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The map label for this gene is hisG

Identifier: 83594104

GI number: 83594104

Start: 3206002

End: 3206685

Strand: Reverse

Name: hisG

Synonym: Rru_A2772

Alternate gene names: 83594104

Gene position: 3206685-3206002 (Counterclockwise)

Preceding gene: 83594106

Following gene: 83594103

Centisome position: 73.67

GC content: 64.77

Gene sequence:

>684_bases
ATGGTGTTCGACGCGCGCGATGGCGCGGACAAACTGGTGATCGCCCTGCCCAAGGGGCGCATTCTCAAAGAGGCTATGCC
GCTGATCGAGGCGGCCGGGCTCTCTCCCGAACCCTCGTTCGATGATCCCGACAGCCGGCAATTGCGCTTTTCCACCAGCG
ATCCCCGGGTGGATATCATCCGGGTGCGCAGCTTCGACGTGGCGACCTTCGTCGCCTTCGGGGCCGCCCATATCGGGGTG
GCGGGCAATGACGTGATCCTTGAGTTCAATTATCCCGAGCTTTACGCCCCGCTTGACCTGGGCATCGGCGCCTGCCGGCT
GTCGGTGGCCGAGGCCGAGCGGTTTTCGGCCGAGGATGATCCGGGGCGCTGGTCGCATATTCGCGTGGCGACCAAATATC
CCGAGATCACCCGCCGCCATTTCGCCGCGCGCGGGGTTCAGGCCGAATGCATCAAGCTCAATGGCGCCATGGAACTGGCC
CCGGCCCTGGGGCTTTGCCGGCGCATCGTCGATCTGGTGTCGAGCGGCGCCACCTTGAAGGCCAATGGCCTAGTCGAGGT
CGAGCGCATCCTTGATGTCACCTCGCGTCTTGTCGTCAACCGCACCGCCATGAAGGTCCGCTCGCGCGAGATGACCGCCT
GGATCGAACGCTTCCGGGAGGCTTGCGATGCCGTTGCGGCTTGA

Upstream 100 bases:

>100_bases
TGGGCCGAGCCTGTGGCTGCGGCGCCTCGGACGAGGTTGGCGGCGTGACGGTTATCCGACGGCCGGACCCACGGCCACCA
CGACGGAAGGCATAGGTTCC

Downstream 100 bases:

>100_bases
GGCCTCCAGCGCCGATTTCGCCCCGGCCTTCGCCGCGCTGCTGGCGGGCAAGCGCGAGAGCGCCCAGGACGTCAACGACG
TGGTGAGCGCGATCCTGGCC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MVFDARDGADKLVIALPKGRILKEAMPLIEAAGLSPEPSFDDPDSRQLRFSTSDPRVDIIRVRSFDVATFVAFGAAHIGV
AGNDVILEFNYPELYAPLDLGIGACRLSVAEAERFSAEDDPGRWSHIRVATKYPEITRRHFAARGVQAECIKLNGAMELA
PALGLCRRIVDLVSSGATLKANGLVEVERILDVTSRLVVNRTAMKVRSREMTAWIERFREACDAVAA

Sequences:

>Translated_227_residues
MVFDARDGADKLVIALPKGRILKEAMPLIEAAGLSPEPSFDDPDSRQLRFSTSDPRVDIIRVRSFDVATFVAFGAAHIGV
AGNDVILEFNYPELYAPLDLGIGACRLSVAEAERFSAEDDPGRWSHIRVATKYPEITRRHFAARGVQAECIKLNGAMELA
PALGLCRRIVDLVSSGATLKANGLVEVERILDVTSRLVVNRTAMKVRSREMTAWIERFREACDAVAA
>Mature_227_residues
MVFDARDGADKLVIALPKGRILKEAMPLIEAAGLSPEPSFDDPDSRQLRFSTSDPRVDIIRVRSFDVATFVAFGAAHIGV
AGNDVILEFNYPELYAPLDLGIGACRLSVAEAERFSAEDDPGRWSHIRVATKYPEITRRHFAARGVQAECIKLNGAMELA
PALGLCRRIVDLVSSGATLKANGLVEVERILDVTSRLVVNRTAMKVRSREMTAWIERFREACDAVAA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=142, Percent_Identity=39.4366197183099, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=201, Percent_Identity=27.363184079602, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_RHORT (Q2RQM6)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_427856.1
- ProteinModelPortal:   Q2RQM6
- SMR:   Q2RQM6
- STRING:   Q2RQM6
- GeneID:   3836212
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A2772
- NMPDR:   fig|1085.1.peg.418
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   LLMFRAE
- PhylomeDB:   Q2RQM6
- ProtClustDB:   PRK01686
- BioCyc:   RRUB269796:RRU_A2772-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24897; Mature: 24897

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFDARDGADKLVIALPKGRILKEAMPLIEAAGLSPEPSFDDPDSRQLRFSTSDPRVDII
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEE
RVRSFDVATFVAFGAAHIGVAGNDVILEFNYPELYAPLDLGIGACRLSVAEAERFSAEDD
EEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCEECCHHCCCHHHHEEHHHHHHCCCCCC
PGRWSHIRVATKYPEITRRHFAARGVQAECIKLNGAMELAPALGLCRRIVDLVSSGATLK
CCCEEEEEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEE
ANGLVEVERILDVTSRLVVNRTAMKVRSREMTAWIERFREACDAVAA
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVFDARDGADKLVIALPKGRILKEAMPLIEAAGLSPEPSFDDPDSRQLRFSTSDPRVDII
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEE
RVRSFDVATFVAFGAAHIGVAGNDVILEFNYPELYAPLDLGIGACRLSVAEAERFSAEDD
EEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCEECCHHCCCHHHHEEHHHHHHCCCCCC
PGRWSHIRVATKYPEITRRHFAARGVQAECIKLNGAMELAPALGLCRRIVDLVSSGATLK
CCCEEEEEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEE
ANGLVEVERILDVTSRLVVNRTAMKVRSREMTAWIERFREACDAVAA
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA