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The map label for this gene is cysK [H]

Identifier: 83592951

GI number: 83592951

Start: 1909415

End: 1910398

Strand: Reverse

Name: cysK [H]

Synonym: Rru_A1616

Alternate gene names: 83592951

Gene position: 1910398-1909415 (Counterclockwise)

Preceding gene: 83592953

Following gene: 83592950

Centisome position: 43.89

GC content: 65.75

Gene sequence:

>984_bases
ATGACCATTCGCGACGGCTTTCTGGGCACCATCGGTGGAACCCCGCTTATTCGTCTGCCCTGGGCCTCGCGGATCACCGG
TCGGGAAATTTTAGGCAAGGCCGAGTTTCTCAATCCCGGCGGTTCGGTCAAGGACCGCGCCGCCCTGGCCATCATCACCG
ACGCCCTGGAGCGCGGCGCCCTCGCGCCCGGCGGCACCATCGTCGAAGGCACGGCCGGCAATACGGGAATCGGCCTGACC
CTGGTCGGCAACGCCATCGGCTGCAAGACGGTGATCGTCATGCCCGAAACCCAAAGCCAGGAAAAAAAGGACGCCCTGCG
CCTGTGCGGGGCCGATCTGCGGCTGGTTGCCGCCCGGCCCTATAAGGATCCCGGCAATTACGTGCGCTACTCCGAAACCC
TGGCCAAGGAATTGGGCGGCTTTTGGGCCAATCAATTCGACAATACGGCCAATCGCGACGGGCACCGCGCCACGACGGGA
CGGGAAATCATCGAGCAATGCGAAGGGCGGCTGGATGCCTTCACCTGCGCCGTCGGCACCGGCGGCACCCTGGCCGGCGT
CGCCCTCGCCCTCAAGGCCCATGACCCGGCCATCAAAGTGGTGCTGGCCGACCCTTTCGGCTCGGCCCTTTATAGCTGGA
TCACCAGCGGCGAGTTGAAGGCCGAGGGCGGATCGGTGACCGAGGGCATCGGCCAGGGACGGGTGACCGCCAATCTGCGC
GACGCTCCGCTTGACGAGGCGGTGCGGATAGGCGACGCCGAAGCGCTGGAGGCGATCTTCGCCATGGTCCGTGAAGACGG
CCTGATGCTAGGCGGATCGAGTGGCGTCAACGTCGCGGCGGCGATGAAGGTCGCCCTTACCCTGCCCAAGGGCAGCCGGG
TGGTCACCATTCTGTGCGACGGCGCCCAACGCTACCAAAGCAAGCTGTTCAACCCCGATTTCCTGCGCTCGAAAGCCCTG
CCGGTTCCCGACTGGCTGGCCTGA

Upstream 100 bases:

>100_bases
CCGGACGCTGTTTTCCCTTGATCGGCGAGAGCGACGTGACACCCTTTCAATTTGAAAGAGCGTCCTTCGTTCACCCCTTT
CTTTCTGGGATCAGGATTCC

Downstream 100 bases:

>100_bases
GCCGGCGATCCCGGTCCACCGGCCAACAGACCATGATAGTTCACGAAAGGAGCCGACGTTCATGACCCGTTCGCGCACCG
AAGCCCTGGTCACCCCCCAG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTIRDGFLGTIGGTPLIRLPWASRITGREILGKAEFLNPGGSVKDRAALAIITDALERGALAPGGTIVEGTAGNTGIGLT
LVGNAIGCKTVIVMPETQSQEKKDALRLCGADLRLVAARPYKDPGNYVRYSETLAKELGGFWANQFDNTANRDGHRATTG
REIIEQCEGRLDAFTCAVGTGGTLAGVALALKAHDPAIKVVLADPFGSALYSWITSGELKAEGGSVTEGIGQGRVTANLR
DAPLDEAVRIGDAEALEAIFAMVREDGLMLGGSSGVNVAAAMKVALTLPKGSRVVTILCDGAQRYQSKLFNPDFLRSKAL
PVPDWLA

Sequences:

>Translated_327_residues
MTIRDGFLGTIGGTPLIRLPWASRITGREILGKAEFLNPGGSVKDRAALAIITDALERGALAPGGTIVEGTAGNTGIGLT
LVGNAIGCKTVIVMPETQSQEKKDALRLCGADLRLVAARPYKDPGNYVRYSETLAKELGGFWANQFDNTANRDGHRATTG
REIIEQCEGRLDAFTCAVGTGGTLAGVALALKAHDPAIKVVLADPFGSALYSWITSGELKAEGGSVTEGIGQGRVTANLR
DAPLDEAVRIGDAEALEAIFAMVREDGLMLGGSSGVNVAAAMKVALTLPKGSRVVTILCDGAQRYQSKLFNPDFLRSKAL
PVPDWLA
>Mature_326_residues
TIRDGFLGTIGGTPLIRLPWASRITGREILGKAEFLNPGGSVKDRAALAIITDALERGALAPGGTIVEGTAGNTGIGLTL
VGNAIGCKTVIVMPETQSQEKKDALRLCGADLRLVAARPYKDPGNYVRYSETLAKELGGFWANQFDNTANRDGHRATTGR
EIIEQCEGRLDAFTCAVGTGGTLAGVALALKAHDPAIKVVLADPFGSALYSWITSGELKAEGGSVTEGIGQGRVTANLRD
APLDEAVRIGDAEALEAIFAMVREDGLMLGGSSGVNVAAAMKVALTLPKGSRVVTILCDGAQRYQSKLFNPDFLRSKALP
VPDWLA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=318, Percent_Identity=37.4213836477987, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI295821200, Length=318, Percent_Identity=37.4213836477987, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4557415, Length=318, Percent_Identity=37.4213836477987, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI11345492, Length=211, Percent_Identity=31.2796208530806, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI2367138, Length=309, Percent_Identity=34.9514563106796, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=37.6175548589342, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562970, Length=310, Percent_Identity=35.8064516129032, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=36.3333333333333, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=34.0983606557377, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17561720, Length=318, Percent_Identity=33.9622641509434, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=32.5227963525836, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=33.968253968254, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=31.4024390243902, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32566672, Length=225, Percent_Identity=32.4444444444444, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71996324, Length=334, Percent_Identity=27.2455089820359, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=38.368580060423, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6321594, Length=338, Percent_Identity=33.4319526627219, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24643623, Length=326, Percent_Identity=35.8895705521472, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20129101, Length=326, Percent_Identity=35.8895705521472, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34249; Mature: 34117

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRDGFLGTIGGTPLIRLPWASRITGREILGKAEFLNPGGSVKDRAALAIITDALERGA
CCCCCCCEECCCCCCEEEECCCCCCCCHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHCC
LAPGGTIVEGTAGNTGIGLTLVGNAIGCKTVIVMPETQSQEKKDALRLCGADLRLVAARP
CCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECC
YKDPGNYVRYSETLAKELGGFWANQFDNTANRDGHRATTGREIIEQCEGRLDAFTCAVGT
CCCCCCEEHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCC
GGTLAGVALALKAHDPAIKVVLADPFGSALYSWITSGELKAEGGSVTEGIGQGRVTANLR
CCHHHHHEEEEECCCCEEEEEEECCHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEECCC
DAPLDEAVRIGDAEALEAIFAMVREDGLMLGGSSGVNVAAAMKVALTLPKGSRVVTILCD
CCCHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEEECCCCCEEEEEEEC
GAQRYQSKLFNPDFLRSKALPVPDWLA
CHHHHHHHCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TIRDGFLGTIGGTPLIRLPWASRITGREILGKAEFLNPGGSVKDRAALAIITDALERGA
CCCCCCEECCCCCCEEEECCCCCCCCHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHCC
LAPGGTIVEGTAGNTGIGLTLVGNAIGCKTVIVMPETQSQEKKDALRLCGADLRLVAARP
CCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECC
YKDPGNYVRYSETLAKELGGFWANQFDNTANRDGHRATTGREIIEQCEGRLDAFTCAVGT
CCCCCCEEHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCC
GGTLAGVALALKAHDPAIKVVLADPFGSALYSWITSGELKAEGGSVTEGIGQGRVTANLR
CCHHHHHEEEEECCCCEEEEEEECCHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEECCC
DAPLDEAVRIGDAEALEAIFAMVREDGLMLGGSSGVNVAAAMKVALTLPKGSRVVTILCD
CCCHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEEECCCCCEEEEEEEC
GAQRYQSKLFNPDFLRSKALPVPDWLA
CHHHHHHHCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA