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The map label for this gene is pyrC [H]

Identifier: 83594268

GI number: 83594268

Start: 3383106

End: 3384467

Strand: Reverse

Name: pyrC [H]

Synonym: Rru_A2936

Alternate gene names: 83594268

Gene position: 3384467-3383106 (Counterclockwise)

Preceding gene: 83594269

Following gene: 83594267

Centisome position: 77.75

GC content: 66.81

Gene sequence:

>1362_bases
GTGGCCCAGTCCTATGATCTGATCCTCAAGGGCGGCACCGCCGTTCTGCCCGGCCGTACCATGCGCGCCGATATCGCCGT
GTGTGGCGGCAAGGTGGTGCGCGTCGGTTTCCTCGATGCCGGATCGGCGCGCCAGACCATCGATTGCGCCGGCTTGCACG
TGCTTCCCGGGGTCATCGATACCCAGGTGCATTTCCGCGAGCCCGGTCTAGAGCACAAGGAGGATCTGGAAAGCGGCACG
CGGGCCGCCGTTCTGGGCGGGGTGACCGGCGTCTTCGAGATGCCCAACACCGCACCGGCCACCGACAGCCCCGAGGCCCT
CGAGGAAAAGCTGACCCGGGCCCAGGGCCGCACATGGTGCGATCACGCCTTTTTCCTGGGGGCGAGCGCGGCTAACGCCG
CAGCCCTTGGCGGCTGGGAACGCCGGGATGGTTGCGCCGGGGTCAAGATCTTCATGGGATCGTCGACCGGCTCGCTGCTG
GTCGATCAGGACGAGGCGATCGCCCGGGTCCTGGCCGGCGGCTTCCGCCGGGTCGCCGTCCATTGCGAGGACGAGGCCCG
CTTGAAGGAGCGCAAGGCCCTGGTGGCCGATGGGGCTTCGGTGGCGCTTCATCCCGAATGGCGCGACGTGGAAACCGCCC
TGGCGGCGACGCGGCGCCTGCTGGCCTTGGCCCGCCAGGCCGGACGCAAGGTGCATGTGCTGCATGTGACCACCGCCGAA
GAAATGGCCCTGTTGCAAGACAACCGCGACATCGCCAGCGTCGAGGTGACCCCCCAGCATCTGACCCTTGCCGCCCCCGA
TTGCTACGAGGGGCTGGGGACCTTCGCCCAGATGAACCCGCCGATTCGCGAGGCTCGCCACCGCGAAGCCCTATGGCGGG
CCCTGGAGCAAGGCGTCGTTGATATCATCGGCTCCGATCACGCGCCCCATACCCTGAAGGAGAAATCCCTTCCCTATCCC
AAAAGCCCCTCGGGCATGCCCGGAGTGCAGACCCTGGTTCCGGTGATGCTTGATCATGTCAACACCGGCAAGCTGAGCCT
GGAACGCTTCGTCGATCTGACCAGCGCCGGACCCGCCCGGGTTTATGACATCGCCGGCAAGGGGCGGATCGCGGCGGGCT
ATGACGCCGATTTCACCGTGGTCGATATGAACGCCGAACGCACCATCACCAACGAATGGATCGCCAGCAAATGCGGCTGG
ACACCGTTTCATGGGCTGAGCGTGCGCGGCTGGCCGGTGATGACCATCATTCGCGGGGCCATCGTCATGCGCGACGGCGC
CCTTCAGGGGCGTCCCTTGGGGGCGCCGGTGCGTTTTCATCCCCTGCCGCCCCTGACGAAGGAGTCCGCCGTTCTTCGGT
AA

Upstream 100 bases:

>100_bases
CGGCCGGCGGGGAGATCTTTGGCATCCCTCCTTTGAAGAAAAAGACCAAGAGCGCGACGCCTTTTTCGAACCGAAGACGC
TATCTGTGGAGAGACGAGAC

Downstream 100 bases:

>100_bases
GCGGGCTGTGACAGCGGGGCGGAAGGCGATAAGCTGACCCGCTTGGTTATGGCAAAGGGATCCGCATGATCAATGGACTG
GCGGACTCGACGGGGTGGAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAQSYDLILKGGTAVLPGRTMRADIAVCGGKVVRVGFLDAGSARQTIDCAGLHVLPGVIDTQVHFREPGLEHKEDLESGT
RAAVLGGVTGVFEMPNTAPATDSPEALEEKLTRAQGRTWCDHAFFLGASAANAAALGGWERRDGCAGVKIFMGSSTGSLL
VDQDEAIARVLAGGFRRVAVHCEDEARLKERKALVADGASVALHPEWRDVETALAATRRLLALARQAGRKVHVLHVTTAE
EMALLQDNRDIASVEVTPQHLTLAAPDCYEGLGTFAQMNPPIREARHREALWRALEQGVVDIIGSDHAPHTLKEKSLPYP
KSPSGMPGVQTLVPVMLDHVNTGKLSLERFVDLTSAGPARVYDIAGKGRIAAGYDADFTVVDMNAERTITNEWIASKCGW
TPFHGLSVRGWPVMTIIRGAIVMRDGALQGRPLGAPVRFHPLPPLTKESAVLR

Sequences:

>Translated_453_residues
MAQSYDLILKGGTAVLPGRTMRADIAVCGGKVVRVGFLDAGSARQTIDCAGLHVLPGVIDTQVHFREPGLEHKEDLESGT
RAAVLGGVTGVFEMPNTAPATDSPEALEEKLTRAQGRTWCDHAFFLGASAANAAALGGWERRDGCAGVKIFMGSSTGSLL
VDQDEAIARVLAGGFRRVAVHCEDEARLKERKALVADGASVALHPEWRDVETALAATRRLLALARQAGRKVHVLHVTTAE
EMALLQDNRDIASVEVTPQHLTLAAPDCYEGLGTFAQMNPPIREARHREALWRALEQGVVDIIGSDHAPHTLKEKSLPYP
KSPSGMPGVQTLVPVMLDHVNTGKLSLERFVDLTSAGPARVYDIAGKGRIAAGYDADFTVVDMNAERTITNEWIASKCGW
TPFHGLSVRGWPVMTIIRGAIVMRDGALQGRPLGAPVRFHPLPPLTKESAVLR
>Mature_452_residues
AQSYDLILKGGTAVLPGRTMRADIAVCGGKVVRVGFLDAGSARQTIDCAGLHVLPGVIDTQVHFREPGLEHKEDLESGTR
AAVLGGVTGVFEMPNTAPATDSPEALEEKLTRAQGRTWCDHAFFLGASAANAAALGGWERRDGCAGVKIFMGSSTGSLLV
DQDEAIARVLAGGFRRVAVHCEDEARLKERKALVADGASVALHPEWRDVETALAATRRLLALARQAGRKVHVLHVTTAEE
MALLQDNRDIASVEVTPQHLTLAAPDCYEGLGTFAQMNPPIREARHREALWRALEQGVVDIIGSDHAPHTLKEKSLPYPK
SPSGMPGVQTLVPVMLDHVNTGKLSLERFVDLTSAGPARVYDIAGKGRIAAGYDADFTVVDMNAERTITNEWIASKCGWT
PFHGLSVRGWPVMTIIRGAIVMRDGALQGRPLGAPVRFHPLPPLTKESAVLR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=414, Percent_Identity=34.2995169082126, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI19923821, Length=473, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4503379, Length=469, Percent_Identity=26.226012793177, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4503375, Length=455, Percent_Identity=26.3736263736264, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4503377, Length=444, Percent_Identity=24.7747747747748, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=24.6666666666667, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503051, Length=446, Percent_Identity=24.4394618834081, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI190194363, Length=452, Percent_Identity=25, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1786722, Length=457, Percent_Identity=33.0415754923414, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87082175, Length=461, Percent_Identity=26.2472885032538, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=404, Percent_Identity=31.6831683168317, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71989490, Length=465, Percent_Identity=29.6774193548387, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17539558, Length=471, Percent_Identity=26.963906581741, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322218, Length=401, Percent_Identity=29.1770573566085, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24642586, Length=389, Percent_Identity=31.8766066838046, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI18859883, Length=438, Percent_Identity=30.1369863013699, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI221377917, Length=481, Percent_Identity=27.8586278586279, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17137462, Length=476, Percent_Identity=27.9411764705882, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48645; Mature: 48514

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSYDLILKGGTAVLPGRTMRADIAVCGGKVVRVGFLDAGSARQTIDCAGLHVLPGVID
CCCCEEEEEECCEEECCCCCEEEEEEECCCEEEEEEEECCCCCCCEEECCCCEECCCCCC
TQVHFREPGLEHKEDLESGTRAAVLGGVTGVFEMPNTAPATDSPEALEEKLTRAQGRTWC
CEEEECCCCCCCHHHHHCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCH
DHAFFLGASAANAAALGGWERRDGCAGVKIFMGSSTGSLLVDQDEAIARVLAGGFRRVAV
HHHHEECCCCCCHHHCCCCCCCCCCCEEEEEEECCCCCEEEECHHHHHHHHHCCCEEEEE
HCEDEARLKERKALVADGASVALHPEWRDVETALAATRRLLALARQAGRKVHVLHVTTAE
EECCHHHHHHHHHHEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
EMALLQDNRDIASVEVTPQHLTLAAPDCYEGLGTFAQMNPPIREARHREALWRALEQGVV
HHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHH
DIIGSDHAPHTLKEKSLPYPKSPSGMPGVQTLVPVMLDHVNTGKLSLERFVDLTSAGPAR
EECCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCE
VYDIAGKGRIAAGYDADFTVVDMNAERTITNEWIASKCGWTPFHGLSVRGWPVMTIIRGA
EEEECCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
IVMRDGALQGRPLGAPVRFHPLPPLTKESAVLR
HEEECCCCCCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AQSYDLILKGGTAVLPGRTMRADIAVCGGKVVRVGFLDAGSARQTIDCAGLHVLPGVID
CCCEEEEEECCEEECCCCCEEEEEEECCCEEEEEEEECCCCCCCEEECCCCEECCCCCC
TQVHFREPGLEHKEDLESGTRAAVLGGVTGVFEMPNTAPATDSPEALEEKLTRAQGRTWC
CEEEECCCCCCCHHHHHCCCCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCH
DHAFFLGASAANAAALGGWERRDGCAGVKIFMGSSTGSLLVDQDEAIARVLAGGFRRVAV
HHHHEECCCCCCHHHCCCCCCCCCCCEEEEEEECCCCCEEEECHHHHHHHHHCCCEEEEE
HCEDEARLKERKALVADGASVALHPEWRDVETALAATRRLLALARQAGRKVHVLHVTTAE
EECCHHHHHHHHHHEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
EMALLQDNRDIASVEVTPQHLTLAAPDCYEGLGTFAQMNPPIREARHREALWRALEQGVV
HHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHH
DIIGSDHAPHTLKEKSLPYPKSPSGMPGVQTLVPVMLDHVNTGKLSLERFVDLTSAGPAR
EECCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCE
VYDIAGKGRIAAGYDADFTVVDMNAERTITNEWIASKCGWTPFHGLSVRGWPVMTIIRGA
EEEECCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
IVMRDGALQGRPLGAPVRFHPLPPLTKESAVLR
HEEECCCCCCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]