQLTPRRR
LDETLAARKPVLRWTPPALKDAAE
>Mature_503_residues
TATFTGNRGLQLEEPLIFELDTPGSTAVDLTPPAPFTDRLGGLTRQGPIGLPGLSEPQVVRHYTRLSQKNYSIDAGFYPL
GSCTMKYNPRLNERMARLPGFADIHPFQPVSTVQGALALMDHLARWLKELTGMPAVALSPAAGAHGELCGMMAIRAALQA
RGDERKVVLVPESAHGTNPATAAACGFKVETIPADARGRVDSAVLTARLGPDVAAVMLTNPNTCGLFEGDIITLSKAVHA
AGAFFYMDGANFNAIVGRVRVGDLGADAMHINLHKTFSTPHGGGGPGAGPTVLSEALAPFAPLPYVVHDTEGFRLIETDL
DAQADGTAPFGRLKGFHGQFGVFVRALCYMMSMGKDGLRQASGDAVLNANYLLASLKDTLSASFEGPCMHEALFDDRFLK
DTGVSTLDFAKALIDEGYHPMTMYFPLVVHGALLIEPTETESRQTLDLFIATLKDLARRARENGAEAFKAAPQLTPRRRL
DETLAARKPVLRWTPPALKDAAE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=459, Percent_Identity=37.2549019607843, Blast_Score=246, Evalue=3e-65,
Organism=Escherichia coli, GI1789269, Length=422, Percent_Identity=40.9952606635071, Blast_Score=260, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17535605, Length=430, Percent_Identity=38.3720930232558, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI32564013, Length=377, Percent_Identity=38.4615384615385, Blast_Score=226, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323843, Length=405, Percent_Identity=40.4938271604938, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24645648, Length=434, Percent_Identity=37.5576036866359, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53948; Mature: 53817

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATFTGNRGLQLEEPLIFELDTPGSTAVDLTPPAPFTDRLGGLTRQGPIGLPGLSEPQV
CCEEEECCCCCEECCCEEEEECCCCCCEEECCCCCCHHHHHCCCCCCCCCCCCCCCCHHH
VRHYTRLSQKNYSIDAGFYPLGSCTMKYNPRLNERMARLPGFADIHPFQPVSTVQGALAL
HHHHHHHHCCCCEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
MDHLARWLKELTGMPAVALSPAAGAHGELCGMMAIRAALQARGDERKVVLVPESAHGTNP
HHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
ATAAACGFKVETIPADARGRVDSAVLTARLGPDVAAVMLTNPNTCGLFEGDIITLSKAVH
CHHHHCCCEEEECCCCCCCCCCHHHEEEECCCCEEEEEEECCCCCCEECCCEEHHHHHHH
AAGAFFYMDGANFNAIVGRVRVGDLGADAMHINLHKTFSTPHGGGGPGAGPTVLSEALAP
HCCEEEEECCCCCEEEEEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHCC
FAPLPYVVHDTEGFRLIETDLDAQADGTAPFGRLKGFHGQFGVFVRALCYMMSMGKDGLR
CCCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
QASGDAVLNANYLLASLKDTLSASFEGPCMHEALFDDRFLKDTGVSTLDFAKALIDEGYH
HCCCCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCC
PMTMYFPLVVHGALLIEPTETESRQTLDLFIATLKDLARRARENGAEAFKAAPQLTPRRR
CHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHH
LDETLAARKPVLRWTPPALKDAAE
HHHHHHHCCCCEECCCHHHHHCCC
>Mature Secondary Structure 
TATFTGNRGLQLEEPLIFELDTPGSTAVDLTPPAPFTDRLGGLTRQGPIGLPGLSEPQV
CEEEECCCCCEECCCEEEEECCCCCCEEECCCCCCHHHHHCCCCCCCCCCCCCCCCHHH
VRHYTRLSQKNYSIDAGFYPLGSCTMKYNPRLNERMARLPGFADIHPFQPVSTVQGALAL
HHHHHHHHCCCCEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
MDHLARWLKELTGMPAVALSPAAGAHGELCGMMAIRAALQARGDERKVVLVPESAHGTNP
HHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
ATAAACGFKVETIPADARGRVDSAVLTARLGPDVAAVMLTNPNTCGLFEGDIITLSKAVH
CHHHHCCCEEEECCCCCCCCCCHHHEEEECCCCEEEEEEECCCCCCEECCCEEHHHHHHH
AAGAFFYMDGANFNAIVGRVRVGDLGADAMHINLHKTFSTPHGGGGPGAGPTVLSEALAP
HCCEEEEECCCCCEEEEEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHCC
FAPLPYVVHDTEGFRLIETDLDAQADGTAPFGRLKGFHGQFGVFVRALCYMMSMGKDGLR
CCCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
QASGDAVLNANYLLASLKDTLSASFEGPCMHEALFDDRFLKDTGVSTLDFAKALIDEGYH
HCCCCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCC
PMTMYFPLVVHGALLIEPTETESRQTLDLFIATLKDLARRARENGAEAFKAAPQLTPRRR
CHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHH
LDETLAARKPVLRWTPPALKDAAE
HHHHHHHCCCCEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]