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The map label for this gene is nadC

Identifier: 83592768

GI number: 83592768

Start: 1690354

End: 1691244

Strand: Reverse

Name: nadC

Synonym: Rru_A1432

Alternate gene names: 83592768

Gene position: 1691244-1690354 (Counterclockwise)

Preceding gene: 83592769

Following gene: 83592755

Centisome position: 38.85

GC content: 69.47

Gene sequence:

>891_bases
ATGAGGCCGAACCACCCCGTTGCCGCGCTGTCGCCCTTCGCCATCGACGAGGCGGTGCGCCGCGCCCTTGCCGAAGACCT
GGGGCGAGCCGGCGATATCACCTCAACGGCCACCATCCCGGCGGCTACCCGGGCGCACGCCCGCTTCGTCGCCCGCCAAC
CGGGCATCCTCGCCGGCCTCGGCTGCGCCCGCAGCGCCTTCGCGCTGCTTGATGATACCGTGACCTTCACCACCCCCCTT
GAGGATGGCGCGGAAATCGCCGCCGGCCAGACGGTGGCCGAGGTCGCCGGCGCGGCGCGGACCATCCTGGCCGCAGAACG
CACCGCCTTGAATTTCCTGGGTCATCTGTCGGGCATCGCCACCCGGACCCGGCGCTTTGGCGATGCCATCGCCCACACCC
GGGCCCGGTTGACCTGCACGCGCAAAACCACCCCGGGCCTGCGCGGCCTGGAGAAATACGCCGTGCGCTGCGGCGGCGGA
TCGAACCATCGCTTCGGTCTTGATGACGCGGTCTTGATCAAGGACAACCACATCGCCGTGGCCGGTGGCGTCAGCGCCGC
CCTGAGCCGCGCCCGGGCCGGCGTCGGTCATATGGTCCGGATCGAGATCGAGGTCGACACCTTGGAACAACTGGCCGAGG
TGCTGGCCGTGGGCGGCGCCGAGGTCGTGCTGCTTGACAATATGGACGCCCCCACCCTGACCCGCGCCGTGGACATGGTG
GCCGGGCGGCTGGTGACCGAGGCTTCGGGCGGGGTGAGCCTGGACACCATCGCCGCCCTGGCCGAAAGCGGTGTCGATTA
CATCTCGGTCGGCGCCCTCACCCATTCGGTGACGACGCTCGATATCGGCCTGGATATCGTCGTCGCCCCCCCGAAAGCTG
AGAGAGCTTAA

Upstream 100 bases:

>100_bases
ACCGCGCGACGGCGCCGTTTGGCCCCTTGCGCACCGTTCCGCCCCACCCCGCCCAGAGCCTGGGGGAGGGTCTGGCCGCA
CCCCCGATGGAGACCCGCTC

Downstream 100 bases:

>100_bases
TCGTCGTCGTCGTCGCGGTCGCCATCGGCGGCGGCTTTCAGGCGAACAAGGTTGGGGATGGTGTAATGGCCGCGACCCTG
GCGCGAGATATAACCTTCCT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MRPNHPVAALSPFAIDEAVRRALAEDLGRAGDITSTATIPAATRAHARFVARQPGILAGLGCARSAFALLDDTVTFTTPL
EDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLSGIATRTRRFGDAIAHTRARLTCTRKTTPGLRGLEKYAVRCGGG
SNHRFGLDDAVLIKDNHIAVAGGVSAALSRARAGVGHMVRIEIEVDTLEQLAEVLAVGGAEVVLLDNMDAPTLTRAVDMV
AGRLVTEASGGVSLDTIAALAESGVDYISVGALTHSVTTLDIGLDIVVAPPKAERA

Sequences:

>Translated_296_residues
MRPNHPVAALSPFAIDEAVRRALAEDLGRAGDITSTATIPAATRAHARFVARQPGILAGLGCARSAFALLDDTVTFTTPL
EDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLSGIATRTRRFGDAIAHTRARLTCTRKTTPGLRGLEKYAVRCGGG
SNHRFGLDDAVLIKDNHIAVAGGVSAALSRARAGVGHMVRIEIEVDTLEQLAEVLAVGGAEVVLLDNMDAPTLTRAVDMV
AGRLVTEASGGVSLDTIAALAESGVDYISVGALTHSVTTLDIGLDIVVAPPKAERA
>Mature_296_residues
MRPNHPVAALSPFAIDEAVRRALAEDLGRAGDITSTATIPAATRAHARFVARQPGILAGLGCARSAFALLDDTVTFTTPL
EDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLSGIATRTRRFGDAIAHTRARLTCTRKTTPGLRGLEKYAVRCGGG
SNHRFGLDDAVLIKDNHIAVAGGVSAALSRARAGVGHMVRIEIEVDTLEQLAEVLAVGGAEVVLLDNMDAPTLTRAVDMV
AGRLVTEASGGVSLDTIAALAESGVDYISVGALTHSVTTLDIGLDIVVAPPKAERA

Specific function: Involved in the catabolism of quinolinic acid (QA)

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family

Homologues:

Organism=Homo sapiens, GI45269149, Length=292, Percent_Identity=33.9041095890411, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=42.0664206642066, Blast_Score=181, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6321162, Length=252, Percent_Identity=32.5396825396825, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADC_RHORU (P77938)

Other databases:

- EMBL:   U65510
- PIR:   T51326
- ProteinModelPortal:   P77938
- SMR:   P77938
- BRENDA:   2.4.2.19
- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00078

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N; SSF51690 Q_phspho_trans

EC number: =2.4.2.19

Molecular weight: Translated: 30536; Mature: 30536

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: BINDING 107-107 BINDING 164-164 BINDING 174-174 BINDING 204-204 BINDING 226-226

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPNHPVAALSPFAIDEAVRRALAEDLGRAGDITSTATIPAATRAHARFVARQPGILAGL
CCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEC
GCARSAFALLDDTVTFTTPLEDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLSGIA
CHHHHHHHHHCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRTRRFGDAIAHTRARLTCTRKTTPGLRGLEKYAVRCGGGSNHRFGLDDAVLIKDNHIAV
HHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHEECCCCCCCCCCCCCEEEEECCCEEE
AGGVSAALSRARAGVGHMVRIEIEVDTLEQLAEVLAVGGAEVVLLDNMDAPTLTRAVDMV
ECCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
AGRLVTEASGGVSLDTIAALAESGVDYISVGALTHSVTTLDIGLDIVVAPPKAERA
HHHHHCCCCCCCCHHHHHHHHHCCCCEEEECHHHHEEEEEEECEEEEECCCCCCCC
>Mature Secondary Structure
MRPNHPVAALSPFAIDEAVRRALAEDLGRAGDITSTATIPAATRAHARFVARQPGILAGL
CCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEC
GCARSAFALLDDTVTFTTPLEDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLSGIA
CHHHHHHHHHCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRTRRFGDAIAHTRARLTCTRKTTPGLRGLEKYAVRCGGGSNHRFGLDDAVLIKDNHIAV
HHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHEECCCCCCCCCCCCCEEEEECCCEEE
AGGVSAALSRARAGVGHMVRIEIEVDTLEQLAEVLAVGGAEVVLLDNMDAPTLTRAVDMV
ECCHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
AGRLVTEASGGVSLDTIAALAESGVDYISVGALTHSVTTLDIGLDIVVAPPKAERA
HHHHHCCCCCCCCHHHHHHHHHCCCCEEEECHHHHEEEEEEECEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706