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The map label for this gene is cvrA [H]

Identifier: 83592415

GI number: 83592415

Start: 1270423

End: 1272255

Strand: Reverse

Name: cvrA [H]

Synonym: Rru_A1079

Alternate gene names: 83592415

Gene position: 1272255-1270423 (Counterclockwise)

Preceding gene: 83592416

Following gene: 83592413

Centisome position: 29.23

GC content: 67.54

Gene sequence:

>1833_bases
ATGGAAATGGACACGATGTTCCTGGCCATTCTGATCGGCGCCGGGCTCATCGGGATTTCGGTGGTCACCAGCCTGATTTC
CTTTCGCGTGGGAGCGCCGCTGCTGCTGGTGTTCCTCGGCGTCGGCCTGTTGGCCGGCCAGGATGGCATCGGCGGCATCG
TCTTCAACGATAGTGGCACCGCCTATTTCATCGGCTCGCTGGCTTTGGCCGTCATCTTGTTTGACAGCGGCTTTTCCACC
CGACTCCAAACCTTTCGGCTGGCCGCCGCCCCCTCCATCGTGCTCGCCACCCTCGGCGTGGCGCTGACCACGGCGCTGGT
CGCCATTCCCAGCCACTCCCTGCTCGGCCTCAGTTGGGAGGAATCGGCGTTGATGGGGGCGGTCGTCGGATCGACCGACG
CGGCGGCCGTCTTCTTTTTGCTGCGCGTCGGCGGCATCTTGATCCGCGACCGGGTGCGCGCCACCCTCGAGGTCGAATCG
AGCACCAACGACCCGATGGCGATCTTTCTGACGATCACCCTGGTTGAACTGGCCTCGGCGGGGGGCTTTTCCGGCGAGGC
CCTGTCGTGGGGCCTGGGGCTCGCCTTCGTGCGCCAGATGGGGCTGGGACTGCTCTGCGGCTGGATCGGCGGCCATCTTC
TGGTGGTGGGCATCAACCGCCTGCGCCTGGAACCGGCGCTTTACCCCATTCTCGGGCTGGCGCTCGCCCTGTTCCTGTTC
GCCGCCGTCTCGATGGTCGACGGCAGCGGCTTCCTGGCCATCTATGTCGCGGGCATGGTCATGGGCAATCGCAAGATGCG
CGGCGGCCCGGCCCTGCGCCGCTTCCAGGAGGCGCTCACCTGGCTGGCCCAGATGACGATGTTCCTGACCCTTGGCCTGT
TCGCCAGCCCGTCGACCTTTATCGACGTCGCCCTGCCCTCGGTGCTGATCGGCTTGTTCCTGGTCTTCGTCGCCCGGCCG
GTGGCCGTCTGGCTCTGCCTGCTGCCCTTTGGCTATGATCGCAACGAAACCGCCTTCGTCGCCTGGGTCGGCCTGCGCGG
CGCGGTGTCGATCCTGCTGGCCATCTTGCCGATCGCCGCCGGACTTGAACACGCCCAGGAGATGTTCAACGCCGCCTTCA
TCGTCGTCGTCACCTCGCTGTTGCTCCAGGGCTGGACCATCCGGCCGATGGCGCGCTGGCTGGGGCTGGTGGTGCCGCCC
CGGTTGGGGCCGGTTGATAAGGTCGAATTGCAACTGCCCTATGGCGGCGACCATGAACTGCTGGTCTACCGCATCGCCAA
GGGCAGCCCGGTGGCCGAGGGCGAGCGCATTCCGCGCTGGGCCCGTCCGTCGCTGGTGGTGCGCGACGGCCGGTCGATGA
AGGTGCTCGATTCCGGCCGGCCCCAGCCCGGCGACCATGTCTATATCTTCTCGGCGCCCCGCCATGGGGCCCTGCTCGAC
CGGCTGTTCGCCCGCCCGACGGCGCTCAGTCCGGCCGACGAGGCCTATTTCGGCGATTTCTCCCTTGATGCCAGCCGTAC
CATGGGCGAACTCGCCACCCTTTACGGCATCAAGGTTCCCGAGGGCGCCCAGGATACCGCCGTCGGCGAATGGCTGACCC
AGCGCCTGGGCGGCGCCCCGGCGCGCGGCGATCGCGTGGTCTTGCCGCCGATCGAGATCATCGTGCGCGAGATGGACAAC
AGCACCGATGTCATCCGCACCATCGGCCTGTCGCTTGATCCGGGCGAGGGCCGGCCGCGCCGGGTGCCGATGTTCCACAA
CGCCCGCGACATCATCGGCAGCGTCCGCGACTGGCGCGCCGCCCGCCGCCGCTTCGCCGCCAAAAACAGCTGA

Upstream 100 bases:

>100_bases
AGACTCGACTTTTGAGACGACGACGCCCTTTCGGGTGGTGGCACGCCGTGGGCGCCGCCCTTAAGGCCGACTCGCCGCCC
GCGACTTCCGTGGAGGACGT

Downstream 100 bases:

>100_bases
CCGGGGTTCAGGGATCGGCGACCGGCGCCCAGAGGACATCGTCGATGGCGTCGGCCCCGGTGCACAGCATGACCAGCCGG
TCGAAGCCCAGGGCGATGCC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MEMDTMFLAILIGAGLIGISVVTSLISFRVGAPLLLVFLGVGLLAGQDGIGGIVFNDSGTAYFIGSLALAVILFDSGFST
RLQTFRLAAAPSIVLATLGVALTTALVAIPSHSLLGLSWEESALMGAVVGSTDAAAVFFLLRVGGILIRDRVRATLEVES
STNDPMAIFLTITLVELASAGGFSGEALSWGLGLAFVRQMGLGLLCGWIGGHLLVVGINRLRLEPALYPILGLALALFLF
AAVSMVDGSGFLAIYVAGMVMGNRKMRGGPALRRFQEALTWLAQMTMFLTLGLFASPSTFIDVALPSVLIGLFLVFVARP
VAVWLCLLPFGYDRNETAFVAWVGLRGAVSILLAILPIAAGLEHAQEMFNAAFIVVVTSLLLQGWTIRPMARWLGLVVPP
RLGPVDKVELQLPYGGDHELLVYRIAKGSPVAEGERIPRWARPSLVVRDGRSMKVLDSGRPQPGDHVYIFSAPRHGALLD
RLFARPTALSPADEAYFGDFSLDASRTMGELATLYGIKVPEGAQDTAVGEWLTQRLGGAPARGDRVVLPPIEIIVREMDN
STDVIRTIGLSLDPGEGRPRRVPMFHNARDIIGSVRDWRAARRRFAAKNS

Sequences:

>Translated_610_residues
MEMDTMFLAILIGAGLIGISVVTSLISFRVGAPLLLVFLGVGLLAGQDGIGGIVFNDSGTAYFIGSLALAVILFDSGFST
RLQTFRLAAAPSIVLATLGVALTTALVAIPSHSLLGLSWEESALMGAVVGSTDAAAVFFLLRVGGILIRDRVRATLEVES
STNDPMAIFLTITLVELASAGGFSGEALSWGLGLAFVRQMGLGLLCGWIGGHLLVVGINRLRLEPALYPILGLALALFLF
AAVSMVDGSGFLAIYVAGMVMGNRKMRGGPALRRFQEALTWLAQMTMFLTLGLFASPSTFIDVALPSVLIGLFLVFVARP
VAVWLCLLPFGYDRNETAFVAWVGLRGAVSILLAILPIAAGLEHAQEMFNAAFIVVVTSLLLQGWTIRPMARWLGLVVPP
RLGPVDKVELQLPYGGDHELLVYRIAKGSPVAEGERIPRWARPSLVVRDGRSMKVLDSGRPQPGDHVYIFSAPRHGALLD
RLFARPTALSPADEAYFGDFSLDASRTMGELATLYGIKVPEGAQDTAVGEWLTQRLGGAPARGDRVVLPPIEIIVREMDN
STDVIRTIGLSLDPGEGRPRRVPMFHNARDIIGSVRDWRAARRRFAAKNS
>Mature_610_residues
MEMDTMFLAILIGAGLIGISVVTSLISFRVGAPLLLVFLGVGLLAGQDGIGGIVFNDSGTAYFIGSLALAVILFDSGFST
RLQTFRLAAAPSIVLATLGVALTTALVAIPSHSLLGLSWEESALMGAVVGSTDAAAVFFLLRVGGILIRDRVRATLEVES
STNDPMAIFLTITLVELASAGGFSGEALSWGLGLAFVRQMGLGLLCGWIGGHLLVVGINRLRLEPALYPILGLALALFLF
AAVSMVDGSGFLAIYVAGMVMGNRKMRGGPALRRFQEALTWLAQMTMFLTLGLFASPSTFIDVALPSVLIGLFLVFVARP
VAVWLCLLPFGYDRNETAFVAWVGLRGAVSILLAILPIAAGLEHAQEMFNAAFIVVVTSLLLQGWTIRPMARWLGLVVPP
RLGPVDKVELQLPYGGDHELLVYRIAKGSPVAEGERIPRWARPSLVVRDGRSMKVLDSGRPQPGDHVYIFSAPRHGALLD
RLFARPTALSPADEAYFGDFSLDASRTMGELATLYGIKVPEGAQDTAVGEWLTQRLGGAPARGDRVVLPPIEIIVREMDN
STDVIRTIGLSLDPGEGRPRRVPMFHNARDIIGSVRDWRAARRRFAAKNS

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=570, Percent_Identity=39.1228070175439, Blast_Score=325, Evalue=7e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 65310; Mature: 65310

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMDTMFLAILIGAGLIGISVVTSLISFRVGAPLLLVFLGVGLLAGQDGIGGIVFNDSGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCCC
AYFIGSLALAVILFDSGFSTRLQTFRLAAAPSIVLATLGVALTTALVAIPSHSLLGLSWE
EEHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCC
ESALMGAVVGSTDAAAVFFLLRVGGILIRDRVRATLEVESSTNDPMAIFLTITLVELASA
HHHHHHHHCCCCHHHHHHHHHHHCCHHEECCCEEEEEEECCCCCCEEEHHHHHHHHHHHC
GGFSGEALSWGLGLAFVRQMGLGLLCGWIGGHLLVVGINRLRLEPALYPILGLALALFLF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHEECHHHHHHHHHHHHHHHH
AAVSMVDGSGFLAIYVAGMVMGNRKMRGGPALRRFQEALTWLAQMTMFLTLGLFASPSTF
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IDVALPSVLIGLFLVFVARPVAVWLCLLPFGYDRNETAFVAWVGLRGAVSILLAILPIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
GLEHAQEMFNAAFIVVVTSLLLQGWTIRPMARWLGLVVPPRLGPVDKVELQLPYGGDHEL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCEECCCCCCCCCCEEEECCCCCCCCE
LVYRIAKGSPVAEGERIPRWARPSLVVRDGRSMKVLDSGRPQPGDHVYIFSAPRHGALLD
EEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEEEEECCCCHHHHH
RLFARPTALSPADEAYFGDFSLDASRTMGELATLYGIKVPEGAQDTAVGEWLTQRLGGAP
HHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
ARGDRVVLPPIEIIVREMDNSTDVIRTIGLSLDPGEGRPRRVPMFHNARDIIGSVRDWRA
CCCCEEECCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ARRRFAAKNS
HHHHHHCCCC
>Mature Secondary Structure
MEMDTMFLAILIGAGLIGISVVTSLISFRVGAPLLLVFLGVGLLAGQDGIGGIVFNDSGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCCC
AYFIGSLALAVILFDSGFSTRLQTFRLAAAPSIVLATLGVALTTALVAIPSHSLLGLSWE
EEHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCC
ESALMGAVVGSTDAAAVFFLLRVGGILIRDRVRATLEVESSTNDPMAIFLTITLVELASA
HHHHHHHHCCCCHHHHHHHHHHHCCHHEECCCEEEEEEECCCCCCEEEHHHHHHHHHHHC
GGFSGEALSWGLGLAFVRQMGLGLLCGWIGGHLLVVGINRLRLEPALYPILGLALALFLF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHEECHHHHHHHHHHHHHHHH
AAVSMVDGSGFLAIYVAGMVMGNRKMRGGPALRRFQEALTWLAQMTMFLTLGLFASPSTF
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IDVALPSVLIGLFLVFVARPVAVWLCLLPFGYDRNETAFVAWVGLRGAVSILLAILPIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
GLEHAQEMFNAAFIVVVTSLLLQGWTIRPMARWLGLVVPPRLGPVDKVELQLPYGGDHEL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCEECCCCCCCCCCEEEECCCCCCCCE
LVYRIAKGSPVAEGERIPRWARPSLVVRDGRSMKVLDSGRPQPGDHVYIFSAPRHGALLD
EEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEEEEECCCCHHHHH
RLFARPTALSPADEAYFGDFSLDASRTMGELATLYGIKVPEGAQDTAVGEWLTQRLGGAP
HHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
ARGDRVVLPPIEIIVREMDNSTDVIRTIGLSLDPGEGRPRRVPMFHNARDIIGSVRDWRA
CCCCEEECCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ARRRFAAKNS
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]