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The map label for this gene is pepB [H]

Identifier: 83591478

GI number: 83591478

Start: 161613

End: 163004

Strand: Direct

Name: pepB [H]

Synonym: Rru_A0138

Alternate gene names: 83591478

Gene position: 161613-163004 (Clockwise)

Preceding gene: 83591477

Following gene: 83591479

Centisome position: 3.71

GC content: 70.4

Gene sequence:

>1392_bases
TTGCTCGATACCCTGATCCTGGCCGCCGCGGGCGGCGCCCCCATTCCCCTTCATCCCGTGACCAAGGCTGGCTGCAAGGC
TTGGTTGTCGGGGCTTGATGCCACGGCCCGGCGGTGGGCCGAGGGGCAAGGCTTCGACGCGGCGCAAGGGACGGTGCTGT
CCCTGCCCGCCGCCGATGGCGCCATCGCCGCCGCCGCCGTGGGCCTGGGCGAGGGGGATGACCCTTACGCCTTCTCGTCG
GCCGCGAGCGCCCTGCCGCCCGGCGATTATCAGTTGGAAACCGCTTCTCTGCCCGCCGGTTGGGCGGCGGAGGCCGCCCT
GGCCTGGGCCCTCGGCACCTATCGCTTCGGCCGCTATCGTCCGACTCTCGCCGAAGGTCCGCGCCCCCGGCTGGTCTGGC
CGGTCGGCGCCGATCGCGCGCGGGTGGAACGGCTGATCACGGCGATCGGTCTGGTGCGCGATCTGGTCAATACCCCCGCC
GAGGATATGGGGCCGGCCGAACTGGCCAAGGCGGCGGGCGACCTTGCCGCCGCCCATGGCGCCACGCTCTCCGTCCTCGT
CGGCGAGGAGTTGCGAACGGCCAATTATCCCCTGATCCATGCCGTCGGCCGGGCCAGCAGCCGGGCGCCCCGGCTGATCG
ATCTGACCTGGGGCGATCCCGGCCACCCCGGCGTGACCCTGGTCGGCAAGGGCGTGTGCTTTGACAGCGGCGGCCTTGAT
CTCAAACCCTCGGCCGGCATGCGGCTGATGAAAAAGGATATGGGCGGCGCCGCCCATGTTCTGGGGCTGGCCGCCCTGAT
CATGGGCCAGAAGTTGCCGGTACGCCTGAGGGTGCTGATCCCGGCGGTGGATAATGCGGTGGCCGGCAACGCCTTTCGCC
CCGGCGATATCCTGACCGCGCGCAATGGGTTGAGCGTCGAGATCGGCAATACGGATGCCGAGGGCCGCTTGGTTCTGGCC
GATGCCCTGGCCGAGGCCTGCGCCGGCGCGCCCGATCTGCTGATCGATTGCGCCACCCTGACCGGGGCGGCCCGCGTTGC
CCTGGGGCCGGATCTACCGGCGCTTTTTTGCGATGACGACGCCTTGGTCGAGGACCTGCTGGCCCAGACCCGCATCACCC
GCGATCCGCTGTGGCGGATGCCGTTATGGGCGCCCTATCGGCGGATGCTCGACAGCAAGGTCGCCGATCTGACCAACGCG
CCCGATGGATCCTTCGCCGGAGCGATCACGGCGGCGCTGTTCCTCAAGGCTTTCGTCGATCCCGAGGTGCGCTGGCTTCA
TCTTGACCTCTTCGCCTGGCAACCCGCCGCCCGGCCCGGACGGCCCGAAGGCGGCGCCGCCCAGGGCCTGCGCGCCCTGA
TGGGACTGATCGAGACGCGGTTCGGCCGGTAG

Upstream 100 bases:

>100_bases
CCCCTCCATCCCGGGGCCATGCGCTATTATCGGAAAGAAGGCATCATCGACCGGCCTGGTCCGATGCAGCCCTGATCTTT
TTTGCGGAGTTTTTCCCGTC

Downstream 100 bases:

>100_bases
AGAAAAGAATCTTTCGCGCCAAAAGCGTGTTTTCAAGTAAAGAAAAGGCTTTGATGTAAATGCAATTGTTTTGGTGCGGT
GCGCGGAAGGCTGGGCATGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLDTLILAAAGGAPIPLHPVTKAGCKAWLSGLDATARRWAEGQGFDAAQGTVLSLPAADGAIAAAAVGLGEGDDPYAFSS
AASALPPGDYQLETASLPAGWAAEAALAWALGTYRFGRYRPTLAEGPRPRLVWPVGADRARVERLITAIGLVRDLVNTPA
EDMGPAELAKAAGDLAAAHGATLSVLVGEELRTANYPLIHAVGRASSRAPRLIDLTWGDPGHPGVTLVGKGVCFDSGGLD
LKPSAGMRLMKKDMGGAAHVLGLAALIMGQKLPVRLRVLIPAVDNAVAGNAFRPGDILTARNGLSVEIGNTDAEGRLVLA
DALAEACAGAPDLLIDCATLTGAARVALGPDLPALFCDDDALVEDLLAQTRITRDPLWRMPLWAPYRRMLDSKVADLTNA
PDGSFAGAITAALFLKAFVDPEVRWLHLDLFAWQPAARPGRPEGGAAQGLRALMGLIETRFGR

Sequences:

>Translated_463_residues
MLDTLILAAAGGAPIPLHPVTKAGCKAWLSGLDATARRWAEGQGFDAAQGTVLSLPAADGAIAAAAVGLGEGDDPYAFSS
AASALPPGDYQLETASLPAGWAAEAALAWALGTYRFGRYRPTLAEGPRPRLVWPVGADRARVERLITAIGLVRDLVNTPA
EDMGPAELAKAAGDLAAAHGATLSVLVGEELRTANYPLIHAVGRASSRAPRLIDLTWGDPGHPGVTLVGKGVCFDSGGLD
LKPSAGMRLMKKDMGGAAHVLGLAALIMGQKLPVRLRVLIPAVDNAVAGNAFRPGDILTARNGLSVEIGNTDAEGRLVLA
DALAEACAGAPDLLIDCATLTGAARVALGPDLPALFCDDDALVEDLLAQTRITRDPLWRMPLWAPYRRMLDSKVADLTNA
PDGSFAGAITAALFLKAFVDPEVRWLHLDLFAWQPAARPGRPEGGAAQGLRALMGLIETRFGR
>Mature_463_residues
MLDTLILAAAGGAPIPLHPVTKAGCKAWLSGLDATARRWAEGQGFDAAQGTVLSLPAADGAIAAAAVGLGEGDDPYAFSS
AASALPPGDYQLETASLPAGWAAEAALAWALGTYRFGRYRPTLAEGPRPRLVWPVGADRARVERLITAIGLVRDLVNTPA
EDMGPAELAKAAGDLAAAHGATLSVLVGEELRTANYPLIHAVGRASSRAPRLIDLTWGDPGHPGVTLVGKGVCFDSGGLD
LKPSAGMRLMKKDMGGAAHVLGLAALIMGQKLPVRLRVLIPAVDNAVAGNAFRPGDILTARNGLSVEIGNTDAEGRLVLA
DALAEACAGAPDLLIDCATLTGAARVALGPDLPALFCDDDALVEDLLAQTRITRDPLWRMPLWAPYRRMLDSKVADLTNA
PDGSFAGAITAALFLKAFVDPEVRWLHLDLFAWQPAARPGRPEGGAAQGLRALMGLIETRFGR

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=369, Percent_Identity=34.4173441734417, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI47155554, Length=394, Percent_Identity=31.9796954314721, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI87082123, Length=340, Percent_Identity=44.1176470588235, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1790710, Length=382, Percent_Identity=34.2931937172775, Blast_Score=175, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=286, Percent_Identity=35.6643356643357, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=226, Percent_Identity=31.858407079646, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355725, Length=300, Percent_Identity=32.6666666666667, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24661038, Length=300, Percent_Identity=32.6666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20129969, Length=286, Percent_Identity=31.4685314685315, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24662227, Length=286, Percent_Identity=29.7202797202797, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221379063, Length=291, Percent_Identity=34.020618556701, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221379062, Length=291, Percent_Identity=34.020618556701, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357381, Length=294, Percent_Identity=34.3537414965986, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21355645, Length=347, Percent_Identity=27.6657060518732, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24662223, Length=347, Percent_Identity=27.6657060518732, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI19922386, Length=297, Percent_Identity=27.6094276094276, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161077148, Length=350, Percent_Identity=28.8571428571429, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI20130057, Length=350, Percent_Identity=28.8571428571429, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI20129963, Length=343, Percent_Identity=25.3644314868805, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646701, Length=203, Percent_Identity=33.9901477832512, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=203, Percent_Identity=33.9901477832512, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=203, Percent_Identity=33.9901477832512, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 48126; Mature: 48126

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTLILAAAGGAPIPLHPVTKAGCKAWLSGLDATARRWAEGQGFDAAQGTVLSLPAADG
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEECCCCCC
AIAAAAVGLGEGDDPYAFSSAASALPPGDYQLETASLPAGWAAEAALAWALGTYRFGRYR
CHHHHHEECCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
PTLAEGPRPRLVWPVGADRARVERLITAIGLVRDLVNTPAEDMGPAELAKAAGDLAAAHG
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
ATLSVLVGEELRTANYPLIHAVGRASSRAPRLIDLTWGDPGHPGVTLVGKGVCFDSGGLD
CEEEEEECCHHHCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCC
LKPSAGMRLMKKDMGGAAHVLGLAALIMGQKLPVRLRVLIPAVDNAVAGNAFRPGDILTA
CCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHCCCCCCCCCEEEE
RNGLSVEIGNTDAEGRLVLADALAEACAGAPDLLIDCATLTGAARVALGPDLPALFCDDD
CCCCEEEECCCCCCCCEEEHHHHHHHHCCCCHHEEEHHHHCCCEEEEECCCCCEEEECCH
ALVEDLLAQTRITRDPLWRMPLWAPYRRMLDSKVADLTNAPDGSFAGAITAALFLKAFVD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PEVRWLHLDLFAWQPAARPGRPEGGAAQGLRALMGLIETRFGR
CCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDTLILAAAGGAPIPLHPVTKAGCKAWLSGLDATARRWAEGQGFDAAQGTVLSLPAADG
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEECCCCCC
AIAAAAVGLGEGDDPYAFSSAASALPPGDYQLETASLPAGWAAEAALAWALGTYRFGRYR
CHHHHHEECCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
PTLAEGPRPRLVWPVGADRARVERLITAIGLVRDLVNTPAEDMGPAELAKAAGDLAAAHG
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
ATLSVLVGEELRTANYPLIHAVGRASSRAPRLIDLTWGDPGHPGVTLVGKGVCFDSGGLD
CEEEEEECCHHHCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCC
LKPSAGMRLMKKDMGGAAHVLGLAALIMGQKLPVRLRVLIPAVDNAVAGNAFRPGDILTA
CCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHCCCCCCCCCEEEE
RNGLSVEIGNTDAEGRLVLADALAEACAGAPDLLIDCATLTGAARVALGPDLPALFCDDD
CCCCEEEECCCCCCCCEEEHHHHHHHHCCCCHHEEEHHHHCCCEEEEECCCCCEEEECCH
ALVEDLLAQTRITRDPLWRMPLWAPYRRMLDSKVADLTNAPDGSFAGAITAALFLKAFVD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PEVRWLHLDLFAWQPAARPGRPEGGAAQGLRALMGLIETRFGR
CCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA