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The map label for this gene is adhA [H]

Identifier: 83592839

GI number: 83592839

Start: 1776810

End: 1777892

Strand: Reverse

Name: adhA [H]

Synonym: Rru_A1503

Alternate gene names: 83592839

Gene position: 1777892-1776810 (Counterclockwise)

Preceding gene: 83592840

Following gene: 83592835

Centisome position: 40.84

GC content: 64.73

Gene sequence:

>1083_bases
TTGCTCTACCAGGAGCATCCCCCTTTGTCGATCCCCACCCTGGGCTTCGCCGCCCAATCCGCGACCACCCCCCTCGCGCC
GTTTTCCTTTGAACGCCGCGATCCCCGGCCCGATGATGTCACCATCGACATCCTCTATTGCGGGGTCTGCCACTCCGATA
TCCATCAAGCGCGCAACGAGTGGCACAACAGCCTGTTTCCCATGGTGCCCGGCCATGAAATCATCGGCACGGTGTCGGCG
GTCGGCGCCAAGGTTAGCGGCTTCAAGGTCGGTGACCGGGTGGGCGTTGGCTGCATGGTCGATTCCTGCCGGGAGTGCGC
GCCCTGCAAAGCCGATCTCGAGCAATATTGCGAAGACGGCGCCACCCTGACCTACAACGGCCGCGACCGCCACGACCATA
GCCTGACCTTCGGCGGCTATTCCGAGCGCATCGTCGTTTCCGAAGCCTTCGTGCTGCGCCTTCCCGATGCGCTGGACGCC
AAATCGGCCGCGCCCTTGCTCTGCGCGGGCATCACCACCTATTCGCCGCTGCGCCATTGGCAGGTGGGGCCGGGAAGCCG
CGTCGCCGTCATCGGCCTGGGCGGCCTGGGCCATATGGGGCTGAAACTCGCCAAGGCGATGGGGGCCGAGGTCAGCTTGT
TCACCCGCTCGCCCGGCAAGGAAGACGAGGCCAAACGCCTGGGCGCCGATCATGTGGTGTTGTCGACCGATGAGGCGCGC
ATGAAGGCGGTGGCCGGCCACTTCAACCTGATCATCGACACCGTGCCCCACCCCCACGATCTCAACCCCTATGTCTCCAC
CCTGGCCTTGGACGGCACCTTGGTGCTGGTCGGCCTGCTTGGTCCCATCGAGCCGGTGATCGACAGCGTGCCGCTGGTCA
TCGGCCGTCGGGCGGTGGCCGGCTCGGCGATCGGCGGCATCGCCGAAACCCAGGAGATGCTTGATTTCTGCGCCGCCAAG
GGCGTGACGGCCGATGTGGAAATGCTTGATATCAACAATATCAACGCCGCCTATGACCGCATGCTCAAAAGCGACGTCCG
CTACCGCTTCGTGATCGACATGGCGACGCTTCGCGGCGCATGA

Upstream 100 bases:

>100_bases
CAAATCGTCGTCGCGCTCTGCTCCAGAGCGCTCGGGATTTGCTCTGTCGCTTGATAACGAAGCAAATCGTCGTCGCGCTC
TGCTCCAGAGCGCTCGGGAT

Downstream 100 bases:

>100_bases
CAAAGACATCGACGCTGCGCGGCGCAGGGCAGAGGCATCGACGCTGCGCGGCGCAGGGCAAAGAGACAGCGACGCCGCGC
GGCGCAAGACAAAACGGGGC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MLYQEHPPLSIPTLGFAAQSATTPLAPFSFERRDPRPDDVTIDILYCGVCHSDIHQARNEWHNSLFPMVPGHEIIGTVSA
VGAKVSGFKVGDRVGVGCMVDSCRECAPCKADLEQYCEDGATLTYNGRDRHDHSLTFGGYSERIVVSEAFVLRLPDALDA
KSAAPLLCAGITTYSPLRHWQVGPGSRVAVIGLGGLGHMGLKLAKAMGAEVSLFTRSPGKEDEAKRLGADHVVLSTDEAR
MKAVAGHFNLIIDTVPHPHDLNPYVSTLALDGTLVLVGLLGPIEPVIDSVPLVIGRRAVAGSAIGGIAETQEMLDFCAAK
GVTADVEMLDINNINAAYDRMLKSDVRYRFVIDMATLRGA

Sequences:

>Translated_360_residues
MLYQEHPPLSIPTLGFAAQSATTPLAPFSFERRDPRPDDVTIDILYCGVCHSDIHQARNEWHNSLFPMVPGHEIIGTVSA
VGAKVSGFKVGDRVGVGCMVDSCRECAPCKADLEQYCEDGATLTYNGRDRHDHSLTFGGYSERIVVSEAFVLRLPDALDA
KSAAPLLCAGITTYSPLRHWQVGPGSRVAVIGLGGLGHMGLKLAKAMGAEVSLFTRSPGKEDEAKRLGADHVVLSTDEAR
MKAVAGHFNLIIDTVPHPHDLNPYVSTLALDGTLVLVGLLGPIEPVIDSVPLVIGRRAVAGSAIGGIAETQEMLDFCAAK
GVTADVEMLDINNINAAYDRMLKSDVRYRFVIDMATLRGA
>Mature_360_residues
MLYQEHPPLSIPTLGFAAQSATTPLAPFSFERRDPRPDDVTIDILYCGVCHSDIHQARNEWHNSLFPMVPGHEIIGTVSA
VGAKVSGFKVGDRVGVGCMVDSCRECAPCKADLEQYCEDGATLTYNGRDRHDHSLTFGGYSERIVVSEAFVLRLPDALDA
KSAAPLLCAGITTYSPLRHWQVGPGSRVAVIGLGGLGHMGLKLAKAMGAEVSLFTRSPGKEDEAKRLGADHVVLSTDEAR
MKAVAGHFNLIIDTVPHPHDLNPYVSTLALDGTLVLVGLLGPIEPVIDSVPLVIGRRAVAGSAIGGIAETQEMLDFCAAK
GVTADVEMLDINNINAAYDRMLKSDVRYRFVIDMATLRGA

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=231, Percent_Identity=29.4372294372294, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073058, Length=231, Percent_Identity=29.4372294372294, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=27.0718232044199, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI34577061, Length=232, Percent_Identity=30.6034482758621, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501929, Length=231, Percent_Identity=29.4372294372294, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71565152, Length=210, Percent_Identity=27.6190476190476, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI156523966, Length=350, Percent_Identity=25.4285714285714, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4501939, Length=350, Percent_Identity=25.4285714285714, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI71565154, Length=243, Percent_Identity=29.6296296296296, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=341, Percent_Identity=54.5454545454545, Blast_Score=347, Evalue=9e-97,
Organism=Escherichia coli, GI87082401, Length=340, Percent_Identity=39.4117647058824, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=30.3514376996805, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788073, Length=217, Percent_Identity=29.0322580645161, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI226510992, Length=257, Percent_Identity=29.9610894941634, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082125, Length=284, Percent_Identity=27.8169014084507, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=270, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787863, Length=264, Percent_Identity=28.4090909090909, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=25.9668508287293, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790045, Length=182, Percent_Identity=29.6703296703297, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=339, Percent_Identity=27.7286135693215, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=28.6135693215339, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=331, Percent_Identity=28.0966767371601, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=26.3888888888889, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=26.2430939226519, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=26.6081871345029, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=231, Percent_Identity=32.034632034632, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=262, Percent_Identity=28.6259541984733, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=347, Percent_Identity=38.0403458213257, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319949, Length=333, Percent_Identity=35.7357357357357, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6323961, Length=328, Percent_Identity=30.7926829268293, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=29.607250755287, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324486, Length=328, Percent_Identity=29.8780487804878, Blast_Score=145, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=29.7619047619048, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319258, Length=352, Percent_Identity=25.2840909090909, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=314, Percent_Identity=26.1146496815287, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=333, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737895, Length=358, Percent_Identity=27.6536312849162, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17737897, Length=213, Percent_Identity=32.3943661971831, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17137530, Length=213, Percent_Identity=30.9859154929577, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 38601; Mature: 38601

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQEHPPLSIPTLGFAAQSATTPLAPFSFERRDPRPDDVTIDILYCGVCHSDIHQARNE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHH
WHNSLFPMVPGHEIIGTVSAVGAKVSGFKVGDRVGVGCMVDSCRECAPCKADLEQYCEDG
HHHCCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCC
ATLTYNGRDRHDHSLTFGGYSERIVVSEAFVLRLPDALDAKSAAPLLCAGITTYSPLRHW
CEEEECCCCCCCCEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCE
QVGPGSRVAVIGLGGLGHMGLKLAKAMGAEVSLFTRSPGKEDEAKRLGADHVVLSTDEAR
ECCCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCEEEEECCHHH
MKAVAGHFNLIIDTVPHPHDLNPYVSTLALDGTLVLVGLLGPIEPVIDSVPLVIGRRAVA
HHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEEHHHCCHHHHHHCCCHHHCCHHHC
GSAIGGIAETQEMLDFCAAKGVTADVEMLDINNINAAYDRMLKSDVRYRFVIDMATLRGA
CHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEEHHHCCC
>Mature Secondary Structure
MLYQEHPPLSIPTLGFAAQSATTPLAPFSFERRDPRPDDVTIDILYCGVCHSDIHQARNE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHH
WHNSLFPMVPGHEIIGTVSAVGAKVSGFKVGDRVGVGCMVDSCRECAPCKADLEQYCEDG
HHHCCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCC
ATLTYNGRDRHDHSLTFGGYSERIVVSEAFVLRLPDALDAKSAAPLLCAGITTYSPLRHW
CEEEECCCCCCCCEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCE
QVGPGSRVAVIGLGGLGHMGLKLAKAMGAEVSLFTRSPGKEDEAKRLGADHVVLSTDEAR
ECCCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCEEEEECCHHH
MKAVAGHFNLIIDTVPHPHDLNPYVSTLALDGTLVLVGLLGPIEPVIDSVPLVIGRRAVA
HHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEEHHHCCHHHHHHCCCHHHCCHHHC
GSAIGGIAETQEMLDFCAAKGVTADVEMLDINNINAAYDRMLKSDVRYRFVIDMATLRGA
CHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]