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The map label for this gene is penA [H]

Identifier: 83592292

GI number: 83592292

Start: 1141416

End: 1143215

Strand: Reverse

Name: penA [H]

Synonym: Rru_A0956

Alternate gene names: 83592292

Gene position: 1143215-1141416 (Counterclockwise)

Preceding gene: 83592293

Following gene: 83592291

Centisome position: 26.26

GC content: 65.56

Gene sequence:

>1800_bases
ATGATCGCCCTGCTCAAAAATCGGCGGGAAAAACGCTTCGTCTATCCGGGGGCGGAAATCCGCTTCGACCGCACGGCCGA
GCGGGGCCGGGGAGCCGATCTGGAAGGCGTCGTCCACCAGGGCATTGAAACCGGCCGCATGCGGCTGATGGTCGCGGCCT
GCCTGTTCGGTTTGGCCTTTTCGGTGATCGGCGGCCGGCTGGTGCAGTTGATGGTCGTGCGCGGTCCGGGCGAGCCGGTG
GCGGTGGTCTCGGCCGAGGACACGCCGATCGAAACCCGCATGGCCCGCGCCGACATCGTCGATCGCAATGGTCTGGTGCT
GGCGACCAATCTGCCCACGGTCAATCTTTACGCCGATACCCGCGCCATCCCCGAGCGCGACCGCCTGCGCGCCATCGCCG
TTCTGCCCACCCTGTTCCCGGAACTGACGGTGGCCGATCTGACGAACAAGATGGTTCCCGGCCGCGCCTTCATCTATCTG
CGCCGCAACCTCACGCCGTCGGAACAGCAATCGGTCAACGACCTGGGAATCCCGGGGCTGCATTTCGAACGCTCCGAGCG
CCGGGTCTATCCGGCCGGCCGCTTGGTCGCCCATGTCGTCGGCGCCACCGATGTCGATAACAACGGCATCGCCGGTCTGG
AAAAGGCCTTCGAAAGCAAGCTGACGAGTTCGGACCTGCCGCTGCGGCTGTCGCTTGACATCCGGGTGCAGCACGCCATT
CACCGCGCCCTGCAAGACAGCATCGACCATTTCCAGGCGATCGGCGGCGCCGCCCTGGTGATGGATGTCGAGACCGCCGA
GGTGGTGGCGATGGTATCGCTGCCCGACTACGAACCCGAAAAGATCGGCGCGGCCAGCGAGGACGCCCGCTTCAACCGGG
CGACGCTCGGCGTGTTCGAAATGGGCTCGACTTTCAAGCTGTTCAACACGGCCCTGGCGCTCGATGCCGGCCTGAAGCTG
TCGGAAAGCTTCGACGCCCGCAATCCGATCCGCATTTCGCGCTTCACCATCACCGATTTCCATCCCGAGGGACGCTGGCT
CAGCATCCCCGAAATCCTGATGTATTCCTCCAACCTGGGCTCGGCGCGCATGGCGGTGGCGGTGGGAACCGACCGCCAGC
GCGAGTTCCTGGGGCGGATGGGGCTGCTTGACGCCATCCCCTTCGAGATCCCCGAGGTCGGCCGGCCGCTGGTTCCCAAT
CCGTGGCGCGAAGTCAGCACCATGACCATCTCGTTTGGTCACGGGCTGTCGGTCACCCCCTTGCATCTGGTCACCGGCGT
TTCCGCCCTGGTCAATGGCGGCCTGCTCCGTCCGCCGACGCTGCTGCTGCGCAGCCCCGAGACCACCCCGGCGGGCAAGC
AGGTTCTCACCACGCAAAACAGCACGGCCATGCGCGCCCTGATGCGTCTGGTGGTCGAAGCCGGGTCGGGCAAGAACGCC
GACGTCAAAGGTTATTACATCGGCGGCAAGACCGGCTCGGCCGAAAAGGAGGGGGCGAGCGGCGGCTATTCCAAAAGCGC
CGTCCGTACCTCGTTCGTCGGCGTCTTTCCGATGACCAAGCCGCGCTACGTGGTGATGGCGATGCTTGATGATCCCAAGG
CGGTCAAGGGCACCTATGGCTATCGGACCGCCGGGTGGAACGCCACGCCGACGGTCGGCCGCATGATTGCCGAAATCGCC
CCGCTTCTTGGAGTGCAACCCGTGCGCGGCGATCCCGCCGTTCAGTTCGGTCCCCAGCTTGTCCAGCAGGTGGGCCTGCG
TTTTGCCGAGCCCGAAGGGGGACGCGGTGTATCTCGATGA

Upstream 100 bases:

>100_bases
CGGGACAGGCCCGCGCCGCCGGCGGCGGCCGGGTCACCGTCACCCCCGTGCCCACGGTCAAACCGATCCTGACCAAGCTT
GCCAAAGCGGGCGGCGGGCA

Downstream 100 bases:

>100_bases
TCTGATCGGCGCCGTTCCGGCGCGGGCCGCCCTGGGCGGCCACCCTGGCCTGGGCGGCCATCCTGGTTTGGCGATCGCCG
GGCTGACGGCCGATTCCCGG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MIALLKNRREKRFVYPGAEIRFDRTAERGRGADLEGVVHQGIETGRMRLMVAACLFGLAFSVIGGRLVQLMVVRGPGEPV
AVVSAEDTPIETRMARADIVDRNGLVLATNLPTVNLYADTRAIPERDRLRAIAVLPTLFPELTVADLTNKMVPGRAFIYL
RRNLTPSEQQSVNDLGIPGLHFERSERRVYPAGRLVAHVVGATDVDNNGIAGLEKAFESKLTSSDLPLRLSLDIRVQHAI
HRALQDSIDHFQAIGGAALVMDVETAEVVAMVSLPDYEPEKIGAASEDARFNRATLGVFEMGSTFKLFNTALALDAGLKL
SESFDARNPIRISRFTITDFHPEGRWLSIPEILMYSSNLGSARMAVAVGTDRQREFLGRMGLLDAIPFEIPEVGRPLVPN
PWREVSTMTISFGHGLSVTPLHLVTGVSALVNGGLLRPPTLLLRSPETTPAGKQVLTTQNSTAMRALMRLVVEAGSGKNA
DVKGYYIGGKTGSAEKEGASGGYSKSAVRTSFVGVFPMTKPRYVVMAMLDDPKAVKGTYGYRTAGWNATPTVGRMIAEIA
PLLGVQPVRGDPAVQFGPQLVQQVGLRFAEPEGGRGVSR

Sequences:

>Translated_599_residues
MIALLKNRREKRFVYPGAEIRFDRTAERGRGADLEGVVHQGIETGRMRLMVAACLFGLAFSVIGGRLVQLMVVRGPGEPV
AVVSAEDTPIETRMARADIVDRNGLVLATNLPTVNLYADTRAIPERDRLRAIAVLPTLFPELTVADLTNKMVPGRAFIYL
RRNLTPSEQQSVNDLGIPGLHFERSERRVYPAGRLVAHVVGATDVDNNGIAGLEKAFESKLTSSDLPLRLSLDIRVQHAI
HRALQDSIDHFQAIGGAALVMDVETAEVVAMVSLPDYEPEKIGAASEDARFNRATLGVFEMGSTFKLFNTALALDAGLKL
SESFDARNPIRISRFTITDFHPEGRWLSIPEILMYSSNLGSARMAVAVGTDRQREFLGRMGLLDAIPFEIPEVGRPLVPN
PWREVSTMTISFGHGLSVTPLHLVTGVSALVNGGLLRPPTLLLRSPETTPAGKQVLTTQNSTAMRALMRLVVEAGSGKNA
DVKGYYIGGKTGSAEKEGASGGYSKSAVRTSFVGVFPMTKPRYVVMAMLDDPKAVKGTYGYRTAGWNATPTVGRMIAEIA
PLLGVQPVRGDPAVQFGPQLVQQVGLRFAEPEGGRGVSR
>Mature_599_residues
MIALLKNRREKRFVYPGAEIRFDRTAERGRGADLEGVVHQGIETGRMRLMVAACLFGLAFSVIGGRLVQLMVVRGPGEPV
AVVSAEDTPIETRMARADIVDRNGLVLATNLPTVNLYADTRAIPERDRLRAIAVLPTLFPELTVADLTNKMVPGRAFIYL
RRNLTPSEQQSVNDLGIPGLHFERSERRVYPAGRLVAHVVGATDVDNNGIAGLEKAFESKLTSSDLPLRLSLDIRVQHAI
HRALQDSIDHFQAIGGAALVMDVETAEVVAMVSLPDYEPEKIGAASEDARFNRATLGVFEMGSTFKLFNTALALDAGLKL
SESFDARNPIRISRFTITDFHPEGRWLSIPEILMYSSNLGSARMAVAVGTDRQREFLGRMGLLDAIPFEIPEVGRPLVPN
PWREVSTMTISFGHGLSVTPLHLVTGVSALVNGGLLRPPTLLLRSPETTPAGKQVLTTQNSTAMRALMRLVVEAGSGKNA
DVKGYYIGGKTGSAEKEGASGGYSKSAVRTSFVGVFPMTKPRYVVMAMLDDPKAVKGTYGYRTAGWNATPTVGRMIAEIA
PLLGVQPVRGDPAVQFGPQLVQQVGLRFAEPEGGRGVSR

