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The map label for this gene is nuoI

Identifier: 83592898

GI number: 83592898

Start: 1844002

End: 1844490

Strand: Direct

Name: nuoI

Synonym: Rru_A1563

Alternate gene names: 83592898

Gene position: 1844002-1844490 (Clockwise)

Preceding gene: 83592897

Following gene: 83592899

Centisome position: 42.36

GC content: 62.99

Gene sequence:

>489_bases
ATGACCTCCATCGTCCGCACGCTCCGCTCCCTGACGCTCTGGGAGCTGGTCTCCGGCATGGCCTTGACCTTCCGCTACAT
GTTGAAGCCGAAGGTGACCATCAATTACCCCTTCGAAAAGGGCTATCTGTCGCCGCGGTTTCGCGGCGAGCATGCCCTGC
GGCGCTATGCCAATGGCGAGGAACGCTGTATCGCCTGCAAGCTGTGCGAGGCGATCTGCCCGGCCCAGGCGATCACCATC
GAAGCCGAACCGCGCACGGATGGCAGCCGGCGGACCACCCGCTATGACATCGACATGACCAAATGCATCTACTGCGGCTT
CTGCGAGGAGGCCTGTCCGGTCGATGCCATCGTCGAGGGACCGAATTTCGAGTTCGCGGCGGAAACCCGCGAGGAACTTC
TGTACAACAAGGCGAAGTTGCTGGCGAACGGCGATCGCTGGGAGCCCGAACTGGCCTTGCGCCTGCGCAAGGACGCCGCC
TACCGCTGA

Upstream 100 bases:

>100_bases
AAGGTCTTCCTGCCCGGTTCGTTGATCTGGGTGGTGCTGACGGCCGGGTTCCTGGTCACTTTCGACATGCTTCCCCGGTA
ACCCTAGGAGTTCCGCACCG

Downstream 100 bases:

>100_bases
TCTTGGCGGCGCGGTGGTGAACCAACCATGGTGCGGCTCCCCGCTTCGGGGGCCGGTTTTTCGGGAACTCAAACGATAAG
CCGCACGCAAGCCAGCGCTC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTSIVRTLRSLTLWELVSGMALTFRYMLKPKVTINYPFEKGYLSPRFRGEHALRRYANGEERCIACKLCEAICPAQAITI
EAEPRTDGSRRTTRYDIDMTKCIYCGFCEEACPVDAIVEGPNFEFAAETREELLYNKAKLLANGDRWEPELALRLRKDAA
YR

Sequences:

>Translated_162_residues
MTSIVRTLRSLTLWELVSGMALTFRYMLKPKVTINYPFEKGYLSPRFRGEHALRRYANGEERCIACKLCEAICPAQAITI
EAEPRTDGSRRTTRYDIDMTKCIYCGFCEEACPVDAIVEGPNFEFAAETREELLYNKAKLLANGDRWEPELALRLRKDAA
YR
>Mature_161_residues
TSIVRTLRSLTLWELVSGMALTFRYMLKPKVTINYPFEKGYLSPRFRGEHALRRYANGEERCIACKLCEAICPAQAITIE
AEPRTDGSRRTTRYDIDMTKCIYCGFCEEACPVDAIVEGPNFEFAAETREELLYNKAKLLANGDRWEPELALRLRKDAAY
R

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=163, Percent_Identity=73.6196319018405, Blast_Score=251, Evalue=2e-67,
Organism=Escherichia coli, GI1788617, Length=147, Percent_Identity=38.7755102040816, Blast_Score=105, Evalue=1e-24,
Organism=Escherichia coli, GI1789075, Length=111, Percent_Identity=31.5315315315315, Blast_Score=61, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555194, Length=155, Percent_Identity=72.9032258064516, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17864306, Length=157, Percent_Identity=74.5222929936306, Blast_Score=248, Evalue=9e-67,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_RHORT (Q2RU32)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426650.1
- HSSP:   Q9I6D2
- ProteinModelPortal:   Q2RU32
- SMR:   Q2RU32
- STRING:   Q2RU32
- GeneID:   3834980
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1563
- NMPDR:   fig|1085.1.peg.2804
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   NYPYEKG
- PhylomeDB:   Q2RU32
- ProtClustDB:   PRK05888
- BioCyc:   RRUB269796:RRU_A1563-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18645; Mature: 18514

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIVRTLRSLTLWELVSGMALTFRYMLKPKVTINYPFEKGYLSPRFRGEHALRRYANGE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCCCCCCCCCHHHHHHHCCCC
ERCIACKLCEAICPAQAITIEAEPRTDGSRRTTRYDIDMTKCIYCGFCEEACPVDAIVEG
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCHHHHHEECCCCCCCCCCEEEEC
PNFEFAAETREELLYNKAKLLANGDRWEPELALRLRKDAAYR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSIVRTLRSLTLWELVSGMALTFRYMLKPKVTINYPFEKGYLSPRFRGEHALRRYANGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCCCCCCCCCHHHHHHHCCCC
ERCIACKLCEAICPAQAITIEAEPRTDGSRRTTRYDIDMTKCIYCGFCEEACPVDAIVEG
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCHHHHHEECCCCCCCCCCEEEEC
PNFEFAAETREELLYNKAKLLANGDRWEPELALRLRKDAAYR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA