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The map label for this gene is hemA [H]

Identifier: 83592482

GI number: 83592482

Start: 1352865

End: 1354130

Strand: Direct

Name: hemA [H]

Synonym: Rru_A1146

Alternate gene names: 83592482

Gene position: 1352865-1354130 (Clockwise)

Preceding gene: 83592481

Following gene: 83592483

Centisome position: 31.08

GC content: 63.11

Gene sequence:

>1266_bases
ATGACCCTGTTCAATTATCAAGATTTCTTCACCAATGAGCTGACGCAGTTACACCGGGAGGGACGCTATCGCGTTTTCGC
CGACCTTGAACGGGAAACGCGGAGCGGCATTCACGCGCTCGATCATCGGACCGGCAAGCGCGTCACCATCTGGTGCTCGA
ACGACTATCTGTCGATGGGCGTCCACCCCGATGTCATTACCGCGGCGCTTGGCGCGTTAGAACACTATGGCGCCGGCGCC
GGCGGCACGCGCAATATCTCGGGCACCAGCCACGAACATGTCTTGCTCGAACGCGAGCTTGCCGACCTGCACGGCAAGCA
ATCGGCCTTGCTGTTCACATCGGGCTATGTCGCGAACGATGCCGCGCTGTCGTCCCTCGGCCGCCTTCTGCCCGGCTGCG
TGATCTTTTCCGACGCTTTGAACCATGCCTCGATGATCGAGGGCATTCGCCGCTCGGGCGCGGAGAAGCGGGTGTTCGCC
CACAACGACTGGCATGATCTTGAACGCCAACTCGCCTCCGTTGACCCCCATCGGCCCAAGCTGATCTGCTTTGAGAGCTG
TTATTCCATGGATGGCGACTTCGCGCCGATGGAGGCGATCTGCGACCTCGCCGAAAAGCACACTGCGTTCACCTATGTCG
ATGAAGTTCATGCCGTCGGCCTTTACGGCGCGCGGGGTGCCGGCATCGCCGAGCGGGATGGTCTTCTCGATCGCATCGAC
ATGTTTCAAGGGACGCTCAGCAAGGGCTTCGGCGCAATGGGCGGCTACATCGCCGGCAGCCTCGAGGCGGTCGATTTCGT
TCGCGGTTTCGCGCCCGGCTTCATTTTCAGCTCGGCCTTGCCGCCCTGCGTCGTCGCCGGCATTCGTGCCGCCCTGCATC
ACCTGAAGGAAGACGATACGCCCCGGCGGGCCCTGGCGAGGCGAACGGCCTCGCTCAAGGCGAAGATGCAGGCGAACGCC
ATCCCGGCTCTGCCCAGCCCCAGTCATATCGTGCCGGTGATGATCGGCGATGCGGCGCTGGCCAAAGCGATAACCGACCG
GCTCATGGTCGAGCATGGGATCTATATTCAGCCGATCAACTACCCGACCGTGCCGCGCGGGACCGAACGGCTGCGCATCA
CGCCAACCCCGCTTCATACCGATGAGGACGAGGACACCCTTGTCGCGGCGCTCGTCGCGATCCGTCAGGAATTCCCGCGT
TGGCGAGAACTGGCACAGGCGGCGCGACCCGACCCTTCCGCCCTGGGCAGGGGGGACGTAGCATGA

Upstream 100 bases:

>100_bases
TGCTTGACGTTCTTCAACAGACCATGGCGGCGGGCGAACACGAAATGCAGCTCGCCAGAGCCATCACAACCCTTGGCCCC
GCCTGCAAGGAGACTTCACA

Downstream 100 bases:

>100_bases
GCGATGCGCTTCTTCCGGTGTTTTCACCGGCATCCGTGCTGTTCGACCATGGCGAAGGGGCTTGGTTGGTCGCGGCCAAT
GGCGAGCGCTATCTTGATTT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTLFNYQDFFTNELTQLHREGRYRVFADLERETRSGIHALDHRTGKRVTIWCSNDYLSMGVHPDVITAALGALEHYGAGA
GGTRNISGTSHEHVLLERELADLHGKQSALLFTSGYVANDAALSSLGRLLPGCVIFSDALNHASMIEGIRRSGAEKRVFA
HNDWHDLERQLASVDPHRPKLICFESCYSMDGDFAPMEAICDLAEKHTAFTYVDEVHAVGLYGARGAGIAERDGLLDRID
MFQGTLSKGFGAMGGYIAGSLEAVDFVRGFAPGFIFSSALPPCVVAGIRAALHHLKEDDTPRRALARRTASLKAKMQANA
IPALPSPSHIVPVMIGDAALAKAITDRLMVEHGIYIQPINYPTVPRGTERLRITPTPLHTDEDEDTLVAALVAIRQEFPR
WRELAQAARPDPSALGRGDVA

Sequences:

>Translated_421_residues
MTLFNYQDFFTNELTQLHREGRYRVFADLERETRSGIHALDHRTGKRVTIWCSNDYLSMGVHPDVITAALGALEHYGAGA
GGTRNISGTSHEHVLLERELADLHGKQSALLFTSGYVANDAALSSLGRLLPGCVIFSDALNHASMIEGIRRSGAEKRVFA
HNDWHDLERQLASVDPHRPKLICFESCYSMDGDFAPMEAICDLAEKHTAFTYVDEVHAVGLYGARGAGIAERDGLLDRID
MFQGTLSKGFGAMGGYIAGSLEAVDFVRGFAPGFIFSSALPPCVVAGIRAALHHLKEDDTPRRALARRTASLKAKMQANA
IPALPSPSHIVPVMIGDAALAKAITDRLMVEHGIYIQPINYPTVPRGTERLRITPTPLHTDEDEDTLVAALVAIRQEFPR
WRELAQAARPDPSALGRGDVA
>Mature_420_residues
TLFNYQDFFTNELTQLHREGRYRVFADLERETRSGIHALDHRTGKRVTIWCSNDYLSMGVHPDVITAALGALEHYGAGAG
GTRNISGTSHEHVLLERELADLHGKQSALLFTSGYVANDAALSSLGRLLPGCVIFSDALNHASMIEGIRRSGAEKRVFAH
NDWHDLERQLASVDPHRPKLICFESCYSMDGDFAPMEAICDLAEKHTAFTYVDEVHAVGLYGARGAGIAERDGLLDRIDM
FQGTLSKGFGAMGGYIAGSLEAVDFVRGFAPGFIFSSALPPCVVAGIRAALHHLKEDDTPRRALARRTASLKAKMQANAI
PALPSPSHIVPVMIGDAALAKAITDRLMVEHGIYIQPINYPTVPRGTERLRITPTPLHTDEDEDTLVAALVAIRQEFPRW
RELAQAARPDPSALGRGDVA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=396, Percent_Identity=48.7373737373737, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI83977440, Length=396, Percent_Identity=48.7373737373737, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI83977444, Length=396, Percent_Identity=48.7373737373737, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI4502025, Length=420, Percent_Identity=46.4285714285714, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI40316939, Length=420, Percent_Identity=46.4285714285714, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI284448556, Length=359, Percent_Identity=38.4401114206128, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI7657118, Length=363, Percent_Identity=37.7410468319559, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4758668, Length=336, Percent_Identity=31.547619047619, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI119220554, Length=415, Percent_Identity=29.3975903614458, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI5454084, Length=255, Percent_Identity=28.2352941176471, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1790046, Length=396, Percent_Identity=34.3434343434343, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=35.1906158357771, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=403, Percent_Identity=34.2431761786601, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI32566772, Length=348, Percent_Identity=30.7471264367816, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=337, Percent_Identity=30.8605341246291, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17560912, Length=337, Percent_Identity=30.8605341246291, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71982617, Length=284, Percent_Identity=25.3521126760563, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=284, Percent_Identity=25.3521126760563, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=424, Percent_Identity=46.6981132075472, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320267, Length=338, Percent_Identity=28.9940828402367, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=272, Percent_Identity=26.1029411764706, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17137420, Length=397, Percent_Identity=48.8664987405542, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24662918, Length=351, Percent_Identity=36.4672364672365, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17136286, Length=325, Percent_Identity=30.7692307692308, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653280, Length=329, Percent_Identity=25.8358662613982, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653276, Length=329, Percent_Identity=25.8358662613982, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653278, Length=329, Percent_Identity=25.8358662613982, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46000; Mature: 45869

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFNYQDFFTNELTQLHREGRYRVFADLERETRSGIHALDHRTGKRVTIWCSNDYLSMG
CCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECC
VHPDVITAALGALEHYGAGAGGTRNISGTSHEHVLLERELADLHGKQSALLFTSGYVAND
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCH
AALSSLGRLLPGCVIFSDALNHASMIEGIRRSGAEKRVFAHNDWHDLERQLASVDPHRPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCCCCC
LICFESCYSMDGDFAPMEAICDLAEKHTAFTYVDEVHAVGLYGARGAGIAERDGLLDRID
EEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHH
MFQGTLSKGFGAMGGYIAGSLEAVDFVRGFAPGFIFSSALPPCVVAGIRAALHHLKEDDT
HHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCC
PRRALARRTASLKAKMQANAIPALPSPSHIVPVMIGDAALAKAITDRLMVEHGIYIQPIN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEECC
YPTVPRGTERLRITPTPLHTDEDEDTLVAALVAIRQEFPRWRELAQAARPDPSALGRGDV
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHCCCCCC
A
C
>Mature Secondary Structure 
TLFNYQDFFTNELTQLHREGRYRVFADLERETRSGIHALDHRTGKRVTIWCSNDYLSMG
CCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECC
VHPDVITAALGALEHYGAGAGGTRNISGTSHEHVLLERELADLHGKQSALLFTSGYVAND
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCH
AALSSLGRLLPGCVIFSDALNHASMIEGIRRSGAEKRVFAHNDWHDLERQLASVDPHRPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCCCCC
LICFESCYSMDGDFAPMEAICDLAEKHTAFTYVDEVHAVGLYGARGAGIAERDGLLDRID
EEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHH
MFQGTLSKGFGAMGGYIAGSLEAVDFVRGFAPGFIFSSALPPCVVAGIRAALHHLKEDDT
HHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCC
PRRALARRTASLKAKMQANAIPALPSPSHIVPVMIGDAALAKAITDRLMVEHGIYIQPIN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEECC
YPTVPRGTERLRITPTPLHTDEDEDTLVAALVAIRQEFPRWRELAQAARPDPSALGRGDV
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]