Click here to switch to the map view.

The map label for this gene is ghrA [H]

Identifier: 83593337

GI number: 83593337

Start: 2311883

End: 2312806

Strand: Direct

Name: ghrA [H]

Synonym: Rru_A2002

Alternate gene names: 83593337

Gene position: 2311883-2312806 (Clockwise)

Preceding gene: 83593335

Following gene: 83593340

Centisome position: 53.11

GC content: 69.7

Gene sequence:

>924_bases
ATGACGATTCTTTTCAACGGCCCGACACTTCCCCAAGAGATCTGGCAAACGGCGCTGCACCGCGCCCTGGCGCCGCGCCC
GCTGGCCGTCTGGCCCGATGTCGATCCGGCTAGCGTCTCCACCCTGATCTGCTGGCGCCATGGCGAAGCGATCATTCCCC
ACTTGCCCAACCTGCAAAGGGTGATCACCCTAAGCGCCGGAGTCGATCACCTGCTGGCCGCCGGCCTGCCCGAAGGGGTG
GAGATCATCCGCCTGGAAGACGCCGGCATGGGGGCGCAGATGGCCGAATACGCCCTGCATTGGGCCCTGCATTTCCAGCG
CGACTTTGATCGCCACATCGCCGCCACCCGGGCCGGCCTGTGGGAAAAACGCCCCTATCGCCCGGCCTCTGACCTTCCTT
GCGGCATCCTCGGCTTTGGAACCCTGGGCCGGGTGGTCGCCGATCGCCTGCTCGCCGCCGGCTTTCCAGTCAATGGCTGG
TCGCGCCGCGGCCAGGGCTATCCGGGCGTGCGCCCCTTTGCCGGAGCCGATCACCTGGAAGCCTTCCTGAAGGCCAGCGA
GATCGTCATCAATCTGCTGCCGGCCACGCCGGAAACCCGCCATCTGCTTGATGAGCGGCGCTTGGCCGCCCTGCGCCCGG
GCGCCGTGGTGATCAACCTCGGACGGGGGGCGACCCTCGACGAGGCGGCGCTGATCGCCGCCCTGAACGCGGGCGCCTTG
CGCGCCGCCGTTCTGGATGTCACCGACCCCGAGCCCCCGGCCGCCGACAGCCCCTTGCGCCGCCATCCCGCCGTCAGCCT
GACCCCGCATCTCGCCGCCGAAACCCTGCCCGACCCGGCCGCCGCCCAGGTCGCCCGGGTGATCAAGGCGGTGGAGCGCG
GCGAAACACCCCCCGGTCTGGTCGCCCGTGACCGGGGGTATTAA

Upstream 100 bases:

>100_bases
CACCGCCGACCAGCCGCTAGACAGCGCTCAGTCGGGGTGATTTGCTGATCCTACCGCCGTTCCCCCCCTCCCCCAAGCCT
GGACCGCCTCAAGGACTGTC

Downstream 100 bases:

>100_bases
AAAACGCTCCCTCAGCGCCCGGTCGAGCGCCGGGGACGGCCCCGGCCGGGCTTGGCGCCCGGCGCCGCGTCGCGCGGGCA
GGACGGGGCGCCGCGCGTCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTILFNGPTLPQEIWQTALHRALAPRPLAVWPDVDPASVSTLICWRHGEAIIPHLPNLQRVITLSAGVDHLLAAGLPEGV
EIIRLEDAGMGAQMAEYALHWALHFQRDFDRHIAATRAGLWEKRPYRPASDLPCGILGFGTLGRVVADRLLAAGFPVNGW
SRRGQGYPGVRPFAGADHLEAFLKASEIVINLLPATPETRHLLDERRLAALRPGAVVINLGRGATLDEAALIAALNAGAL
RAAVLDVTDPEPPAADSPLRRHPAVSLTPHLAAETLPDPAAAQVARVIKAVERGETPPGLVARDRGY

Sequences:

>Translated_307_residues
MTILFNGPTLPQEIWQTALHRALAPRPLAVWPDVDPASVSTLICWRHGEAIIPHLPNLQRVITLSAGVDHLLAAGLPEGV
EIIRLEDAGMGAQMAEYALHWALHFQRDFDRHIAATRAGLWEKRPYRPASDLPCGILGFGTLGRVVADRLLAAGFPVNGW
SRRGQGYPGVRPFAGADHLEAFLKASEIVINLLPATPETRHLLDERRLAALRPGAVVINLGRGATLDEAALIAALNAGAL
RAAVLDVTDPEPPAADSPLRRHPAVSLTPHLAAETLPDPAAAQVARVIKAVERGETPPGLVARDRGY
>Mature_306_residues
TILFNGPTLPQEIWQTALHRALAPRPLAVWPDVDPASVSTLICWRHGEAIIPHLPNLQRVITLSAGVDHLLAAGLPEGVE
IIRLEDAGMGAQMAEYALHWALHFQRDFDRHIAATRAGLWEKRPYRPASDLPCGILGFGTLGRVVADRLLAAGFPVNGWS
RRGQGYPGVRPFAGADHLEAFLKASEIVINLLPATPETRHLLDERRLAALRPGAVVINLGRGATLDEAALIAALNAGALR
AAVLDVTDPEPPAADSPLRRHPAVSLTPHLAAETLPDPAAAQVARVIKAVERGETPPGLVARDRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=234, Percent_Identity=29.4871794871795, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI6912396, Length=233, Percent_Identity=26.6094420600858, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI145580578, Length=142, Percent_Identity=34.5070422535211, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4557499, Length=142, Percent_Identity=34.5070422535211, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI61743967, Length=170, Percent_Identity=31.1764705882353, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI145580575, Length=142, Percent_Identity=34.5070422535211, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4557497, Length=170, Percent_Identity=31.1764705882353, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87081824, Length=313, Percent_Identity=39.297124600639, Blast_Score=207, Evalue=5e-55,
Organism=Escherichia coli, GI87082289, Length=252, Percent_Identity=30.1587301587302, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789279, Length=189, Percent_Identity=28.042328042328, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=221, Percent_Identity=29.8642533936652, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=144, Percent_Identity=34.0277777777778, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=168, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322116, Length=279, Percent_Identity=26.5232974910394, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28571528, Length=141, Percent_Identity=30.4964539007092, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574286, Length=232, Percent_Identity=26.7241379310345, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921140, Length=191, Percent_Identity=30.3664921465969, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585516, Length=146, Percent_Identity=29.4520547945205, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585514, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574282, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45552429, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574284, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551003, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 32964; Mature: 32833

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILFNGPTLPQEIWQTALHRALAPRPLAVWPDVDPASVSTLICWRHGEAIIPHLPNLQR
CEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHEEEEEEECCCEECCCCCCHHH
VITLSAGVDHLLAAGLPEGVEIIRLEDAGMGAQMAEYALHWALHFQRDFDRHIAATRAGL
EEEHHHCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WEKRPYRPASDLPCGILGFGTLGRVVADRLLAAGFPVNGWSRRGQGYPGVRPFAGADHLE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHH
AFLKASEIVINLLPATPETRHLLDERRLAALRPGAVVINLGRGATLDEAALIAALNAGAL
HHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHH
RAAVLDVTDPEPPAADSPLRRHPAVSLTPHLAAETLPDPAAAQVARVIKAVERGETPPGL
EEEEEECCCCCCCCCCCCHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
VARDRGY
CCCCCCC
>Mature Secondary Structure 
TILFNGPTLPQEIWQTALHRALAPRPLAVWPDVDPASVSTLICWRHGEAIIPHLPNLQR
EEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHEEEEEEECCCEECCCCCCHHH
VITLSAGVDHLLAAGLPEGVEIIRLEDAGMGAQMAEYALHWALHFQRDFDRHIAATRAGL
EEEHHHCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WEKRPYRPASDLPCGILGFGTLGRVVADRLLAAGFPVNGWSRRGQGYPGVRPFAGADHLE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHH
AFLKASEIVINLLPATPETRHLLDERRLAALRPGAVVINLGRGATLDEAALIAALNAGAL
HHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHH
RAAVLDVTDPEPPAADSPLRRHPAVSLTPHLAAETLPDPAAAQVARVIKAVERGETPPGL
EEEEEECCCCCCCCCCCCHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
VARDRGY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA