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The map label for this gene is groEL

Identifier: 83591926

GI number: 83591926

Start: 696742

End: 698388

Strand: Direct

Name: groEL

Synonym: Rru_A0587

Alternate gene names: 83591926

Gene position: 696742-698388 (Clockwise)

Preceding gene: 83591925

Following gene: 83591932

Centisome position: 16.01

GC content: 63.93

Gene sequence:

>1647_bases
ATGGCTGCCAAGGACGTTAAATTCTCCACCGATGCCCGTGACCGTTTGCTGCGCGGCGTCGACATCCTGGCCAATGCGGT
CAAGGTGACGCTTGGCCCCAAGGGTCGCAATGTCGTGCTCGACAAGAGCTACGGCGCCCCGCGCATCACCAAGGACGGCG
TCTCCGTCGCCAAGGAAATCGAACTTAAGGACAAGTTCGAGAACATGGGCGCGCAGATGGTCAAGGAAGTCGCTTCCAAG
TCCGCTGACGTCGCCGGCGACGGCACCACCACCGCCACCGTGCTGGCCCAGGCCATCGTCCGCGAGGGCGTGAAGTCGGT
TGCCGCCGGCATGAACCCGATGGACCTCAAGCGCGGCATCGATCTCGCCGTTCTCGCCGTCGTCGAGGACGTCAAGAAGC
GCTCGAAGAAGATCAAGACCTCGGCCGAAGTCGCCCAGGTCGGCACCATCTCGGCCAATGGCGACGAGGAAGTCGGCAAG
ATCATCGCCACGGCGATGGAAAAGGTCGGCAACGAGGGTGTCATCACCGTCGAGGAAGCCAAGGGTCTGGACACCGAACT
CGACGTCGTCGAGGGCATGCAGTTCGACCGCGGCTACCTGTCGCCCTACTTCGTGACCAACGCCGAGAAGATGGTCGCCG
ATCTCGAGAACCCCTACATCCTTCTTCACGAGAAGAAGCTGTCGGGTCTTCAGGCTCTGCTGCCGGTGCTCGAGGCCGTC
GTTCAGTCGTCGCGCCCGCTGCTGATCATCGCCGAGGACGTCGAGGGCGAGGCCCTGGCCACCCTGGTCGTCAACAAGCT
GCGTGGTGGCCTGAAGGTCGCCGCCGTCAAGGCCCCGGGCTTTGGCGATCGTCGCAAGGCGATGCTCGAGGACATCGCCA
TCCTGACCGGTGGTCAGGTGATCAGCGAAGACCTGGGTATCAAGCTTGAGAACGTCACCATCGACATGCTTGGCACCGCC
AAGAAGGTGACGATCACCAAGGAAGAGACCACCCTGGTCGACGGCGCCGGCGACAAGAAGGACATCGAGGCCCGTTGCTC
GCAGATCCGCGCCAACATCGAAGACACCAGCAGCGATTACGATCGTGAGAAGCTGCAGGAGCGTCTGGCGAAGCTCGCCG
GCGGTGTCGCGGTGATCAAGGTCGGCGGTGCCACCGAGACCGAAGTGAAGGAAAAGAAGGACCGCGTGGACGACGCGATG
CACGCCACCCGTGCCGCCGTCGAAGAGGGTGTCGTCGCCGGTGGCGGTGTCGCTCTTCTGCACGCCATCCGCTCGCTCGA
CTCCGTGAAGGGTGCCAACCCCGATCAGAACGTCGGTATCGAGATCGTTCGCCGCGCCCTGCAGGCTCCGGTGCGTCAGA
TCGCCGAGAACGCCGGCGTTGACGGCGCCGTGGTCGCCGGCAAGCTGCTCGAGAACAGCGACACCGATTTCGGCTACAAC
GCCCAGACCGGCATCTACGAGAACCTGGTCACGGCCGGCGTGATCGATCCGACCAAGGTGGTCCGCGCTGCCCTTCAGGG
CGCCGCCTCCATCGCCGGTCTGCTGATCACCACCGAAGCGATGGTCGCCGAGATCCCCGAGAAGAAGGACGCCATGCCGT
CGCCCGATATGGGTGGCATGGGTGGCATGGGCGGCATGGGCTTCTAA

Upstream 100 bases:

>100_bases
ATCATGGGCATCGTCGCCTAACTGACGAAGCCTGTCCGCCCGATCTCCGGCTTAGTGAAGACCGGACATAGACGACGACG
TTACAGAGGAATTTCTGCAC

Downstream 100 bases:

>100_bases
GCCCAACCGCCTCTCGCCAAGCGCCAAAGGAAAGGGCCGTCTCCGCAAGGAGGCGGCCCTTTTCCATTGTGAGGGGGGGG
ATCAGAGCAAATCCCAAGCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAAKDVKFSTDARDRLLRGVDILANAVKVTLGPKGRNVVLDKSYGAPRITKDGVSVAKEIELKDKFENMGAQMVKEVASK
SADVAGDGTTTATVLAQAIVREGVKSVAAGMNPMDLKRGIDLAVLAVVEDVKKRSKKIKTSAEVAQVGTISANGDEEVGK
IIATAMEKVGNEGVITVEEAKGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILLHEKKLSGLQALLPVLEAV
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVTIDMLGTA
KKVTITKEETTLVDGAGDKKDIEARCSQIRANIEDTSSDYDREKLQERLAKLAGGVAVIKVGGATETEVKEKKDRVDDAM
HATRAAVEEGVVAGGGVALLHAIRSLDSVKGANPDQNVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLENSDTDFGYN
AQTGIYENLVTAGVIDPTKVVRAALQGAASIAGLLITTEAMVAEIPEKKDAMPSPDMGGMGGMGGMGF

Sequences:

>Translated_548_residues
MAAKDVKFSTDARDRLLRGVDILANAVKVTLGPKGRNVVLDKSYGAPRITKDGVSVAKEIELKDKFENMGAQMVKEVASK
SADVAGDGTTTATVLAQAIVREGVKSVAAGMNPMDLKRGIDLAVLAVVEDVKKRSKKIKTSAEVAQVGTISANGDEEVGK
IIATAMEKVGNEGVITVEEAKGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILLHEKKLSGLQALLPVLEAV
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVTIDMLGTA
KKVTITKEETTLVDGAGDKKDIEARCSQIRANIEDTSSDYDREKLQERLAKLAGGVAVIKVGGATETEVKEKKDRVDDAM
HATRAAVEEGVVAGGGVALLHAIRSLDSVKGANPDQNVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLENSDTDFGYN
AQTGIYENLVTAGVIDPTKVVRAALQGAASIAGLLITTEAMVAEIPEKKDAMPSPDMGGMGGMGGMGF
>Mature_547_residues
AAKDVKFSTDARDRLLRGVDILANAVKVTLGPKGRNVVLDKSYGAPRITKDGVSVAKEIELKDKFENMGAQMVKEVASKS
ADVAGDGTTTATVLAQAIVREGVKSVAAGMNPMDLKRGIDLAVLAVVEDVKKRSKKIKTSAEVAQVGTISANGDEEVGKI
IATAMEKVGNEGVITVEEAKGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILLHEKKLSGLQALLPVLEAVV
QSSRPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVTIDMLGTAK
KVTITKEETTLVDGAGDKKDIEARCSQIRANIEDTSSDYDREKLQERLAKLAGGVAVIKVGGATETEVKEKKDRVDDAMH
ATRAAVEEGVVAGGGVALLHAIRSLDSVKGANPDQNVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLENSDTDFGYNA
QTGIYENLVTAGVIDPTKVVRAALQGAASIAGLLITTEAMVAEIPEKKDAMPSPDMGGMGGMGGMGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=54.3396226415094, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=54.3396226415094, Blast_Score=573, Evalue=1e-163,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=67.7966101694915, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=53.4090909090909, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI193210679, Length=239, Percent_Identity=49.3723849372385, Blast_Score=225, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.0836501901141, Blast_Score=585, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=55.2182163187856, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=55.2182163187856, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=51.6190476190476, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=51.6190476190476, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=51.6190476190476, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17864606, Length=545, Percent_Identity=44.954128440367, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=37.4291115311909, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=37.4291115311909, Blast_Score=338, Evalue=4e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_RHORT (Q2RWV4)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425678.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2RWV4
- SMR:   Q2RWV4
- STRING:   Q2RWV4
- GeneID:   3834477
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0587
- NMPDR:   fig|1085.1.peg.1753
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- PhylomeDB:   Q2RWV4
- ProtClustDB:   PRK12849
- BioCyc:   RRUB269796:RRU_A0587-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57637; Mature: 57506

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSTDARDRLLRGVDILANAVKVTLGPKGRNVVLDKSYGAPRITKDGVSVAKEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELKDKFENMGAQMVKEVASKSADVAGDGTTTATVLAQAIVREGVKSVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DLAVLAVVEDVKKRSKKIKTSAEVAQVGTISANGDEEVGKIIATAMEKVGNEGVITVEEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCC
KGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILLHEKKLSGLQALLPVLEAV
CCCCCHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVTIDMLGTAKKVTITKEETTLVDGAGDKKDIEARCSQIRANIEDTSSDY
HHHHHCEEEEEEEEEEECCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
DREKLQERLAKLAGGVAVIKVGGATETEVKEKKDRVDDAMHATRAAVEEGVVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
HAIRSLDSVKGANPDQNVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLENSDTDFGYN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
AQTGIYENLVTAGVIDPTKVVRAALQGAASIAGLLITTEAMVAEIPEKKDAMPSPDMGGM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
GGMGGMGF
CCCCCCCC
>Mature Secondary Structure 
AAKDVKFSTDARDRLLRGVDILANAVKVTLGPKGRNVVLDKSYGAPRITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELKDKFENMGAQMVKEVASKSADVAGDGTTTATVLAQAIVREGVKSVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DLAVLAVVEDVKKRSKKIKTSAEVAQVGTISANGDEEVGKIIATAMEKVGNEGVITVEEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCC
KGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILLHEKKLSGLQALLPVLEAV
CCCCCHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVTIDMLGTAKKVTITKEETTLVDGAGDKKDIEARCSQIRANIEDTSSDY
HHHHHCEEEEEEEEEEECCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
DREKLQERLAKLAGGVAVIKVGGATETEVKEKKDRVDDAMHATRAAVEEGVVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
HAIRSLDSVKGANPDQNVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLENSDTDFGYN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
AQTGIYENLVTAGVIDPTKVVRAALQGAASIAGLLITTEAMVAEIPEKKDAMPSPDMGGM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
GGMGGMGF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA