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The map label for this gene is leuE [H]

Identifier: 83593465

GI number: 83593465

Start: 2473203

End: 2473811

Strand: Direct

Name: leuE [H]

Synonym: Rru_A2130

Alternate gene names: 83593465

Gene position: 2473203-2473811 (Clockwise)

Preceding gene: 83593464

Following gene: 83593475

Centisome position: 56.82

GC content: 67.0

Gene sequence:

>609_bases
ATGCCCATCGAGAACCTGATCGCCTTCACCGGCGCCCTGGCCCTGGCCGCCGCCATTCCCGGCCCGGGAATGCTGGGATT
GATCGGCTGGACGCTGGGACGGGGCACCAGCGCTGCCTTCGGCTATGCCCTCGGTCTGCTGTGCGGCGATCTGATCTATC
TCAGTCTGGCCGCCGCCGGAATGGCCGCCCTCGCCGAAACCATGGGCGAGGCCTTTTTGGTCATCAAGCTGGCCGGCGGC
GCCTATCTGATCTGGATGGGCGTTAAGTTGTGGCGCAGCCATCCCACCGGCGACATGGTCGCCGATGAAAAGGGCATCTC
GCGCAGCGCCCTGGTCGCCGGCCTGACCACCACCCTGGCCAATCCCAAGACCATCATCTTCTATATGGGCATCATGCCGA
TGGTGGTTGATATGCACGCCATGACCCCGGGCGTGCTGGCCGAACTGGCCGGGCTGGTGGTGATCGTCTTGAGCTTGGTG
TGCCTTCCCTATGTCGTTGCCGCCCAAAGGGCGCGCCGCCTGATGCGCAGCCCGCGCGCGCTGGCCCGCCTCAACAAGGG
GGCCGGCGTCGCCCTGATCGGCGTCGGCGCCTCCGTCGCCGCCTCCTGA

Upstream 100 bases:

>100_bases
AAAGCCGAAAAAATCTAAGCCTGAGCCCGAGAAAAACGCACTCTCCCGCCCGGGCATGGCGGCGCTAGGATACCTTTTCC
CTAAGGAGTCCAAGCTCGCC

Downstream 100 bases:

>100_bases
CCCCCGGGGGACTTCCCCCGAAGGCCGGAGAGCCGGCAGGATCCGTGTAAACTAGACCTGTAGAAGGTGGCTATGAATTT
ACCTGAAACCAGCCATTGAG

Product: lysine exporter protein LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MPIENLIAFTGALALAAAIPGPGMLGLIGWTLGRGTSAAFGYALGLLCGDLIYLSLAAAGMAALAETMGEAFLVIKLAGG
AYLIWMGVKLWRSHPTGDMVADEKGISRSALVAGLTTTLANPKTIIFYMGIMPMVVDMHAMTPGVLAELAGLVVIVLSLV
CLPYVVAAQRARRLMRSPRALARLNKGAGVALIGVGASVAAS

Sequences:

>Translated_202_residues
MPIENLIAFTGALALAAAIPGPGMLGLIGWTLGRGTSAAFGYALGLLCGDLIYLSLAAAGMAALAETMGEAFLVIKLAGG
AYLIWMGVKLWRSHPTGDMVADEKGISRSALVAGLTTTLANPKTIIFYMGIMPMVVDMHAMTPGVLAELAGLVVIVLSLV
CLPYVVAAQRARRLMRSPRALARLNKGAGVALIGVGASVAAS
>Mature_201_residues
PIENLIAFTGALALAAAIPGPGMLGLIGWTLGRGTSAAFGYALGLLCGDLIYLSLAAAGMAALAETMGEAFLVIKLAGGA
YLIWMGVKLWRSHPTGDMVADEKGISRSALVAGLTTTLANPKTIIFYMGIMPMVVDMHAMTPGVLAELAGLVVIVLSLVC
LPYVVAAQRARRLMRSPRALARLNKGAGVALIGVGASVAAS

Specific function: Exporter of leucine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=186, Percent_Identity=29.5698924731183, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786522, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788099, Length=190, Percent_Identity=25.7894736842105, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 20694; Mature: 20563

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIENLIAFTGALALAAAIPGPGMLGLIGWTLGRGTSAAFGYALGLLCGDLIYLSLAAAG
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MAALAETMGEAFLVIKLAGGAYLIWMGVKLWRSHPTGDMVADEKGISRSALVAGLTTTLA
HHHHHHHHCCEEEEEEECCCEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
NPKTIIFYMGIMPMVVDMHAMTPGVLAELAGLVVIVLSLVCLPYVVAAQRARRLMRSPRA
CCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LARLNKGAGVALIGVGASVAAS
HHHHCCCCCEEEEECCCHHCCC
>Mature Secondary Structure 
PIENLIAFTGALALAAAIPGPGMLGLIGWTLGRGTSAAFGYALGLLCGDLIYLSLAAAG
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MAALAETMGEAFLVIKLAGGAYLIWMGVKLWRSHPTGDMVADEKGISRSALVAGLTTTLA
HHHHHHHHCCEEEEEEECCCEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
NPKTIIFYMGIMPMVVDMHAMTPGVLAELAGLVVIVLSLVCLPYVVAAQRARRLMRSPRA
CCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LARLNKGAGVALIGVGASVAAS
HHHHCCCCCEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA