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The map label for this gene is hppA

Identifier: 83593153

GI number: 83593153

Start: 2116926

End: 2119034

Strand: Reverse

Name: hppA

Synonym: Rru_A1818

Alternate gene names: 83593153

Gene position: 2119034-2116926 (Counterclockwise)

Preceding gene: 83593154

Following gene: 83593152

Centisome position: 48.68

GC content: 64.77

Gene sequence:

>2109_bases
ATGGCTGGCATCTATCTTTTCGTCGTAGCCGCCGCACTCGCGGCCCTTGGTTATGGCGCTCTCACCATCAAAACAATCAT
GGCGGCTGATGCCGGCACCGCGCGGATGCAGGAGATTTCCGGCGCCGTGCAGGAAGGCGCCAGCGCGTTTCTCAATCGTC
AGTACAAGACCATCGCCGTCGTCGGCGCGGTTGTTTTCGTTATTCTGACGGCGCTTCTTGGCATCTCGGTCGGCTTCGGC
TTTCTGATCGGCGCCGTGTGCTCGGGCATCGCCGGTTATGTCGGCATGTACATCTCGGTGCGCGCCAATGTGCGCGTCGC
CGCCGGGGCCCAGCAGGGACTGGCCCGGGGTCTGGAACTCGCCTTCCAGTCGGGCGCGGTGACCGGCATGCTGGTGGCCG
GTCTGGCCCTGCTGTCGGTGGCCTTCTATTACATCCTGCTCGTCGGCATCGGCGCGACCGGCCGCGCGCTGATCGATCCG
CTGGTGGCTCTGGGCTTTGGCGCCTCGCTGATCTCGATCTTCGCCCGTCTGGGTGGCGGCATCTTCACCAAGGGCGCCGA
CGTGGGCGCCGATCTGGTGGGCAAGGTCGAAGCGGGGATCCCCGAGGATGACCCGCGCAATCCCGCCGTCATCGCCGACA
ACGTGGGCGATAACGTGGGCGATTGCGCCGGCATGGCGGCCGACCTGTTCGAGACCTATGCCGTGACCGTCGTCGCCACC
ATGGTCCTGGCCTCGATCTTCTTCGCCGGCGTTCCGGCGATGACCTCGATGATGGCCTATCCGCTGGCGATCGGCGGGGT
CTGCATCCTGGCCTCGATCCTCGGCACCAAGTTCGTGAAGCTTGGCCCCAAGAACAACATCATGGGGGCGCTCTATCGCG
GCTTCCTGGTGTCGGCGGGAGCGTCCTTCGTCGGGATCATCCTGGCCACGGCGATCGTCCCGGGCTTTGGCGACATCCAG
GGCGCCAACGGGGTGCTCTATTCGGGCTTCGACCTGTTCTTGTGCGCCGTCATCGGCCTGCTGGTCACCGGTTTGCTGAT
CTGGGTCACCGAATATTACACCGGCACCAATTTCCGGCCGGTCCGTTCGGTCGCCAAGGCCTCGACCACCGGCCACGGCA
CCAACGTGATCCAGGGTCTGGCGATTTCGATGGAGGCGACGGCCCTGCCGGCGCTGATCATCTGCGCGGCCATCATCACC
ACCTATCAGCTGTCGGGTCTGTTTGGCATCGCCATCACCGTGACCAGCATGCTGGCTTTGGCCGGGATGGTCGTGGCGCT
CGACGCCTATGGTCCGGTGACCGATAACGCCGGCGGCATCGCCGAAATGGCCAATCTGCCCGAGGACGTGCGCAAGACCA
CCGATGCGCTCGACGCCGTTGGCAACACCACCAAGGCGGTGACCAAGGGCTATGCTATCGGTTCGGCCGGCCTTGGCGCC
CTGGTGCTGTTCGCCGCCTATACCGAGGATCTGGCCTTCTTCAAGGCCAATGTCGACGCCTATCCGGCCTTCGCCGGGGT
GGATGTCAACTTCTCGCTGTCGAGCCCCTATGTGGTGGTCGGCCTGTTCATCGGCGGCCTGCTGCCCTATCTGTTCGGCT
CGATGGGCATGACCGCCGTCGGCCGCGCCGCTGGCAGCGTCGTCGAGGAGGTTCGCCGTCAGTTCCGCGAAATCCCGGGC
ATCATGGAAGGCACCGCCAAGCCGGAATACGGCCGCTGCGTCGACATGCTGACCAAGGCGGCGATCAAGGAGATGATCAT
CCCCTCGCTGCTGCCGGTTCTGGCGCCGATCGTGCTGTACTTCGTTATCCTCGGCATCGCCGATAAATCGGCCGCCTTCT
CGGCCCTGGGCGCCATGCTGCTCGGCGTGATCGTCACCGGTCTTTTCGTGGCGATCTCGATGACCGCCGGTGGCGGCGCC
TGGGACAACGCCAAGAAGTACATCGAAGACGGCCACTACGGTGGCAAGGGGTCGGAAGCCCATAAGGCCGCCGTCACCGG
CGACACCGTTGGCGATCCGTACAAGGACACCGCCGGTCCGGCGGTCAATCCGATGATCAAGATCACCAACATCGTCGCCC
TGCTGCTGCTGGCGGTGCTGGCCCACTAA

Upstream 100 bases:

>100_bases
TTGCGGCGAAGACCCGGCGGTCGATGTGGCTATTCGATCGCGGCGGGGTTTTTCCGCATTGCCCGCCGTTAGGCCCATTC
AGGGAGGGATCGAACGAATC

Downstream 100 bases:

>100_bases
CTCCGGCGATCGCTGGAAAACGACGCGGGGGCCCGGAGAGTGATCCGGGCCCCCGTTTTCATATGCCCAAGACTGGATTT
CAGAGTAAAAAAAAGAGTGT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase

Number of amino acids: Translated: 702; Mature: 701

Protein sequence:

>702_residues
MAGIYLFVVAAALAALGYGALTIKTIMAADAGTARMQEISGAVQEGASAFLNRQYKTIAVVGAVVFVILTALLGISVGFG
FLIGAVCSGIAGYVGMYISVRANVRVAAGAQQGLARGLELAFQSGAVTGMLVAGLALLSVAFYYILLVGIGATGRALIDP
LVALGFGASLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVVAT
MVLASIFFAGVPAMTSMMAYPLAIGGVCILASILGTKFVKLGPKNNIMGALYRGFLVSAGASFVGIILATAIVPGFGDIQ
GANGVLYSGFDLFLCAVIGLLVTGLLIWVTEYYTGTNFRPVRSVAKASTTGHGTNVIQGLAISMEATALPALIICAAIIT
TYQLSGLFGIAITVTSMLALAGMVVALDAYGPVTDNAGGIAEMANLPEDVRKTTDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYTEDLAFFKANVDAYPAFAGVDVNFSLSSPYVVVGLFIGGLLPYLFGSMGMTAVGRAAGSVVEEVRRQFREIPG
IMEGTAKPEYGRCVDMLTKAAIKEMIIPSLLPVLAPIVLYFVILGIADKSAAFSALGAMLLGVIVTGLFVAISMTAGGGA
WDNAKKYIEDGHYGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAH

Sequences:

>Translated_702_residues
MAGIYLFVVAAALAALGYGALTIKTIMAADAGTARMQEISGAVQEGASAFLNRQYKTIAVVGAVVFVILTALLGISVGFG
FLIGAVCSGIAGYVGMYISVRANVRVAAGAQQGLARGLELAFQSGAVTGMLVAGLALLSVAFYYILLVGIGATGRALIDP
LVALGFGASLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVVAT
MVLASIFFAGVPAMTSMMAYPLAIGGVCILASILGTKFVKLGPKNNIMGALYRGFLVSAGASFVGIILATAIVPGFGDIQ
GANGVLYSGFDLFLCAVIGLLVTGLLIWVTEYYTGTNFRPVRSVAKASTTGHGTNVIQGLAISMEATALPALIICAAIIT
TYQLSGLFGIAITVTSMLALAGMVVALDAYGPVTDNAGGIAEMANLPEDVRKTTDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYTEDLAFFKANVDAYPAFAGVDVNFSLSSPYVVVGLFIGGLLPYLFGSMGMTAVGRAAGSVVEEVRRQFREIPG
IMEGTAKPEYGRCVDMLTKAAIKEMIIPSLLPVLAPIVLYFVILGIADKSAAFSALGAMLLGVIVTGLFVAISMTAGGGA
WDNAKKYIEDGHYGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAH
>Mature_701_residues
AGIYLFVVAAALAALGYGALTIKTIMAADAGTARMQEISGAVQEGASAFLNRQYKTIAVVGAVVFVILTALLGISVGFGF
LIGAVCSGIAGYVGMYISVRANVRVAAGAQQGLARGLELAFQSGAVTGMLVAGLALLSVAFYYILLVGIGATGRALIDPL
VALGFGASLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVVATM
VLASIFFAGVPAMTSMMAYPLAIGGVCILASILGTKFVKLGPKNNIMGALYRGFLVSAGASFVGIILATAIVPGFGDIQG
ANGVLYSGFDLFLCAVIGLLVTGLLIWVTEYYTGTNFRPVRSVAKASTTGHGTNVIQGLAISMEATALPALIICAAIITT
YQLSGLFGIAITVTSMLALAGMVVALDAYGPVTDNAGGIAEMANLPEDVRKTTDALDAVGNTTKAVTKGYAIGSAGLGAL
VLFAAYTEDLAFFKANVDAYPAFAGVDVNFSLSSPYVVVGLFIGGLLPYLFGSMGMTAVGRAAGSVVEEVRRQFREIPGI
MEGTAKPEYGRCVDMLTKAAIKEMIIPSLLPVLAPIVLYFVILGIADKSAAFSALGAMLLGVIVTGLFVAISMTAGGGAW
DNAKKYIEDGHYGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAH

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA_RHORT (O68460)

Other databases:

- EMBL:   AF044912
- EMBL:   CP000230
- EMBL:   AJ549291
- RefSeq:   YP_426905.1
- STRING:   O68460
- GeneID:   3835242
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1818
- NMPDR:   fig|1085.1.peg.2393
- eggNOG:   COG3808
- HOGENOM:   HBG593668
- OMA:   AYLARQY
- ProtClustDB:   PRK00733
- BioCyc:   RRUB269796:RRU_A1818-MONOMER
- BRENDA:   3.6.1.1
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 71548; Mature: 71417

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf4f9890)-; HASH(0xf47e2ec)-; HASH(0xf7640e8)-; HASH(0xf9594b0)-; HASH(0xfdf59d4)-; HASH(0xff56184)-; HASH(0xfffbd90)-; HASH(0xfecbf28)-; HASH(0xcbe2fdc)-; HASH(0xfd4309c)-; HASH(0xcbe31e0)-; HASH(0xeea7470)-; HASH(0xf8e69ac)-; HASH(0xf8540f4)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIYLFVVAAALAALGYGALTIKTIMAADAGTARMQEISGAVQEGASAFLNRQYKTIAV
CCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VGAVVFVILTALLGISVGFGFLIGAVCSGIAGYVGMYISVRANVRVAAGAQQGLARGLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCHHHHHHHHHHH
AFQSGAVTGMLVAGLALLSVAFYYILLVGIGATGRALIDPLVALGFGASLISIFARLGGG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
IFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVVAT
EEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
MVLASIFFAGVPAMTSMMAYPLAIGGVCILASILGTKFVKLGPKNNIMGALYRGFLVSAG
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCC
ASFVGIILATAIVPGFGDIQGANGVLYSGFDLFLCAVIGLLVTGLLIWVTEYYTGTNFRP
HHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VRSVAKASTTGHGTNVIQGLAISMEATALPALIICAAIITTYQLSGLFGIAITVTSMLAL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMVVALDAYGPVTDNAGGIAEMANLPEDVRKTTDALDAVGNTTKAVTKGYAIGSAGLGA
HHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHH
LVLFAAYTEDLAFFKANVDAYPAFAGVDVNFSLSSPYVVVGLFIGGLLPYLFGSMGMTAV
HHHHHHHHHHHHHHHCCCCCCCCEECCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHH
GRAAGSVVEEVRRQFREIPGIMEGTAKPEYGRCVDMLTKAAIKEMIIPSLLPVLAPIVLY
HHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVILGIADKSAAFSALGAMLLGVIVTGLFVAISMTAGGGAWDNAKKYIEDGHYGGKGSEA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC
HKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAH
CHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
AGIYLFVVAAALAALGYGALTIKTIMAADAGTARMQEISGAVQEGASAFLNRQYKTIAV
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VGAVVFVILTALLGISVGFGFLIGAVCSGIAGYVGMYISVRANVRVAAGAQQGLARGLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCHHHHHHHHHHH
AFQSGAVTGMLVAGLALLSVAFYYILLVGIGATGRALIDPLVALGFGASLISIFARLGGG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
IFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVVAT
EEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
MVLASIFFAGVPAMTSMMAYPLAIGGVCILASILGTKFVKLGPKNNIMGALYRGFLVSAG
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCC
ASFVGIILATAIVPGFGDIQGANGVLYSGFDLFLCAVIGLLVTGLLIWVTEYYTGTNFRP
HHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VRSVAKASTTGHGTNVIQGLAISMEATALPALIICAAIITTYQLSGLFGIAITVTSMLAL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMVVALDAYGPVTDNAGGIAEMANLPEDVRKTTDALDAVGNTTKAVTKGYAIGSAGLGA
HHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHH
LVLFAAYTEDLAFFKANVDAYPAFAGVDVNFSLSSPYVVVGLFIGGLLPYLFGSMGMTAV
HHHHHHHHHHHHHHHCCCCCCCCEECCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHH
GRAAGSVVEEVRRQFREIPGIMEGTAKPEYGRCVDMLTKAAIKEMIIPSLLPVLAPIVLY
HHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVILGIADKSAAFSALGAMLLGVIVTGLFVAISMTAGGGAWDNAKKYIEDGHYGGKGSEA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC
HKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAH
CHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9630689; 11956221