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The map label for this gene is csgA [H]

Identifier: 83593280

GI number: 83593280

Start: 2253749

End: 2254432

Strand: Reverse

Name: csgA [H]

Synonym: Rru_A1945

Alternate gene names: 83593280

Gene position: 2254432-2253749 (Counterclockwise)

Preceding gene: 83593281

Following gene: 83593279

Centisome position: 51.79

GC content: 67.4

Gene sequence:

>684_bases
ATGTCGACCATTCTTATCTCCGGGGCCAATCGTGGCCTGGGCCTGGAATTCGCCCGGCAGTATCGCCAGGAAGGGCATCG
GGTGATCGGCACCTGCCGCGATCCCGGCAAGGCTGGCGATCTTCTGGCCCTTGGCGCCGAGGTCCTGCCCCTTGACGTGG
CCGATCTGGCCGCCGTCGCCGGCTTCGGCGCGGTGGTGGGGGACCAGCCCGTCGATCTGTTCATCAACAATGCCGGCGTT
TATGGCGGACGCCACAGCGAACAGGATCTGGGCGAGGTCGACAGCCGCGTTTGGCTTGAAACCCTGGTGGTCAATACCAT
CGCTCCGCTCAAGCTGACCGAGGCGATCTTGCCCAATCTCGAGCGGGCCGAGGCGGCGAAGGCCGTCTATCTGTCCTCGA
AGATGGGGTCGATGGCGGCCAATAGCGCCGGCGGCGCCTATATCTACCGCTCGTCCAAAGCCGCCCTGAATGCCGTGGTC
CGCAGCCTCGCCGCCGATCTGGCCGATCGCGCCATCGTCGTCGCCGCCCTCCATCCGGGCTGGGTGCGCACCGATATGGG
CGGTCCCGATGGCGACATCGACGCCGGGGAGTCGATCGCCGGCCTGCGCCGGGTGATCGCCGCCCTGGCCACCACCGATA
GCGGCCGCTTCCTGGCCTATGACGGTGGCGAGGTGCCCTGGTAG

Upstream 100 bases:

>100_bases
CTTGCGTCATAGCGCTTTGGGCGGAAAAAGCGACCGTCGGCGTTCCCCGCCCGCAGCGCGCCGCCGCCTCCCCATCGGTC
CGCTTCTCAAGGAGACGCCC

Downstream 100 bases:

>100_bases
ACCCCAATCGACATAAGAAAAAATCCGCCAATCGTCTACCTTGCCGATTATTGATCGTATCGCATCTATGATAAAGTGTG
AAACGCCCGCCGCCTTTCCA

Product: short-chain dehydrogenase/reductase sDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSTILISGANRGLGLEFARQYRQEGHRVIGTCRDPGKAGDLLALGAEVLPLDVADLAAVAGFGAVVGDQPVDLFINNAGV
YGGRHSEQDLGEVDSRVWLETLVVNTIAPLKLTEAILPNLERAEAAKAVYLSSKMGSMAANSAGGAYIYRSSKAALNAVV
RSLAADLADRAIVVAALHPGWVRTDMGGPDGDIDAGESIAGLRRVIAALATTDSGRFLAYDGGEVPW

Sequences:

>Translated_227_residues
MSTILISGANRGLGLEFARQYRQEGHRVIGTCRDPGKAGDLLALGAEVLPLDVADLAAVAGFGAVVGDQPVDLFINNAGV
YGGRHSEQDLGEVDSRVWLETLVVNTIAPLKLTEAILPNLERAEAAKAVYLSSKMGSMAANSAGGAYIYRSSKAALNAVV
RSLAADLADRAIVVAALHPGWVRTDMGGPDGDIDAGESIAGLRRVIAALATTDSGRFLAYDGGEVPW
>Mature_226_residues
STILISGANRGLGLEFARQYRQEGHRVIGTCRDPGKAGDLLALGAEVLPLDVADLAAVAGFGAVVGDQPVDLFINNAGVY
GGRHSEQDLGEVDSRVWLETLVVNTIAPLKLTEAILPNLERAEAAKAVYLSSKMGSMAANSAGGAYIYRSSKAALNAVVR
SLAADLADRAIVVAALHPGWVRTDMGGPDGDIDAGESIAGLRRVIAALATTDSGRFLAYDGGEVPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=196, Percent_Identity=31.1224489795918, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559962, Length=247, Percent_Identity=32.3886639676113, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17558994, Length=240, Percent_Identity=32.9166666666667, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI72001658, Length=239, Percent_Identity=31.7991631799163, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17532177, Length=244, Percent_Identity=31.5573770491803, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559964, Length=247, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193207563, Length=240, Percent_Identity=31.25, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17558990, Length=249, Percent_Identity=31.7269076305221, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17558992, Length=243, Percent_Identity=33.7448559670782, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558996, Length=250, Percent_Identity=28, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17542178, Length=247, Percent_Identity=31.9838056680162, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17541382, Length=256, Percent_Identity=28.515625, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=194, Percent_Identity=28.8659793814433, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=249, Percent_Identity=27.3092369477912, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=34.8, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21358495, Length=199, Percent_Identity=32.6633165829146, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24643142, Length=186, Percent_Identity=32.7956989247312, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 23614; Mature: 23483

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTILISGANRGLGLEFARQYRQEGHRVIGTCRDPGKAGDLLALGAEVLPLDVADLAAVA
CCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHH
GFGAVVGDQPVDLFINNAGVYGGRHSEQDLGEVDSRVWLETLVVNTIAPLKLTEAILPNL
HHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
ERAEAAKAVYLSSKMGSMAANSAGGAYIYRSSKAALNAVVRSLAADLADRAIVVAALHPG
HHHHHHHHHHHHHHHCCHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCEEEEEEECCC
WVRTDMGGPDGDIDAGESIAGLRRVIAALATTDSGRFLAYDGGEVPW
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
STILISGANRGLGLEFARQYRQEGHRVIGTCRDPGKAGDLLALGAEVLPLDVADLAAVA
CEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHH
GFGAVVGDQPVDLFINNAGVYGGRHSEQDLGEVDSRVWLETLVVNTIAPLKLTEAILPNL
HHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
ERAEAAKAVYLSSKMGSMAANSAGGAYIYRSSKAALNAVVRSLAADLADRAIVVAALHPG
HHHHHHHHHHHHHHHCCHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCEEEEEEECCC
WVRTDMGGPDGDIDAGESIAGLRRVIAALATTDSGRFLAYDGGEVPW
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]