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The map label for this gene is lysC [H]

Identifier: 83592082

GI number: 83592082

Start: 868663

End: 869883

Strand: Direct

Name: lysC [H]

Synonym: Rru_A0743

Alternate gene names: 83592082

Gene position: 868663-869883 (Clockwise)

Preceding gene: 83592079

Following gene: 83592083

Centisome position: 19.96

GC content: 62.24

Gene sequence:

>1221_bases
ATGGCGCGCATCGTGATGAAATTCGGCGGAACCTCCGTCGGCGACGTGGATCGTATCCGCAACGTCGCCCGGCGGGTCAA
GGCCGAGGTTGACGCCGGCAATGAGGTGGCGGTGGTGGTCTCGGCCATGTCGGGAGAGACCAATCGTCTGGTCGGCTTCT
GCGATTCCATGACCAACATGTACGACGCGCGGGAATATGATGCCGTGGTCGCCACCGGGGAACAGGTGACCATCGGGCTT
CTGGCCATCGCCTTGCAAGATATCGGCGTCGAGGCGCGGTCGTGGATGGGCTGGCAGATCCCGATCCATACGGACGAGGC
CCACGGCAAGGCCCGCATCCTGTCGATCGACACCACCGTGCTCGAACAGCGTCTGGCCAGCGGTCAGGTGGCGGTGGTCG
CCGGTTTCCAGGGGCTGGGACCGAATAATCGCGTGACCACCCTGGGCCGTGGCGGCTCCGATACCTCGGCCGTCGCCCTG
GCCGCGGCGCTGAAGGCCGATCGTTGCGATATCTACACCGATGTCGACGGCGTCTATACGACCGATCCGCGGATTGTGCC
CAAGGCGCGGAAGCTTGACAGAATTACCTATGAGGAGATGCTGGAGCAGGCATCCTTGGGGGCCAAGGTCCTTCAGACCC
GGTCGGTGGAAATGGCCATGAAGCACCGGGTTCGGGTCCGTGTGCTGTCAAGCTTCAGCGATGCGCCCGGAACCCTGGTA
TGCGACGAGGATGAGATCGTGGAAAAGGAATTGGTAAGCGGCATTGCTTATAGTCGCGATGAGGCCAAGATCACTCTGGT
CAAGGTTTCCGACCGGCCGGGCGTGGCGGCGCGGATCTTCGGGCCCTTGGCCGACGCCAATATCAATGTCGATATGATCG
TGCAGAACGTGTCCGAGGACGGTCATTCGACCGATCTCACCTTTACCTTGCCGCGCAGCGATCTCGCCCGCGCCCTCAAG
GTTCTGGAAGGGGCGCGCGACGATATCAACTATCGCGAACTGACGACCAGCAGCGCCGTGGTCAAGGTTTCGGTCATCGG
CGTCGGCATGCGCAGCCATGCCGGGGTCGCCCAGACGATGTTCCGGGCCCTTTCCGAAAAAGGCATCAATATCCATGTGA
TCTCCACCTCGGAGATCAAGGTGTCGGTGCTGATCGCCGAGGAATACATGGAACTCGCGGTACGCGCGCTGCACTCCGCC
TATGGGCTGGATGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGGCCCCGCGGTGTCGGACGCGTGGCGCCGGGGGCGAGGCGCGGTCCGCGGCAGTTTCCGCGCGCTCGACTGGACCTGA
TACGAGGAAGGCAGCACGCC

Downstream 100 bases:

>100_bases
GGCGGAGCGGAACGATGAAGGACGCGGCGATGAACGGGTGGGCGGAAGAACGGCTGGACGAGCTTTGGGCCCGTGGCCGC
GCCTTCCTGGGCTGCGATAC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MARIVMKFGGTSVGDVDRIRNVARRVKAEVDAGNEVAVVVSAMSGETNRLVGFCDSMTNMYDAREYDAVVATGEQVTIGL
LAIALQDIGVEARSWMGWQIPIHTDEAHGKARILSIDTTVLEQRLASGQVAVVAGFQGLGPNNRVTTLGRGGSDTSAVAL
AAALKADRCDIYTDVDGVYTTDPRIVPKARKLDRITYEEMLEQASLGAKVLQTRSVEMAMKHRVRVRVLSSFSDAPGTLV
CDEDEIVEKELVSGIAYSRDEAKITLVKVSDRPGVAARIFGPLADANINVDMIVQNVSEDGHSTDLTFTLPRSDLARALK
VLEGARDDINYRELTTSSAVVKVSVIGVGMRSHAGVAQTMFRALSEKGINIHVISTSEIKVSVLIAEEYMELAVRALHSA
YGLDAA

Sequences:

>Translated_406_residues
MARIVMKFGGTSVGDVDRIRNVARRVKAEVDAGNEVAVVVSAMSGETNRLVGFCDSMTNMYDAREYDAVVATGEQVTIGL
LAIALQDIGVEARSWMGWQIPIHTDEAHGKARILSIDTTVLEQRLASGQVAVVAGFQGLGPNNRVTTLGRGGSDTSAVAL
AAALKADRCDIYTDVDGVYTTDPRIVPKARKLDRITYEEMLEQASLGAKVLQTRSVEMAMKHRVRVRVLSSFSDAPGTLV
CDEDEIVEKELVSGIAYSRDEAKITLVKVSDRPGVAARIFGPLADANINVDMIVQNVSEDGHSTDLTFTLPRSDLARALK
VLEGARDDINYRELTTSSAVVKVSVIGVGMRSHAGVAQTMFRALSEKGINIHVISTSEIKVSVLIAEEYMELAVRALHSA
YGLDAA
>Mature_405_residues
ARIVMKFGGTSVGDVDRIRNVARRVKAEVDAGNEVAVVVSAMSGETNRLVGFCDSMTNMYDAREYDAVVATGEQVTIGLL
AIALQDIGVEARSWMGWQIPIHTDEAHGKARILSIDTTVLEQRLASGQVAVVAGFQGLGPNNRVTTLGRGGSDTSAVALA
AALKADRCDIYTDVDGVYTTDPRIVPKARKLDRITYEEMLEQASLGAKVLQTRSVEMAMKHRVRVRVLSSFSDAPGTLVC
DEDEIVEKELVSGIAYSRDEAKITLVKVSDRPGVAARIFGPLADANINVDMIVQNVSEDGHSTDLTFTLPRSDLARALKV
LEGARDDINYRELTTSSAVVKVSVIGVGMRSHAGVAQTMFRALSEKGINIHVISTSEIKVSVLIAEEYMELAVRALHSAY
GLDAA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=474, Percent_Identity=29.957805907173, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1790455, Length=465, Percent_Identity=30.3225806451613, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790376, Length=239, Percent_Identity=27.6150627615063, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=369, Percent_Identity=25.2032520325203, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43708; Mature: 43577

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVMKFGGTSVGDVDRIRNVARRVKAEVDAGNEVAVVVSAMSGETNRLVGFCDSMTNM
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEHHHHHHHH
YDAREYDAVVATGEQVTIGLLAIALQDIGVEARSWMGWQIPIHTDEAHGKARILSIDTTV
HCCHHCCEEEECCCCHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCEEEEEEHHHH
LEQRLASGQVAVVAGFQGLGPNNRVTTLGRGGSDTSAVALAAALKADRCDIYTDVDGVYT
HHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEECCCCEEE
TDPRIVPKARKLDRITYEEMLEQASLGAKVLQTRSVEMAMKHRVRVRVLSSFSDAPGTLV
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEE
CDEDEIVEKELVSGIAYSRDEAKITLVKVSDRPGVAARIFGPLADANINVDMIVQNVSED
ECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEECCCC
GHSTDLTFTLPRSDLARALKVLEGARDDINYRELTTSSAVVKVSVIGVGMRSHAGVAQTM
CCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHEEECCCEEEEEEEEEECCCCCCCHHHHH
FRALSEKGINIHVISTSEIKVSVLIAEEYMELAVRALHSAYGLDAA
HHHHHHCCCEEEEEEECCEEEEEEEHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ARIVMKFGGTSVGDVDRIRNVARRVKAEVDAGNEVAVVVSAMSGETNRLVGFCDSMTNM
CEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEHHHHHHHH
YDAREYDAVVATGEQVTIGLLAIALQDIGVEARSWMGWQIPIHTDEAHGKARILSIDTTV
HCCHHCCEEEECCCCHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCCEEEEEEHHHH
LEQRLASGQVAVVAGFQGLGPNNRVTTLGRGGSDTSAVALAAALKADRCDIYTDVDGVYT
HHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEECCCCEEE
TDPRIVPKARKLDRITYEEMLEQASLGAKVLQTRSVEMAMKHRVRVRVLSSFSDAPGTLV
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEE
CDEDEIVEKELVSGIAYSRDEAKITLVKVSDRPGVAARIFGPLADANINVDMIVQNVSED
ECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEECCCC
GHSTDLTFTLPRSDLARALKVLEGARDDINYRELTTSSAVVKVSVIGVGMRSHAGVAQTM
CCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHEEECCCEEEEEEEEEECCCCCCCHHHHH
FRALSEKGINIHVISTSEIKVSVLIAEEYMELAVRALHSAYGLDAA
HHHHHHCCCEEEEEEECCEEEEEEEHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]