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The map label for this gene is lldP [H]

Identifier: 83592745

GI number: 83592745

Start: 1664211

End: 1665854

Strand: Reverse

Name: lldP [H]

Synonym: Rru_A1409

Alternate gene names: 83592745

Gene position: 1665854-1664211 (Counterclockwise)

Preceding gene: 83592746

Following gene: 83592744

Centisome position: 38.27

GC content: 60.89

Gene sequence:

>1644_bases
ATGCAACCCTGGACCCAAGTTTACGACCCTTTTGGAAACATCTGGCTCTCATCGCTTGTCGCGGTGATTCCCATCATTTT
CTTCTTTGTCGCCCTGGCGGTCTTTCGTATGAAGGGCGCTCTGGCCGGCACGATCACGGTGCTGCTGGCTTTGGCCGTCG
CGGTGTTTTTCTACCAGATGCCGGTGGCCTCGGCCCTGATGTCGGGGATCCAGGGATTTCTCTTCGGCCTGTGGCCAATC
GCCTGGATCATCATCGCCGCGGTGTTTTTGTATAAGGTCACGGTCAAGACCGGCCAGTTCGACATCATCCGCGCCTCGGT
GATCTCGATCACCGAAGACCAGCGCCTACAGATGTTGATGATCGGCTTTTCCTTTGGCGCCTTCTTGGAAGGCGCGGCCG
GTTTCGGCGCCCCGGTGGCGATCACCGCCGCCCTGTTGGTTGGCCTGGGCTTCAATCCGCTTTATGCCGCCGGGCTGTGC
CTGATCGCCAATACCGCCCCGGTGGCCTTTGGCGCGGTCGGCATTCCGATCATCGTCGCCGGACAGGTTTCGGGCGTCGA
TACCTTCAAGATCGGCGCCATGGCCGGTCGCCAATTGCCGTTCCTGGCGGTTTTCGTGCCGTTCTGGCTGATCTTCATCA
TGGATGGCTGGAAGGGCGTCAAGGAGACATGGCCGGCGGTGCTGGTCGCCGGCGGCAGCTTCGCCCTTTGCGTCTTCCTG
ACCTCCAACTACATCGGCCCCGAACTGCCCGACATCATTTCCGCCCTGGTCAGCCTGATCGCCATCACCGTCTTCCTGAA
ATATTGGAAGCCCAAGCGTATTTTCCGCTTCAAGGACACCACCGAGGCCGAACGCCACGCCCATGATTATTCCCTGGGCC
AGATCCTGCGGGCTTGGTCGCCCTTCCTCATCCTGACGCTGATGGTCACGCTGTGGAGCCTCAAGCCCTTCAAGGCCCTG
TTCGCCAAGGGCGCCGAACTGGCCTTCACCAATCTGACCTGGGAAGTGCCCTTCCTGCATAACCTGATCGCCAAGGTTCC
GCCGATCGTGCCGACGATCAAAGAGGTTCCGGCGGTCTATACGCTGAACCTGATATCGGCCACCGGCACCGCCATTCTGA
TCGCCGCCATCATCGCCATCGTCGCCCTGTCGATGCGTCCGACCGACGGCCTGAAAACCCTGGGCGAGACCTTCCGCGAA
TTGAAGCTGCCGATCTACACCATCGGCACCGTTCTCGCCTTCGCCTATGTCGCCAACGCCTCGGGGCTGTCGACGACCCT
GGCCCTGCTGCTGGCCGGAGCGGGTGACAGCTTCCCCTTCTTCTCGCCGGTTCTCGGCTGGCTGGGCGTCTTCCTGACCG
GGTCGGACACCTCGTCAAACGCCCTGTTTGGCGCCTTGCAGGCGACCACCGCCCATCAAATCGGCGTCAGTGACGTCTTG
TTGGTCGCGGCCAACACCACCGGTGGCGTCACCGGCAAGATGATTTCGCCGCAATCGATCGCCGTCGCCTGCGCCGCCGT
CGGATTGATCGGTCACGAGGCCAATCTGTTCCGCTTCACCCTGAAACACAGCCTGTTCTTCCTGCTAATCATCTGCGTGA
TGACCACCCTTCAAGCCTATGTCTTCCCCTGGATGATTCCTTAA

Upstream 100 bases:

>100_bases
CGCGTCGAAGCCGCCGACCAACAAGATCAAGAAACCACGACAACAGAACAGGCCTAAAAAAACGCCAGCGCCCTGGCATC
CATGAAAATCGGGAGGATTC

Downstream 100 bases:

>100_bases
AAAGGCGCGGGCGGGCGGCAAGCCCGGATTGGCTTTCCGCCCGCCCACCGTGATGACGGGCCTTGGCATACCACAAGGGA
TATGACCTAATAGGTGTAGA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MQPWTQVYDPFGNIWLSSLVAVIPIIFFFVALAVFRMKGALAGTITVLLALAVAVFFYQMPVASALMSGIQGFLFGLWPI
AWIIIAAVFLYKVTVKTGQFDIIRASVISITEDQRLQMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIANTAPVAFGAVGIPIIVAGQVSGVDTFKIGAMAGRQLPFLAVFVPFWLIFIMDGWKGVKETWPAVLVAGGSFALCVFL
TSNYIGPELPDIISALVSLIAITVFLKYWKPKRIFRFKDTTEAERHAHDYSLGQILRAWSPFLILTLMVTLWSLKPFKAL
FAKGAELAFTNLTWEVPFLHNLIAKVPPIVPTIKEVPAVYTLNLISATGTAILIAAIIAIVALSMRPTDGLKTLGETFRE
LKLPIYTIGTVLAFAYVANASGLSTTLALLLAGAGDSFPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQIGVSDVL
LVAANTTGGVTGKMISPQSIAVACAAVGLIGHEANLFRFTLKHSLFFLLIICVMTTLQAYVFPWMIP

Sequences:

>Translated_547_residues
MQPWTQVYDPFGNIWLSSLVAVIPIIFFFVALAVFRMKGALAGTITVLLALAVAVFFYQMPVASALMSGIQGFLFGLWPI
AWIIIAAVFLYKVTVKTGQFDIIRASVISITEDQRLQMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIANTAPVAFGAVGIPIIVAGQVSGVDTFKIGAMAGRQLPFLAVFVPFWLIFIMDGWKGVKETWPAVLVAGGSFALCVFL
TSNYIGPELPDIISALVSLIAITVFLKYWKPKRIFRFKDTTEAERHAHDYSLGQILRAWSPFLILTLMVTLWSLKPFKAL
FAKGAELAFTNLTWEVPFLHNLIAKVPPIVPTIKEVPAVYTLNLISATGTAILIAAIIAIVALSMRPTDGLKTLGETFRE
LKLPIYTIGTVLAFAYVANASGLSTTLALLLAGAGDSFPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQIGVSDVL
LVAANTTGGVTGKMISPQSIAVACAAVGLIGHEANLFRFTLKHSLFFLLIICVMTTLQAYVFPWMIP
>Mature_547_residues
MQPWTQVYDPFGNIWLSSLVAVIPIIFFFVALAVFRMKGALAGTITVLLALAVAVFFYQMPVASALMSGIQGFLFGLWPI
AWIIIAAVFLYKVTVKTGQFDIIRASVISITEDQRLQMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIANTAPVAFGAVGIPIIVAGQVSGVDTFKIGAMAGRQLPFLAVFVPFWLIFIMDGWKGVKETWPAVLVAGGSFALCVFL
TSNYIGPELPDIISALVSLIAITVFLKYWKPKRIFRFKDTTEAERHAHDYSLGQILRAWSPFLILTLMVTLWSLKPFKAL
FAKGAELAFTNLTWEVPFLHNLIAKVPPIVPTIKEVPAVYTLNLISATGTAILIAAIIAIVALSMRPTDGLKTLGETFRE
LKLPIYTIGTVLAFAYVANASGLSTTLALLLAGAGDSFPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQIGVSDVL
LVAANTTGGVTGKMISPQSIAVACAAVGLIGHEANLFRFTLKHSLFFLLIICVMTTLQAYVFPWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=67.513611615245, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=64.5161290322581, Blast_Score=689, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58650; Mature: 58650

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPWTQVYDPFGNIWLSSLVAVIPIIFFFVALAVFRMKGALAGTITVLLALAVAVFFYQM
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVASALMSGIQGFLFGLWPIAWIIIAAVFLYKVTVKTGQFDIIRASVISITEDQRLQMLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCHHEEHE
IGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIANTAPVAFGAVGIPIIVA
EHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECCCCHHHCCCCCCEEEE
GQVSGVDTFKIGAMAGRQLPFLAVFVPFWLIFIMDGWKGVKETWPAVLVAGGSFALCVFL
CCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCEEEEEE
TSNYIGPELPDIISALVSLIAITVFLKYWKPKRIFRFKDTTEAERHAHDYSLGQILRAWS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHH
PFLILTLMVTLWSLKPFKALFAKGAELAFTNLTWEVPFLHNLIAKVPPIVPTIKEVPAVY
HHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCEEECHHHHHHHHHCCCCCCCHHHCCCEE
TLNLISATGTAILIAAIIAIVALSMRPTDGLKTLGETFRELKLPIYTIGTVLAFAYVANA
EEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
SGLSTTLALLLAGAGDSFPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQIGVSDVL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
LVAANTTGGVTGKMISPQSIAVACAAVGLIGHEANLFRFTLKHSLFFLLIICVMTTLQAY
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VFPWMIP
HCCCCCC
>Mature Secondary Structure
MQPWTQVYDPFGNIWLSSLVAVIPIIFFFVALAVFRMKGALAGTITVLLALAVAVFFYQM
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVASALMSGIQGFLFGLWPIAWIIIAAVFLYKVTVKTGQFDIIRASVISITEDQRLQMLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCHHEEHE
IGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIANTAPVAFGAVGIPIIVA
EHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECCCCHHHCCCCCCEEEE
GQVSGVDTFKIGAMAGRQLPFLAVFVPFWLIFIMDGWKGVKETWPAVLVAGGSFALCVFL
CCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCEEEEEE
TSNYIGPELPDIISALVSLIAITVFLKYWKPKRIFRFKDTTEAERHAHDYSLGQILRAWS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHH
PFLILTLMVTLWSLKPFKALFAKGAELAFTNLTWEVPFLHNLIAKVPPIVPTIKEVPAVY
HHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCEEECHHHHHHHHHCCCCCCCHHHCCCEE
TLNLISATGTAILIAAIIAIVALSMRPTDGLKTLGETFRELKLPIYTIGTVLAFAYVANA
EEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
SGLSTTLALLLAGAGDSFPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQIGVSDVL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
LVAANTTGGVTGKMISPQSIAVACAAVGLIGHEANLFRFTLKHSLFFLLIICVMTTLQAY
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VFPWMIP
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]