Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 83593247

GI number: 83593247

Start: 2216803

End: 2217549

Strand: Direct

Name: fabG [C]

Synonym: Rru_A1912

Alternate gene names: 83593247

Gene position: 2216803-2217549 (Clockwise)

Preceding gene: 83593245

Following gene: 83593249

Centisome position: 50.93

GC content: 70.68

Gene sequence:

>747_bases
ATGGATCATCCCCGCCGCGCCTGTGTGACCGGAGCCGCCAATGGCATCGGCCGGGCCATCGCCCTGCATCTGTCGCGCTT
GGGCTGGAGCGTCGCCGGGCTGGATCGCGATGGCGGCGGTCTGGCGGCGATGGCCGCCGCCGCCAAGGCCGAAGGGCTGG
CCGCCCCCCTTCTGGCGACCGTCGACGTCCGCGATGAGGCCGCCCTGGCGGCCGCCTTGGCCCAGGCCGCCGGCCCCGAG
GAGACTCTGCACGGCCTCGTCTGTTGCGCCGGACGGACGACGGCCCATAGCGGCCCGCCGGAGGATCTCGCCCTGGCCGA
CTGGCAAAAGTTCATCGATATCAACCTGACCGGCCCGTTCCTGTGCGCCAAGCACGCCATCAAGGCCCTGGAGCGGGGGC
GGGGCGCGATCGTCATGATCGCCTCGACCCGCGCCCATCAGTCCGAACCGGGAACCGAGGCCTATGCGGCATCGAAGGGG
GGACTGCTGGCCCTGACCCATGCCCTGGCCCTCTCGCTGTCCAATCGGGTGCGGGTCAACGCCATCTCGCCCGGCTGGAT
CGCCACCAGCGGCGTGGAAGACCTGCGCCCGGAGGATCATGCCCAGCATCCGGCCGGCCGGGTCGGCCTGCCCGGCGATA
TCGCCGCCGCCACCGCCTGGTTGCTCTCCGACGACGCCGGCTTCATGACCGGCGCCGAATTGATCGTTGATGGCGGCATG
ACGCGCAAGATGATCTACCGCGATTAA

Upstream 100 bases:

>100_bases
CCGATCCCCCCTATCAAACGACCGCCCTTGTCGGGTATAGGGGAACGCTGATCGCCAAGCCGCCGCCCCGTTGCGCCCTT
TCATCCTTTCGGAGGTTGCC

Downstream 100 bases:

>100_bases
GCCGCTGTCCTAAAAAGCTTTTTAGCGCACCGCCGGCGCGGCTGGCGCGACCGCGGGGGGCGCGGAGGGGACGATCAGCG
GCAGATCCTGGGAGCGCGGG

Product: short-chain dehydrogenase/reductase sDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MDHPRRACVTGAANGIGRAIALHLSRLGWSVAGLDRDGGGLAAMAAAAKAEGLAAPLLATVDVRDEAALAAALAQAAGPE
ETLHGLVCCAGRTTAHSGPPEDLALADWQKFIDINLTGPFLCAKHAIKALERGRGAIVMIASTRAHQSEPGTEAYAASKG
GLLALTHALALSLSNRVRVNAISPGWIATSGVEDLRPEDHAQHPAGRVGLPGDIAAATAWLLSDDAGFMTGAELIVDGGM
TRKMIYRD

Sequences:

>Translated_248_residues
MDHPRRACVTGAANGIGRAIALHLSRLGWSVAGLDRDGGGLAAMAAAAKAEGLAAPLLATVDVRDEAALAAALAQAAGPE
ETLHGLVCCAGRTTAHSGPPEDLALADWQKFIDINLTGPFLCAKHAIKALERGRGAIVMIASTRAHQSEPGTEAYAASKG
GLLALTHALALSLSNRVRVNAISPGWIATSGVEDLRPEDHAQHPAGRVGLPGDIAAATAWLLSDDAGFMTGAELIVDGGM
TRKMIYRD
>Mature_248_residues
MDHPRRACVTGAANGIGRAIALHLSRLGWSVAGLDRDGGGLAAMAAAAKAEGLAAPLLATVDVRDEAALAAALAQAAGPE
ETLHGLVCCAGRTTAHSGPPEDLALADWQKFIDINLTGPFLCAKHAIKALERGRGAIVMIASTRAHQSEPGTEAYAASKG
GLLALTHALALSLSNRVRVNAISPGWIATSGVEDLRPEDHAQHPAGRVGLPGDIAAATAWLLSDDAGFMTGAELIVDGGM
TRKMIYRD

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=32.5396825396825, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=30.8300395256917, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=31.8725099601594, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=30.1255230125523, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI59889578, Length=170, Percent_Identity=34.1176470588235, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923817, Length=248, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=28.6852589641434, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4758504, Length=219, Percent_Identity=32.4200913242009, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=240, Percent_Identity=34.1666666666667, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=32.6446280991736, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=35.3658536585366, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=31.7829457364341, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=31.1538461538462, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=27.3469387755102, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1789378, Length=237, Percent_Identity=29.535864978903, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=29.5546558704453, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787526, Length=230, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=33.587786259542, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=244, Percent_Identity=30.7377049180328, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=32.2448979591837, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=28.5140562248996, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=28.4, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=29.1497975708502, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=27.3062730627306, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=26.615969581749, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=27.3764258555133, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=27.4809160305344, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=27.2388059701493, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=246, Percent_Identity=30.0813008130081, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644339, Length=242, Percent_Identity=30.5785123966942, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=245, Percent_Identity=32.2448979591837, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357041, Length=243, Percent_Identity=30.4526748971193, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=30.4878048780488, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=29.5081967213115, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=29.4820717131474, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644337, Length=232, Percent_Identity=30.1724137931034, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=29.7520661157025, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24641232, Length=202, Percent_Identity=28.7128712871287, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=228, Percent_Identity=30.2631578947368, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25457; Mature: 25457

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHPRRACVTGAANGIGRAIALHLSRLGWSVAGLDRDGGGLAAMAAAAKAEGLAAPLLAT
CCCCHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHCCCCCCCEEE
VDVRDEAALAAALAQAAGPEETLHGLVCCAGRTTAHSGPPEDLALADWQKFIDINLTGPF
ECCCHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHEEEECCCCHH
LCAKHAIKALERGRGAIVMIASTRAHQSEPGTEAYAASKGGLLALTHALALSLSNRVRVN
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCEEEE
AISPGWIATSGVEDLRPEDHAQHPAGRVGLPGDIAAATAWLLSDDAGFMTGAELIVDGGM
EECCCCEEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCC
TRKMIYRD
CCEEEECC
>Mature Secondary Structure
MDHPRRACVTGAANGIGRAIALHLSRLGWSVAGLDRDGGGLAAMAAAAKAEGLAAPLLAT
CCCCHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHCCCCCCCEEE
VDVRDEAALAAALAQAAGPEETLHGLVCCAGRTTAHSGPPEDLALADWQKFIDINLTGPF
ECCCHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHEEEECCCCHH
LCAKHAIKALERGRGAIVMIASTRAHQSEPGTEAYAASKGGLLALTHALALSLSNRVRVN
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCEEEE
AISPGWIATSGVEDLRPEDHAQHPAGRVGLPGDIAAATAWLLSDDAGFMTGAELIVDGGM
EECCCCEEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCC
TRKMIYRD
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934833; 10984043 [H]