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The map label for this gene is nrdF [H]

Identifier: 83592781

GI number: 83592781

Start: 1709777

End: 1710853

Strand: Direct

Name: nrdF [H]

Synonym: Rru_A1445

Alternate gene names: 83592781

Gene position: 1709777-1710853 (Clockwise)

Preceding gene: 83592780

Following gene: 83592782

Centisome position: 39.28

GC content: 61.19

Gene sequence:

>1077_bases
ATGACCATCGCGCAGCTCAATCCCCTCGATCTGGTCAACAGCGGTCGCATCGGCCTGCTGCAAGGCTCGGGCGCCTACAA
CGTCGAACGCTATCCCTGGGCCTATGAGTTCTGGAAGAAGCAACAACAGGTCCACTGGATGGGCGAGGAGGTGCCGCTGG
GCGAGGACCTCAAGGACTGGGCCTCCGATCGCGTTTCCGACCAGGAGCGCAACCTGCTGACCCAGATCTTTCGCTTTTTC
ACCCAGTCGGACGTGGAGGTCAGCGACAATTACCTCAAGCGCTATATGCCCATCTTCCAGCCGCTGGAAATCCAGATGAT
GATGGCCGCCTTCACCAACATGGAGACCATCCATATCGACGCCTATGCCCTGCTGCTAACCACGCTCGGCATGCCGCGGA
CCGAGTTTTCGGCCTTCCGCGACTATGCCGCCATGCGTGACAAGGCCGATTACATGCACACCTTCGGCGTCGGCACCATG
GCCGACGTGTCGCGCACGCTGGCCATGTTCGGCGCCTTCACCGAAGGCATGGCGCTGTTCGCCAGCTTCGCCATGCTGCT
GAACTTCCCCCGTCACAACAAGATGAAGGGCATGGGCCAGATCGTCACCTGGTCGGTGCGTGACGAATCCCTGCATTGCC
AGGGTATCATCCGTCTGTTCCACGAATGGAACCGCGAAACCGGCGCGCTGACCAAGCCGGTGCGCGACGACATCCTGGAC
GTGGCGACAACCATGGTCGGACTGGAAGAGAAGTTCGTCGATCTCGCCTTCGAGCTGGGCGCGATCGAGGGCATGCGCGC
CGAGGACATCAAATCCTACGTCCGCTACGTCGCCGACTGGCGGCTGACCCAGTTGAAACTGCCCATCCTTTATGGTCATT
TCCGCGAAACCGAGGCGGGTTACGAACAACTCAGGCCCCACCCCTTGCCCTGGCTGGTGGAAATCCTCAACGGCGTCGAA
CACGCCAATTTCTTCGAACAGCGATCCACCGAATATTCCAAGGCGGCAACCCAAGGCGCCTGGGACGGTCCGGACGGCGT
CTGGGCGGCGTTCGACCGCCTGCGCACCGCCCAATGA

Upstream 100 bases:

>100_bases
GCGCCGCCTTCGTCGGCAGGGAAAAGCCGAGCGGGGAAACGTCATCGGCCCCGCGCGCCGATTACGATGAATGCCTAGCC
TGCCAATAGAGAGACCGGCC

Downstream 100 bases:

>100_bases
CGGTCGCGAGAGGAAAATTCCCCCTGCGAAAGAACCTCGGAACGAAGCGGGCGTCGACTCGTTAGAGGGGCTGTCGGCCA
AGCCGGCAAGGCCTTTAACA

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTIAQLNPLDLVNSGRIGLLQGSGAYNVERYPWAYEFWKKQQQVHWMGEEVPLGEDLKDWASDRVSDQERNLLTQIFRFF
TQSDVEVSDNYLKRYMPIFQPLEIQMMMAAFTNMETIHIDAYALLLTTLGMPRTEFSAFRDYAAMRDKADYMHTFGVGTM
ADVSRTLAMFGAFTEGMALFASFAMLLNFPRHNKMKGMGQIVTWSVRDESLHCQGIIRLFHEWNRETGALTKPVRDDILD
VATTMVGLEEKFVDLAFELGAIEGMRAEDIKSYVRYVADWRLTQLKLPILYGHFRETEAGYEQLRPHPLPWLVEILNGVE
HANFFEQRSTEYSKAATQGAWDGPDGVWAAFDRLRTAQ

Sequences:

>Translated_358_residues
MTIAQLNPLDLVNSGRIGLLQGSGAYNVERYPWAYEFWKKQQQVHWMGEEVPLGEDLKDWASDRVSDQERNLLTQIFRFF
TQSDVEVSDNYLKRYMPIFQPLEIQMMMAAFTNMETIHIDAYALLLTTLGMPRTEFSAFRDYAAMRDKADYMHTFGVGTM
ADVSRTLAMFGAFTEGMALFASFAMLLNFPRHNKMKGMGQIVTWSVRDESLHCQGIIRLFHEWNRETGALTKPVRDDILD
VATTMVGLEEKFVDLAFELGAIEGMRAEDIKSYVRYVADWRLTQLKLPILYGHFRETEAGYEQLRPHPLPWLVEILNGVE
HANFFEQRSTEYSKAATQGAWDGPDGVWAAFDRLRTAQ
>Mature_357_residues
TIAQLNPLDLVNSGRIGLLQGSGAYNVERYPWAYEFWKKQQQVHWMGEEVPLGEDLKDWASDRVSDQERNLLTQIFRFFT
QSDVEVSDNYLKRYMPIFQPLEIQMMMAAFTNMETIHIDAYALLLTTLGMPRTEFSAFRDYAAMRDKADYMHTFGVGTMA
DVSRTLAMFGAFTEGMALFASFAMLLNFPRHNKMKGMGQIVTWSVRDESLHCQGIIRLFHEWNRETGALTKPVRDDILDV
ATTMVGLEEKFVDLAFELGAIEGMRAEDIKSYVRYVADWRLTQLKLPILYGHFRETEAGYEQLRPHPLPWLVEILNGVEH
ANFFEQRSTEYSKAATQGAWDGPDGVWAAFDRLRTAQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=313, Percent_Identity=25.5591054313099, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI289177074, Length=312, Percent_Identity=25, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI260064013, Length=304, Percent_Identity=25.3289473684211, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557845, Length=310, Percent_Identity=24.8387096774194, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI289177076, Length=294, Percent_Identity=25.1700680272109, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551968, Length=305, Percent_Identity=26.5573770491803, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193206379, Length=255, Percent_Identity=26.2745098039216, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322434, Length=313, Percent_Identity=24.9201277955272, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18079279, Length=309, Percent_Identity=25.8899676375405, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 41235; Mature: 41103

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAQLNPLDLVNSGRIGLLQGSGAYNVERYPWAYEFWKKQQQVHWMGEEVPLGEDLKDW
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ASDRVSDQERNLLTQIFRFFTQSDVEVSDNYLKRYMPIFQPLEIQMMMAAFTNMETIHID
HHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEHH
AYALLLTTLGMPRTEFSAFRDYAAMRDKADYMHTFGVGTMADVSRTLAMFGAFTEGMALF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASFAMLLNFPRHNKMKGMGQIVTWSVRDESLHCQGIIRLFHEWNRETGALTKPVRDDILD
HHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
VATTMVGLEEKFVDLAFELGAIEGMRAEDIKSYVRYVADWRLTQLKLPILYGHFRETEAG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHEEECHHHHCCHHHHHHH
YEQLRPHPLPWLVEILNGVEHANFFEQRSTEYSKAATQGAWDGPDGVWAAFDRLRTAQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TIAQLNPLDLVNSGRIGLLQGSGAYNVERYPWAYEFWKKQQQVHWMGEEVPLGEDLKDW
CCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ASDRVSDQERNLLTQIFRFFTQSDVEVSDNYLKRYMPIFQPLEIQMMMAAFTNMETIHID
HHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEHH
AYALLLTTLGMPRTEFSAFRDYAAMRDKADYMHTFGVGTMADVSRTLAMFGAFTEGMALF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASFAMLLNFPRHNKMKGMGQIVTWSVRDESLHCQGIIRLFHEWNRETGALTKPVRDDILD
HHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
VATTMVGLEEKFVDLAFELGAIEGMRAEDIKSYVRYVADWRLTQLKLPILYGHFRETEAG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHEEECHHHHCCHHHHHHH
YEQLRPHPLPWLVEILNGVEHANFFEQRSTEYSKAATQGAWDGPDGVWAAFDRLRTAQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]