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The map label for this gene is hutU

Identifier: 83592640

GI number: 83592640

Start: 1538781

End: 1540451

Strand: Direct

Name: hutU

Synonym: Rru_A1304

Alternate gene names: 83592640

Gene position: 1538781-1540451 (Clockwise)

Preceding gene: 83592639

Following gene: 83592652

Centisome position: 35.35

GC content: 67.86

Gene sequence:

>1671_bases
ATGTCCGATCGTCTCGACAATCAGCGCGTGGTGCGCGCCCCCCGTGGCCCCGAGATCACTTGCAAAAGCTGGCTGTCGGA
AGCCCCTTTGCGCATGTTGATGAACAACCTCGACCCCGAGGTGGCTGAAAAGCCGGAAGAATTGGTGGTTTATGGCGGCA
TCGGCCGGGCGGCGCGCAATTGGCAATGCTATGACCAGATCGTCGCCGCGCTCAAGCGCCTGGAAGACGATGAAACCCTG
TTGGTCCAATCGGGCAAGGCGGTGGGCGTGTTCAAAACCCACCGCGACGCCCCGCGCGTGCTGATCGCCAATTCCAATCT
GGTGCCCCATTGGGCGACCTGGGAGACCTTTCACGCCCTCGACCGCGCCGGGCTGATGATGTACGGCCAGATGACCGCCG
GGTCGTGGATCTATATCGGCAGCCAGGGCATCGTTCAGGGCACCTATGAGACCTTCGTCGAAGCCGGGCGGCGCCATTAC
GGTGGGTCTTTGGCCGGACGCTGGATCCTGACCGGCGGCTTGGGCGGTATGGGCGGCGCCCAGCCGCTGGCCGCCACCAT
GGCCGGGGCGTCGATGCTGGCGGTGGAGTGCCAGCCCAGTCGCATCGAGGCGCGGCTGCGCACGGGCTATCTTGATCGCC
AGACCGCCGATCTTGATCAAGCCCTGGCCTGGATCGCCGAGGCCGGCGCTCCGGGGGCCAAGCCGGTTTCCGTCGGCCTG
CTCGGCAATGCCGCCGAGGTGTTTCCCGAGCTGGTCAAGCGTGGCGTCCGCCCCGATCTGGTGACCGACCAGACCTCGGC
CCACGACCCGCTGAACGGCTATCTGCCCGCCGGGTGGAGCCTGGAGCGTTGGGAGCGGGGGCGCGAGCGCGCGCCGGCCG
AGGTGATCGCCGCGGCCAAGGCGTCGATGGCGACCCAGGTGCGCGCCATGCTGGCCTTCCACGCCCAGGGCATTCCCACC
GTCGATTACGGCAACAACATCCGCCAAAGGGCGCTTGAGGAAGGGGTGAGCGACGCCTTCGCCTTCCCCGGCTTCGTGCC
GGCCTATATCCGGCCGCTGTTTTGCCGGGGCATCGGTCCCTTCCGCTGGGCGGCGCTGTCGGGCGATCCCGAGGATATCT
ATCGCACCGACGCCAAGGTGAAGGAGCTGATCCCCGATGATCCCCATCTGCACACCTGGCTCGACATGGCGCGCGAGCGT
ATCCACTTCCAGGGACTGCCCTCGCGCATCTGCTGGGTCGGCCTGGGCGATCGCCATCGCCTGGGGCTGGCCTTCAACGC
CATGGTGGCGAGCGGTGAATTAAAGGCGCCGGTGGTCATCGGCCGCGACCACCTTGACAGCGGCTCTGTCGCCAGCCCCA
ACCGCGAGACCGAGGCGATGCGCGACGGCTCCGACGCCGTGTCGGACTGGCCGTTGCTCAACGCCCTGCTCAATACCGCC
GGCGGCGCCACTTGGGTCAGCCTGCACCACGGCGGCGGCGTCGGCATGGGCTTTTCCCAGCATGCGGGCATGGTCATCGT
CTGCGACGGCAGCGAGGACGCGGCGCGGCGCATCGGCCGCGTGCTGTGGAACGACCCGGCCACCGGCGTCATGCGCCACG
CCGACGCCGGCTACGACGACGCCATCGCCTGCGCCCGGGAAAAAGGTCTGGACCTGCCGTTCTTGGGGTAA

Upstream 100 bases:

>100_bases
CGCTGGGGCTCAACCCCTGTCATGCCGTGGTGCGGGCCGGCGAACCACGGCCGCCGCGCGCCCCCTTTTGATCCTCACCC
CAAGGAGCTGAGCCTTCGCC

Downstream 100 bases:

>100_bases
GGAGGCTGGTCAACGAGGGGGAGGGAGCGGGCGGGCTTCGAGGGGGGCGCCAAGCGCCCGGGCGACCTTGAGCACGGTTT
CAAAGCGCGGCTTGGCGCCG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSDRLDNQRVVRAPRGPEITCKSWLSEAPLRMLMNNLDPEVAEKPEELVVYGGIGRAARNWQCYDQIVAALKRLEDDETL
LVQSGKAVGVFKTHRDAPRVLIANSNLVPHWATWETFHALDRAGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRRHY
GGSLAGRWILTGGLGGMGGAQPLAATMAGASMLAVECQPSRIEARLRTGYLDRQTADLDQALAWIAEAGAPGAKPVSVGL
LGNAAEVFPELVKRGVRPDLVTDQTSAHDPLNGYLPAGWSLERWERGRERAPAEVIAAAKASMATQVRAMLAFHAQGIPT
VDYGNNIRQRALEEGVSDAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYRTDAKVKELIPDDPHLHTWLDMARER
IHFQGLPSRICWVGLGDRHRLGLAFNAMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTA
GGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEDAARRIGRVLWNDPATGVMRHADAGYDDAIACAREKGLDLPFLG

Sequences:

>Translated_556_residues
MSDRLDNQRVVRAPRGPEITCKSWLSEAPLRMLMNNLDPEVAEKPEELVVYGGIGRAARNWQCYDQIVAALKRLEDDETL
LVQSGKAVGVFKTHRDAPRVLIANSNLVPHWATWETFHALDRAGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRRHY
GGSLAGRWILTGGLGGMGGAQPLAATMAGASMLAVECQPSRIEARLRTGYLDRQTADLDQALAWIAEAGAPGAKPVSVGL
LGNAAEVFPELVKRGVRPDLVTDQTSAHDPLNGYLPAGWSLERWERGRERAPAEVIAAAKASMATQVRAMLAFHAQGIPT
VDYGNNIRQRALEEGVSDAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYRTDAKVKELIPDDPHLHTWLDMARER
IHFQGLPSRICWVGLGDRHRLGLAFNAMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTA
GGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEDAARRIGRVLWNDPATGVMRHADAGYDDAIACAREKGLDLPFLG
>Mature_555_residues
SDRLDNQRVVRAPRGPEITCKSWLSEAPLRMLMNNLDPEVAEKPEELVVYGGIGRAARNWQCYDQIVAALKRLEDDETLL
VQSGKAVGVFKTHRDAPRVLIANSNLVPHWATWETFHALDRAGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRRHYG
GSLAGRWILTGGLGGMGGAQPLAATMAGASMLAVECQPSRIEARLRTGYLDRQTADLDQALAWIAEAGAPGAKPVSVGLL
GNAAEVFPELVKRGVRPDLVTDQTSAHDPLNGYLPAGWSLERWERGRERAPAEVIAAAKASMATQVRAMLAFHAQGIPTV
DYGNNIRQRALEEGVSDAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYRTDAKVKELIPDDPHLHTWLDMARERI
HFQGLPSRICWVGLGDRHRLGLAFNAMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAG
GATWVSLHHGGGVGMGFSQHAGMVIVCDGSEDAARRIGRVLWNDPATGVMRHADAGYDDAIACAREKGLDLPFLG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=565, Percent_Identity=34.8672566371681, Blast_Score=296, Evalue=5e-80,
Organism=Homo sapiens, GI260306182, Length=617, Percent_Identity=32.5769854132901, Blast_Score=276, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71997891, Length=549, Percent_Identity=36.7941712204007, Blast_Score=320, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_RHORT (Q2RUU0)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426392.1
- ProteinModelPortal:   Q2RUU0
- SMR:   Q2RUU0
- STRING:   Q2RUU0
- GeneID:   3833612
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1304
- NMPDR:   fig|1085.1.peg.3062
- eggNOG:   COG2987
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   RRUB269796:RRU_A1304-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60224; Mature: 60093

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 411-411

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRLDNQRVVRAPRGPEITCKSWLSEAPLRMLMNNLDPEVAEKPEELVVYGGIGRAARN
CCCCCCCCCEEECCCCCCCHHHHHHHHCHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCC
WQCYDQIVAALKRLEDDETLLVQSGKAVGVFKTHRDAPRVLIANSNLVPHWATWETFHAL
CHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHH
DRAGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRRHYGGSLAGRWILTGGLGGMGGA
HHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAATMAGASMLAVECQPSRIEARLRTGYLDRQTADLDQALAWIAEAGAPGAKPVSVGL
CHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEE
LGNAAEVFPELVKRGVRPDLVTDQTSAHDPLNGYLPAGWSLERWERGRERAPAEVIAAAK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
ASMATQVRAMLAFHAQGIPTVDYGNNIRQRALEEGVSDAFAFPGFVPAYIRPLFCRGIGP
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
FRWAALSGDPEDIYRTDAKVKELIPDDPHLHTWLDMARERIHFQGLPSRICWVGLGDRHR
CEEEECCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCE
LGLAFNAMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTA
ECEEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
GGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEDAARRIGRVLWNDPATGVMRHADAGYDD
CCCEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCH
AIACAREKGLDLPFLG
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDRLDNQRVVRAPRGPEITCKSWLSEAPLRMLMNNLDPEVAEKPEELVVYGGIGRAARN
CCCCCCCCEEECCCCCCCHHHHHHHHCHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCC
WQCYDQIVAALKRLEDDETLLVQSGKAVGVFKTHRDAPRVLIANSNLVPHWATWETFHAL
CHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHH
DRAGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRRHYGGSLAGRWILTGGLGGMGGA
HHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAATMAGASMLAVECQPSRIEARLRTGYLDRQTADLDQALAWIAEAGAPGAKPVSVGL
CHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEE
LGNAAEVFPELVKRGVRPDLVTDQTSAHDPLNGYLPAGWSLERWERGRERAPAEVIAAAK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
ASMATQVRAMLAFHAQGIPTVDYGNNIRQRALEEGVSDAFAFPGFVPAYIRPLFCRGIGP
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
FRWAALSGDPEDIYRTDAKVKELIPDDPHLHTWLDMARERIHFQGLPSRICWVGLGDRHR
CEEEECCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCE
LGLAFNAMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTA
ECEEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
GGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEDAARRIGRVLWNDPATGVMRHADAGYDD
CCCEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCH
AIACAREKGLDLPFLG
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA