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The map label for this gene is guaB [H]

Identifier: 83593293

GI number: 83593293

Start: 2266376

End: 2267533

Strand: Direct

Name: guaB [H]

Synonym: Rru_A1958

Alternate gene names: 83593293

Gene position: 2266376-2267533 (Clockwise)

Preceding gene: 83593292

Following gene: 83593294

Centisome position: 52.07

GC content: 70.64

Gene sequence:

>1158_bases
ATGATCGAGGGATTGCGCAGCGGCCTCAGCTTCGACGACGTGCTGCTGGTTCCCGGGCGGACCCGGGCGCGCAGCCGCGC
CGATATCACCCTTGCCAGCCGCTTCTCCCGGCGCATCGCCTTGGCCTTGCCGCTGGTCTCGGCCAATGTGCCGTGGTGCA
CGCAAGCGCCGATGGCGATCGCCCTGGGCCGCTTGGGCGGGCTGGGCGTTCTTCACCGCATGTGCGCCATCGAGGATCAG
GAACGTCAGGTCGCCCTGGTCAAGGCGGCGCCCGTCGATGGCGAAGACGCGGCGCGGGCAACCGTCGATGACGGGGGCGC
CCTAATCGCCGCCGCCGCCGTCGGCGCCAAGCCCGAGGATCTGGAGCGCGCCGACCGCTTGGTGGCGGCGGGCTGCGACG
CCCTGGTCGTCGATATCGCCCATGGCCATGCCGATTACGCCCTCGATACCATCGCCGCGCTGAAAAGCCGCCATCCGCAA
ATTGATGTCATCGGCGGCAATGTTGCCACCGCCGAGGGCACGGCCGATCTGATCGCCGCCGGGGCCGATGCCATCAAGGT
CGGCATCGGTCCGGGCGGCATCTGCACCACCCGGCGGGTGGCCGGGGCCGGGGTGCCGCAGATGACGGCGATCGCCGATT
GCGTCGGCGTCGCCCGCGCCCGGAACGTGCCGGTGATCGCCGATGGCGGCATCCGCTTCTCGGGCGATATCGTCAAGGCC
CTGGCCGTCGGCGCCGCCTCGGTGATGCTGGGCAGCCTGCTGGCCGGAACCGATGAAAGCGCCGCCGTCTTCATCGACCA
CCAGGGGCGGCGCTGCAAGGCGACCACCGGCTTCGTCACCCTCGGCGTCGGACTGACCCGCAAACGCCTGCGCGGCGAGA
AGATCAACGCCGAGGATCTCGACGCCTATGTCGCCGAAGGGGTGGAATCGACCTTCGAGGCCTCGGGTCCGCTGGCCCGG
CTGATCGGTCAGCTTGCCGGGGGGATACGCTCGGGCGTCAGCTATGGCGGCGCCCTGAGCATCGCCGAACTTCAGGACAA
GGCCCGCTTCATCCGCGTCAGCGAAGCCGGGCGGGCGGAAAGCCGCCCCCATGCCCTGGACCGCGCCCCCGCCCCGCCCC
CCGATTACGCGAGGCTGTTCGTCGAGGAGGAGGCCTGA

Upstream 100 bases:

>100_bases
GTGATTCCTGCCTGCTGCGCTTGAAGGGCTTCGCCGAGAACGGCCTGGAGGATCCGGTGCGCTATGTCGGGGCGCGGTCA
CGGGCGGCGGGGTGAGCGCG

Downstream 100 bases:

>100_bases
GCATGTTCGGCCGGAACCCTGCGCGCGGCCCCGACCCCGGCGATGGTGAAAGCCTGTGGATCCAGGAAGTTTTCTACACC
TTGCAGGGCGAAGGGCCGTT

Product: GMP reductase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MIEGLRSGLSFDDVLLVPGRTRARSRADITLASRFSRRIALALPLVSANVPWCTQAPMAIALGRLGGLGVLHRMCAIEDQ
ERQVALVKAAPVDGEDAARATVDDGGALIAAAAVGAKPEDLERADRLVAAGCDALVVDIAHGHADYALDTIAALKSRHPQ
IDVIGGNVATAEGTADLIAAGADAIKVGIGPGGICTTRRVAGAGVPQMTAIADCVGVARARNVPVIADGGIRFSGDIVKA
LAVGAASVMLGSLLAGTDESAAVFIDHQGRRCKATTGFVTLGVGLTRKRLRGEKINAEDLDAYVAEGVESTFEASGPLAR
LIGQLAGGIRSGVSYGGALSIAELQDKARFIRVSEAGRAESRPHALDRAPAPPPDYARLFVEEEA

Sequences:

>Translated_385_residues
MIEGLRSGLSFDDVLLVPGRTRARSRADITLASRFSRRIALALPLVSANVPWCTQAPMAIALGRLGGLGVLHRMCAIEDQ
ERQVALVKAAPVDGEDAARATVDDGGALIAAAAVGAKPEDLERADRLVAAGCDALVVDIAHGHADYALDTIAALKSRHPQ
IDVIGGNVATAEGTADLIAAGADAIKVGIGPGGICTTRRVAGAGVPQMTAIADCVGVARARNVPVIADGGIRFSGDIVKA
LAVGAASVMLGSLLAGTDESAAVFIDHQGRRCKATTGFVTLGVGLTRKRLRGEKINAEDLDAYVAEGVESTFEASGPLAR
LIGQLAGGIRSGVSYGGALSIAELQDKARFIRVSEAGRAESRPHALDRAPAPPPDYARLFVEEEA
>Mature_385_residues
MIEGLRSGLSFDDVLLVPGRTRARSRADITLASRFSRRIALALPLVSANVPWCTQAPMAIALGRLGGLGVLHRMCAIEDQ
ERQVALVKAAPVDGEDAARATVDDGGALIAAAAVGAKPEDLERADRLVAAGCDALVVDIAHGHADYALDTIAALKSRHPQ
IDVIGGNVATAEGTADLIAAGADAIKVGIGPGGICTTRRVAGAGVPQMTAIADCVGVARARNVPVIADGGIRFSGDIVKA
LAVGAASVMLGSLLAGTDESAAVFIDHQGRRCKATTGFVTLGVGLTRKRLRGEKINAEDLDAYVAEGVESTFEASGPLAR
LIGQLAGGIRSGVSYGGALSIAELQDKARFIRVSEAGRAESRPHALDRAPAPPPDYARLFVEEEA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=353, Percent_Identity=31.1614730878187, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI50541954, Length=353, Percent_Identity=31.1614730878187, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541952, Length=353, Percent_Identity=31.1614730878187, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541948, Length=353, Percent_Identity=31.1614730878187, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI217035146, Length=300, Percent_Identity=33, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI217035152, Length=276, Percent_Identity=34.7826086956522, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI34328930, Length=300, Percent_Identity=33, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI217035148, Length=300, Percent_Identity=33, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI156616279, Length=276, Percent_Identity=34.7826086956522, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI34328928, Length=276, Percent_Identity=34.7826086956522, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI217035150, Length=300, Percent_Identity=33, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI156104880, Length=354, Percent_Identity=29.3785310734463, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI66933016, Length=295, Percent_Identity=34.2372881355932, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1788855, Length=282, Percent_Identity=46.0992907801418, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786293, Length=353, Percent_Identity=28.328611898017, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560440, Length=370, Percent_Identity=30.8108108108108, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71994385, Length=312, Percent_Identity=32.6923076923077, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71994389, Length=222, Percent_Identity=36.4864864864865, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323464, Length=267, Percent_Identity=34.0823970037453, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323585, Length=249, Percent_Identity=35.7429718875502, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322012, Length=268, Percent_Identity=33.5820895522388, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319352, Length=125, Percent_Identity=40, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571163, Length=277, Percent_Identity=36.4620938628159, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24641071, Length=277, Percent_Identity=36.4620938628159, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24641073, Length=277, Percent_Identity=36.4620938628159, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 39584; Mature: 39584

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEGLRSGLSFDDVLLVPGRTRARSRADITLASRFSRRIALALPLVSANVPWCTQAPMAI
CCCCHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHEEEEEEHHCCCCCCCCCCCHHH
ALGRLGGLGVLHRMCAIEDQERQVALVKAAPVDGEDAARATVDDGGALIAAAAVGAKPED
HHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCCCCHH
LERADRLVAAGCDALVVDIAHGHADYALDTIAALKSRHPQIDVIGGNVATAEGTADLIAA
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCEEECCCCHHHHHC
GADAIKVGIGPGGICTTRRVAGAGVPQMTAIADCVGVARARNVPVIADGGIRFSGDIVKA
CCCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHH
LAVGAASVMLGSLLAGTDESAAVFIDHQGRRCKATTGFVTLGVGLTRKRLRGEKINAEDL
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCEEEECCCHHHHHHCCCCCCHHHH
DAYVAEGVESTFEASGPLARLIGQLAGGIRSGVSYGGALSIAELQDKARFIRVSEAGRAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCHHEEEEECCCCCC
SRPHALDRAPAPPPDYARLFVEEEA
CCCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MIEGLRSGLSFDDVLLVPGRTRARSRADITLASRFSRRIALALPLVSANVPWCTQAPMAI
CCCCHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHEEEEEEHHCCCCCCCCCCCHHH
ALGRLGGLGVLHRMCAIEDQERQVALVKAAPVDGEDAARATVDDGGALIAAAAVGAKPED
HHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCCCCHH
LERADRLVAAGCDALVVDIAHGHADYALDTIAALKSRHPQIDVIGGNVATAEGTADLIAA
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCEEECCCCHHHHHC
GADAIKVGIGPGGICTTRRVAGAGVPQMTAIADCVGVARARNVPVIADGGIRFSGDIVKA
CCCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHH
LAVGAASVMLGSLLAGTDESAAVFIDHQGRRCKATTGFVTLGVGLTRKRLRGEKINAEDL
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCEEEECCCHHHHHHCCCCCCHHHH
DAYVAEGVESTFEASGPLARLIGQLAGGIRSGVSYGGALSIAELQDKARFIRVSEAGRAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCHHEEEEECCCCCC
SRPHALDRAPAPPPDYARLFVEEEA
CCCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961392; 9403685; 10758003 [H]