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The map label for this gene is ldc [H]

Identifier: 83593028

GI number: 83593028

Start: 1984037

End: 1985302

Strand: Direct

Name: ldc [H]

Synonym: Rru_A1693

Alternate gene names: 83593028

Gene position: 1984037-1985302 (Clockwise)

Preceding gene: 83593027

Following gene: 83593029

Centisome position: 45.58

GC content: 65.96

Gene sequence:

>1266_bases
ATGCACAATCAAGCCATCCGGGCCAACCAGCCCGAAGAGCCGCCCGACGCCTTCATCGCCGCGGAATCCCGCCCGCCGGG
CGGCGCCCCGACCCTTGCCCTCGTCGCCGAACCCCCGCGCTGGGTGGCGACCGGCATCACCGAAAAGATGGCGGCGTTCC
TGGCCGAAGAGCCCGAAACCCCCTGTCTCGTCGTCGACCTTGACGTGGTCGAAGGCAATTACCGCGCCCTGCGCGGCGCT
CTGCCCCAGGCGGAGGTCTACTATGCGGTGAAATCGAACCCGGCGCCGCCGCTTGTCGCCCGGCTGATCGCCCTGGGATC
GAGTTTCGATACCGCCAGCCTTCCCGAGATCGACCTGTGCCTCGGCCTGGGGGCCGATCCGGCCAAGCTGTCGTTCGGGA
ACACCATCAAGAAATCAAAAGACATCGCCGCGGCCTATGAACGCGGTGTTCGGCTATTCGCCTTCGATGCGGAGGAGGAG
CTGGAAAAGCTCGCCGAACACGCGCCCGGTTCGCAGGTGTTCTGCCGCTTGTTCGTTGACAATGTCGGGGCCGAATGGCC
GCTGTCGCGCAAGTTCGGCTGTTCCGTCGCCATGGCCGGCGATCTGCTGATCAAGGCCCAGGCCCTGGGCCTTGAAGCCC
ACGGCGTGTCGTTCCACGTCGGCTCGCAGCAAAAAGACCTTGGCCAGTGGGATGTCGCCCTGGAAAAGGCCGCCGAGCTG
TTCCGCGATCTGGCCGCCGTCGGCATCACCCTCAAGATGGTCAATCTTGGCGGTGGCCTGCCGACGTCTTATGGCAACCG
CTTGCCCTATGGCGTCGATGAATACGGCGCCCATGTCCTGGGCGCGGTCGACCGCTTGTTCGATGGCCCGCGTCCGCGGC
TGATCGTCGAGCCCGGCCGCTATATGGGCGGCAACGCCGGCGTGCTGGAGACCGAGGTGGTTCTGGTGTCGCGCAAGGAC
GCCGCCGACGATCGGCGCTGGGTCTATATCGACGCCGGCCGCTTCAACGGCCTGGCCGAGACCGAGGGCGAGGCCATCCG
CTACCCGATCATCAGCGACAAGGACGACGGCGAGACCGGTCCGGTCATCATCGCCGGCCCGACCTGCGACAGCGTCGATA
TCCTGTATGACAAGGCCGGTTACACCCTGCCGCTGTCGCTCAAGGCGGGAGACCGTCTTCGCCTGCTGTCGACGGGCGCC
TATACCACGTCCTATGCCTCGGTCGGCTTCAACGGCTTCCTGCCGCTCAAGGCCCACTACCTGTAA

Upstream 100 bases:

>100_bases
TGGCCTATCCGTCTTGTCCGCCTTCGGTGCCTGTCCACCGAACGTTCGCTCGCGCGAGAAATCCTGCGCCAGGGCAGGAT
TTCCCATTGTGGAGAAGCTG

Downstream 100 bases:

>100_bases
GATCGCCTTTGGTGATTGACCGGCCCGGACCGCCTTGGCGCAGTCCGGGCCGTTTTTGTTGCGCCGGTCCCAAGCCGACG
CCAGATAACAGGGCAGGTGG

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MHNQAIRANQPEEPPDAFIAAESRPPGGAPTLALVAEPPRWVATGITEKMAAFLAEEPETPCLVVDLDVVEGNYRALRGA
LPQAEVYYAVKSNPAPPLVARLIALGSSFDTASLPEIDLCLGLGADPAKLSFGNTIKKSKDIAAAYERGVRLFAFDAEEE
LEKLAEHAPGSQVFCRLFVDNVGAEWPLSRKFGCSVAMAGDLLIKAQALGLEAHGVSFHVGSQQKDLGQWDVALEKAAEL
FRDLAAVGITLKMVNLGGGLPTSYGNRLPYGVDEYGAHVLGAVDRLFDGPRPRLIVEPGRYMGGNAGVLETEVVLVSRKD
AADDRRWVYIDAGRFNGLAETEGEAIRYPIISDKDDGETGPVIIAGPTCDSVDILYDKAGYTLPLSLKAGDRLRLLSTGA
YTTSYASVGFNGFLPLKAHYL

Sequences:

>Translated_421_residues
MHNQAIRANQPEEPPDAFIAAESRPPGGAPTLALVAEPPRWVATGITEKMAAFLAEEPETPCLVVDLDVVEGNYRALRGA
LPQAEVYYAVKSNPAPPLVARLIALGSSFDTASLPEIDLCLGLGADPAKLSFGNTIKKSKDIAAAYERGVRLFAFDAEEE
LEKLAEHAPGSQVFCRLFVDNVGAEWPLSRKFGCSVAMAGDLLIKAQALGLEAHGVSFHVGSQQKDLGQWDVALEKAAEL
FRDLAAVGITLKMVNLGGGLPTSYGNRLPYGVDEYGAHVLGAVDRLFDGPRPRLIVEPGRYMGGNAGVLETEVVLVSRKD
AADDRRWVYIDAGRFNGLAETEGEAIRYPIISDKDDGETGPVIIAGPTCDSVDILYDKAGYTLPLSLKAGDRLRLLSTGA
YTTSYASVGFNGFLPLKAHYL
>Mature_421_residues
MHNQAIRANQPEEPPDAFIAAESRPPGGAPTLALVAEPPRWVATGITEKMAAFLAEEPETPCLVVDLDVVEGNYRALRGA
LPQAEVYYAVKSNPAPPLVARLIALGSSFDTASLPEIDLCLGLGADPAKLSFGNTIKKSKDIAAAYERGVRLFAFDAEEE
LEKLAEHAPGSQVFCRLFVDNVGAEWPLSRKFGCSVAMAGDLLIKAQALGLEAHGVSFHVGSQQKDLGQWDVALEKAAEL
FRDLAAVGITLKMVNLGGGLPTSYGNRLPYGVDEYGAHVLGAVDRLFDGPRPRLIVEPGRYMGGNAGVLETEVVLVSRKD
AADDRRWVYIDAGRFNGLAETEGEAIRYPIISDKDDGETGPVIIAGPTCDSVDILYDKAGYTLPLSLKAGDRLRLLSTGA
YTTSYASVGFNGFLPLKAHYL

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=376, Percent_Identity=31.6489361702128, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI16506287, Length=396, Percent_Identity=27.020202020202, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI22538418, Length=378, Percent_Identity=26.4550264550265, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI21361583, Length=378, Percent_Identity=26.4550264550265, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789203, Length=398, Percent_Identity=26.8844221105528, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=372, Percent_Identity=32.5268817204301, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25141365, Length=358, Percent_Identity=23.1843575418994, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=381, Percent_Identity=28.8713910761155, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24586472, Length=365, Percent_Identity=32.0547945205479, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24586474, Length=366, Percent_Identity=33.879781420765, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 45058; Mature: 45058

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNQAIRANQPEEPPDAFIAAESRPPGGAPTLALVAEPPRWVATGITEKMAAFLAEEPET
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
PCLVVDLDVVEGNYRALRGALPQAEVYYAVKSNPAPPLVARLIALGSSFDTASLPEIDLC
CEEEEEEEEECCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEE
LGLGADPAKLSFGNTIKKSKDIAAAYERGVRLFAFDAEEELEKLAEHAPGSQVFCRLFVD
EECCCCCCEECCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCHHHHHHEEHH
NVGAEWPLSRKFGCSVAMAGDLLIKAQALGLEAHGVSFHVGSQQKDLGQWDVALEKAAEL
HCCCCCCCCCCCCCEEEEECCEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHH
FRDLAAVGITLKMVNLGGGLPTSYGNRLPYGVDEYGAHVLGAVDRLFDGPRPRLIVEPGR
HHHHHHHCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCC
YMGGNAGVLETEVVLVSRKDAADDRRWVYIDAGRFNGLAETEGEAIRYPIISDKDDGETG
CCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCC
PVIIAGPTCDSVDILYDKAGYTLPLSLKAGDRLRLLSTGAYTTSYASVGFNGFLPLKAHY
CEEEECCCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCEEEEC
L
C
>Mature Secondary Structure
MHNQAIRANQPEEPPDAFIAAESRPPGGAPTLALVAEPPRWVATGITEKMAAFLAEEPET
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
PCLVVDLDVVEGNYRALRGALPQAEVYYAVKSNPAPPLVARLIALGSSFDTASLPEIDLC
CEEEEEEEEECCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEE
LGLGADPAKLSFGNTIKKSKDIAAAYERGVRLFAFDAEEELEKLAEHAPGSQVFCRLFVD
EECCCCCCEECCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCHHHHHHEEHH
NVGAEWPLSRKFGCSVAMAGDLLIKAQALGLEAHGVSFHVGSQQKDLGQWDVALEKAAEL
HCCCCCCCCCCCCCEEEEECCEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHH
FRDLAAVGITLKMVNLGGGLPTSYGNRLPYGVDEYGAHVLGAVDRLFDGPRPRLIVEPGR
HHHHHHHCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCC
YMGGNAGVLETEVVLVSRKDAADDRRWVYIDAGRFNGLAETEGEAIRYPIISDKDDGETG
CCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCC
PVIIAGPTCDSVDILYDKAGYTLPLSLKAGDRLRLLSTGAYTTSYASVGFNGFLPLKAHY
CEEEECCCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCEEEEC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]