Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 83593340

GI number: 83593340

Start: 2316143

End: 2317330

Strand: Direct

Name: acdA [H]

Synonym: Rru_A2005

Alternate gene names: 83593340

Gene position: 2316143-2317330 (Clockwise)

Preceding gene: 83593337

Following gene: 83593341

Centisome position: 53.21

GC content: 64.9

Gene sequence:

>1188_bases
ATGACCCGATCTCCGCTTGCCAATTGGGATGACCTGCTCGACCTGGACGGCGCTTTGGCCGAAGACGAGCGGATGATCCG
CGACAGCGCCCGGGCCTATTGCCAGGACAAGCTGATGCCCCGGGTGGTCGAGGCCAACCGTCACGAACATTTCGACCGGG
CGATCATGACCGAGATGGGGGCGCTTGGCCTGCTTGGTCCGACCATCCCCGAGGAATACGGCGGCCCCGGCGTCAACCAT
GTCGCCTATGGGCTAATCGCGCGGGAGGTCGAGCGCGTCGACAGCGGCTATCGTTCGGCGATGAGCGTGCAGTCCTCGCT
GGTCATGCATCCGATCTACGCCTATGGCAGCGACGCGCAGAAGGCCACTTGGCTGCCGGCCTTGGCCAGCGGCGAGAAGA
TCGGCTGTTTCGGCCTGACCGAGCCCGACCATGGCTCCGATCCCGGTTCGATGAAGACGCGGGCGACCAAAACCGCCGGC
GGCTATCGGCTGAACGGCGCCAAGATGTGGATCACCAACAGCCCGATCGCCGATCTCGCCGTGGTCTGGGCCAAATCCGA
GGCCCATGACGACAAGATCCGCGGCTTCCTGGTCGAACGCGGCATGAAGGGCTTTTCCACCCCGAAGATCGAGGGCAAGT
TCTCGCTGCGCGCCTCGCTCACCGGCGAAATCGTCCTCGATGATTGCGTCGTGCCCGAAGCCAACCTGCTGCCTTTGGCC
GAAGGATTGGCCGGGCCCTTTGGTTGCCTGAACAAGGCGCGCTATGGCATCTCGTGGGGGGCGATGGGCGCGGCCGAGTT
CTGCTGGCACGCCGCCCGCCAGTATACCCTCGACCGCCTGCAGTTCGGCCGGCCGCTGGCCGCCACCCAGCTTATCCAGA
AGAAACTGGCCGACATGCAGACCGAGATCACGCTCGGCCTTTTGGGCTCGCTGCGCGTCGGCCGGCTGCTTGACGAGGGC
AAAGCGCGGCCCGAGGCGATTTCCCTGGTCAAGCGCAACAACGCCGGCAAGGCGCTTGATATCGCCCGCGTCGCCCGCGA
CATGCACGGCGGCAACGGCATCGCCGATGAATTCCACGTCATCCGCCATGTGATGAACCTGGAAAGCGTCAATACCTACG
AGGGCACCCACGATGTCCACGCCCTGATCCTCGGCCGCGCCCAAACCGGGTTGCAGGCCTTCTTCTAA

Upstream 100 bases:

>100_bases
ATATCAAAAAATGATCGATCCCATAAAAACTCTGTTTTTGACCTATGGCAAGCACCCGCCCACACTGGCGTCATGCTTTC
GCCCGTAAGGAGCCGCCGCG

Downstream 100 bases:

>100_bases
GGCATCCCAGCCATGGCCGCAGCCCTTGATGGCATTCGCGTTCTTGATTTGTCCCGCGTGCTGGCCGGCCCCTGGGCCAG
TCAGGCCCTGGCCGACCTGG

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTRSPLANWDDLLDLDGALAEDERMIRDSARAYCQDKLMPRVVEANRHEHFDRAIMTEMGALGLLGPTIPEEYGGPGVNH
VAYGLIAREVERVDSGYRSAMSVQSSLVMHPIYAYGSDAQKATWLPALASGEKIGCFGLTEPDHGSDPGSMKTRATKTAG
GYRLNGAKMWITNSPIADLAVVWAKSEAHDDKIRGFLVERGMKGFSTPKIEGKFSLRASLTGEIVLDDCVVPEANLLPLA
EGLAGPFGCLNKARYGISWGAMGAAEFCWHAARQYTLDRLQFGRPLAATQLIQKKLADMQTEITLGLLGSLRVGRLLDEG
KARPEAISLVKRNNAGKALDIARVARDMHGGNGIADEFHVIRHVMNLESVNTYEGTHDVHALILGRAQTGLQAFF

Sequences:

>Translated_395_residues
MTRSPLANWDDLLDLDGALAEDERMIRDSARAYCQDKLMPRVVEANRHEHFDRAIMTEMGALGLLGPTIPEEYGGPGVNH
VAYGLIAREVERVDSGYRSAMSVQSSLVMHPIYAYGSDAQKATWLPALASGEKIGCFGLTEPDHGSDPGSMKTRATKTAG
GYRLNGAKMWITNSPIADLAVVWAKSEAHDDKIRGFLVERGMKGFSTPKIEGKFSLRASLTGEIVLDDCVVPEANLLPLA
EGLAGPFGCLNKARYGISWGAMGAAEFCWHAARQYTLDRLQFGRPLAATQLIQKKLADMQTEITLGLLGSLRVGRLLDEG
KARPEAISLVKRNNAGKALDIARVARDMHGGNGIADEFHVIRHVMNLESVNTYEGTHDVHALILGRAQTGLQAFF
>Mature_394_residues
TRSPLANWDDLLDLDGALAEDERMIRDSARAYCQDKLMPRVVEANRHEHFDRAIMTEMGALGLLGPTIPEEYGGPGVNHV
AYGLIAREVERVDSGYRSAMSVQSSLVMHPIYAYGSDAQKATWLPALASGEKIGCFGLTEPDHGSDPGSMKTRATKTAGG
YRLNGAKMWITNSPIADLAVVWAKSEAHDDKIRGFLVERGMKGFSTPKIEGKFSLRASLTGEIVLDDCVVPEANLLPLAE
GLAGPFGCLNKARYGISWGAMGAAEFCWHAARQYTLDRLQFGRPLAATQLIQKKLADMQTEITLGLLGSLRVGRLLDEGK
ARPEAISLVKRNNAGKALDIARVARDMHGGNGIADEFHVIRHVMNLESVNTYEGTHDVHALILGRAQTGLQAFF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=67.8571428571429, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI7669494, Length=372, Percent_Identity=66.9354838709677, Blast_Score=510, Evalue=1e-144,
Organism=Homo sapiens, GI4557233, Length=369, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI226958412, Length=400, Percent_Identity=33, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=30.6849315068493, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI226958414, Length=335, Percent_Identity=33.7313432835821, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI21361497, Length=349, Percent_Identity=31.8051575931232, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=28.8770053475936, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=28.8770053475936, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI76496475, Length=342, Percent_Identity=32.1637426900585, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI4557235, Length=342, Percent_Identity=32.1637426900585, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=28.4574468085106, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=28.1578947368421, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI48976061, Length=283, Percent_Identity=25.4416961130742, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI211971008, Length=283, Percent_Identity=25.4416961130742, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786223, Length=347, Percent_Identity=25.9365994236311, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=24.3386243386243, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=65.7216494845361, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=33.0666666666667, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71985184, Length=365, Percent_Identity=32.6027397260274, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=30.1333333333333, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17508101, Length=365, Percent_Identity=29.8630136986301, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=271, Percent_Identity=34.3173431734317, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17534899, Length=375, Percent_Identity=29.3333333333333, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=27.9452054794521, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=261, Percent_Identity=32.183908045977, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=380, Percent_Identity=25.5263157894737, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=31.6017316017316, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=27.6752767527675, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17551932, Length=276, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17505929, Length=394, Percent_Identity=24.6192893401015, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562446, Length=290, Percent_Identity=26.551724137931, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920834, Length=395, Percent_Identity=64.5569620253165, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=32.1621621621622, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=31.5508021390374, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=30.958904109589, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.7333333333333, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=30.3191489361702, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI281363737, Length=371, Percent_Identity=30.188679245283, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43001; Mature: 42869

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSPLANWDDLLDLDGALAEDERMIRDSARAYCQDKLMPRVVEANRHEHFDRAIMTEMG
CCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ALGLLGPTIPEEYGGPGVNHVAYGLIAREVERVDSGYRSAMSVQSSLVMHPIYAYGSDAQ
CHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KATWLPALASGEKIGCFGLTEPDHGSDPGSMKTRATKTAGGYRLNGAKMWITNSPIADLA
CCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCHHHEECCCCEEECCEEEEEECCCHHHHE
VVWAKSEAHDDKIRGFLVERGMKGFSTPKIEGKFSLRASLTGEIVLDDCVVPEANLLPLA
EEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCHHH
EGLAGPFGCLNKARYGISWGAMGAAEFCWHAARQYTLDRLQFGRPLAATQLIQKKLADMQ
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TEITLGLLGSLRVGRLLDEGKARPEAISLVKRNNAGKALDIARVARDMHGGNGIADEFHV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
IRHVMNLESVNTYEGTHDVHALILGRAQTGLQAFF
HHHHHHHHCCCCCCCCHHHHHHEEHHHHHHHHHCC
>Mature Secondary Structure 
TRSPLANWDDLLDLDGALAEDERMIRDSARAYCQDKLMPRVVEANRHEHFDRAIMTEMG
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ALGLLGPTIPEEYGGPGVNHVAYGLIAREVERVDSGYRSAMSVQSSLVMHPIYAYGSDAQ
CHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KATWLPALASGEKIGCFGLTEPDHGSDPGSMKTRATKTAGGYRLNGAKMWITNSPIADLA
CCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCHHHEECCCCEEECCEEEEEECCCHHHHE
VVWAKSEAHDDKIRGFLVERGMKGFSTPKIEGKFSLRASLTGEIVLDDCVVPEANLLPLA
EEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCHHH
EGLAGPFGCLNKARYGISWGAMGAAEFCWHAARQYTLDRLQFGRPLAATQLIQKKLADMQ
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TEITLGLLGSLRVGRLLDEGKARPEAISLVKRNNAGKALDIARVARDMHGGNGIADEFHV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
IRHVMNLESVNTYEGTHDVHALILGRAQTGLQAFF
HHHHHHHHCCCCCCCCHHHHHHEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]