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The map label for this gene is nqo1 [H]

Identifier: 83592895

GI number: 83592895

Start: 1839593

End: 1840882

Strand: Direct

Name: nqo1 [H]

Synonym: Rru_A1560

Alternate gene names: 83592895

Gene position: 1839593-1840882 (Clockwise)

Preceding gene: 83592894

Following gene: 83592896

Centisome position: 42.26

GC content: 65.19

Gene sequence:

>1290_bases
ATGCTGAACGATAAGGACCGCATCTTCACCAACCTCTACGGCTTTCAGGACTGGCGTCTGGCCGGGGCGCGCAAGCGCGG
CGATTGGGATGGCACCGGCGCCATCCTCGCCAAGGGCCGCGATGGCATCATCAATGAAATGAAGGCCTCGGGGTTGCGGG
GCCGTGGCGGCGCCGGCTTCCCCACCGGTCTCAAATGGTCGTTCATGCCCAAGGATATCGGCGAGCGGCCGCATTATCTG
GTGGTCAATGCCGACGAGGGCGAGCCCGGCACCTGCAAAGACCGCGACATGATGCGCTTTGATCCGCATAAGCTGATCGA
AGGCTGCCTGATCGCCGGTTTCGCCATGGGCGCCCATGTCGCCTATATCTATATCCGCGGCGAATTCTTCCGCGAGGCCG
AGCATCTGGAATTCGCCATCGCCGAGGCCCGCGAGGCCGGGCTGCTTGGCCCCAACGCCTGCGGCTCGGGCTGGGACATG
GAGGTTTATGTCCATCGCGGCGCCGGCGCCTATATCTGCGGCGAGGAAACCGCCCTGATCCAGTCGCTGGAGGGCAAGAA
GGGCCAGCCGCGCCTCAAGCCGCCATTTCCCGCCGGTGTCGGCCTTTATGGCTGCCCGACCACGGTCAACAACGTCGAAA
GCATCGCCGTCGCCCCCACCATCCTGCGCCGGGGCGGCGCCTGGTTCGCCGGGTTGGGCCGCGAGAACAATACGGGAACC
AAGGTCTTTTGCATTTCCGGCCATGTCAACAAGCCGTGCAATGTCGAAGAGGAAATGGGCATCCCCTTGCGCGAGCTGAT
CGACAAGCACGCCGGCGGGGTGCGCGGCGGCTGGGACAATCTGCTGGGCGTCATCCCCGGCGGTGCCTCGGTGCCGGTGC
TGCCGCGCGAGTTGTGCGACGATGTCTTGATGGATTTCGACAGCCTGAAGGCGGTGAAATCCGGTCTGGGCACGGCGGCG
GTGATGGTCATGGACAAATCGACCGACATCGTCCGCGCCATCGCCCGGCTGTCGGCGTTCTATACCCATGAAAGCTGCGG
CCAGTGCACGCCGTGCCGCGAGGGAACGGGCTGGCTGTCGCGGGTGATGACCCGCTTGGTCAATGGCGACGCGGCGATCG
AGGAGATCGACGTGCTTGAGCAGGTGACCCGCCAGATCGAGGGGCATACCATCTGCGCCCTGGGGGATGCCGCCGCCTGG
CCGATCCAGGGGTTGATCCGTCATTTCCGACCCGAGATCGAACGCCGCATCATCGAGAAGCGCGGCGGCCGGTCCGTCGC
CGCCGAATAG

Upstream 100 bases:

>100_bases
CGCCGGGCTCGCAATCGGGTCGCCAGGGGGCTTGCCCCGAGGGTGGGCCGACGACCCTGAAAAGTTTCTGTACCGCCGAT
AAGGCCGGGGGGAGCGTGTG

Downstream 100 bases:

>100_bases
ACCTTCCAGGGGGTGAAGCAAACCATGCCCAAGCTGACGATCGACGGCATCGCGGTGGAGGTCCCCGCCGGCACCACGAT
CTTGCAGGCGGCCGAAAGCA

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 1; NDH-1, chain 1 [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLNDKDRIFTNLYGFQDWRLAGARKRGDWDGTGAILAKGRDGIINEMKASGLRGRGGAGFPTGLKWSFMPKDIGERPHYL
VVNADEGEPGTCKDRDMMRFDPHKLIEGCLIAGFAMGAHVAYIYIRGEFFREAEHLEFAIAEAREAGLLGPNACGSGWDM
EVYVHRGAGAYICGEETALIQSLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGGAWFAGLGRENNTGT
KVFCISGHVNKPCNVEEEMGIPLRELIDKHAGGVRGGWDNLLGVIPGGASVPVLPRELCDDVLMDFDSLKAVKSGLGTAA
VMVMDKSTDIVRAIARLSAFYTHESCGQCTPCREGTGWLSRVMTRLVNGDAAIEEIDVLEQVTRQIEGHTICALGDAAAW
PIQGLIRHFRPEIERRIIEKRGGRSVAAE

Sequences:

>Translated_429_residues
MLNDKDRIFTNLYGFQDWRLAGARKRGDWDGTGAILAKGRDGIINEMKASGLRGRGGAGFPTGLKWSFMPKDIGERPHYL
VVNADEGEPGTCKDRDMMRFDPHKLIEGCLIAGFAMGAHVAYIYIRGEFFREAEHLEFAIAEAREAGLLGPNACGSGWDM
EVYVHRGAGAYICGEETALIQSLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGGAWFAGLGRENNTGT
KVFCISGHVNKPCNVEEEMGIPLRELIDKHAGGVRGGWDNLLGVIPGGASVPVLPRELCDDVLMDFDSLKAVKSGLGTAA
VMVMDKSTDIVRAIARLSAFYTHESCGQCTPCREGTGWLSRVMTRLVNGDAAIEEIDVLEQVTRQIEGHTICALGDAAAW
PIQGLIRHFRPEIERRIIEKRGGRSVAAE
>Mature_429_residues
MLNDKDRIFTNLYGFQDWRLAGARKRGDWDGTGAILAKGRDGIINEMKASGLRGRGGAGFPTGLKWSFMPKDIGERPHYL
VVNADEGEPGTCKDRDMMRFDPHKLIEGCLIAGFAMGAHVAYIYIRGEFFREAEHLEFAIAEAREAGLLGPNACGSGWDM
EVYVHRGAGAYICGEETALIQSLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGGAWFAGLGRENNTGT
KVFCISGHVNKPCNVEEEMGIPLRELIDKHAGGVRGGWDNLLGVIPGGASVPVLPRELCDDVLMDFDSLKAVKSGLGTAA
VMVMDKSTDIVRAIARLSAFYTHESCGQCTPCREGTGWLSRVMTRLVNGDAAIEEIDVLEQVTRQIEGHTICALGDAAAW
PIQGLIRHFRPEIERRIIEKRGGRSVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=416, Percent_Identity=71.3942307692308, Blast_Score=634, Evalue=0.0,
Organism=Homo sapiens, GI260656005, Length=416, Percent_Identity=71.3942307692308, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1788620, Length=413, Percent_Identity=44.7941888619855, Blast_Score=334, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17531727, Length=418, Percent_Identity=69.8564593301435, Blast_Score=626, Evalue=1e-180,
Organism=Drosophila melanogaster, GI19920794, Length=416, Percent_Identity=71.875, Blast_Score=652, Evalue=0.0,
Organism=Drosophila melanogaster, GI45550452, Length=428, Percent_Identity=66.1214953271028, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24653819, Length=424, Percent_Identity=50.7075471698113, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24653817, Length=424, Percent_Identity=47.4056603773585, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46566; Mature: 46566

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDKDRIFTNLYGFQDWRLAGARKRGDWDGTGAILAKGRDGIINEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCHHEECCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKDIGERPHYLVVNADEGEPGTCKDRDMMRFDPHKLIEGCLIAGFAMGAHV
CCCCEEEECCHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEE
AYIYIRGEFFREAEHLEFAIAEAREAGLLGPNACGSGWDMEVYVHRGAGAYICGEETALI
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
QSLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGGAWFAGLGRENNTGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCC
KVFCISGHVNKPCNVEEEMGIPLRELIDKHAGGVRGGWDNLLGVIPGGASVPVLPRELCD
EEEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCCHHHHHH
DVLMDFDSLKAVKSGLGTAAVMVMDKSTDIVRAIARLSAFYTHESCGQCTPCREGTGWLS
HHHHCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RVMTRLVNGDAAIEEIDVLEQVTRQIEGHTICALGDAAAWPIQGLIRHFRPEIERRIIEK
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
RGGRSVAAE
CCCCCCCCC
>Mature Secondary Structure
MLNDKDRIFTNLYGFQDWRLAGARKRGDWDGTGAILAKGRDGIINEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCHHEECCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKDIGERPHYLVVNADEGEPGTCKDRDMMRFDPHKLIEGCLIAGFAMGAHV
CCCCEEEECCHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEE
AYIYIRGEFFREAEHLEFAIAEAREAGLLGPNACGSGWDMEVYVHRGAGAYICGEETALI
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
QSLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGGAWFAGLGRENNTGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCC
KVFCISGHVNKPCNVEEEMGIPLRELIDKHAGGVRGGWDNLLGVIPGGASVPVLPRELCD
EEEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCCHHHHHH
DVLMDFDSLKAVKSGLGTAAVMVMDKSTDIVRAIARLSAFYTHESCGQCTPCREGTGWLS
HHHHCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
RVMTRLVNGDAAIEEIDVLEQVTRQIEGHTICALGDAAAWPIQGLIRHFRPEIERRIIEK
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
RGGRSVAAE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1905152; 1909571; 1605643 [H]