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The map label for this gene is fumC [H]

Identifier: 83593464

GI number: 83593464

Start: 2471638

End: 2473101

Strand: Direct

Name: fumC [H]

Synonym: Rru_A2129

Alternate gene names: 83593464

Gene position: 2471638-2473101 (Clockwise)

Preceding gene: 83593463

Following gene: 83593465

Centisome position: 56.78

GC content: 66.8

Gene sequence:

>1464_bases
ATGCCCGCGTCGCCTCCCCCGCCCGCCCCCGCCACCCGCCGCGAAACCGACAGCATGGGCGCCATCGACGTCCCGGCCGA
TCGCTATTGGGGGGCGCAGACCCAGCGCTCGCTTGAGCATTTCTCGATCGGCATCGAGCGCATGCCCGAAGCCCTGATCC
GCTCCTTCGGCACCTTGAAAGAGGCGGCCGCCTTCGCCAACCGCTCGCTTGGCCAGCTTGACGAGACGCGCGCCGATTTG
ATCGTGACCGCCGCCCGCGAGGTCGCCGAGGGACGGCTGTCGGAGCATTTCCCCCTGCGGGTCTGGCAGACCGGCAGCGG
CACCCAGACCAACATGAACGTCAACGAGGTGATCGCCAATCGGGCGATTGAACTAAGCGGCGGCGTGCTGGGCTCGAAAA
CGCCGATCCACCCCAATGATCACGTCAATATGGCGCAATCGTCCAATGACACCTTCCCCACCGCCATGCATATGGCGGCG
GTCACGGCGCTGTCGTGCACGCTGCTGCCGCAGGTGCGCGGCCTGCGCGCCAGCCTTGCGCAAAAGGCGAAGCTTTTCGC
GCCCATCGTCAAGATCGGCCGCACCCACCTGCAAGACGCCGTGCCTTTAACCCTGGGGCAGGAGTTTTCGGGCTATGTCG
CCCAGCTCGATCAGGCGATCGACCGCCTGGAAGCCACCCTGCCCGGCTTGCGCGAACTGGCCTTGGGCGGCACGGCGGTG
GGCACCGGTCTCAACACCCATCCGGCCTTCGCCGTCCGCGCCATCGCCCGCATCAGCGAAATCACCGGCCATCCCTTCCG
TCAGGCCGATAATCTGTTCGCCGCCCTGGCCGCCCATGATGCCATGGTCGCCGCCAGCGCCGGTCTGCGCGGTCTGGCCG
TGGCCTTGACCAAGATCGCCAATGATATCCGCTGGCTGGGCAGCGGTCCGCGCTGCGGGCTGGGCGAATTGATCCTGCCC
GAGAATGAGCCGGGGTCGTCGATCATGCCGGGCAAGGTCAATCCCACCCAATGTGAAAGCCTGCTGATGATCTGCCTTCA
GGTGATGGCCGCCGATGGCGCCGTGGCCATGGCCGGGTCCCAGGGCAATTTCGAACTCAATGTCCACAAGCCGCTGATCG
CCTATAACGTCTTGCAGGCGATCACCCTGCTCGCCGATGGCTGCAAGGCTTTCACCCACTTCCTGGTCGAGGGCCTGAGC
GCCGACGAGACGCGGATCGCCGAAATGGTCGATCGTTCGCTGATGCTGGTGACGGCGCTTACCCCGTCGATCGGCTATGA
CCGCGCCGCCGCCATCGCCAAGGCCGCCCATGCCAACGGCACCACCCTGCGCGAGGAAACCCTGGCCAGCGGCCTGATGG
ACGACGCGGCCTTCACCGCCGCCGTTCAGCCCGCCCGCATGGCCCATCCCCATGGGACAGCCGACGACATCGACAAGGAC
GGCGGAGGGCCGCGCCAAGGCTAG

Upstream 100 bases:

>100_bases
CGGCCCTTGGCCCAATCTGCGGGTTTCCTGATCTTTCCCCGGCCGCCGCTCCGCCTCATATTCACAGGCACCCGCGCCGA
CGATCGAAGGATCCCCGCCC

Downstream 100 bases:

>100_bases
CAAAGCCGAAAAAATCTAAGCCTGAGCCCGAGAAAAACGCACTCTCCCGCCCGGGCATGGCGGCGCTAGGATACCTTTTC
CCTAAGGAGTCCAAGCTCGC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MPASPPPPAPATRRETDSMGAIDVPADRYWGAQTQRSLEHFSIGIERMPEALIRSFGTLKEAAAFANRSLGQLDETRADL
IVTAAREVAEGRLSEHFPLRVWQTGSGTQTNMNVNEVIANRAIELSGGVLGSKTPIHPNDHVNMAQSSNDTFPTAMHMAA
VTALSCTLLPQVRGLRASLAQKAKLFAPIVKIGRTHLQDAVPLTLGQEFSGYVAQLDQAIDRLEATLPGLRELALGGTAV
GTGLNTHPAFAVRAIARISEITGHPFRQADNLFAALAAHDAMVAASAGLRGLAVALTKIANDIRWLGSGPRCGLGELILP
ENEPGSSIMPGKVNPTQCESLLMICLQVMAADGAVAMAGSQGNFELNVHKPLIAYNVLQAITLLADGCKAFTHFLVEGLS
ADETRIAEMVDRSLMLVTALTPSIGYDRAAAIAKAAHANGTTLREETLASGLMDDAAFTAAVQPARMAHPHGTADDIDKD
GGGPRQG

Sequences:

>Translated_487_residues
MPASPPPPAPATRRETDSMGAIDVPADRYWGAQTQRSLEHFSIGIERMPEALIRSFGTLKEAAAFANRSLGQLDETRADL
IVTAAREVAEGRLSEHFPLRVWQTGSGTQTNMNVNEVIANRAIELSGGVLGSKTPIHPNDHVNMAQSSNDTFPTAMHMAA
VTALSCTLLPQVRGLRASLAQKAKLFAPIVKIGRTHLQDAVPLTLGQEFSGYVAQLDQAIDRLEATLPGLRELALGGTAV
GTGLNTHPAFAVRAIARISEITGHPFRQADNLFAALAAHDAMVAASAGLRGLAVALTKIANDIRWLGSGPRCGLGELILP
ENEPGSSIMPGKVNPTQCESLLMICLQVMAADGAVAMAGSQGNFELNVHKPLIAYNVLQAITLLADGCKAFTHFLVEGLS
ADETRIAEMVDRSLMLVTALTPSIGYDRAAAIAKAAHANGTTLREETLASGLMDDAAFTAAVQPARMAHPHGTADDIDKD
GGGPRQG
>Mature_486_residues
PASPPPPAPATRRETDSMGAIDVPADRYWGAQTQRSLEHFSIGIERMPEALIRSFGTLKEAAAFANRSLGQLDETRADLI
VTAAREVAEGRLSEHFPLRVWQTGSGTQTNMNVNEVIANRAIELSGGVLGSKTPIHPNDHVNMAQSSNDTFPTAMHMAAV
TALSCTLLPQVRGLRASLAQKAKLFAPIVKIGRTHLQDAVPLTLGQEFSGYVAQLDQAIDRLEATLPGLRELALGGTAVG
TGLNTHPAFAVRAIARISEITGHPFRQADNLFAALAAHDAMVAASAGLRGLAVALTKIANDIRWLGSGPRCGLGELILPE
NEPGSSIMPGKVNPTQCESLLMICLQVMAADGAVAMAGSQGNFELNVHKPLIAYNVLQAITLLADGCKAFTHFLVEGLSA
DETRIAEMVDRSLMLVTALTPSIGYDRAAAIAKAAHANGTTLREETLASGLMDDAAFTAAVQPARMAHPHGTADDIDKDG
GGPRQG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=58.695652173913, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI266458395, Length=79, Percent_Identity=45.5696202531646, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=57.8947368421053, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=38.3116883116883, Blast_Score=318, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=60, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=59.6330275229358, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=57.3913043478261, Blast_Score=525, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=58.0993520518359, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=58.7852494577007, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=58.7852494577007, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=58.008658008658, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24583245, Length=466, Percent_Identity=52.7896995708155, Blast_Score=481, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51353; Mature: 51222

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASPPPPAPATRRETDSMGAIDVPADRYWGAQTQRSLEHFSIGIERMPEALIRSFGTLK
CCCCCCCCCCCCCCCCCCCCCEECCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EAAAFANRSLGQLDETRADLIVTAAREVAEGRLSEHFPLRVWQTGSGTQTNMNVNEVIAN
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHH
RAIELSGGVLGSKTPIHPNDHVNMAQSSNDTFPTAMHMAAVTALSCTLLPQVRGLRASLA
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKAKLFAPIVKIGRTHLQDAVPLTLGQEFSGYVAQLDQAIDRLEATLPGLRELALGGTAV
HHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHH
GTGLNTHPAFAVRAIARISEITGHPFRQADNLFAALAAHDAMVAASAGLRGLAVALTKIA
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
NDIRWLGSGPRCGLGELILPENEPGSSIMPGKVNPTQCESLLMICLQVMAADGAVAMAGS
HHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECC
QGNFELNVHKPLIAYNVLQAITLLADGCKAFTHFLVEGLSADETRIAEMVDRSLMLVTAL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEHHH
TPSIGYDRAAAIAKAAHANGTTLREETLASGLMDDAAFTAAVQPARMAHPHGTADDIDKD
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
GGGPRQG
CCCCCCC
>Mature Secondary Structure 
PASPPPPAPATRRETDSMGAIDVPADRYWGAQTQRSLEHFSIGIERMPEALIRSFGTLK
CCCCCCCCCCCCCCCCCCCCEECCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EAAAFANRSLGQLDETRADLIVTAAREVAEGRLSEHFPLRVWQTGSGTQTNMNVNEVIAN
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHH
RAIELSGGVLGSKTPIHPNDHVNMAQSSNDTFPTAMHMAAVTALSCTLLPQVRGLRASLA
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKAKLFAPIVKIGRTHLQDAVPLTLGQEFSGYVAQLDQAIDRLEATLPGLRELALGGTAV
HHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHH
GTGLNTHPAFAVRAIARISEITGHPFRQADNLFAALAAHDAMVAASAGLRGLAVALTKIA
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
NDIRWLGSGPRCGLGELILPENEPGSSIMPGKVNPTQCESLLMICLQVMAADGAVAMAGS
HHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECC
QGNFELNVHKPLIAYNVLQAITLLADGCKAFTHFLVEGLSADETRIAEMVDRSLMLVTAL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEHHH
TPSIGYDRAAAIAKAAHANGTTLREETLASGLMDDAAFTAAVQPARMAHPHGTADDIDKD
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
GGGPRQG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]