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The map label for this gene is cynR [H]

Identifier: 83592025

GI number: 83592025

Start: 810066

End: 810950

Strand: Direct

Name: cynR [H]

Synonym: Rru_A0686

Alternate gene names: 83592025

Gene position: 810066-810950 (Clockwise)

Preceding gene: 83592023

Following gene: 83592026

Centisome position: 18.61

GC content: 73.56

Gene sequence:

>885_bases
ATGCGGTTCGATCTGATCGATCTGGCGCTGTTCGTTCATGTCGTCGAGGCGGGCAGCCTGACCGCCGGGGCCGGGCGGGC
CCATCTGGCGCTGGCTTCGGCCAGCGCGCGGATCAAGGGCATGGAGGACCTGCTTGGCGCGGCGCTGCTCGAGCGCGGCC
GACGCGGCGTCAGCCCGACCCCGGCCGGGCGCATGGTGCTCCACCACGCCCGCGTGGTGCTGGACCAGATGGAGCGGCTG
CGCGGCGATCTTGGCGGATTTTCCCGGGGCTGGCGCGGGGTGGTGCGGCTGGCGGCCAATACGGCGGCCGTGACCGGGGC
TTTGGCCGATGACCTGGGGCCGTTCCTGCGCGACCAGCCGCTGATCGATGTTGATCTCAGCGAACGCACCAGCGCCCGCA
TCATCGCCGCCCTGGCTGAAGGCGCGGTCGATCTGGGGATCGTGTCGGACGCGGTCGAGGCGGGCGGCCTCCAGGCCCGG
CCCTATCGCCGCGACCGGCTGGTGGTGGTGATGGCGCCCGACCATCCTTTGGCCGCTTGCGCGGAGTTGTCCTTCGCCCG
GGTCCTGGCCGAGGACGGGGTGGGGCTGGGCGAGGGGGCCGCCCTGCAGGACTATCTGGAGCGTCAGGCCCGGCGCCTTG
GCCTCAGCCCCCGGCTGCGGGTGCGGCTGCGCGGCTTCGAGGCGGTCTGCCGCTTGGTCGCCCAGGGGATCGGTCTGGCG
GTGATCCCCGAAGACGCCGCCCGGCGGGCGGGAGCGGCGGTGGCACAGGTGCCTTTGGCCGAGCCCTGGGCGACCCGGGT
GCTGCTGGTCCGCGCCCGCGATTTCGCGACGCTCGCCCCCCCGGCCCGCCGGCTTGCCGATCATCTTGCTCCGCCCTTCC
CTTGA

Upstream 100 bases:

>100_bases
AGATCGAGCGGGTCCATGGCCCATCCTTGACCGCTTTTCCCAAGGCCCGCAATGTGGGATTTGCGAAGAATGGCTTCGTC
TTATCCGAAGGCACAAGCCG

Downstream 100 bases:

>100_bases
CGCTGGGGGGATCGACCCTTAGCCTTTGAGCCTGCCGCTCCGGCCCGGGCCGGGGCATATCGTTCCTTGTGCGGGACCCT
CCCTGATGACCGGACCAGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRFDLIDLALFVHVVEAGSLTAGAGRAHLALASASARIKGMEDLLGAALLERGRRGVSPTPAGRMVLHHARVVLDQMERL
RGDLGGFSRGWRGVVRLAANTAAVTGALADDLGPFLRDQPLIDVDLSERTSARIIAALAEGAVDLGIVSDAVEAGGLQAR
PYRRDRLVVVMAPDHPLAACAELSFARVLAEDGVGLGEGAALQDYLERQARRLGLSPRLRVRLRGFEAVCRLVAQGIGLA
VIPEDAARRAGAAVAQVPLAEPWATRVLLVRARDFATLAPPARRLADHLAPPFP

Sequences:

>Translated_294_residues
MRFDLIDLALFVHVVEAGSLTAGAGRAHLALASASARIKGMEDLLGAALLERGRRGVSPTPAGRMVLHHARVVLDQMERL
RGDLGGFSRGWRGVVRLAANTAAVTGALADDLGPFLRDQPLIDVDLSERTSARIIAALAEGAVDLGIVSDAVEAGGLQAR
PYRRDRLVVVMAPDHPLAACAELSFARVLAEDGVGLGEGAALQDYLERQARRLGLSPRLRVRLRGFEAVCRLVAQGIGLA
VIPEDAARRAGAAVAQVPLAEPWATRVLLVRARDFATLAPPARRLADHLAPPFP
>Mature_294_residues
MRFDLIDLALFVHVVEAGSLTAGAGRAHLALASASARIKGMEDLLGAALLERGRRGVSPTPAGRMVLHHARVVLDQMERL
RGDLGGFSRGWRGVVRLAANTAAVTGALADDLGPFLRDQPLIDVDLSERTSARIIAALAEGAVDLGIVSDAVEAGGLQAR
PYRRDRLVVVMAPDHPLAACAELSFARVLAEDGVGLGEGAALQDYLERQARRLGLSPRLRVRLRGFEAVCRLVAQGIGLA
VIPEDAARRAGAAVAQVPLAEPWATRVLLVRARDFATLAPPARRLADHLAPPFP

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=292, Percent_Identity=26.3698630136986, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693105, Length=286, Percent_Identity=25.1748251748252, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI157672245, Length=280, Percent_Identity=26.7857142857143, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI2367136, Length=261, Percent_Identity=26.0536398467433, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788297, Length=293, Percent_Identity=26.962457337884, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87081904, Length=202, Percent_Identity=31.6831683168317, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=24.8979591836735, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787530, Length=236, Percent_Identity=25.4237288135593, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786401, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787806, Length=263, Percent_Identity=22.0532319391635, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790399, Length=269, Percent_Identity=24.1635687732342, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788481, Length=302, Percent_Identity=25.1655629139073, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789639, Length=256, Percent_Identity=26.953125, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31168; Mature: 31168

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLIDLALFVHVVEAGSLTAGAGRAHLALASASARIKGMEDLLGAALLERGRRGVSPT
CCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
PAGRMVLHHARVVLDQMERLRGDLGGFSRGWRGVVRLAANTAAVTGALADDLGPFLRDQP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LIDVDLSERTSARIIAALAEGAVDLGIVSDAVEAGGLQARPYRRDRLVVVMAPDHPLAAC
CEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHH
AELSFARVLAEDGVGLGEGAALQDYLERQARRLGLSPRLRVRLRGFEAVCRLVAQGIGLA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEE
VIPEDAARRAGAAVAQVPLAEPWATRVLLVRARDFATLAPPARRLADHLAPPFP
EECCHHHHHHCCHHHCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MRFDLIDLALFVHVVEAGSLTAGAGRAHLALASASARIKGMEDLLGAALLERGRRGVSPT
CCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
PAGRMVLHHARVVLDQMERLRGDLGGFSRGWRGVVRLAANTAAVTGALADDLGPFLRDQP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LIDVDLSERTSARIIAALAEGAVDLGIVSDAVEAGGLQARPYRRDRLVVVMAPDHPLAAC
CEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHH
AELSFARVLAEDGVGLGEGAALQDYLERQARRLGLSPRLRVRLRGFEAVCRLVAQGIGLA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEE
VIPEDAARRAGAAVAQVPLAEPWATRVLLVRARDFATLAPPARRLADHLAPPFP
EECCHHHHHHCCHHHCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]