Click here to switch to the map view.

The map label for this gene is nrdA [H]

Identifier: 83592780

GI number: 83592780

Start: 1707876

End: 1709765

Strand: Direct

Name: nrdA [H]

Synonym: Rru_A1444

Alternate gene names: 83592780

Gene position: 1707876-1709765 (Clockwise)

Preceding gene: 83592778

Following gene: 83592781

Centisome position: 39.24

GC content: 64.92

Gene sequence:

>1890_bases
ATGTCGTCCGCGCCCGCTTTTGATTTCGACCGCCAGGGCAATCTGGTGGCGTCGCCTCCACGCCAGTCGCATCAGCCCAC
ATCGCAAATCCGGCGGCGGCCGCACCCCCCCGAAACATCCGAAATCCGCCTTGAGCGCTCGCGCGACGACAAACTGAACG
CCTTTGGCAAGGCGATGCTGGGTGACCGCTATTTGCTGCCGGGCGAAGGCATCCAGGACATGTTCGCCCGCGTTTCCTGC
GCCTTCGCCGATAACGCCGCCCACGCCCAGCGCCTGTACGACGCCATGTCGAAGCTGTGGTTCATGCCGGCGACGCCGAT
CCTGTCCAACGGTGGCACCCAGCGCGGGCTGCCCATCTCGTGCTTCCTGAACACGGTTCCCGACAGCTTGGAGGGTATCG
TCGCCATCTGGAACGAGAATGTGGATCTGGCCTCCAACGGCGGCGGTATCGGGACTTATTGGGGCGGCGTGCGTTCGATC
GGCGAGGCGGTGAAGGGCAATGGCGCCACCTCCGGCATCATCCCATTCATTCGGGTGATGGACAGCCTGACGCTGGCCAT
TTCCCAAGGCTCGCTGCGGCGCGGCTCGGCGGCGGTGTATCTCGACATCCACCACCCCGAGATCGAGGAATTCCTGGAGA
TCCGCAAGGCCTCGGGCGATTTCAACCGCAAGAGCCTGAACCTGCACCACGCCATCAATATCACCGACGACTTCATGGAG
GCGGTGCGCGACGATCGGCAATTCGCCCTGAAAAGCCCCAAGAGCGGCGAGGTGCTGCGCAGCGTCGGCGCCCGCCAGCT
CTGGCAGAAAATCCTGGAAACCCGCTTGCAGACCGGCGAGCCGTATCTGCTGTTCACCGACACCGTCAACCGCGCCCTGC
CCAAACACCAGCGCGACTTGGGCCTGCGGGTGTCGTCCTCCAATCTGTGCGCCGAGATCACCCTTCCGACGGGGCGCGAC
CATCGCGGCCAGGAGCGCACGGCCGTATGCTGCCTGTCGTCGCTCAACATCGAGACCTGGGACGAATGGGAGAACGCCCC
CGGCTTCATCGAAGACGTGCTGCGCTTCCTTGACAACGTGCTGAGCCATTTCATCGAGACGGCGCCCGACGGCATGGAGC
GCGCGGCCTATGCCGCCATGCGCGAGCGCTCGGTCGGCTTGGGCGTCATGGGGTTCCATTCCTTTTTGCAGGCCCGCGGC
ATCCCCTTCGAAAGCGCGCTTGCCAAGTCGTGGAACCTGCGCCTCTTCCGCAAGATCCGCCGCGACGCGGACGCCGCTTC
GGTGGATCTGGCCGACGAGCGCGGCGCCTGCCCGGATGCCGCGGAGCGCGGCATGAAGGCCCGCTTCAGCGCCAAGCTGG
CCATCGCGCCCACCGCCTCCATCAGCATCATCTGCGGCGGCACCAGCGCCTGCGTCGAACCGATTCCGGCCAACGTCTAC
ACCCACAAAACCCTGTCTGGTTCGTTCTCGGTGCGCAACCCGCACCTTGCGCGCCGGCTCGCGGACAAGGGCCTCGATAC
CGCCGAGACGTGGCAATCCATCATCGAGCACGAAGGCTCGGTCCAACACCTGGAAGGCTTGAGCGACGACGAGAAGCTGG
TGTTCCGCACCGCCTTCGAGATCGACCAGCGTTGGATCATCGATCTGGCCGCCGACCGCGCCCCCTTCATCTGCCAAAGC
CAGTCCATCAACCTGTATCTGCCCGCCGACGCCGACAAATGGGACCTGCACATGTTGCACTGGACGGCATGGCGGCGCGG
CCTGAAAAGCCTCTATTACTGCCGGTCCAAATCGGTGCAGCGCGCCGCCTTCGTCGGCAGGGAAAAGCCGAGCGGGGAAA
CGTCATCGGCCCCGCGCGCCGATTACGATGAATGCCTAGCCTGCCAATAG

Upstream 100 bases:

>100_bases
AACGTCCGCGGGCGGGGTGTCCCGATGGGGCGCATGCCGGCTTGTGCCCGCATGGCGTCTCTCCCCTCCCACCTTTCATC
ATCCCTGAGGGGGATCGCCG

Downstream 100 bases:

>100_bases
AGAGACCGGCCATGACCATCGCGCAGCTCAATCCCCTCGATCTGGTCAACAGCGGTCGCATCGGCCTGCTGCAAGGCTCG
GGCGCCTACAACGTCGAACG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MSSAPAFDFDRQGNLVASPPRQSHQPTSQIRRRPHPPETSEIRLERSRDDKLNAFGKAMLGDRYLLPGEGIQDMFARVSC
AFADNAAHAQRLYDAMSKLWFMPATPILSNGGTQRGLPISCFLNTVPDSLEGIVAIWNENVDLASNGGGIGTYWGGVRSI
GEAVKGNGATSGIIPFIRVMDSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKASGDFNRKSLNLHHAINITDDFME
AVRDDRQFALKSPKSGEVLRSVGARQLWQKILETRLQTGEPYLLFTDTVNRALPKHQRDLGLRVSSSNLCAEITLPTGRD
HRGQERTAVCCLSSLNIETWDEWENAPGFIEDVLRFLDNVLSHFIETAPDGMERAAYAAMRERSVGLGVMGFHSFLQARG
IPFESALAKSWNLRLFRKIRRDADAASVDLADERGACPDAAERGMKARFSAKLAIAPTASISIICGGTSACVEPIPANVY
THKTLSGSFSVRNPHLARRLADKGLDTAETWQSIIEHEGSVQHLEGLSDDEKLVFRTAFEIDQRWIIDLAADRAPFICQS
QSINLYLPADADKWDLHMLHWTAWRRGLKSLYYCRSKSVQRAAFVGREKPSGETSSAPRADYDECLACQ

Sequences:

>Translated_629_residues
MSSAPAFDFDRQGNLVASPPRQSHQPTSQIRRRPHPPETSEIRLERSRDDKLNAFGKAMLGDRYLLPGEGIQDMFARVSC
AFADNAAHAQRLYDAMSKLWFMPATPILSNGGTQRGLPISCFLNTVPDSLEGIVAIWNENVDLASNGGGIGTYWGGVRSI
GEAVKGNGATSGIIPFIRVMDSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKASGDFNRKSLNLHHAINITDDFME
AVRDDRQFALKSPKSGEVLRSVGARQLWQKILETRLQTGEPYLLFTDTVNRALPKHQRDLGLRVSSSNLCAEITLPTGRD
HRGQERTAVCCLSSLNIETWDEWENAPGFIEDVLRFLDNVLSHFIETAPDGMERAAYAAMRERSVGLGVMGFHSFLQARG
IPFESALAKSWNLRLFRKIRRDADAASVDLADERGACPDAAERGMKARFSAKLAIAPTASISIICGGTSACVEPIPANVY
THKTLSGSFSVRNPHLARRLADKGLDTAETWQSIIEHEGSVQHLEGLSDDEKLVFRTAFEIDQRWIIDLAADRAPFICQS
QSINLYLPADADKWDLHMLHWTAWRRGLKSLYYCRSKSVQRAAFVGREKPSGETSSAPRADYDECLACQ
>Mature_628_residues
SSAPAFDFDRQGNLVASPPRQSHQPTSQIRRRPHPPETSEIRLERSRDDKLNAFGKAMLGDRYLLPGEGIQDMFARVSCA
FADNAAHAQRLYDAMSKLWFMPATPILSNGGTQRGLPISCFLNTVPDSLEGIVAIWNENVDLASNGGGIGTYWGGVRSIG
EAVKGNGATSGIIPFIRVMDSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKASGDFNRKSLNLHHAINITDDFMEA
VRDDRQFALKSPKSGEVLRSVGARQLWQKILETRLQTGEPYLLFTDTVNRALPKHQRDLGLRVSSSNLCAEITLPTGRDH
RGQERTAVCCLSSLNIETWDEWENAPGFIEDVLRFLDNVLSHFIETAPDGMERAAYAAMRERSVGLGVMGFHSFLQARGI
PFESALAKSWNLRLFRKIRRDADAASVDLADERGACPDAAERGMKARFSAKLAIAPTASISIICGGTSACVEPIPANVYT
HKTLSGSFSVRNPHLARRLADKGLDTAETWQSIIEHEGSVQHLEGLSDDEKLVFRTAFEIDQRWIIDLAADRAPFICQSQ
SINLYLPADADKWDLHMLHWTAWRRGLKSLYYCRSKSVQRAAFVGREKPSGETSSAPRADYDECLACQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=616, Percent_Identity=31.9805194805195, Blast_Score=280, Evalue=3e-75,
Organism=Escherichia coli, GI1789030, Length=634, Percent_Identity=26.9716088328076, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI2367133, Length=383, Percent_Identity=26.6318537859008, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17555242, Length=652, Percent_Identity=31.2883435582822, Blast_Score=278, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6320914, Length=623, Percent_Identity=31.3001605136437, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6322123, Length=625, Percent_Identity=30.4, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17352481, Length=632, Percent_Identity=29.746835443038, Blast_Score=248, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 69756; Mature: 69624

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPAFDFDRQGNLVASPPRQSHQPTSQIRRRPHPPETSEIRLERSRDDKLNAFGKAML
CCCCCCCCCCCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHH
GDRYLLPGEGIQDMFARVSCAFADNAAHAQRLYDAMSKLWFMPATPILSNGGTQRGLPIS
CCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCEEE
CFLNTVPDSLEGIVAIWNENVDLASNGGGIGTYWGGVRSIGEAVKGNGATSGIIPFIRVM
EEEHHCCCHHCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKASGDFNRKSLNLHHAINITDDFME
HHHHEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHH
AVRDDRQFALKSPKSGEVLRSVGARQLWQKILETRLQTGEPYLLFTDTVNRALPKHQRDL
HHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCHHHHC
GLRVSSSNLCAEITLPTGRDHRGQERTAVCCLSSLNIETWDEWENAPGFIEDVLRFLDNV
CCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHH
LSHFIETAPDGMERAAYAAMRERSVGLGVMGFHSFLQARGIPFESALAKSWNLRLFRKIR
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
RDADAASVDLADERGACPDAAERGMKARFSAKLAIAPTASISIICGGTSACVEPIPANVY
HCCCCCEEECCCCCCCCCCHHHCCCHHHHCEEEEEECCCEEEEEECCCHHHCCCCCCCCE
THKTLSGSFSVRNPHLARRLADKGLDTAETWQSIIEHEGSVQHLEGLSDDEKLVFRTAFE
EEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHH
IDQRWIIDLAADRAPFICQSQSINLYLPADADKWDLHMLHWTAWRRGLKSLYYCRSKSVQ
CCCCEEEEECCCCCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
RAAFVGREKPSGETSSAPRADYDECLACQ
HHHHHCCCCCCCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
SSAPAFDFDRQGNLVASPPRQSHQPTSQIRRRPHPPETSEIRLERSRDDKLNAFGKAML
CCCCCCCCCCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHH
GDRYLLPGEGIQDMFARVSCAFADNAAHAQRLYDAMSKLWFMPATPILSNGGTQRGLPIS
CCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCEEE
CFLNTVPDSLEGIVAIWNENVDLASNGGGIGTYWGGVRSIGEAVKGNGATSGIIPFIRVM
EEEHHCCCHHCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKASGDFNRKSLNLHHAINITDDFME
HHHHEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHH
AVRDDRQFALKSPKSGEVLRSVGARQLWQKILETRLQTGEPYLLFTDTVNRALPKHQRDL
HHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHCCCHHHHC
GLRVSSSNLCAEITLPTGRDHRGQERTAVCCLSSLNIETWDEWENAPGFIEDVLRFLDNV
CCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHH
LSHFIETAPDGMERAAYAAMRERSVGLGVMGFHSFLQARGIPFESALAKSWNLRLFRKIR
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
RDADAASVDLADERGACPDAAERGMKARFSAKLAIAPTASISIICGGTSACVEPIPANVY
HCCCCCEEECCCCCCCCCCHHHCCCHHHHCEEEEEECCCEEEEEECCCHHHCCCCCCCCE
THKTLSGSFSVRNPHLARRLADKGLDTAETWQSIIEHEGSVQHLEGLSDDEKLVFRTAFE
EEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHH
IDQRWIIDLAADRAPFICQSQSINLYLPADADKWDLHMLHWTAWRRGLKSLYYCRSKSVQ
CCCCEEEEECCCCCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
RAAFVGREKPSGETSSAPRADYDECLACQ
HHHHHCCCCCCCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]