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The map label for this gene is prs [H]

Identifier: 83591984

GI number: 83591984

Start: 766783

End: 767715

Strand: Direct

Name: prs [H]

Synonym: Rru_A0645

Alternate gene names: 83591984

Gene position: 766783-767715 (Clockwise)

Preceding gene: 83591983

Following gene: 83591985

Centisome position: 17.62

GC content: 63.99

Gene sequence:

>933_bases
ATGAAGATCCTGGCCTGCAACAGCAATCGCCCGCTTGCCGAGGCGATCGCTACCTATCTCAACCTCGAGCTGACCCATGC
GAGTGTCAGGCGGTTCAGCGACATGGAGGTCTGGGTAGAGATCCTCGAAAATGTGCGCGGCGAGGATGTGTTCGTGGTCC
AGTCGACCAGCTATCCGGCCAACGACCATTTGATGGAGACCCTGGTCACCCTTGATGCCCTCAAGCGCGGTTCGGCGCGT
CGGGTGACCGCCGTCATCCCCTATTTCGGCTACGCCCGTCAGGATCGCAAGACCGGCCCGCGCACCCCGATCACCGCCAA
GCTGGTTGCCAATCTCATCACCAGCGCCGGCGCCAACCGCGTGGTGACGCTGGATCTGCATTCCGGCCAGATCCAGGGCT
TCTTCGATATTCCTTTGGATAATCTCTACGCCGCCCCGGTGTTCTCCAAGCACATCATCGAGAACTTCAAGGGCACGCGG
CCGATGATCATTTCGCCCGATGTCGGCGGCGTGGTCCGCGCCCGTGAACTGGCCCGGCGGATCGAGGCCGATCTGGCGAT
CATCGACAAGCGGCGCGAGCGCGCCGGCGTGTCGGAGGTGATGAACATCATCGGCGACGTGCGCGGCCGCGATTGCATCC
TGGTCGATGACATCGTCGATTCCGCCGGCACGCTGTGCAACGCCGCCGTGGCCCTGAAGAACGCCGGCGCCACCTCGGTG
GCCGCCTATGTGACCCATGGCGTGCTTTCGGGCGGCGCCGTCGCCCGCGTCACCAGCTCGCCGCTCGACAGCCTGTGCAT
CACCGACAGCATTCAGGCGACGGAAGCCATGCGCCTTGCGCGCAATGTCCACCAGATTTCCATCGCGCCGCTGATGGCCG
AGGCCATGCGCCGGATCAGCCAGGAAGCCTCGGTGTCGAGCCTGTTCAACTAA

Upstream 100 bases:

>100_bases
GTTCGCGCCGGGCCTCCTGACAGCCGGCGCGTTTTTCCTCCCGTCCAACCACCATCGACCCGGCCCCTGACGCCGCCGCC
GTATTCCTGGAGAGCCCGGT

Downstream 100 bases:

>100_bases
GCCGACCGGCGGCGCCCGCCCCGCTGGCGGGCGCTTCCTTCTTTTTTTGTTTTTTCGATCCTTCCCCCAGACCTCGGAGA
CTCGCCGATGCCCGGAGCCA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKILACNSNRPLAEAIATYLNLELTHASVRRFSDMEVWVEILENVRGEDVFVVQSTSYPANDHLMETLVTLDALKRGSAR
RVTAVIPYFGYARQDRKTGPRTPITAKLVANLITSAGANRVVTLDLHSGQIQGFFDIPLDNLYAAPVFSKHIIENFKGTR
PMIISPDVGGVVRARELARRIEADLAIIDKRRERAGVSEVMNIIGDVRGRDCILVDDIVDSAGTLCNAAVALKNAGATSV
AAYVTHGVLSGGAVARVTSSPLDSLCITDSIQATEAMRLARNVHQISIAPLMAEAMRRISQEASVSSLFN

Sequences:

