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The map label for this gene is zitB [H]

Identifier: 83593033

GI number: 83593033

Start: 1988154

End: 1989167

Strand: Direct

Name: zitB [H]

Synonym: Rru_A1698

Alternate gene names: 83593033

Gene position: 1988154-1989167 (Clockwise)

Preceding gene: 83593029

Following gene: 83593046

Centisome position: 45.68

GC content: 65.29

Gene sequence:

>1014_bases
ATGCATACCCATGATCTTTCTCCCTGGACCCATGATCACGTCTATGCCACCGGCGGCGAGGCGGCGGCGGAACGGCGAAC
GCGGCTCGTCGTCGCCCTCACCGTGGCGATGATGGGGCTGGAAATCGTTGTCGGCACCCTGACCAATTCGATGGCGCTGC
TGGCCGATGGTTTTCACATGGCCACCCATGCGGCGGCCCTTGGCATCGCCGCCTTCGCCTATGCCCATGCCCGCCGCCAC
GCCTTTGATCGCCGCTACAGCTTTGGCACCGGCAAGGTCGGCGCCTTGGCGGCTTTCACCAGCGCCATCATCCTCGGCGT
TGTCGCCCTGGGGATGGTCTGGGAATCGGCCAGCCGCTTTTTCAGCGTGCAGACCATCGCCTTTGAACAGGCCCTGATCG
TCGCCACGCTCGGCCTTGTCGTCAATCTGCTGTCGGTGCTGATCCTCGGCGGCCCCGGTCAGGCCCCTCACCATGACCAT
GGGCACGATCATGGGCATGGGCATGGGCACGACCACGGGCACGGCGCCCATGAGGATCACAACATCCGCGCCGCCTATCT
GCATGTGATGGCCGATGCCGTCACCTCGGTTCTGGCGATCGTCGCCTTGCTCTTTGGCAAATATATGGGCTGGTGGTGGC
TTGATCCGCTGATCGGCATCGTCGGTGCCGCGGTCATCGGGCGTTGGGCCTGGGGGCTGATGATGCGCTCGGGCGCGGTG
CTGCTGGATCATAGCGCCGACAAGGGCTTGGAAGACGAAGTGCGCATGGCGATCGAGGGCGACGGCACGGCGATCAACCG
GGTGGCCGATCTTCATCTGTGGCAGGTCGGCCCCGGCCATTGGGCGGCGATCGTCTCGGTGGTCAGCGATATCGTCCAGC
CGATCGCCCACTACCGCGCCCTGTTGGCCGAGGTCCATGAACTCAGCCATGTGACCATCGAGGTCCAGGCCTGCGCCGGA
TGCGAGGGCGATTGCGGCTGCGCCTGCGGCGCTGCGACCGCTTCCGCCGTATAA

Upstream 100 bases:

>100_bases
TTATGGCGCTCCCCTTCGCAATGCGGCTTGTTCGAGGGCAAGCAGAGCGCTACTAAGTCTCATTCAACACCGTCCGGCGG
TCGACGGCAAGGAGGACTCC

Downstream 100 bases:

>100_bases
GCGAAAAGCGTTTTCGCTCAAACGGATGGCTCGTGAACCTCGATGATCATCCCATCATGGGCCGGCACGACCCCGGGCGG
CAGGCGGTCCAGGGTCGCCC

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MHTHDLSPWTHDHVYATGGEAAAERRTRLVVALTVAMMGLEIVVGTLTNSMALLADGFHMATHAAALGIAAFAYAHARRH
AFDRRYSFGTGKVGALAAFTSAIILGVVALGMVWESASRFFSVQTIAFEQALIVATLGLVVNLLSVLILGGPGQAPHHDH
GHDHGHGHGHDHGHGAHEDHNIRAAYLHVMADAVTSVLAIVALLFGKYMGWWWLDPLIGIVGAAVIGRWAWGLMMRSGAV
LLDHSADKGLEDEVRMAIEGDGTAINRVADLHLWQVGPGHWAAIVSVVSDIVQPIAHYRALLAEVHELSHVTIEVQACAG
CEGDCGCACGAATASAV

Sequences:

>Translated_337_residues
MHTHDLSPWTHDHVYATGGEAAAERRTRLVVALTVAMMGLEIVVGTLTNSMALLADGFHMATHAAALGIAAFAYAHARRH
AFDRRYSFGTGKVGALAAFTSAIILGVVALGMVWESASRFFSVQTIAFEQALIVATLGLVVNLLSVLILGGPGQAPHHDH
GHDHGHGHGHDHGHGAHEDHNIRAAYLHVMADAVTSVLAIVALLFGKYMGWWWLDPLIGIVGAAVIGRWAWGLMMRSGAV
LLDHSADKGLEDEVRMAIEGDGTAINRVADLHLWQVGPGHWAAIVSVVSDIVQPIAHYRALLAEVHELSHVTIEVQACAG
CEGDCGCACGAATASAV
>Mature_337_residues
MHTHDLSPWTHDHVYATGGEAAAERRTRLVVALTVAMMGLEIVVGTLTNSMALLADGFHMATHAAALGIAAFAYAHARRH
AFDRRYSFGTGKVGALAAFTSAIILGVVALGMVWESASRFFSVQTIAFEQALIVATLGLVVNLLSVLILGGPGQAPHHDH
GHDHGHGHGHDHGHGAHEDHNIRAAYLHVMADAVTSVLAIVALLFGKYMGWWWLDPLIGIVGAAVIGRWAWGLMMRSGAV
LLDHSADKGLEDEVRMAIEGDGTAINRVADLHLWQVGPGHWAAIVSVVSDIVQPIAHYRALLAEVHELSHVTIEVQACAG
CEGDCGCACGAATASAV

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=355, Percent_Identity=25.3521126760563, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI222080086, Length=338, Percent_Identity=22.7810650887574, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40255009, Length=338, Percent_Identity=22.7810650887574, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI52352805, Length=322, Percent_Identity=22.9813664596273, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786966, Length=318, Percent_Identity=30.5031446540881, Blast_Score=91, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI32564488, Length=255, Percent_Identity=32.5490196078431, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193210990, Length=338, Percent_Identity=27.2189349112426, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555794, Length=325, Percent_Identity=27.0769230769231, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555796, Length=312, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=166, Percent_Identity=27.710843373494, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=203, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24656728, Length=329, Percent_Identity=24.3161094224924, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24656724, Length=329, Percent_Identity=24.3161094224924, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24656720, Length=329, Percent_Identity=24.3161094224924, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24656715, Length=329, Percent_Identity=24.3161094224924, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357035, Length=329, Percent_Identity=24.3161094224924, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35660; Mature: 35660

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure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HHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]