Click here to switch to the map view.

The map label for this gene is hisD

Identifier: 83594103

GI number: 83594103

Start: 3204714

End: 3206018

Strand: Reverse

Name: hisD

Synonym: Rru_A2771

Alternate gene names: 83594103

Gene position: 3206018-3204714 (Counterclockwise)

Preceding gene: 83594104

Following gene: 83594102

Centisome position: 73.65

GC content: 70.42

Gene sequence:

>1305_bases
ATGCCGTTGCGGCTTGAGGCCTCCAGCGCCGATTTCGCCCCGGCCTTCGCCGCGCTGCTGGCGGGCAAGCGCGAGAGCGC
CCAGGACGTCAACGACGTGGTGAGCGCGATCCTGGCCGATGTGCGCCTGCGCGGCGACGATGCCCTGATCGATTACACGG
CGCGCTTTGACAAGATGACCGTTTCGGCCGAGGGCCTGCGCTTTAGCGACGACGAGGTGGACACCGCCGTCGCCCTGATC
GAGCCGGCCTTGCGCGATGCCCTGGCCCTGGCGGCCAAGCGCATCACCCGCTTCCATGAACGCCAGATGCCCACGGCGAT
CTCGTTCACCGACGAGGACGGCGTGCGGCTGGGCCAGCGCTGGACGGCGGTTTCCGCCGCCGGGCTTTACGTGCCGGGCG
GTCTCGCGGCCTATCCGTCCTCGGTGCTGATGAACGCCCTGCCGGCCAAGGTGGCGGGCGTCGAACGGCTGGTCATGGTG
GTGCCGACGCCGGCCGGGCGGATCAATCCGCTGGTGCTGGCGGCGGCCAAGCTGGCCGGCGTCGATGAGATCTATCGCGT
CGGCGGCGCCCAGGCGGTGGCGGCCCTGGCCTATGGCACGCGGACCATCGCCCCCGTCGACAAGATCGTCGGCCCCGGCA
ACGCCTATGTCGCCGCCGCCAAACGTCAGGTTTTCGGCACCGTCGGCATCGATATGATCGCCGGTCCCTCGGAGATCCTG
GTGGTCGCCGATGGCGCCAATGATCCCGACTGGATCGCCCTTGACCTGCTGTCCCAGGCCGAGCACGACGCCGCCGCCCA
ATCGATCCTGATCACCGATGATCGGGCCTTCGCCGATCGGGTGGAGCGCGCGGTGACCGACCGCCTGCGGACGCTGTCGC
GCACCGAGATCGCCAGCGCCTCCTGGCGCGACCACGGGGCGATCATCCTGGTGGGCGATCTGTTGCGCGACGCCCCGGCC
CTGGTCGACAAGGTGGCGCCCGAGCATCTGGAACTGGCGGTGGCCGATCCCGACGCCCTGGCGGCGCGCGTGCGCCACGC
CGGCGCGATCTTCCTTGGGCGCTATACCCCCGAAGCCATCGGCGATTACATCGCCGGGCCCAACCATGTGCTGCCAACCT
CGCGCACGGCGCGTTTCTCGTCGGGGCTTGGGGTGCTCGACTTCATGAAGCGGACGACGCTGGTCGGCTGCGGAGCCGAG
TCGCTGGGGGCGATCGGACCAAGCGCCGTCCGTCTGGCCCGGGCCGAAGGGCTTGAGGCCCACGGGCTGTCGGTGGCGGC
CCGCATGAACCGGGGCTGGGAGTAG

Upstream 100 bases:

>100_bases
ATCCTTGATGTCACCTCGCGTCTTGTCGTCAACCGCACCGCCATGAAGGTCCGCTCGCGCGAGATGACCGCCTGGATCGA
ACGCTTCCGGGAGGCTTGCG

Downstream 100 bases:

>100_bases
ACATGGAGGAGGGCGAGCTGAAGGATACGGATCATCTGATCGATATTCAGCTCGACGAAGTGACCTTCGTGCGCCGGCGG
CCCGAGGTGGAGCACGAACG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MPLRLEASSADFAPAFAALLAGKRESAQDVNDVVSAILADVRLRGDDALIDYTARFDKMTVSAEGLRFSDDEVDTAVALI
EPALRDALALAAKRITRFHERQMPTAISFTDEDGVRLGQRWTAVSAAGLYVPGGLAAYPSSVLMNALPAKVAGVERLVMV
VPTPAGRINPLVLAAAKLAGVDEIYRVGGAQAVAALAYGTRTIAPVDKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEIL
VVADGANDPDWIALDLLSQAEHDAAAQSILITDDRAFADRVERAVTDRLRTLSRTEIASASWRDHGAIILVGDLLRDAPA
LVDKVAPEHLELAVADPDALAARVRHAGAIFLGRYTPEAIGDYIAGPNHVLPTSRTARFSSGLGVLDFMKRTTLVGCGAE
SLGAIGPSAVRLARAEGLEAHGLSVAARMNRGWE

Sequences:

>Translated_434_residues
MPLRLEASSADFAPAFAALLAGKRESAQDVNDVVSAILADVRLRGDDALIDYTARFDKMTVSAEGLRFSDDEVDTAVALI
EPALRDALALAAKRITRFHERQMPTAISFTDEDGVRLGQRWTAVSAAGLYVPGGLAAYPSSVLMNALPAKVAGVERLVMV
VPTPAGRINPLVLAAAKLAGVDEIYRVGGAQAVAALAYGTRTIAPVDKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEIL
VVADGANDPDWIALDLLSQAEHDAAAQSILITDDRAFADRVERAVTDRLRTLSRTEIASASWRDHGAIILVGDLLRDAPA
LVDKVAPEHLELAVADPDALAARVRHAGAIFLGRYTPEAIGDYIAGPNHVLPTSRTARFSSGLGVLDFMKRTTLVGCGAE
SLGAIGPSAVRLARAEGLEAHGLSVAARMNRGWE
>Mature_433_residues
PLRLEASSADFAPAFAALLAGKRESAQDVNDVVSAILADVRLRGDDALIDYTARFDKMTVSAEGLRFSDDEVDTAVALIE
PALRDALALAAKRITRFHERQMPTAISFTDEDGVRLGQRWTAVSAAGLYVPGGLAAYPSSVLMNALPAKVAGVERLVMVV
PTPAGRINPLVLAAAKLAGVDEIYRVGGAQAVAALAYGTRTIAPVDKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEILV
VADGANDPDWIALDLLSQAEHDAAAQSILITDDRAFADRVERAVTDRLRTLSRTEIASASWRDHGAIILVGDLLRDAPAL
VDKVAPEHLELAVADPDALAARVRHAGAIFLGRYTPEAIGDYIAGPNHVLPTSRTARFSSGLGVLDFMKRTTLVGCGAES
LGAIGPSAVRLARAEGLEAHGLSVAARMNRGWE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=41.6666666666667, Blast_Score=286, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=418, Percent_Identity=37.3205741626794, Blast_Score=250, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_RHORT (Q2RQM7)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_427855.1
- ProteinModelPortal:   Q2RQM7
- SMR:   Q2RQM7
- STRING:   Q2RQM7
- GeneID:   3836211
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2771
- NMPDR:   fig|1085.1.peg.417
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   ARDRIEF
- PhylomeDB:   Q2RQM7
- ProtClustDB:   PRK00877
- BioCyc:   RRUB269796:RRU_A2771-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 45649; Mature: 45517

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 328-328 ACT_SITE 329-329 BINDING 130-130 BINDING 191-191 BINDING 214-214 BINDING 237-237 BINDING 259-259 BINDING 262-262 BINDING 329-329 BINDING 362-362 BINDING 416-416 BINDING 421-421

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRLEASSADFAPAFAALLAGKRESAQDVNDVVSAILADVRLRGDDALIDYTARFDKMT
CCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHCEEE
VSAEGLRFSDDEVDTAVALIEPALRDALALAAKRITRFHERQMPTAISFTDEDGVRLGQR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHCCH
WTAVSAAGLYVPGGLAAYPSSVLMNALPAKVAGVERLVMVVPTPAGRINPLVLAAAKLAG
HHEEEECCEECCCCHHHCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHC
VDEIYRVGGAQAVAALAYGTRTIAPVDKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEIL
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHCCHHEECCCCEEE
VVADGANDPDWIALDLLSQAEHDAAAQSILITDDRAFADRVERAVTDRLRTLSRTEIASA
EEECCCCCCCEEHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
SWRDHGAIILVGDLLRDAPALVDKVAPEHLELAVADPDALAARVRHAGAIFLGRYTPEAI
CCCCCCEEEEEHHHHHCHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCEEEEECCCHHHH
GDYIAGPNHVLPTSRTARFSSGLGVLDFMKRTTLVGCGAESLGAIGPSAVRLARAEGLEA
HHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHEEECCHHHHCCCCHHHHHHHHHCCCCC
HGLSVAARMNRGWE
CCHHHHHHHCCCCC
>Mature Secondary Structure 
PLRLEASSADFAPAFAALLAGKRESAQDVNDVVSAILADVRLRGDDALIDYTARFDKMT
CEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHCEEE
VSAEGLRFSDDEVDTAVALIEPALRDALALAAKRITRFHERQMPTAISFTDEDGVRLGQR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHCCH
WTAVSAAGLYVPGGLAAYPSSVLMNALPAKVAGVERLVMVVPTPAGRINPLVLAAAKLAG
HHEEEECCEECCCCHHHCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHC
VDEIYRVGGAQAVAALAYGTRTIAPVDKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEIL
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHCCHHEECCCCEEE
VVADGANDPDWIALDLLSQAEHDAAAQSILITDDRAFADRVERAVTDRLRTLSRTEIASA
EEECCCCCCCEEHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
SWRDHGAIILVGDLLRDAPALVDKVAPEHLELAVADPDALAARVRHAGAIFLGRYTPEAI
CCCCCCEEEEEHHHHHCHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCEEEEECCCHHHH
GDYIAGPNHVLPTSRTARFSSGLGVLDFMKRTTLVGCGAESLGAIGPSAVRLARAEGLEA
HHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHEEECCHHHHCCCCHHHHHHHHHCCCCC
HGLSVAARMNRGWE
CCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA