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The map label for this gene is phaA [H]

Identifier: 83592805

GI number: 83592805

Start: 1736050

End: 1737225

Strand: Reverse

Name: phaA [H]

Synonym: Rru_A1469

Alternate gene names: 83592805

Gene position: 1737225-1736050 (Counterclockwise)

Preceding gene: 83592806

Following gene: 83592804

Centisome position: 39.91

GC content: 69.73

Gene sequence:

>1176_bases
ATGAACGACATCGTCATCGCCGCCGCCGCGCGCACCGCCGTCGGCGCCTTCACCGGGTCTTTGTCCAGCCTTCCCGCCCA
TAGCCTGGGCGCCAGCGTCATCACCGACCTGCTCACGCGCGGCAAGATCGCCGCCGGCGAGATCGACGACGTGCTGCTTG
GTCAGGTCCTGACCGCCGCCCAGGGCCAGAACCCGGCCCGCCAAGCCGCCATCGCCGCCGGACTGCCGGCGTCAAGCACC
GCCTTGACGATCAATCAGGTCTGCGGTTCGGGGCTGCGCGCCGTCGCCCTTGGCGCCCAGGCCATCGCCTGCGGCGATGC
CGAGGTGGTGATCGCCGGCGGGCAGGAATCGATGAGCCTCGCCCCCCACGCCGTCTTGCTGCGCGCCGGGGTGAAAATGG
GGCCGGCCGAAATGGTCGACACCATGATCAAGGACGGCCTGTGGGAGGCCTTCCACGGCTATCACATGGGCATCACCGCC
GAAACCGTCGCCCAGGCCTTCGGCATCGACCGCGCCACCCAGGACGCCTTCGCCCTCGCCTCGCAGCAAAAAGCCGCCGC
CGCCCAGCGCGAGGGACGCTTCGTCGACGAGATCGTTGCGGTCTGCGTGCGCAGCCGCAAGGGCGAGGTCCTGGTCGACA
GCGATGAGCACCTGAAGCCCGATACCACCGCCCAGAGCCTGGCCAAACTGCGCCCGGCCTTCACCAAGGATGGCACGGTC
ACCGCCGGCAACGCCTCGGGGCTTAACGACGGCGCCGCCGGGGTTTTGCTGATGAGCGCCGAAAACGCCGCCAAACGCGG
GGTGACGCCGCTTGCCCGCGTCGTATCCTGGGCCACCGCCGGCGTCGATCCCGCCGTGATGGGCACCGGGCCGATCCCGG
CCTCGCGCAAGGCCCTGGCCAAGGCCGGCTGGACCATCGACGACCTGGATCTGATCGAGGCCAACGAGGCTTTCGCCGCC
CAGGCGATCGCCGTCAACCGCGAGATGGGCTGGGATACCGCGAAGGTCAACGTCAATGGCGGCGCCATCGCCATCGGCCA
TCCCATCGGCGCCTCGGGCGCGCGCATCCTGGTCAGCCTGCTCCATGAAATGACCCGGCGTGACGCGAAAAAGGCCCTGG
CGACGCTGTGCATCGGCGGCGGCATGGGCATCGCGCTCTGCGTCGAACGGCCCTAA

Upstream 100 bases:

>100_bases
GCTCAGCGCCCGCTCGACCGGCCTCGTGGTCTCCGTCGTCGGCACGGTCTGCGGGGAAAGCGAAGCGATTTCACAAACCC
TGGCCAAGGCGGTCTGAACC

Downstream 100 bases:

>100_bases
GCCCCCGTTCGCCGTCTCTTTCGTTTTCCCTCCCACCCGCTCCGCCGTCCTGGCGACGACGGAGCGCAAGGCTATTTTTT
TGCCCTTTTCCTCAACCAAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNDIVIAAAARTAVGAFTGSLSSLPAHSLGASVITDLLTRGKIAAGEIDDVLLGQVLTAAQGQNPARQAAIAAGLPASST
ALTINQVCGSGLRAVALGAQAIACGDAEVVIAGGQESMSLAPHAVLLRAGVKMGPAEMVDTMIKDGLWEAFHGYHMGITA
ETVAQAFGIDRATQDAFALASQQKAAAAQREGRFVDEIVAVCVRSRKGEVLVDSDEHLKPDTTAQSLAKLRPAFTKDGTV
TAGNASGLNDGAAGVLLMSAENAAKRGVTPLARVVSWATAGVDPAVMGTGPIPASRKALAKAGWTIDDLDLIEANEAFAA
QAIAVNREMGWDTAKVNVNGGAIAIGHPIGASGARILVSLLHEMTRRDAKKALATLCIGGGMGIALCVERP

Sequences:

>Translated_391_residues
MNDIVIAAAARTAVGAFTGSLSSLPAHSLGASVITDLLTRGKIAAGEIDDVLLGQVLTAAQGQNPARQAAIAAGLPASST
ALTINQVCGSGLRAVALGAQAIACGDAEVVIAGGQESMSLAPHAVLLRAGVKMGPAEMVDTMIKDGLWEAFHGYHMGITA
ETVAQAFGIDRATQDAFALASQQKAAAAQREGRFVDEIVAVCVRSRKGEVLVDSDEHLKPDTTAQSLAKLRPAFTKDGTV
TAGNASGLNDGAAGVLLMSAENAAKRGVTPLARVVSWATAGVDPAVMGTGPIPASRKALAKAGWTIDDLDLIEANEAFAA
QAIAVNREMGWDTAKVNVNGGAIAIGHPIGASGARILVSLLHEMTRRDAKKALATLCIGGGMGIALCVERP
>Mature_391_residues
MNDIVIAAAARTAVGAFTGSLSSLPAHSLGASVITDLLTRGKIAAGEIDDVLLGQVLTAAQGQNPARQAAIAAGLPASST
ALTINQVCGSGLRAVALGAQAIACGDAEVVIAGGQESMSLAPHAVLLRAGVKMGPAEMVDTMIKDGLWEAFHGYHMGITA
ETVAQAFGIDRATQDAFALASQQKAAAAQREGRFVDEIVAVCVRSRKGEVLVDSDEHLKPDTTAQSLAKLRPAFTKDGTV
TAGNASGLNDGAAGVLLMSAENAAKRGVTPLARVVSWATAGVDPAVMGTGPIPASRKALAKAGWTIDDLDLIEANEAFAA
QAIAVNREMGWDTAKVNVNGGAIAIGHPIGASGARILVSLLHEMTRRDAKKALATLCIGGGMGIALCVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=50.383631713555, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=43.7974683544304, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=40.0510204081633, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=40.25, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=31.0588235294118, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.4347826086957, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=55.2429667519182, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=55.8673469387755, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=47, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=41.7085427135678, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=33.6515513126492, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=43.7017994858612, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=40.5194805194805, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=37.0558375634518, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=31.0588235294118, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=33.3333333333333, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=41.0891089108911, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=38.974358974359, Blast_Score=230, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=55.3846153846154, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.3076923076923, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=40.3598971722365, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=32.7830188679245, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 39706; Mature: 39706

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDIVIAAAARTAVGAFTGSLSSLPAHSLGASVITDLLTRGKIAAGEIDDVLLGQVLTAA
CCCEEEEEHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QGQNPARQAAIAAGLPASSTALTINQVCGSGLRAVALGAQAIACGDAEVVIAGGQESMSL
CCCCHHHHHHHHCCCCCCCCEEEHHHHHCCCHHHHHHCCCEEEECCCEEEEECCCCCCCC
APHAVLLRAGVKMGPAEMVDTMIKDGLWEAFHGYHMGITAETVAQAFGIDRATQDAFALA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCHHHHHHHHHH
SQQKAAAAQREGRFVDEIVAVCVRSRKGEVLVDSDEHLKPDTTAQSLAKLRPAFTKDGTV
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCEE
TAGNASGLNDGAAGVLLMSAENAAKRGVTPLARVVSWATAGVDPAVMGTGPIPASRKALA
EECCCCCCCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHH
KAGWTIDDLDLIEANEAFAAQAIAVNREMGWDTAKVNVNGGAIAIGHPIGASGARILVSL
HCCCCCCCCHHEECCHHHHHHHHEECCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHH
LHEMTRRDAKKALATLCIGGGMGIALCVERP
HHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MNDIVIAAAARTAVGAFTGSLSSLPAHSLGASVITDLLTRGKIAAGEIDDVLLGQVLTAA
CCCEEEEEHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QGQNPARQAAIAAGLPASSTALTINQVCGSGLRAVALGAQAIACGDAEVVIAGGQESMSL
CCCCHHHHHHHHCCCCCCCCEEEHHHHHCCCHHHHHHCCCEEEECCCEEEEECCCCCCCC
APHAVLLRAGVKMGPAEMVDTMIKDGLWEAFHGYHMGITAETVAQAFGIDRATQDAFALA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCHHHHHHHHHH
SQQKAAAAQREGRFVDEIVAVCVRSRKGEVLVDSDEHLKPDTTAQSLAKLRPAFTKDGTV
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCEE
TAGNASGLNDGAAGVLLMSAENAAKRGVTPLARVVSWATAGVDPAVMGTGPIPASRKALA
EECCCCCCCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHH
KAGWTIDDLDLIEANEAFAAQAIAVNREMGWDTAKVNVNGGAIAIGHPIGASGARILVSL
HCCCCCCCCHHEECCHHHHHHHHEECCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHH
LHEMTRRDAKKALATLCIGGGMGIALCVERP
HHHHHHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8566717 [H]