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The map label for this gene is gcvPA

Identifier: 83594379

GI number: 83594379

Start: 3512245

End: 3513591

Strand: Reverse

Name: gcvPA

Synonym: Rru_A3049

Alternate gene names: 83594379

Gene position: 3513591-3512245 (Counterclockwise)

Preceding gene: 83594380

Following gene: 83594378

Centisome position: 80.72

GC content: 68.45

Gene sequence:

>1347_bases
ATGCGTTACCTCCCCCATTCCGAGGCCGACCGCGCCGCCATGCTCGCCACCATCGGCGCGGCTTCGGTCGAAGATCTGTT
TCGTGACGTCCCGCGCGAGGCCCTGGATCAGGCCGCCTTCGACGCCTTGCCCGATCACGGCGGCGAGATGGAGGTCGAGC
GCGCGCTTTCGGCCCTGGCGGCGCGCAATCTGACCGCCGGATCGGTGCCCTGCTTCCTGGGCGCGGGATCCTATCGCCAC
CATGTGCCCGCCGCCGTCGACGCCCTGATCCAGCGCGGCGAATTCCTGACCTCCTATACCCCCTATCAGGCCGAGGTCAG
CCAGGGCACGCTTCAGTATCTGTTCGAGTTCCAGACCCAGGTGGCGCTGATCACCGGCATGGAGGTGGCCAACGCCTCGA
TGTACGATGGCGCCACCGCCTGCGCCGAGGCGGCGGCCATGGCCGTGCGCATCACCCGCCGGCGCAAGGTGCTGATGGCC
GGCGGGCTGCATCCCCATTACACCGCGACCACCCAGACCCTGCTGGCCTGCCTGGGCCATGAGGGCGAGGGGCTGCCCCC
CGATCCGCTGGCCCTGGGCGATCTGATCGGGCGCGTCGGCTCCGACACCGCCTGCGTTATCGTTCAGAACCCGGATTTCT
TTGGCCGTTTGCGCGATCTGTCGCCGCTGGCCGAGGCCTGCCACGCCGCCGGCGCCCTGCTGGTGGTGGCGGTATGCGAG
CCGGTGTCGCTGGGTCTGGTCGCCCCGCCGGGCGCCATGGGCGCCGATATCGTGGTGGCCGAGGGTCATGCCCTGGGCTC
GCCGACCGGTTTTGGCGGTCCCGGCGTCGGGCTGTTCGCCACCCGCGAGAAATACCTGCGCCAGATGCCCGGCCGGCTGG
CCGGCGAGACGCTCGATGAAAGCGGCAAGCGCGGTTATGTGCTGACGCTGTCAACCCGCGAGCAGCATATCCGCCGCGAG
AAGGCGACCTCGAACATCTGCACCAATTCGGGGCTGATCGCCCTGGCCTTCACCATCCATATGACCTTGCTGGGCGAGGC
GGGCTTTACCCGGCTGGCGTGGATCAACCACGCCAATGCCGTCGCCTTGGCCGAGAAGCTGGCGCGGGTGAAGGGGGTGA
AGGTTCTGCCCGAGACCTTCTTCAACGAGTTCACCCTGCGCCTGCCCAAGCCCGCCGCCGAAGTCGTCGAGGCTTTGGCC
GCACGGTCGATCCTGGCGGGCGTGCCGGTCTCGCGCTTCCTGCCGACCTATCCCGAGCTGGCCAATCTGCTGCTGGTCAA
CGCCACGGAATTGACCACGCCCGAGGATGCCGACGCCCTGGTGGCCGCCCTGAAAGAGGTGCTTTAA

Upstream 100 bases:

>100_bases
TGGATCAAGAAGCCTACGACGCCTTCGTCGGCGAGCTCGATTAACCAAGCGGCGCCGCCACCGGCCCGTCCGGGCATTTT
TTCGAGGCTGAAGGACTCCC

Downstream 100 bases:

>100_bases
ATGACCGCGACCTTCACCGGCAACCGCGGGCTTCAGCTTGAAGAGCCCCTGATTTTCGAACTCGACACCCCCGGCTCGAC
GGCGGTCGATCTGACGCCGC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRYLPHSEADRAAMLATIGAASVEDLFRDVPREALDQAAFDALPDHGGEMEVERALSALAARNLTAGSVPCFLGAGSYRH
HVPAAVDALIQRGEFLTSYTPYQAEVSQGTLQYLFEFQTQVALITGMEVANASMYDGATACAEAAAMAVRITRRRKVLMA
GGLHPHYTATTQTLLACLGHEGEGLPPDPLALGDLIGRVGSDTACVIVQNPDFFGRLRDLSPLAEACHAAGALLVVAVCE
PVSLGLVAPPGAMGADIVVAEGHALGSPTGFGGPGVGLFATREKYLRQMPGRLAGETLDESGKRGYVLTLSTREQHIRRE
KATSNICTNSGLIALAFTIHMTLLGEAGFTRLAWINHANAVALAEKLARVKGVKVLPETFFNEFTLRLPKPAAEVVEALA
ARSILAGVPVSRFLPTYPELANLLLVNATELTTPEDADALVAALKEVL

Sequences:

>Translated_448_residues
MRYLPHSEADRAAMLATIGAASVEDLFRDVPREALDQAAFDALPDHGGEMEVERALSALAARNLTAGSVPCFLGAGSYRH
HVPAAVDALIQRGEFLTSYTPYQAEVSQGTLQYLFEFQTQVALITGMEVANASMYDGATACAEAAAMAVRITRRRKVLMA
GGLHPHYTATTQTLLACLGHEGEGLPPDPLALGDLIGRVGSDTACVIVQNPDFFGRLRDLSPLAEACHAAGALLVVAVCE
PVSLGLVAPPGAMGADIVVAEGHALGSPTGFGGPGVGLFATREKYLRQMPGRLAGETLDESGKRGYVLTLSTREQHIRRE
KATSNICTNSGLIALAFTIHMTLLGEAGFTRLAWINHANAVALAEKLARVKGVKVLPETFFNEFTLRLPKPAAEVVEALA
ARSILAGVPVSRFLPTYPELANLLLVNATELTTPEDADALVAALKEVL
>Mature_448_residues
MRYLPHSEADRAAMLATIGAASVEDLFRDVPREALDQAAFDALPDHGGEMEVERALSALAARNLTAGSVPCFLGAGSYRH
HVPAAVDALIQRGEFLTSYTPYQAEVSQGTLQYLFEFQTQVALITGMEVANASMYDGATACAEAAAMAVRITRRRKVLMA
GGLHPHYTATTQTLLACLGHEGEGLPPDPLALGDLIGRVGSDTACVIVQNPDFFGRLRDLSPLAEACHAAGALLVVAVCE
PVSLGLVAPPGAMGADIVVAEGHALGSPTGFGGPGVGLFATREKYLRQMPGRLAGETLDESGKRGYVLTLSTREQHIRRE
KATSNICTNSGLIALAFTIHMTLLGEAGFTRLAWINHANAVALAEKLARVKGVKVLPETFFNEFTLRLPKPAAEVVEALA
ARSILAGVPVSRFLPTYPELANLLLVNATELTTPEDADALVAALKEVL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=405, Percent_Identity=35.8024691358025, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1789269, Length=408, Percent_Identity=31.6176470588235, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535605, Length=401, Percent_Identity=35.6608478802993, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323843, Length=409, Percent_Identity=32.0293398533007, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24645648, Length=389, Percent_Identity=34.9614395886889, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_RHORT (Q2RPV1)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428131.1
- ProteinModelPortal:   Q2RPV1
- SMR:   Q2RPV1
- STRING:   Q2RPV1
- GeneID:   3836495
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3049
- NMPDR:   fig|1085.1.peg.690
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   RRUB269796:RRU_A3049-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 47385; Mature: 47385

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPHSEADRAAMLATIGAASVEDLFRDVPREALDQAAFDALPDHGGEMEVERALSALA
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ARNLTAGSVPCFLGAGSYRHHVPAAVDALIQRGEFLTSYTPYQAEVSQGTLQYLFEFQTQ
HCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHH
VALITGMEVANASMYDGATACAEAAAMAVRITRRRKVLMAGGLHPHYTATTQTLLACLGH
HHEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCC
EGEGLPPDPLALGDLIGRVGSDTACVIVQNPDFFGRLRDLSPLAEACHAAGALLVVAVCE
CCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCHHHHHHHHCCHHEEEEHHC
PVSLGLVAPPGAMGADIVVAEGHALGSPTGFGGPGVGLFATREKYLRQMPGRLAGETLDE
CCCCCEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCHHC
SGKRGYVLTLSTREQHIRREKATSNICTNSGLIALAFTIHMTLLGEAGFTRLAWINHANA
CCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHH
VALAEKLARVKGVKVLPETFFNEFTLRLPKPAAEVVEALAARSILAGVPVSRFLPTYPEL
HHHHHHHHHHCCCHHHHHHHHCHHEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHH
ANLLLVNATELTTPEDADALVAALKEVL
HHEEEEECCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MRYLPHSEADRAAMLATIGAASVEDLFRDVPREALDQAAFDALPDHGGEMEVERALSALA
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ARNLTAGSVPCFLGAGSYRHHVPAAVDALIQRGEFLTSYTPYQAEVSQGTLQYLFEFQTQ
HCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHH
VALITGMEVANASMYDGATACAEAAAMAVRITRRRKVLMAGGLHPHYTATTQTLLACLGH
HHEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCC
EGEGLPPDPLALGDLIGRVGSDTACVIVQNPDFFGRLRDLSPLAEACHAAGALLVVAVCE
CCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCHHHHHHHHCCHHEEEEHHC
PVSLGLVAPPGAMGADIVVAEGHALGSPTGFGGPGVGLFATREKYLRQMPGRLAGETLDE
CCCCCEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCHHC
SGKRGYVLTLSTREQHIRREKATSNICTNSGLIALAFTIHMTLLGEAGFTRLAWINHANA
CCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHH
VALAEKLARVKGVKVLPETFFNEFTLRLPKPAAEVVEALAARSILAGVPVSRFLPTYPEL
HHHHHHHHHHCCCHHHHHHHHCHHEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCCCHHH
ANLLLVNATELTTPEDADALVAALKEVL
HHEEEEECCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA