Click here to switch to the map view.

The map label for this gene is nuoN [H]

Identifier: 83592969

GI number: 83592969

Start: 1925017

End: 1926489

Strand: Reverse

Name: nuoN [H]

Synonym: Rru_A1634

Alternate gene names: 83592969

Gene position: 1926489-1925017 (Counterclockwise)

Preceding gene: 83592970

Following gene: 83592968

Centisome position: 44.26

GC content: 66.87

Gene sequence:

>1473_bases
ATGAGCGCCGCCCCCGCCCTGTCGCTGGCCTGGATCCTTGCCACGCCGCTGGCCGCCACCCTGGTGATCGCCTTGAACGC
CAAGCGCCCGCGCCTGGGCGAGGCCATCGGCGTGATCGCCGCCCTGCTTACCTTTGCCCAGGTCGCCGCCTTGACCCCGA
CGGTTCTGGCCGGCGGGCGCCCGACGCTGGTGATGCTTTCGGTGATGGACACCATTCCCCTTGTCTTCACCCTTGATCCG
CTCGGCCTGCTGTTCGCCCTGGTCGCCGCCGCCCTGTGGATTCCCGCCGGGCTCTATTCCATCGCTTATCTGCGGGCCAA
CCACGAGGCCCATCAACCGCGCTTCCATGCCTATTTCGCCTTGGCCATCGCCTGCACCCTGGGCATCGCCCTGGCGGGCA
ACCTGTTCACGCTGTTCTTGTTTTACGAGGCGCTGACGCTTTCGACCTATCCGCTGATCACCCATCAGGGCACGGCCCAG
GCCGTGCGCGCCGGGCGGATCTATATGGGAATGCTGCTCGTCCCCTCGATCGGTCTGCTGCTGGTTGCCATCATCCTGAC
CCATAGCTTGGCCGGACGGATGGATTTCCAGCCCGGCGGCATCCTGGCCGGGCGGATCGATGGCCCGCTGGTCGGCCTGT
TGTTGGCCTTGTTCGTTTTCGGCACGGCCAAGGCCGCCCTGATGCCGTTCCACCGCTGGCTGCCCGCCGCCATGGTGGCC
CCCACCCCGGTCAGCGCCCTGCTGCACGCGGTGGCGGTGGTCAAGGCCGGGGTTTTCACCATCGCCAAGGTAGTGATCTC
GATCTTCGGCATCGACCTGCTGGCGGCCAGTTCCTGGACCGGCTGGCTGACCTGGGTGGCCGGGATCAGCGTCATCCTGG
CGTCGCTCATCGCCCTGCGTCAGGACAATCTGAAACGGCGGCTGGCCTATTCGACGATCAGCCAATTGGCCTATGTGGTG
ATGGCGCTGTCGCTGTTCTCGCCGCTCGGCGTGCTGGCCGCTGGCCTGCATATCGTCGTCCACGCCTTTGGCAAGATCAC
CTTGTTCTTCGCCGCCGGGGCCATCCACACCGCCACCCATAAGGACAGCGTTAGCCAGTTCGCCGGCATCGGCCGCGCCA
TGCCCTGGACCATGGGCGCCTTCGCCGTCGCCAGCCTGTCGATGATCGGCCTGCCGCCGACCGCCGGTTTCCTGTCGAAA
TGGGGGATCTTCTCGGCCGCCTTCCAGGGGCAGACCTGGGGGGTGGTCGCCGTGCTGATCGCCTCGACGGTGCTTAACGC
CGCCTATTTCCTGCCGATCCTGCATACGGCCTTTCTCAAGCCCCCGCCGGGCGAAGCCGGAGCCAAGATCGCCGAGGCTC
CGCCGCTGATGGTGGCGGCGCTGTGTTTGACGGCCTTTGGCACGCTGGCGCTGTTCTTCCTGCCCGGGCTGCCCTTCACC
CTTGCCCGCCAGCTTGCCGGAGTCGGCCCATGA

Upstream 100 bases:

>100_bases
TGTGGATCGCCGCCCTGGCCAATATCGGCTTTGGCCTGAACACCACCTGGACCCTGGGGCTGGCCAAACGCGCGGCGTCG
GCCCTGATGGGACTCCCCTC

Downstream 100 bases:

>100_bases
TCCCCCCCCGCCGTCCGATGACCCGTCCGATGACCCGCCTGTGGATCCTCGGCCTGATCGCCCTGGCGCTGAGCGTTCTG
GCCGAGGTGCCGGTCGGCCA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSAAPALSLAWILATPLAATLVIALNAKRPRLGEAIGVIAALLTFAQVAALTPTVLAGGRPTLVMLSVMDTIPLVFTLDP
LGLLFALVAAALWIPAGLYSIAYLRANHEAHQPRFHAYFALAIACTLGIALAGNLFTLFLFYEALTLSTYPLITHQGTAQ
AVRAGRIYMGMLLVPSIGLLLVAIILTHSLAGRMDFQPGGILAGRIDGPLVGLLLALFVFGTAKAALMPFHRWLPAAMVA
PTPVSALLHAVAVVKAGVFTIAKVVISIFGIDLLAASSWTGWLTWVAGISVILASLIALRQDNLKRRLAYSTISQLAYVV
MALSLFSPLGVLAAGLHIVVHAFGKITLFFAAGAIHTATHKDSVSQFAGIGRAMPWTMGAFAVASLSMIGLPPTAGFLSK
WGIFSAAFQGQTWGVVAVLIASTVLNAAYFLPILHTAFLKPPPGEAGAKIAEAPPLMVAALCLTAFGTLALFFLPGLPFT
LARQLAGVGP

Sequences:

>Translated_490_residues
MSAAPALSLAWILATPLAATLVIALNAKRPRLGEAIGVIAALLTFAQVAALTPTVLAGGRPTLVMLSVMDTIPLVFTLDP
LGLLFALVAAALWIPAGLYSIAYLRANHEAHQPRFHAYFALAIACTLGIALAGNLFTLFLFYEALTLSTYPLITHQGTAQ
AVRAGRIYMGMLLVPSIGLLLVAIILTHSLAGRMDFQPGGILAGRIDGPLVGLLLALFVFGTAKAALMPFHRWLPAAMVA
PTPVSALLHAVAVVKAGVFTIAKVVISIFGIDLLAASSWTGWLTWVAGISVILASLIALRQDNLKRRLAYSTISQLAYVV
MALSLFSPLGVLAAGLHIVVHAFGKITLFFAAGAIHTATHKDSVSQFAGIGRAMPWTMGAFAVASLSMIGLPPTAGFLSK
WGIFSAAFQGQTWGVVAVLIASTVLNAAYFLPILHTAFLKPPPGEAGAKIAEAPPLMVAALCLTAFGTLALFFLPGLPFT
LARQLAGVGP
>Mature_489_residues
SAAPALSLAWILATPLAATLVIALNAKRPRLGEAIGVIAALLTFAQVAALTPTVLAGGRPTLVMLSVMDTIPLVFTLDPL
GLLFALVAAALWIPAGLYSIAYLRANHEAHQPRFHAYFALAIACTLGIALAGNLFTLFLFYEALTLSTYPLITHQGTAQA
VRAGRIYMGMLLVPSIGLLLVAIILTHSLAGRMDFQPGGILAGRIDGPLVGLLLALFVFGTAKAALMPFHRWLPAAMVAP
TPVSALLHAVAVVKAGVFTIAKVVISIFGIDLLAASSWTGWLTWVAGISVILASLIALRQDNLKRRLAYSTISQLAYVVM
ALSLFSPLGVLAAGLHIVVHAFGKITLFFAAGAIHTATHKDSVSQFAGIGRAMPWTMGAFAVASLSMIGLPPTAGFLSKW
GIFSAAFQGQTWGVVAVLIASTVLNAAYFLPILHTAFLKPPPGEAGAKIAEAPPLMVAALCLTAFGTLALFFLPGLPFTL
ARQLAGVGP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=409, Percent_Identity=29.0953545232274, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI251831116, Length=329, Percent_Identity=24.9240121580547, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788827, Length=419, Percent_Identity=29.8329355608592, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788829, Length=456, Percent_Identity=28.2894736842105, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1788614, Length=366, Percent_Identity=31.9672131147541, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1788831, Length=344, Percent_Identity=29.9418604651163, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI145693160, Length=395, Percent_Identity=26.8354430379747, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788613, Length=361, Percent_Identity=25.207756232687, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI2367154, Length=197, Percent_Identity=28.4263959390863, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51162; Mature: 51031

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPALSLAWILATPLAATLVIALNAKRPRLGEAIGVIAALLTFAQVAALTPTVLAGGR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCC
PTLVMLSVMDTIPLVFTLDPLGLLFALVAAALWIPAGLYSIAYLRANHEAHQPRFHAYFA
CHHHHHHHHHHHCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LAIACTLGIALAGNLFTLFLFYEALTLSTYPLITHQGTAQAVRAGRIYMGMLLVPSIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LVAIILTHSLAGRMDFQPGGILAGRIDGPLVGLLLALFVFGTAKAALMPFHRWLPAAMVA
HHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
PTPVSALLHAVAVVKAGVFTIAKVVISIFGIDLLAASSWTGWLTWVAGISVILASLIALR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QDNLKRRLAYSTISQLAYVVMALSLFSPLGVLAAGLHIVVHAFGKITLFFAAGAIHTATH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
KDSVSQFAGIGRAMPWTMGAFAVASLSMIGLPPTAGFLSKWGIFSAAFQGQTWGVVAVLI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
ASTVLNAAYFLPILHTAFLKPPPGEAGAKIAEAPPLMVAALCLTAFGTLALFFLPGLPFT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
LARQLAGVGP
HHHHHHCCCC
>Mature Secondary Structure 
SAAPALSLAWILATPLAATLVIALNAKRPRLGEAIGVIAALLTFAQVAALTPTVLAGGR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCC
PTLVMLSVMDTIPLVFTLDPLGLLFALVAAALWIPAGLYSIAYLRANHEAHQPRFHAYFA
CHHHHHHHHHHHCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LAIACTLGIALAGNLFTLFLFYEALTLSTYPLITHQGTAQAVRAGRIYMGMLLVPSIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LVAIILTHSLAGRMDFQPGGILAGRIDGPLVGLLLALFVFGTAKAALMPFHRWLPAAMVA
HHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
PTPVSALLHAVAVVKAGVFTIAKVVISIFGIDLLAASSWTGWLTWVAGISVILASLIALR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QDNLKRRLAYSTISQLAYVVMALSLFSPLGVLAAGLHIVVHAFGKITLFFAAGAIHTATH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
KDSVSQFAGIGRAMPWTMGAFAVASLSMIGLPPTAGFLSKWGIFSAAFQGQTWGVVAVLI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
ASTVLNAAYFLPILHTAFLKPPPGEAGAKIAEAPPLMVAALCLTAFGTLALFFLPGLPFT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
LARQLAGVGP
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA