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The map label for this gene is alkK [H]

Identifier: 83592652

GI number: 83592652

Start: 1552600

End: 1554240

Strand: Direct

Name: alkK [H]

Synonym: Rru_A1316

Alternate gene names: 83592652

Gene position: 1552600-1554240 (Clockwise)

Preceding gene: 83592640

Following gene: 83592653

Centisome position: 35.67

GC content: 67.58

Gene sequence:

>1641_bases
ATGATATCCGCGACGATGATGACCACGCCGCTTCTTCTCTCCGGCGTGATCGAGCACGCGGCGCGCTGCCATGGCGAAAC
CGAGGTGGTTTCGCGCCGGGACGACGGAACCCTGCACCGCCAAACCTACGCCGACACCGCGTCGCGGGCCCGTCGTCTGG
CCCGGGCCCTGATCGAGCTGGGGGCGGCGCCCGGCGATGCCATCGGCACCCTGGCTTGGAACGGCAACCGCCATCTGGAA
CTCTATTACGGTGTTCCGGGGGCGGGGATGGTTTGCCACACCATCAATCCCCGGCTGTTCGCCGAGCAGATCGCCTTTAT
CATCAAAGACGCCGGCGACCGCTTTTTGTTCGTCGATCCCGGCTTCCTCGGCTTGCTTGCGGGGATTTTGCCCGATCTTC
CCGCCCTTGAAGCGGTGGTGGTGATGGACGATCACGCCCCCGCGGCCGAGCTTGCCGGGGTTCGCCTGCTGGCTTACGAG
GAGGTACTGGCCGCCCAGACCGATGACGCCTTCGACTGGCCGTCGTTCGATGAAAACGCCGCGGCGGGCATCTGTTACAC
CTCGGGCACCACGGGCAACCCCAAGGGGGTCGTCTATTCCCACCGGTCGACCATCTTGCATGCGCTCAGCGCCGTGCAGC
CCGATGTCTTCGCCCTGTCGGCCCGGGATACGGTGATGCCGGTGGTGCCGATGTTCCATGTCAACGCCTGGGGGATGCCC
CATGCGGCGCCGATGGTCGGGGCCAAGCTGGTGCTGCCCGGTGGACGGCTTGATGGCGCCAGCCTGATCGAGCTGATTCG
CGGCGAACAGGTGACCGCCACCGCCGGGGTGCCGACGGTCTGGCAGGGGCTGCTCGGCCACGTCGAGGCCAAGGGCGGCG
GATTGGCGCCGCTGGACCGGGTGGTGATCGGCGGGGCGGCCTGTCCGCAGAGCATGATGAGCCGGTTCGCCGCCTTGGGA
ACCCGGGCGATCCACGCCTGGGGGATGACCGAGACCAGCCCGCTGTGCGTCGCCAGCGTTTTGACGGCGCGCCACCGTGA
CCTGGGCGAGGACGAGGCCCTGCGCCTGCGCCTCAAGCAGGGGCGGCCGGCCTTCGGGGCGGAGTTGCGCATCGTCGACC
ATGCCGGTCGGGCCTTGCCCTGGGATGGGGTGACGCGCGGCATGCTCGAGGTGCGCGGCCCGTGGATCTGCGCGGGCTAT
CTCAACAATCCCGACCGCACCGCTTTTTCCGCCGATGGCTGGTTCGCCACCGGTGACGTGGCGACGATCACCACCGACGG
CTTCATGGACATCGTCGATCGCACCAAGGACGTCATCAAATCGGGTGGCGAATGGATCAGTTCGATCGCCCTGGAAAACA
TCGCCATCGGCCATCCGGCGGTGCGTGAGGTCGCCGCCATCGCCCGCCCCGATGCGCGCTGGGGCGAGCGTCCCCGCTTG
ATCGTCGCCCTGCGCGAGGGCGCGACGCTGACCCCGGGCGAAATGGCGGCGTGGTTCGAGGGCAAGGTGGCGAAATGGTG
GATCCCCGATGATTTGGTGATCGTGGAAACCCTGCCCCATACGGCGACCGGCAAACTTCAAAAGCGCGAGCTGCGCCAAG
TCTATGGCGCCGAGCGGCTGGAAAGCGCCCAAGCCCTATAG

Upstream 100 bases:

>100_bases
ATTCTTGGGAGCCGGCGCCTTGGTTTTCCCTTGATAAGACGCCGCCGCCCGGAGCGGAAAACCCGACCGGGGATGAAAAA
ACAATTGGGAGGATCGATAG

Downstream 100 bases:

>100_bases
AATATCATTCTAGATAAAAATATTAGACAGAAATTCTAAAAATTCCCCCGGTCCAACCCGGGGCAAGGCCGGCGACAAGG
CCTGGAACAAGGGAGGAGAC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MISATMMTTPLLLSGVIEHAARCHGETEVVSRRDDGTLHRQTYADTASRARRLARALIELGAAPGDAIGTLAWNGNRHLE
LYYGVPGAGMVCHTINPRLFAEQIAFIIKDAGDRFLFVDPGFLGLLAGILPDLPALEAVVVMDDHAPAAELAGVRLLAYE
EVLAAQTDDAFDWPSFDENAAAGICYTSGTTGNPKGVVYSHRSTILHALSAVQPDVFALSARDTVMPVVPMFHVNAWGMP
HAAPMVGAKLVLPGGRLDGASLIELIRGEQVTATAGVPTVWQGLLGHVEAKGGGLAPLDRVVIGGAACPQSMMSRFAALG
TRAIHAWGMTETSPLCVASVLTARHRDLGEDEALRLRLKQGRPAFGAELRIVDHAGRALPWDGVTRGMLEVRGPWICAGY
LNNPDRTAFSADGWFATGDVATITTDGFMDIVDRTKDVIKSGGEWISSIALENIAIGHPAVREVAAIARPDARWGERPRL
IVALREGATLTPGEMAAWFEGKVAKWWIPDDLVIVETLPHTATGKLQKRELRQVYGAERLESAQAL

Sequences:

>Translated_546_residues
MISATMMTTPLLLSGVIEHAARCHGETEVVSRRDDGTLHRQTYADTASRARRLARALIELGAAPGDAIGTLAWNGNRHLE
LYYGVPGAGMVCHTINPRLFAEQIAFIIKDAGDRFLFVDPGFLGLLAGILPDLPALEAVVVMDDHAPAAELAGVRLLAYE
EVLAAQTDDAFDWPSFDENAAAGICYTSGTTGNPKGVVYSHRSTILHALSAVQPDVFALSARDTVMPVVPMFHVNAWGMP
HAAPMVGAKLVLPGGRLDGASLIELIRGEQVTATAGVPTVWQGLLGHVEAKGGGLAPLDRVVIGGAACPQSMMSRFAALG
TRAIHAWGMTETSPLCVASVLTARHRDLGEDEALRLRLKQGRPAFGAELRIVDHAGRALPWDGVTRGMLEVRGPWICAGY
LNNPDRTAFSADGWFATGDVATITTDGFMDIVDRTKDVIKSGGEWISSIALENIAIGHPAVREVAAIARPDARWGERPRL
IVALREGATLTPGEMAAWFEGKVAKWWIPDDLVIVETLPHTATGKLQKRELRQVYGAERLESAQAL
>Mature_546_residues
MISATMMTTPLLLSGVIEHAARCHGETEVVSRRDDGTLHRQTYADTASRARRLARALIELGAAPGDAIGTLAWNGNRHLE
LYYGVPGAGMVCHTINPRLFAEQIAFIIKDAGDRFLFVDPGFLGLLAGILPDLPALEAVVVMDDHAPAAELAGVRLLAYE
EVLAAQTDDAFDWPSFDENAAAGICYTSGTTGNPKGVVYSHRSTILHALSAVQPDVFALSARDTVMPVVPMFHVNAWGMP
HAAPMVGAKLVLPGGRLDGASLIELIRGEQVTATAGVPTVWQGLLGHVEAKGGGLAPLDRVVIGGAACPQSMMSRFAALG
TRAIHAWGMTETSPLCVASVLTARHRDLGEDEALRLRLKQGRPAFGAELRIVDHAGRALPWDGVTRGMLEVRGPWICAGY
LNNPDRTAFSADGWFATGDVATITTDGFMDIVDRTKDVIKSGGEWISSIALENIAIGHPAVREVAAIARPDARWGERPRL
IVALREGATLTPGEMAAWFEGKVAKWWIPDDLVIVETLPHTATGKLQKRELRQVYGAERLESAQAL

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=528, Percent_Identity=27.8409090909091, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI187761345, Length=538, Percent_Identity=26.5799256505576, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI187761343, Length=538, Percent_Identity=26.5799256505576, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI58082049, Length=375, Percent_Identity=25.3333333333333, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI38505220, Length=362, Percent_Identity=26.2430939226519, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI157311624, Length=369, Percent_Identity=26.5582655826558, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI157311622, Length=369, Percent_Identity=26.5582655826558, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI42544132, Length=370, Percent_Identity=25.1351351351351, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI28416953, Length=564, Percent_Identity=22.6950354609929, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI57165412, Length=485, Percent_Identity=23.2989690721649, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI57165410, Length=492, Percent_Identity=23.5772357723577, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI122937307, Length=272, Percent_Identity=25.7352941176471, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI145693145, Length=357, Percent_Identity=31.3725490196078, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=25.5859375, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788107, Length=517, Percent_Identity=24.9516441005803, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1786810, Length=386, Percent_Identity=29.0155440414508, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1789201, Length=365, Percent_Identity=26.3013698630137, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790505, Length=548, Percent_Identity=22.6277372262774, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788595, Length=493, Percent_Identity=22.5152129817444, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786801, Length=378, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994703, Length=539, Percent_Identity=28.3858998144712, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994694, Length=539, Percent_Identity=28.3858998144712, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994690, Length=539, Percent_Identity=28.3858998144712, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17560308, Length=535, Percent_Identity=26.9158878504673, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17559526, Length=440, Percent_Identity=25.9090909090909, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17558820, Length=513, Percent_Identity=24.5614035087719, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=518, Percent_Identity=23.5521235521236, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=515, Percent_Identity=23.1067961165049, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=503, Percent_Identity=25.6461232604374, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17560140, Length=517, Percent_Identity=22.2437137330754, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=367, Percent_Identity=24.7956403269755, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71996755, Length=505, Percent_Identity=21.7821782178218, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319699, Length=499, Percent_Identity=23.4468937875752, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323903, Length=506, Percent_Identity=22.5296442687747, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320852, Length=351, Percent_Identity=25.0712250712251, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581924, Length=557, Percent_Identity=26.9299820466786, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI18859661, Length=475, Percent_Identity=26.5263157894737, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21355181, Length=496, Percent_Identity=22.7822580645161, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656500, Length=499, Percent_Identity=23.4468937875752, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653035, Length=503, Percent_Identity=22.0675944333996, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648257, Length=481, Percent_Identity=21.8295218295218, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI161076582, Length=513, Percent_Identity=21.8323586744639, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356441, Length=500, Percent_Identity=21.8, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130357, Length=365, Percent_Identity=23.8356164383562, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24648260, Length=503, Percent_Identity=23.0616302186879, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356947, Length=513, Percent_Identity=23.0019493177388, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358303, Length=477, Percent_Identity=20.9643605870021, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI62472339, Length=386, Percent_Identity=23.3160621761658, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667959, Length=386, Percent_Identity=23.3160621761658, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24667955, Length=383, Percent_Identity=23.2375979112272, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 58487; Mature: 58487

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISATMMTTPLLLSGVIEHAARCHGETEVVSRRDDGTLHRQTYADTASRARRLARALIEL
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GAAPGDAIGTLAWNGNRHLELYYGVPGAGMVCHTINPRLFAEQIAFIIKDAGDRFLFVDP
CCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEECC
GFLGLLAGILPDLPALEAVVVMDDHAPAAELAGVRLLAYEEVLAAQTDDAFDWPSFDENA
CHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCCC
AAGICYTSGTTGNPKGVVYSHRSTILHALSAVQPDVFALSARDTVMPVVPMFHVNAWGMP
CCEEEEECCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCC
HAAPMVGAKLVLPGGRLDGASLIELIRGEQVTATAGVPTVWQGLLGHVEAKGGGLAPLDR
CCCHHCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHCEECCCCCCCCHHH
VVIGGAACPQSMMSRFAALGTRAIHAWGMTETSPLCVASVLTARHRDLGEDEALRLRLKQ
HEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHEECC
GRPAFGAELRIVDHAGRALPWDGVTRGMLEVRGPWICAGYLNNPDRTAFSADGWFATGDV
CCCCCCCEEEEEECCCCCCCCCHHHHHHHEECCCEEEEECCCCCCCCEEECCCCEEECCE
ATITTDGFMDIVDRTKDVIKSGGEWISSIALENIAIGHPAVREVAAIARPDARWGERPRL
EEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCEE
IVALREGATLTPGEMAAWFEGKVAKWWIPDDLVIVETLPHTATGKLQKRELRQVYGAERL
EEEEECCCCCCCCHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCHHHH
ESAQAL
HHHCCC
>Mature Secondary Structure
MISATMMTTPLLLSGVIEHAARCHGETEVVSRRDDGTLHRQTYADTASRARRLARALIEL
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GAAPGDAIGTLAWNGNRHLELYYGVPGAGMVCHTINPRLFAEQIAFIIKDAGDRFLFVDP
CCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEECC
GFLGLLAGILPDLPALEAVVVMDDHAPAAELAGVRLLAYEEVLAAQTDDAFDWPSFDENA
CHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCCC
AAGICYTSGTTGNPKGVVYSHRSTILHALSAVQPDVFALSARDTVMPVVPMFHVNAWGMP
CCEEEEECCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCC
HAAPMVGAKLVLPGGRLDGASLIELIRGEQVTATAGVPTVWQGLLGHVEAKGGGLAPLDR
CCCHHCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHCEECCCCCCCCHHH
VVIGGAACPQSMMSRFAALGTRAIHAWGMTETSPLCVASVLTARHRDLGEDEALRLRLKQ
HEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHEECC
GRPAFGAELRIVDHAGRALPWDGVTRGMLEVRGPWICAGYLNNPDRTAFSADGWFATGDV
CCCCCCCEEEEEECCCCCCCCCHHHHHHHEECCCEEEEECCCCCCCCEEECCCCEEECCE
ATITTDGFMDIVDRTKDVIKSGGEWISSIALENIAIGHPAVREVAAIARPDARWGERPRL
EEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCCCCCEE
IVALREGATLTPGEMAAWFEGKVAKWWIPDDLVIVETLPHTATGKLQKRELRQVYGAERL
EEEEECCCCCCCCHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCHHHH
ESAQAL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]