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The map label for this gene is nuoH

Identifier: 83592897

GI number: 83592897

Start: 1842969

End: 1843982

Strand: Direct

Name: nuoH

Synonym: Rru_A1562

Alternate gene names: 83592897

Gene position: 1842969-1843982 (Clockwise)

Preceding gene: 83592896

Following gene: 83592898

Centisome position: 42.34

GC content: 61.05

Gene sequence:

>1014_bases
ATGGCTGACTTCTGGGGGGGCTATCTCTGGCCCGCGATCATCATCGTTCTGCAGTGTCTGGCCATCATCTTGCCGATGCT
GGGCGCCATCGCCTATTTGACCTATGCCGAGCGCAAGGTCATCGGCGCCATGCAAATGCGCAAGGGGCCCAATGTCGTCG
GCCCCTTCGGCCTGCTCCAGCCGCTGGCCGATGGCGTCAAGCTGTTCCTCAAGGAAACCATCATCCCCACCGGGGCCAAC
CGCGCGGTGTTCATCATCGCGCCGCTGATGACCTTCATTCTGGCTTTGATCGCCTGGGCGGTGATCCCGTTCGACGCCGG
CTGGGTGGTCGCCGATATCAATGTCGGCGTGCTCTACCTGTTCGCCGTCTCGGGGCTGGGCGTCTATGGCATCATCATGG
CCGGCTGGGCGTCGAACTCGAAATACGCCTTCTTGGGCGGTCTGCGCTCGGCGGCGCAGATGGTGTCTTATGAAGTGGCG
ATGGGGCTGATCATCATCGCCGTCATCTTGTCGGCGGGATCGATGAACCTGTCCGATATCGTCGAGGCCCAGCGCCAGGG
GGTGTGGTACTTCATTCCCCACTTCCCGATGTTCGTGATGTTCCTGGTGTCGATCCTGGCCGAGACCAACCGCGCCCCCT
TCGACCTTCCCGAAGCGGAAGCCGAACTGGTTTCGGGCTATAACGTCGAATATTCGGCCATGCCCTTCGCCCTGTTCTTC
CTGGGCGAATACGGCAACATGATCCTGATGAGCGGCATCACCGCCATCTTGTTCCTGGGTGGCTGGTTGCCGCCGGTCGA
TATCGCGCCGTTCAACTGGATCCCGGGGATTATCTGGTTCTTCCTCAAGATCGCCCTGATCCTGTTCGTCTTCCTGTGGG
TTCGCGCCACCTTCCCGCGCTACCGCTACGATCAGCTGATGCGCCTGGGGTGGAAGGTCTTCCTGCCCGGTTCGTTGATC
TGGGTGGTGCTGACGGCCGGGTTCCTGGTCACTTTCGACATGCTTCCCCGGTAA

Upstream 100 bases:

>100_bases
GCCAATTACTATATGACCTGCCCGATCAGCCGAGCGTCGCCGACCATGGCCGAATGCACGCGGGTCTTCCTCAATGGCTC
TTTGAAGCGGACGGGAACCG

Downstream 100 bases:

>100_bases
CCCTAGGAGTTCCGCACCGATGACCTCCATCGTCCGCACGCTCCGCTCCCTGACGCTCTGGGAGCTGGTCTCCGGCATGG
CCTTGACCTTCCGCTACATG

Product: respiratory-chain NADH dehydrogenase, subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MADFWGGYLWPAIIIVLQCLAIILPMLGAIAYLTYAERKVIGAMQMRKGPNVVGPFGLLQPLADGVKLFLKETIIPTGAN
RAVFIIAPLMTFILALIAWAVIPFDAGWVVADINVGVLYLFAVSGLGVYGIIMAGWASNSKYAFLGGLRSAAQMVSYEVA
MGLIIIAVILSAGSMNLSDIVEAQRQGVWYFIPHFPMFVMFLVSILAETNRAPFDLPEAEAELVSGYNVEYSAMPFALFF
LGEYGNMILMSGITAILFLGGWLPPVDIAPFNWIPGIIWFFLKIALILFVFLWVRATFPRYRYDQLMRLGWKVFLPGSLI
WVVLTAGFLVTFDMLPR

Sequences:

>Translated_337_residues
MADFWGGYLWPAIIIVLQCLAIILPMLGAIAYLTYAERKVIGAMQMRKGPNVVGPFGLLQPLADGVKLFLKETIIPTGAN
RAVFIIAPLMTFILALIAWAVIPFDAGWVVADINVGVLYLFAVSGLGVYGIIMAGWASNSKYAFLGGLRSAAQMVSYEVA
MGLIIIAVILSAGSMNLSDIVEAQRQGVWYFIPHFPMFVMFLVSILAETNRAPFDLPEAEAELVSGYNVEYSAMPFALFF
LGEYGNMILMSGITAILFLGGWLPPVDIAPFNWIPGIIWFFLKIALILFVFLWVRATFPRYRYDQLMRLGWKVFLPGSLI
WVVLTAGFLVTFDMLPR
>Mature_336_residues
ADFWGGYLWPAIIIVLQCLAIILPMLGAIAYLTYAERKVIGAMQMRKGPNVVGPFGLLQPLADGVKLFLKETIIPTGANR
AVFIIAPLMTFILALIAWAVIPFDAGWVVADINVGVLYLFAVSGLGVYGIIMAGWASNSKYAFLGGLRSAAQMVSYEVAM
GLIIIAVILSAGSMNLSDIVEAQRQGVWYFIPHFPMFVMFLVSILAETNRAPFDLPEAEAELVSGYNVEYSAMPFALFFL
GEYGNMILMSGITAILFLGGWLPPVDIAPFNWIPGIIWFFLKIALILFVFLWVRATFPRYRYDQLMRLGWKVFLPGSLIW
VVLTAGFLVTFDMLPR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=291, Percent_Identity=45.7044673539519, Blast_Score=262, Evalue=3e-70,
Organism=Escherichia coli, GI1788618, Length=315, Percent_Identity=43.8095238095238, Blast_Score=281, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_RHORT (Q2RU33)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426649.1
- STRING:   Q2RU33
- GeneID:   3834979
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1562
- NMPDR:   fig|1085.1.peg.2805
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   SSHKAMF
- PhylomeDB:   Q2RU33
- BioCyc:   RRUB269796:RRU_A1562-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 37320; Mature: 37189

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf16c754)-; HASH(0xf92f010)-; HASH(0xf780cac)-; HASH(0xf92cee4)-; HASH(0xf92ee84)-; HASH(0xf34b404)-; HASH(0xf92f064)-; HASH(0xf7af8d8)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFWGGYLWPAIIIVLQCLAIILPMLGAIAYLTYAERKVIGAMQMRKGPNVVGPFGLLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
PLADGVKLFLKETIIPTGANRAVFIIAPLMTFILALIAWAVIPFDAGWVVADINVGVLYL
HHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
FAVSGLGVYGIIMAGWASNSKYAFLGGLRSAAQMVSYEVAMGLIIIAVILSAGSMNLSDI
HHHHCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VEAQRQGVWYFIPHFPMFVMFLVSILAETNRAPFDLPEAEAELVSGYNVEYSAMPFALFF
HHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHH
LGEYGNMILMSGITAILFLGGWLPPVDIAPFNWIPGIIWFFLKIALILFVFLWVRATFPR
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YRYDQLMRLGWKVFLPGSLIWVVLTAGFLVTFDMLPR
HHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
ADFWGGYLWPAIIIVLQCLAIILPMLGAIAYLTYAERKVIGAMQMRKGPNVVGPFGLLQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
PLADGVKLFLKETIIPTGANRAVFIIAPLMTFILALIAWAVIPFDAGWVVADINVGVLYL
HHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
FAVSGLGVYGIIMAGWASNSKYAFLGGLRSAAQMVSYEVAMGLIIIAVILSAGSMNLSDI
HHHHCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VEAQRQGVWYFIPHFPMFVMFLVSILAETNRAPFDLPEAEAELVSGYNVEYSAMPFALFF
HHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHH
LGEYGNMILMSGITAILFLGGWLPPVDIAPFNWIPGIIWFFLKIALILFVFLWVRATFPR
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YRYDQLMRLGWKVFLPGSLIWVVLTAGFLVTFDMLPR
HHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA