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The map label for this gene is ribE [H]

Identifier: 83593159

GI number: 83593159

Start: 2122948

End: 2123538

Strand: Reverse

Name: ribE [H]

Synonym: Rru_A1824

Alternate gene names: 83593159

Gene position: 2123538-2122948 (Counterclockwise)

Preceding gene: 83593160

Following gene: 83593158

Centisome position: 48.79

GC content: 63.28

Gene sequence:

>591_bases
ATGTTCACAGGGATCATCAGCGATCTCGGAGCCGTGCGTGAGATCACTCAGGCCGGCGATACCCGCCTGACCTTTTCCAC
CGCCTATGAGACCGAGGGCGTGGCCATCGGCGCCTCGATCGCCTGCTCGGGCTGCTGCCTGACGGTGATCGACAAGGGGC
CGGGGTGGTTCGCGGTTCAGGCTTCGGGCGAGACCTTGTCGAAAACCACCCTGGGCCTGTGGACGGTCGGCAGTCCGGTC
AATTTCGAGCGCGCCCTGGCCGTTGGCGACGAGTTGGGCGGCCATATCGTTTCGGGCCATGTGGATGGCGTGGCCGAGGT
TCTCGAGGTCGCACCCGAGGGGGAAAGCCACCGCTTCCGCTTCCGCGTTCCCGAAGATCTGAAGAAATTCATCGCCCCCA
AGGGCTCGGTCGCCATCGACGGCGTTTCGCTGACGGTGAACGAGGTCGAGGGCGCGGTCTTTGGCGTTAACATCATTCCC
CACACCTTCCAGGCCACCACATTCGGGCGACTTGCTCCCGGAAGCCGCGTGAACATGGAAATCGACATGCTGGCGCGCTA
TGTTGCGCGTCTTCTTCACCCCGATGACTGA

Upstream 100 bases:

>100_bases
GAGGCCTGCCAGACCCTGGGGGATGACCGGCTGGAGCTATACGCCAGATCCCGTGACCCCCTTTCCCCCGCCCCCTGAAC
CCCGGGACTACGGAGCAATC

Downstream 100 bases:

>100_bases
CGGAACCTCTCCCGTGCCCTATCGCGATTATCTGGCTTCCCCGGAAGACATCATCGAAGATGCCCGTCAGGGCAAAATGT
TCATCCTGGTCGATGACGAG

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MFTGIISDLGAVREITQAGDTRLTFSTAYETEGVAIGASIACSGCCLTVIDKGPGWFAVQASGETLSKTTLGLWTVGSPV
NFERALAVGDELGGHIVSGHVDGVAEVLEVAPEGESHRFRFRVPEDLKKFIAPKGSVAIDGVSLTVNEVEGAVFGVNIIP
HTFQATTFGRLAPGSRVNMEIDMLARYVARLLHPDD

Sequences:

>Translated_196_residues
MFTGIISDLGAVREITQAGDTRLTFSTAYETEGVAIGASIACSGCCLTVIDKGPGWFAVQASGETLSKTTLGLWTVGSPV
NFERALAVGDELGGHIVSGHVDGVAEVLEVAPEGESHRFRFRVPEDLKKFIAPKGSVAIDGVSLTVNEVEGAVFGVNIIP
HTFQATTFGRLAPGSRVNMEIDMLARYVARLLHPDD
>Mature_196_residues
MFTGIISDLGAVREITQAGDTRLTFSTAYETEGVAIGASIACSGCCLTVIDKGPGWFAVQASGETLSKTTLGLWTVGSPV
NFERALAVGDELGGHIVSGHVDGVAEVLEVAPEGESHRFRFRVPEDLKKFIAPKGSVAIDGVSLTVNEVEGAVFGVNIIP
HTFQATTFGRLAPGSRVNMEIDMLARYVARLLHPDD

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=185, Percent_Identity=39.4594594594595, Blast_Score=123, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319733, Length=205, Percent_Identity=34.1463414634146, Blast_Score=108, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 20718; Mature: 20718

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIISDLGAVREITQAGDTRLTFSTAYETEGVAIGASIACSGCCLTVIDKGPGWFAVQ
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCEECCCEEEEEEECCCCEEEEE
ASGETLSKTTLGLWTVGSPVNFERALAVGDELGGHIVSGHVDGVAEVLEVAPEGESHRFR
ECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCEEE
FRVPEDLKKFIAPKGSVAIDGVSLTVNEVEGAVFGVNIIPHTFQATTFGRLAPGSRVNME
EECCHHHHHHHCCCCCEEEECEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEE
IDMLARYVARLLHPDD
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFTGIISDLGAVREITQAGDTRLTFSTAYETEGVAIGASIACSGCCLTVIDKGPGWFAVQ
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCEECCCEEEEEEECCCCEEEEE
ASGETLSKTTLGLWTVGSPVNFERALAVGDELGGHIVSGHVDGVAEVLEVAPEGESHRFR
ECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCEEE
FRVPEDLKKFIAPKGSVAIDGVSLTVNEVEGAVFGVNIIPHTFQATTFGRLAPGSRVNME
EECCHHHHHHHCCCCCEEEECEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEE
IDMLARYVARLLHPDD
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144477 [H]