>Translated_310_residues
MKILACNSNRPLAEAIATYLNLELTHASVRRFSDMEVWVEILENVRGEDVFVVQSTSYPANDHLMETLVTLDALKRGSAR
RVTAVIPYFGYARQDRKTGPRTPITAKLVANLITSAGANRVVTLDLHSGQIQGFFDIPLDNLYAAPVFSKHIIENFKGTR
PMIISPDVGGVVRARELARRIEADLAIIDKRRERAGVSEVMNIIGDVRGRDCILVDDIVDSAGTLCNAAVALKNAGATSV
AAYVTHGVLSGGAVARVTSSPLDSLCITDSIQATEAMRLARNVHQISIAPLMAEAMRRISQEASVSSLFN
>Mature_310_residues
MKILACNSNRPLAEAIATYLNLELTHASVRRFSDMEVWVEILENVRGEDVFVVQSTSYPANDHLMETLVTLDALKRGSAR
RVTAVIPYFGYARQDRKTGPRTPITAKLVANLITSAGANRVVTLDLHSGQIQGFFDIPLDNLYAAPVFSKHIIENFKGTR
PMIISPDVGGVVRARELARRIEADLAIIDKRRERAGVSEVMNIIGDVRGRDCILVDDIVDSAGTLCNAAVALKNAGATSV
AAYVTHGVLSGGAVARVTSSPLDSLCITDSIQATEAMRLARNVHQISIAPLMAEAMRRISQEASVSSLFN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=46.9453376205788, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=45.9807073954984, Blast_Score=277, Evalue=9e-75,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=44.6601941747573, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=44.2307692307692, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=32.4561403508772, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI194018537, Length=338, Percent_Identity=32.8402366863905, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=32.6388888888889, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=32.6388888888889, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=32.6388888888889, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=32.6388888888889, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=51.7684887459807, Blast_Score=327, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=45.016077170418, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=45.016077170418, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=45.016077170418, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.9838187702265, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=34.0236686390533, Blast_Score=181, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=45.1612903225806, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=42.443729903537, Blast_Score=252, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=42.9487179487179, Blast_Score=245, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=40.3061224489796, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=40.3669724770642, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=45.016077170418, Blast_Score=270, Evalue=8e-73,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=41.9161676646707, Blast_Score=257, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=31.9088319088319, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=31.9088319088319, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=31.9088319088319, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=31.9088319088319, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24651462, Length=370, Percent_Identity=31.3513513513514, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24651464, Length=370, Percent_Identity=31.3513513513514, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45552010, Length=370, Percent_Identity=31.3513513513514, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33599; Mature: 33599

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILACNSNRPLAEAIATYLNLELTHASVRRFSDMEVWVEILENVRGEDVFVVQSTSYPA
CEEEEECCCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
NDHLMETLVTLDALKRGSARRVTAVIPYFGYARQDRKTGPRTPITAKLVANLITSAGANR
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
VVTLDLHSGQIQGFFDIPLDNLYAAPVFSKHIIENFKGTRPMIISPDVGGVVRARELARR
EEEEEECCCCCCEEEECCHHHEECCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHH
IEADLAIIDKRRERAGVSEVMNIIGDVRGRDCILVDDIVDSAGTLCNAAVALKNAGATSV
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
AAYVTHGVLSGGAVARVTSSPLDSLCITDSIQATEAMRLARNVHQISIAPLMAEAMRRIS
HHHHHHHHHCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEASVSSLFN
HHHHHHHHCC
>Mature Secondary Structure
MKILACNSNRPLAEAIATYLNLELTHASVRRFSDMEVWVEILENVRGEDVFVVQSTSYPA
CEEEEECCCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
NDHLMETLVTLDALKRGSARRVTAVIPYFGYARQDRKTGPRTPITAKLVANLITSAGANR
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
VVTLDLHSGQIQGFFDIPLDNLYAAPVFSKHIIENFKGTRPMIISPDVGGVVRARELARR
EEEEEECCCCCCEEEECCHHHEECCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHH
IEADLAIIDKRRERAGVSEVMNIIGDVRGRDCILVDDIVDSAGTLCNAAVALKNAGATSV
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
AAYVTHGVLSGGAVARVTSSPLDSLCITDSIQATEAMRLARNVHQISIAPLMAEAMRRIS
HHHHHHHHHCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEASVSSLFN
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA