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The map label for this gene is proA

Identifier: 83592574

GI number: 83592574

Start: 1460671

End: 1461954

Strand: Reverse

Name: proA

Synonym: Rru_A1238

Alternate gene names: 83592574

Gene position: 1461954-1460671 (Counterclockwise)

Preceding gene: 83592575

Following gene: 83592573

Centisome position: 33.59

GC content: 69.24

Gene sequence:

>1284_bases
GTGAACGACGCCGCACGCCTGACCACCGATGATATTCCGGGGCTGATGATCGACATCGGCCGCCGGGCCCGCGCCGCCGG
CCGCATCCTGGCCCTGGCGCCCGCCGCCGCCCGCAACGCCGCCCTGCTGGCCGGCGCGGCGGCCCTGCGCGCCGAGGCCG
GGGCCATCGCCTTGGAAAACGCCAAGGACATGAGCGCCGGCCGGGCCAAGGGCCTGACCGACGCCCTGCTCGACCGCCTG
GAACTGACTCCGGCGCGGATCGAGGCGATGGCCAAGGGCCTGGAAGACATCGCCGCCCTGCCCGATCCCGTCGGCACGGT
ACTGGCCGGATGGCAGCGGCCCAATGGCCTGCGCATCGAGCGCGTCAGGGTGCCGATCGGGGTGATCGGCGTTATCTATG
AGAGCCGGCCCAATGTCACCGCCGATGCCGGGGCGCTGTGCTTGAAGGCCGGCAACGCGGCGATCCTGCGCGGCGGCTCG
GAAAGCTTCAATTCCTCGCGCGCCATCCACCGCTGTCTGGCCGCCGGACTGCGGGCGGCCGGCCTGCCCGAGGACGCCAT
CCAAAGCGTTCCCACCCCCGACCGCGCCGCCGTCGGCATGCTGCTGACCATGACCGATTTCATCGATGTCATCGTGCCGC
GCGGCGGAAAATCACTGATCGAACGGGTGAGCGCCGAAAGCAAGGTGCCGCTGTTCAAGCACCTCGAAGGCCTCTGCCAC
ACCTATATCCATGCCAAGGCCGATCCGCAAAAGGCCTTGAGTGTCACGGTGAACGCCAAGATGCGGCGCACCGGGGTCTG
CGGCTCGACCGAAACCATCCTGGTCGACCGGGCGATCGCCGCCACGATCCTGCCGCCGCTGCTCGACGCCCTGGCCAAGG
CCGGCTGCGCCCTGCGCGGCGACGAGGAGACCCGCGCCTTCTCCGAGCGGGTCGGTCCGGCCACCGCCGAGGACTGGGAC
ACCGAATACCTGGACGCCATCGTCTCGATCCGCGTCGTGGCCGATCTCGACGAGGCCCTGGCCCATATCGCCGCCCATTC
CAGCGATCACACCGATTGCATCCTGACCGAGGACGCCGCCGCCGCCGAGCGCTTCCTGACCGAGGTCGACAGCGCCATCG
TCATGCACAACGCCTCGACCCAATTCGCCGATGGTGGCGAATTCGGCATGGGGGCCGAGATCGGCATCAGCACCGGCCGC
CTGCATGCCCGGGGACCGGTCGGCGTCGAGCAACTGACCATCTTCAAATACAAGGTTCGCGGCACCGGCCAAACCAGACC
ATGA

Upstream 100 bases:

>100_bases
TGCTGGGATACCGTGGGCGCGAGGAACTGATCCACCGCGATGATCTGGTGCTCGACAGCCGCTTCCGGCACCGCGACGAG
GACGGGGAAGGACACCGATC

Downstream 100 bases:

>100_bases
CGGTCGCCCCATGAAGGTCAGGTCGTGACGGCGCGCCGCGGGGAACCCGCCCTGGGCAAGGCCCAGGCCCCCTCGCCCTG
GGGCGATGGCCGACGCTCGC

Product: glutamate-5-semialdehyde dehydrogenase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNDAARLTTDDIPGLMIDIGRRARAAGRILALAPAAARNAALLAGAAALRAEAGAIALENAKDMSAGRAKGLTDALLDRL
ELTPARIEAMAKGLEDIAALPDPVGTVLAGWQRPNGLRIERVRVPIGVIGVIYESRPNVTADAGALCLKAGNAAILRGGS
ESFNSSRAIHRCLAAGLRAAGLPEDAIQSVPTPDRAAVGMLLTMTDFIDVIVPRGGKSLIERVSAESKVPLFKHLEGLCH
TYIHAKADPQKALSVTVNAKMRRTGVCGSTETILVDRAIAATILPPLLDALAKAGCALRGDEETRAFSERVGPATAEDWD
TEYLDAIVSIRVVADLDEALAHIAAHSSDHTDCILTEDAAAAERFLTEVDSAIVMHNASTQFADGGEFGMGAEIGISTGR
LHARGPVGVEQLTIFKYKVRGTGQTRP

Sequences:

>Translated_427_residues
MNDAARLTTDDIPGLMIDIGRRARAAGRILALAPAAARNAALLAGAAALRAEAGAIALENAKDMSAGRAKGLTDALLDRL
ELTPARIEAMAKGLEDIAALPDPVGTVLAGWQRPNGLRIERVRVPIGVIGVIYESRPNVTADAGALCLKAGNAAILRGGS
ESFNSSRAIHRCLAAGLRAAGLPEDAIQSVPTPDRAAVGMLLTMTDFIDVIVPRGGKSLIERVSAESKVPLFKHLEGLCH
TYIHAKADPQKALSVTVNAKMRRTGVCGSTETILVDRAIAATILPPLLDALAKAGCALRGDEETRAFSERVGPATAEDWD
TEYLDAIVSIRVVADLDEALAHIAAHSSDHTDCILTEDAAAAERFLTEVDSAIVMHNASTQFADGGEFGMGAEIGISTGR
LHARGPVGVEQLTIFKYKVRGTGQTRP
>Mature_427_residues
MNDAARLTTDDIPGLMIDIGRRARAAGRILALAPAAARNAALLAGAAALRAEAGAIALENAKDMSAGRAKGLTDALLDRL
ELTPARIEAMAKGLEDIAALPDPVGTVLAGWQRPNGLRIERVRVPIGVIGVIYESRPNVTADAGALCLKAGNAAILRGGS
ESFNSSRAIHRCLAAGLRAAGLPEDAIQSVPTPDRAAVGMLLTMTDFIDVIVPRGGKSLIERVSAESKVPLFKHLEGLCH
TYIHAKADPQKALSVTVNAKMRRTGVCGSTETILVDRAIAATILPPLLDALAKAGCALRGDEETRAFSERVGPATAEDWD
TEYLDAIVSIRVVADLDEALAHIAAHSSDHTDCILTEDAAAAERFLTEVDSAIVMHNASTQFADGGEFGMGAEIGISTGR
LHARGPVGVEQLTIFKYKVRGTGQTRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=405, Percent_Identity=37.037037037037, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI62912457, Length=405, Percent_Identity=37.037037037037, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=43.1372549019608, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=38.4057971014493, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=38.4057971014493, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=37.0023419203747, Blast_Score=276, Evalue=5e-75,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=37.8378378378378, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_RHORT (Q2RV06)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426326.1
- ProteinModelPortal:   Q2RV06
- SMR:   Q2RV06
- STRING:   Q2RV06
- GeneID:   3833736
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1238
- NMPDR:   fig|1085.1.peg.3128
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   Q2RV06
- BioCyc:   RRUB269796:RRU_A1238-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44759; Mature: 44759

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDAARLTTDDIPGLMIDIGRRARAAGRILALAPAAARNAALLAGAAALRAEAGAIALEN
CCCCCCCCCCCCCCCEECCCHHHHHHCCEEEECCCHHCCHHHHHHHHHHHHCCCEEEECC
AKDMSAGRAKGLTDALLDRLELTPARIEAMAKGLEDIAALPDPVGTVLAGWQRPNGLRIE
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEE
RVRVPIGVIGVIYESRPNVTADAGALCLKAGNAAILRGGSESFNSSRAIHRCLAAGLRAA
EEECCEEEEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCC
GLPEDAIQSVPTPDRAAVGMLLTMTDFIDVIVPRGGKSLIERVSAESKVPLFKHLEGLCH
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
TYIHAKADPQKALSVTVNAKMRRTGVCGSTETILVDRAIAATILPPLLDALAKAGCALRG
HHHHCCCCCCCEEEEEEECHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DEETRAFSERVGPATAEDWDTEYLDAIVSIRVVADLDEALAHIAAHSSDHTDCILTEDAA
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
AAERFLTEVDSAIVMHNASTQFADGGEFGMGAEIGISTGRLHARGPVGVEQLTIFKYKVR
HHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCEECCCCCCEECCCCCCHHEEEEEEEEEC
GTGQTRP
CCCCCCC
>Mature Secondary Structure
MNDAARLTTDDIPGLMIDIGRRARAAGRILALAPAAARNAALLAGAAALRAEAGAIALEN
CCCCCCCCCCCCCCCEECCCHHHHHHCCEEEECCCHHCCHHHHHHHHHHHHCCCEEEECC
AKDMSAGRAKGLTDALLDRLELTPARIEAMAKGLEDIAALPDPVGTVLAGWQRPNGLRIE
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEE
RVRVPIGVIGVIYESRPNVTADAGALCLKAGNAAILRGGSESFNSSRAIHRCLAAGLRAA
EEECCEEEEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCC
GLPEDAIQSVPTPDRAAVGMLLTMTDFIDVIVPRGGKSLIERVSAESKVPLFKHLEGLCH
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
TYIHAKADPQKALSVTVNAKMRRTGVCGSTETILVDRAIAATILPPLLDALAKAGCALRG
HHHHCCCCCCCEEEEEEECHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
DEETRAFSERVGPATAEDWDTEYLDAIVSIRVVADLDEALAHIAAHSSDHTDCILTEDAA
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
AAERFLTEVDSAIVMHNASTQFADGGEFGMGAEIGISTGRLHARGPVGVEQLTIFKYKVR
HHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCEECCCCCCEECCCCCCHHEEEEEEEEEC
GTGQTRP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA