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The map label for this gene is ribBA [H]

Identifier: 83593158

GI number: 83593158

Start: 2121822

End: 2122955

Strand: Reverse

Name: ribBA [H]

Synonym: Rru_A1823

Alternate gene names: 83593158

Gene position: 2122955-2121822 (Counterclockwise)

Preceding gene: 83593159

Following gene: 83593157

Centisome position: 48.77

GC content: 65.61

Gene sequence:

>1134_bases
ATGACTGACGGAACCTCTCCCGTGCCCTATCGCGATTATCTGGCTTCCCCGGAAGACATCATCGAAGATGCCCGTCAGGG
CAAAATGTTCATCCTGGTCGATGACGAGAACCGGGAAAACGAAGGCGATCTGGTGATCCCGGCGCAAATGGCGACGGCCG
AGGTGGTCAATTTCATGGCCAAGCACGGCCGTGGCTTGATCTGTCTGGCGATGACCCGCGAGCGCTGCGAGCAGCTTGAT
CTGCCGTTGATGGCCCAGCAGAACAGCTCGCGCCATTCCACCGCCTTCACCATCAGCATCGAAGCCAAGGATGGGGTGAC
GACGGGGATTTCCGCCGCCGACCGGGCGCTGACCATCCAGGTCGCCATCGATCCGGCCAAGGGGCGGGGCGATATCGCCA
CCCCCGGCCACGTGTTCCCGCTGGTCGCCCGCGATGGCGGCGTGCTGGTGCGCGCCGGCCATACGGAAGCCGCCGTTGAT
GTCGCCCGCATGGCCGGGCTGGTGCCCGCCGGCGTCATCTGTGAGGTGATGAACGACGATGGCACCATGGCCCGCATGCC
CGATCTGGTGCGCTTCGCCCAGGAACACGGGCTGAAGGTCGGCACCATCGCCGATCTGATCGCCTATCGGCGGACCAAGG
AACGGCTGGTGCGCCGCGAGTTGGAGACCGATTTCCGCTCGGTTCACGGCGGCGACTGGCGGATGATGCTGTATGTCTCG
ACCGTGTCCTATGGCGAACACATCGCCCTGGTCAAGGGCGATCCGCGCGGCAGCGATCCGGTTCTGGTGCGCATGCATGC
GCTGAACGTGCTCGACGACGTGCTGGGCGACAGCGACGGCAATGCCCATGGCCAGCTTCACCGGGCGATGGACGTGATCG
GCCGGGCGGGGCGCGGCGTGCTGGTGCTGATCCGCGAGGGTCGGCCGACGGCGCTGTCGGAACGCCTGCGCGCGCGCATC
GAACAGGGGCCGAGCGCCCAGCGTCTGGTCGATTACGGGGTGGGGGCGCAGATCCTGCTTGATCTTGGCGTGACCGATAT
GACGCTTCTGACCAATACGCCCAAGCATATCATCGGCCTGGAGGGCTACGGCCTGCGCGTGGCCGGCCATCAGCCCCTTT
CGGACAAGGAGTGA

Upstream 100 bases:

>100_bases
ACCTTCCAGGCCACCACATTCGGGCGACTTGCTCCCGGAAGCCGCGTGAACATGGAAATCGACATGCTGGCGCGCTATGT
TGCGCGTCTTCTTCACCCCG

Downstream 100 bases:

>100_bases
CGCGGCAATGTCGACGACCGGCGGTCCCCGCATTCTTATCGTTGAAGCCCGCTTCTACGAGGAGATTACCGATAATCTGG
TGCGCGGCGCCGTGCAGGCG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTDGTSPVPYRDYLASPEDIIEDARQGKMFILVDDENRENEGDLVIPAQMATAEVVNFMAKHGRGLICLAMTRERCEQLD
LPLMAQQNSSRHSTAFTISIEAKDGVTTGISAADRALTIQVAIDPAKGRGDIATPGHVFPLVARDGGVLVRAGHTEAAVD
VARMAGLVPAGVICEVMNDDGTMARMPDLVRFAQEHGLKVGTIADLIAYRRTKERLVRRELETDFRSVHGGDWRMMLYVS
TVSYGEHIALVKGDPRGSDPVLVRMHALNVLDDVLGDSDGNAHGQLHRAMDVIGRAGRGVLVLIREGRPTALSERLRARI
EQGPSAQRLVDYGVGAQILLDLGVTDMTLLTNTPKHIIGLEGYGLRVAGHQPLSDKE

Sequences:

>Translated_377_residues
MTDGTSPVPYRDYLASPEDIIEDARQGKMFILVDDENRENEGDLVIPAQMATAEVVNFMAKHGRGLICLAMTRERCEQLD
LPLMAQQNSSRHSTAFTISIEAKDGVTTGISAADRALTIQVAIDPAKGRGDIATPGHVFPLVARDGGVLVRAGHTEAAVD
VARMAGLVPAGVICEVMNDDGTMARMPDLVRFAQEHGLKVGTIADLIAYRRTKERLVRRELETDFRSVHGGDWRMMLYVS
TVSYGEHIALVKGDPRGSDPVLVRMHALNVLDDVLGDSDGNAHGQLHRAMDVIGRAGRGVLVLIREGRPTALSERLRARI
EQGPSAQRLVDYGVGAQILLDLGVTDMTLLTNTPKHIIGLEGYGLRVAGHQPLSDKE
>Mature_376_residues
TDGTSPVPYRDYLASPEDIIEDARQGKMFILVDDENRENEGDLVIPAQMATAEVVNFMAKHGRGLICLAMTRERCEQLDL
PLMAQQNSSRHSTAFTISIEAKDGVTTGISAADRALTIQVAIDPAKGRGDIATPGHVFPLVARDGGVLVRAGHTEAAVDV
ARMAGLVPAGVICEVMNDDGTMARMPDLVRFAQEHGLKVGTIADLIAYRRTKERLVRRELETDFRSVHGGDWRMMLYVST
VSYGEHIALVKGDPRGSDPVLVRMHALNVLDDVLGDSDGNAHGQLHRAMDVIGRAGRGVLVLIREGRPTALSERLRARIE
QGPSAQRLVDYGVGAQILLDLGVTDMTLLTNTPKHIIGLEGYGLRVAGHQPLSDKE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=206, Percent_Identity=49.0291262135922, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI1787533, Length=156, Percent_Identity=30.7692307692308, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320695, Length=199, Percent_Identity=41.7085427135678, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40905; Mature: 40774

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGTSPVPYRDYLASPEDIIEDARQGKMFILVDDENRENEGDLVIPAQMATAEVVNFMA
CCCCCCCCCHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHH
KHGRGLICLAMTRERCEQLDLPLMAQQNSSRHSTAFTISIEAKDGVTTGISAADRALTIQ
HCCCCEEEEEECHHHHHHCCCCEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEE
VAIDPAKGRGDIATPGHVFPLVARDGGVLVRAGHTEAAVDVARMAGLVPAGVICEVMNDD
EEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCC
GTMARMPDLVRFAQEHGLKVGTIADLIAYRRTKERLVRRELETDFRSVHGGDWRMMLYVS
CCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
TVSYGEHIALVKGDPRGSDPVLVRMHALNVLDDVLGDSDGNAHGQLHRAMDVIGRAGRGV
EECCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCE
LVLIREGRPTALSERLRARIEQGPSAQRLVDYGVGAQILLDLGVTDMTLLTNTPKHIIGL
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCCEEEECCCCCCEEEC
EGYGLRVAGHQPLSDKE
CCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TDGTSPVPYRDYLASPEDIIEDARQGKMFILVDDENRENEGDLVIPAQMATAEVVNFMA
CCCCCCCCHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHH
KHGRGLICLAMTRERCEQLDLPLMAQQNSSRHSTAFTISIEAKDGVTTGISAADRALTIQ
HCCCCEEEEEECHHHHHHCCCCEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEE
VAIDPAKGRGDIATPGHVFPLVARDGGVLVRAGHTEAAVDVARMAGLVPAGVICEVMNDD
EEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCC
GTMARMPDLVRFAQEHGLKVGTIADLIAYRRTKERLVRRELETDFRSVHGGDWRMMLYVS
CCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
TVSYGEHIALVKGDPRGSDPVLVRMHALNVLDDVLGDSDGNAHGQLHRAMDVIGRAGRGV
EECCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCE
LVLIREGRPTALSERLRARIEQGPSAQRLVDYGVGAQILLDLGVTDMTLLTNTPKHIIGL
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCCEEEECCCCCCEEEC
EGYGLRVAGHQPLSDKE
CCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]