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=566, Percent_Identity=29.1519434628975, Blast_Score=207, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64874; Mature: 64874

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALLKNRREKRFVYPGAEIRFDRTAERGRGADLEGVVHQGIETGRMRLMVAACLFGLAF
CCCCCCCCCCCEEECCCCCEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
SVIGGRLVQLMVVRGPGEPVAVVSAEDTPIETRMARADIVDRNGLVLATNLPTVNLYADT
HHHHHHEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHEECCCCEEEEECCCEEEEEECC
RAIPERDRLRAIAVLPTLFPELTVADLTNKMVPGRAFIYLRRNLTPSEQQSVNDLGIPGL
CCCCCHHHHEEEHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHCHHHCCCCCC
HFERSERRVYPAGRLVAHVVGATDVDNNGIAGLEKAFESKLTSSDLPLRLSLDIRVQHAI
EEECCCCEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEHHHHHH
HRALQDSIDHFQAIGGAALVMDVETAEVVAMVSLPDYEPEKIGAASEDARFNRATLGVFE
HHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECCCCCHHHCCCCCCCCCCCCEEEEEEE
MGSTFKLFNTALALDAGLKLSESFDARNPIRISRFTITDFHPEGRWLSIPEILMYSSNLG
CCCHHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEEEEEECCCCCEECCCHHEEECCCCC
SARMAVAVGTDRQREFLGRMGLLDAIPFEIPEVGRPLVPNPWREVSTMTISFGHGLSVTP
CCEEEEEECCCHHHHHHHHHCCHHCCCCCCHHCCCCCCCCCCCCCEEEEEEECCCCCCCH
LHLVTGVSALVNGGLLRPPTLLLRSPETTPAGKQVLTTQNSTAMRALMRLVVEAGSGKNA
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCC
DVKGYYIGGKTGSAEKEGASGGYSKSAVRTSFVGVFPMTKPRYVVMAMLDDPKAVKGTYG
CEEEEEECCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCEEEEEEECCCCCCCCCCC
YRTAGWNATPTVGRMIAEIAPLLGVQPVRGDPAVQFGPQLVQQVGLRFAEPEGGRGVSR
CEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCHHHHHHHCCEECCCCCCCCCCC
>Mature Secondary Structure
MIALLKNRREKRFVYPGAEIRFDRTAERGRGADLEGVVHQGIETGRMRLMVAACLFGLAF
CCCCCCCCCCCEEECCCCCEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
SVIGGRLVQLMVVRGPGEPVAVVSAEDTPIETRMARADIVDRNGLVLATNLPTVNLYADT
HHHHHHEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHEECCCCEEEEECCCEEEEEECC
RAIPERDRLRAIAVLPTLFPELTVADLTNKMVPGRAFIYLRRNLTPSEQQSVNDLGIPGL
CCCCCHHHHEEEHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHCHHHCCCCCC
HFERSERRVYPAGRLVAHVVGATDVDNNGIAGLEKAFESKLTSSDLPLRLSLDIRVQHAI
EEECCCCEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEHHHHHH
HRALQDSIDHFQAIGGAALVMDVETAEVVAMVSLPDYEPEKIGAASEDARFNRATLGVFE
HHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECCCCCHHHCCCCCCCCCCCCEEEEEEE
MGSTFKLFNTALALDAGLKLSESFDARNPIRISRFTITDFHPEGRWLSIPEILMYSSNLG
CCCHHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEEEEEECCCCCEECCCHHEEECCCCC
SARMAVAVGTDRQREFLGRMGLLDAIPFEIPEVGRPLVPNPWREVSTMTISFGHGLSVTP
CCEEEEEECCCHHHHHHHHHCCHHCCCCCCHHCCCCCCCCCCCCCEEEEEEECCCCCCCH
LHLVTGVSALVNGGLLRPPTLLLRSPETTPAGKQVLTTQNSTAMRALMRLVVEAGSGKNA
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCC
DVKGYYIGGKTGSAEKEGASGGYSKSAVRTSFVGVFPMTKPRYVVMAMLDDPKAVKGTYG
CEEEEEECCCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCEEEEEEECCCCCCCCCCC
YRTAGWNATPTVGRMIAEIAPLLGVQPVRGDPAVQFGPQLVQQVGLRFAEPEGGRGVSR
CEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCHHHHHHHCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]